A*STAR Patents

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Publication Number Title Abstract
WO2019139541A1 Method and system for in vivo detection of adipose tissue browning Provided are a system and a method for in vivo detection of adipose tissue browning. The system includes a fiber probe configured to illuminate light on an adipose tissue site; a spectrometer configured to obtain diffuse reflectance spectrum information from the adipose tissue site; a chromophore measure determining module configured to determine a fraction of lipid chromophore with respect to lipid chromophore and water chromophore based on spectrally unmixing the diffuse reflectance spectrum information in a region of 1050 nm to 1400 nm; and a browning detector module configured to detect adipose tissue browning based on the fraction determined above.
US20190216702A1 Use of Polyamines in Compositions and Methods for Inducing or Promoting Skin Darkening and Regulating Melanogenesis The present disclosure provides a method of inducing or promoting darkening of the skin and/or melanogenesis, a method of treating a skin condition or disorder, in particular hypopigmentation, comprising administration of a polycationic aliphatic amine, wherein said polycationic aliphatic amine preferably is putrescine, spermidine and spermine. The invention further includes corresponding methods of reducing or preventing darkening of skin and/or melanogenesis, or related methods of treating a skin condition or disorder, comprising administration of at least an inhibitor of polycationic aliphatic amine transport or synthesis, wherein said inhibitor is preferably trimer44NMe or difluoromethylornithine (DFMO) respectively.
US10350172 Stimuli-responsive interpolymer complex coated hollow silica vesicles A porous hollow silica particle with an interpolymer complex immobilized thereon is provided. The interpolymer complex comprises a first polymer immobilized to a surface of the silica particle, and a second polymer complexed with the first polymer. Pharmaceutical compositions comprising the silica particle, and methods of forming the silica particle are also provided.
WO2019135714A1 Water-dispersible conducting poly(azulene-co-3,4-ethylenedioxythiophene), preparation method and uses thereof The present disclosure provides for (i) a water-dispersible and electrically conductive copolymer formed by polymerizing at least one optionally substituted azulene and at least one optionally substituted 3,4-ethylenedioxythiophene, wherein each of the at least one optionally substituted azulene and the at least one optionally substituted 3,4- ethylenedioxythiophene is in a monomeric form, oligomeric form, or polymeric form, and (ii) a polymeric composite comprising such a copolymer, and a dispersant comprising polystyrene sulfonate, wherein the polystyrene sulfonate forms an ionic interaction with the at least one optionally substituted azulene of the copolymer. The present disclosure also provides for a method of synthesizing the polymeric composite.
WO2019135711A1 A fire extinguishing formulation for dry powder fire-extinguishers and method of producing the formulation The present disclosure provides for a formulation for use in a dry powder fire extinguisher. The formulation comprises a carrier fluid and a fire-retardant intumescent silicate material disposed in the carrier fluid, wherein the fire-retardant material comprises water glass and colloidal silica, wherein the water glass and the colloidal silica are different materials. The present disclosure also provides for a fire extinguishing composition comprising the formulation for use in a dry powder fire extinguisher. The present disclosure further provides for a method of producing the formulation. The method comprises providing a liquid mixture comprising mixing colloidal silica and water glass to form a fire-retardant intumescent silicate material in a liquid mixture, wherein the water glass and the colloidal silica are different materials, drying the liquid mixture to obtain the fire-retardant intumescent silicate material, and disposing the fire-retardant intumescent silicate material in a carrier fluid to form the formulation.
US20190214736A1 Antenna, assembly, and methods of forming the same Various embodiments may relate to an antenna. The antenna may include a ridge reflector arranged along a plane. The ridge reflector may be configured to enhance an emission of at least one electromagnetic wave source providing an electromagnetic wave signal to the antenna and further configured to direct the electromagnetic wave signal in a direction at least substantially perpendicular to the plane. The ridge reflector may define a space along the plane for allowing the electromagnetic wave signal to be directed in the direction at least substantially perpendicular to the plane. The ridge reflector may include at least one of a dielectric material and a semiconductor material.
EP3506910A1 Method of treating cancer by antisense oligonucleotides targeting prdm15 The present invention relates to antisense oligonucleotides for modulating the activity of PRDM15 and use thereof in the treatment of cancer. In particular, said antisense oligonucleotides are capable of inducing the skipping of an exon of a PRDM15 mRNA. The present invention also relates to a method for determining prognosis in a patient with cancer, or selecting a therapeutic strategy for a patient with cancer, by assessing the level of PRDM15 nucleic acid, protein or activity in a sample.
EP3507601A1 Methods for the identification, targeting and isolation of human dendritic cell (DC) precursors "pre-dc" and their uses thereof Biomarkers for the detection and identification of a precursor of conventional dendritic cell (cDC) (pre-DC) and its cell subsets (pre-cDC1 or pre-cDC2), are defined, which include CD169, CD327, AXL, CD271, CD324 and combinations thereof for detecting pre-DCs. Methods for detecting a disease or condition, prognosis of an existing disease or condition comprising determining the number of pre-DC cells in sample from a subject as compared to control, as well as methods of treating a patient comprising administration of antibodies against CD169, CD327, AXL, CD271, CD324 and combinations thereof are also disclosed. In addition, an immunogenic composition comprising one or more binding molecules specific for one or more biomarkers or antigen of a target disease and/or one or more cells selected from the group consisting of early pre-DC, pre-cDC1 and pre-cDC2 are also disclosed for eliciting an immune response against an infectious disease or cancer.
CN109997178A Computer system for alerting emergency services A computer system for alerting emergency services is disclosed. The system includes: at least one monitoring device; at least one physical symptom device, each body symptom device being a motion sensor device, an image capture device, or an audio sink device; a transmitter; a processor; and a memory. Memory storage: a predetermined baseline for one or more vital signs of the patient; at least one baseline of physical symptoms, each baseline of physical symptoms corresponding to the device of the at least one physical symptom device and being a predetermined baseline motion, a predetermined baseline of facial features of the patient Arrange, or schedule, baseline speech. The memory also stores instructions that, when executed by the processor, cause: the at least one monitoring device measures one or more vital signs of the patient; the processor compares the vital signs to respective predetermined baselines of one or more vital signs; And if the measured vital signs exceed a predetermined baseline, detecting one or more physical symptoms corresponding to at least one baseline of physical symptoms by causing the motion sensor device to measure motion of one or more arms of the patient; The capture device images the facial arrangement of the patient's face, and/or the audio receiver device listens to the patient's voice. The instructions further cause the processor to compare one or more physical symptoms to a corresponding baseline of physical symptoms; and if the at least one physical symptom of the one or more physical symptoms deviates from the corresponding physical symptom, using the transmitter to initiate an emergency Service contact.
US10344301 Mutants of the bacteriophage lambda integrase The present invention refers to lambda integrases comprising at least one amino acid mutation at positions 43, 319 and 336 of the lambda integrase as set forth in SEQ ID NO: 1. The invention further refers to nucleic acid molecules comprising the nucleotide sequence encoding the mutant lambda integrase and to host cells containing these nucleic acid molecules. The invention also refers to methods of recombining a nucleic acid of interest into a target nucleic acid in the presence of the mutant lambda integrase and sequence specific recombination kits.
CN106461676B Method for predicting toxicity of compounds based on nuclear factor kappa B translocation A method of screening for toxicity of a compound is provided. The method comprises contacting a test compound with a test cell population, the nuclear factor (NF)-κB in the test cell population is not activated prior to exposure; determining the nuclear localization level of NF-κB in the test population after contact; and The nuclear localization levels of NF-κB in the control group exposed to the compounds were compared. An increase in the nuclear localization level of NF-κB in the test population relative to the control population indicates that the test compound damages the cells and/or induces a pro-inflammatory response and is therefore toxic to the cell types used in the method.
WO2019132782A1 Compounds for treating eye diseases and methods thereof A compound of formula (I) or a salt, solvate or prodrug thereof: wherein R1 and R4 are independently selected from C1-C5 alkyl, C1-C5 haloalkyl, C1-C5 alkenyl, C1-C5 haloalkenyl, C1-C5 alkynyl, C1-C5 haloalkynyl, C1-C5 alkoxy or C1-C5 haloalkoxy; R2 is an optionally substituted heteroaryl selected from optionally substituted tetrazolyl or optionally substituted imidazopyridinyl; and R3 is selected from H or optionally substituted alkyl.
WO2019132783A1 Method for assessing slip resistance of a surface Disclosed herein is method for assessing slip resistance of a surface. The method comprises capturing a plurality of images of the surface; determining a micro-facet normal distribution from the plurality of images; and constructing a one-dimensional (1-D) specular reflectance profile of the surface from the micro-facet normal distribution. One or more surface roughness properties is then inferred from the 1D specular reflectance profile.
WO2019132768A1 Alert versus fatigue discriminator Described is a computer system for establishing an electroencephalogram (EEG) model for discriminating between alert and fatigue states. The computer system comprises a receiver module for receiving an alert state segment and one or more EEG fatigue data of at least one subject, a segment selector for selecting one of the one or more fatigue data segments, an EEG classifier trainer for training an EEG classifier by extracting an EEG feature space from the alert state segment and assumed maximum fatigue segment, and a maximum fatigue identifier module for identifying a segment of maximum fatigue by applying the EEG classifier to each of the fatigue data segments. The computer system further comprises a segment comparator for determining if the segment of maximum fatigue is consistent with the assumed maximum fatigue segment and a limit setter for setting the segment of maximum fatigue as a revised assumed maximum fatigue segment.
WO2019132764A1 Tracing traffic in the internet A traceback solution is provided. For a network of autonomous systems, the traceback solution traces the autonomous system path taken by traffic flows. Every link in the traceback path is created, verified, and audited by autonomous systems. Multiple autonomous systems may take part in the process, making the system robust against fake information. The database used to store the validated traceback paths is a decentralized and distributed storage. Multiple copies of the database may be maintained by the network of autonomous systems. The database may be accessible by any participating autonomous system; and is not accessible from outside the network of autonomous systems. The traceback solution achieves both validation and non-repudiation property among the ASes. The traceback solution mitigates some important attack scenarios that might be targeted specifically at the traceback solution.
US20190207424A1 Synchronized time-division wireless power transfer for multiple voltage applications A wirelessly powered implantable medical device, a system for synchronized time-division wireless power transfer, and a method for closed-loop carrier waveform adaption for wireless power control are provided. The system for synchronized time-division wireless power transfer includes a wireless transmitter for generating and transmitting time-division wireless power transfer signals and a wirelessly powered device. The wirelessly powered device includes a wireless receiver for receiving the time-division wireless power transfer signals and a time division switching module. The time division switching module is coupled to the wireless receiver and generates multiple supply voltages synchronized to the time-division wireless power transfer signals for powering different circuitry of the wirelessly powered device.
CN109952096A Use of polyamines in compositions and methods for inducing or promoting skin blackening and regulating melanogenesis The present disclosure provides a method of inducing or promoting darkening of the skin and/or melanogenesis, a method of treating a skin condition or disorder, in particular hypopigmentation, comprising administration of a polycationic aliphatic amine, wherein said polycationic aliphatic amine preferably is putrescine, spermidine and spermine. The invention further includes corresponding methods of reducing or preventing darkening of skin and/or melanogenesis, or related methods of treating a skin condition or disorder, comprising administration of at least an inhibitor of polycationic aliphatic amine transport or synthesis, wherein said inhibitor is preferably trimer44NMe or difluoromethylornithine (DFMO) respectively.
WO2019125308A1 2 dimensional variable line spacing grating based optical spectrometer This invention relates to a spectrometer comprising a 2 dimensional detector and a 2 dimensional grating. The 2 dimensional detector is adapted to capturing multiple spectra within a lower resolution broad range (LRBR) and a higher resolution broad range (HRBR) simultaneously. The 2 dimensional grating has grooves with variable groove density and period function. The groove density G(z) and period function d(y, z) are adaptable to focus incident EUV/X-ray source from a slit onto the 2 dimensional detector where z is a direction along the grooves and y is a direction across the grooves.
WO2019125305A1 Location-based wireless communication access over a satellite communication network A number of Satellite VDES MAC protocols are provided. The Satellite VDES MAC protocol provides a significant improvement in the overall throughput in the satellite communication system. In one aspect, a method, a computer readable medium, and an apparatus for wireless communication are provided. The apparatus may determine a geographical location of a terrestrial vessel. The apparatus may determine a subset of time slots in a frame of an uplink communication channel based on the geographical location. The apparatus may select at least one candidate time slot from the subset of time slots. The apparatus may transmit a message using the at least one candidate time slot.
US20190194309A1 Macrophage stimulating protein receptor (or RON - recepteur d' origine nantais) antibodies and uses thereof Disclosed are monoclonal antibodies that bind specifically to macrophage stimulating protein receptor (or RON—Recepteur d' Origine Nantais). Also provided are the chimeric antigen receptors, bispecific antibodies, bivalent antibodies and biTE thereof, as well as pharmaceutical compositions and uses of said antibodies for the treatment of cancer and fibrosis and an ex vivo method of evaluating the status of a cancer patient using said antibodies. In particular, two monoclonal antibodies, 7G8 and 6D4, demonstrating good therapeutic efficacy in inhibiting tumour growth in human xenograft mice models and sensitivity in human xenograft mouse tumour imaging models are provided.
EP2855502B1 Methods for reducing levels of protein-contaminant complexes and aggregates in protein preparations by treatment with electropositive organic additives Methods for reduction of aggregate levels in antibody and other protein preparations through treatment with low concentrations of electropositive organic additives (e.g., ethacridine, chlorhexidine, or polyethylenimine) in combination with ureides (e.g., urea, uric acid, or allantoin) or organic modulators (e.g., nonionic organic polymers, surfactants, organic solvent or ureides). Some aspects of the invention relate to methods for reducing the level of aggregates in conjunction with clarification of cell culture harvest. It further relates to the integration of these capabilities with other purification methods to achieve the desired level of final purification.
US10332266 Method and device for traffic sign recognition Embodiments provide a method for recognizing a traffic sign from an input image. The method may include extracting image features from the input image; modifying the image features based on a predetermined image saliency map to determine modified image features; determining a plurality of traffic sign candidates by applying an adaptive boosting algorithm on the modified image features; determining a confidence score for each traffic sign candidate by applying a support vector regression algorithm; and recognizing a traffic sign based on the confidence score for each traffic sign candidate.
US10329322 Methods for reducing aggregate content of protein preparations by treatment with aryl anions A method of reducing the aggregate content in a preparation having a target protein includes contacting the preparation with an aryl anion to form a mixture and contacting the mixture with at least one electropositive solid to remove excess aryl anion.
CN109923129A Macrophage stimulating protein receptor (or RON-Recepteur d, Origina Nantais) antibody and use thereof Disclosed are monoclonal antibodies that bind specifically to macrophage stimulating protein receptor (or RON—Recepteur d' Origine Nantais). Also provided are the chimeric antigen receptors, bispecific antibodies, bivalent antibodies and biTE thereof, as well as pharmaceutical compositions and uses of said antibodies for the treatment of cancer and fibrosis and an ex vivo method of evaluating the status of a cancer patient using said antibodies. In particular, two monoclonal antibodies, 7G8 and 6D4, demonstrating good therapeutic efficacy in inhibiting tumour growth in human xenograft mice models and sensitivity in human xenograft mouse tumour imaging models are provided.
CN109922823A Diagnosis and treatment of pre-eclampsia The invention relates to an ELABELA polypeptide or nucleic acid for use in the treatment, alleviation or prophylaxis of pre-eclampsia in an individual. In another aspect of the invention, there is provided a method of diagnosing or detecting the susceptibility of an individual to pre-eclampsia, wherein the method comprises detecting modulation, preferably down -regulation of expression, amount or activity of ELABELA.
CN105992767B WNT pathway regulator The present invention relates to dihydropyrazolo[l,5-a]pyrimidine compounds of formula I, defined herein, as WNT pathways modulators, processes for making them, and pharmaceutical compositions comprising them. Methods of treatment of conditions mediated by WNT pathway signalling including cancer, fibrosis, stem cell and diabetic retinopathy, rheumatoid arthritis, psoriasis and myocardial infarction, comprising the compounds of formula I are also provided.
US20190185564A1 Anti-TIM-3 Antibodies Anti-TIM-3 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.
US20190185478A1 Wnt pathway modulators The present invention relates to compounds of formula (I),_x000D_
  • combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein
  • R1 represents H; optionally substituted alkyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkoxy, NH2, —NHC1-3alkyl and —N(C1-3alkyl)2); —C(O)Oalkyl; haloalkyl; haloalkoxy; or -alkylaryl;
  • each R2 independently represents H; optionally substituted alkyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkoxy, NH2, —NHC1-3alkyl and —N(C1-3alkyl)2); -alkylaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, —C(O)OC1-6alkyl, —C(O)C1-6alkyl and —C(O)NHC1-6alkyl); —NHalkyl; —N(alkyl)2; amino; hydroxyl; alkoxy or halo;
  • n represents 0, 1 or 2;
  • R3 represents H or alkyl;
  • R4 represents H or alkyl;
  • R5 represents H or alkyl;
  • W and X each independently represent C═O; C═S; or CH2;
  • Y represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, —C(O)OC1-6alkyl, —C(O)C1-6alkyl and —C(O)NHC1-6alkyl); and
  • Z represents optionally substituted alkyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkoxy, NH2, —NHC1-3alkyl and —N(C1-3alkyl)2); aryl; heteroaryl; -alkylaryl;-alkylheteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, —C(O)OC1-6alkyl, —C(O)C1-6alkyl and —C(O)NHC1-6alkyl); -alkylcarbocyclyl wherein carbocyclyl is optionally substituted (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkoxy and halo); -alkylheterocyclyl wherein heterocyclyl is optionally substituted (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, —C(O)OC1-6alkyl, —C(O)C1-6alkyl and —C(O)NHC1-6alkyl); -arylcarbocyclyl wherein carbocyclyl is optionally substituted (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkoxy and halo); or -arylheterocyclyl wherein heterocyclyl is optionally substituted (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, —C(O)OC1-6alkyl, —C(O)C1-6alkyl and —C(O)NHC1-6alkyl).
WO2019117807A1 Heparin and heparan sulphate oligosaccharides Isolated heparin or heparan sulphate oligosaccharide fragments having a chain length of at least 10 saccharides and no more than 50 saccharides, which are capable of binding BMP2, are disclosed. Also disclosed is the use of the same heparin or heparan sulphate oligosaccharide fragments in kits and pharmaceutical compositions, and the use of the same heparan sulphate oligosaccharide fragments in the repair and/or regeneration of connective tissue and bones, and the treatment of wounds.
WO2019117808A1 Laser system and method of forming the same Various embodiments may relate to a laser system. The laser system may include an oscillator, a first amplifier stage optically coupled to the oscillator, a gain equalizer stage optically coupled to the first amplifier stage, a pulse picker stage optically coupled to the gain equalizer stage, a second amplifier stage optically coupled to the pulse picker stage, and a third amplifier stage optically coupled to the second amplifier stage.
US20190187337A1 A method of forming nano-patterns on a substrate This application relates to a method of forming nano-patterns on a substrate comprising the step of forming a plurality of nanostructures on a dielectric substrate, wherein the nanostructures are dimensioned or spaced apart from each other by a scaling factor of the dielectric substrate with reference to a silicon substrate. There is also provided a method of forming a nano-patterned substrate comprising the step of forming a plurality of nanostructures on a dielectric substrate, wherein said dielectric substrate comprises an anti-reflectance layer disposed on a base substrate. There is also provided a method of forming a nano-patterned substrate comprising the steps of forming a plurality of nano structures on a dielectric substrate, wherein the dielectric substrate comprises an anti-reflectance layer disposed on a base substrate, wherein the nanostructures comprise a dielectric material, and wherein the nanostructures are dimensioned or spaced apart from each other by a scaling factor of the dielectric material with reference to a silicon substrate.
US20190185677A1 A Method for Forming a Titania-Coated Inorganic Particle A method of forming a titania-coated inorganic particle comprising the steps of (a) stirring a mixture of a titania precursor such as a titanium alkoxide and an inorganic particle such as a hollow glass particles in an organic solvent such as an alcohol for more than 1 h to cause adsorption of the titania precursor on the surface of the inorganic particle; and (b) adding water dropwise to the mixture under stirring to convert the titania precursor to titania which then forms a coating on the inorganic particle. A method for forming a paint formulation, a titania-coated inorganic particle, a paint formulation comprising a titania-coated inorganic particle and use of a titania-coated inorganic particle in a paint formulation is also described.
CN109906381A Method for identifying, targeting, and isolating human dendritic cell (DC) precursor "pre-DC" and its use Biomarkers for the detection and identification of a precursor of conventional dendritic cell (cDC) (pre-DC) and its cell subsets (pre-cDC1 or pre-cDC2), are defined, which include CD169, CD327, AXL, CD271, CD324 and combinations thereof for detecting pre-DCs. Methods for detecting a disease or condition, prognosis of an existing disease or condition comprising determining the number of pre-DC cells in sample from a subject as compared to control, as well as methods of treating a patient comprising administration of antibodies against CD169, CD327, AXL, CD271, CD324 and combinations thereof are also disclosed. In addition, an immunogenic composition comprising one or more binding molecules specific for one or more biomarkers or antigen of a target disease and/or one or more cells selected from the group consisting of early pre-DC, pre-cDC1 and pre-cDC2 are also disclosed for eliciting an immune response against an infectious disease or cancer.
US10323228 Differentiation of hepatocyte-like cells from stem cells Disclosed are methods of differentiating stem cells in order to obtain hepatocyte-like cells, the method comprising the steps of a) subjecting definitive endoderm to at least one epigenetic modulator to obtain hepatoblasts and b) subjecting the hepatoblasts to at least one stem cell differentiation pathway inhibitor to obtain hepatocyte-like cells; wherein steps a) and b) do not comprise the use of a growth factor. In one preferred embodiment, the epigenetic modulator may be sodium butyrate and/or DMSO and the stem cell differentiation pathway inhibitor may be SB431542 and/or DMSO. Also disclosed are hepatocyte-like cells obtained from the method and uses of these cells such as drug screening.
US10325176 Methods and systems for assessing retinal images, and obtaining information from retinal images A method of assessing the quality of an retinal image (such as a fundus image) includes selecting at least one region of interest within a retinal image corresponding to a particular structure of the eye (e.g. the optic disc or the macula), and a quality score is calculated in respect of the, or each, region-of-interest. Each region of interest is typically one associated with pathology, as the optic disc and the macula are. Optionally, a quality score may be calculated also in respect of the eye as a whole (i.e. over the entire image, if the entire image corresponds to the retina).
WO2019112520A1 Immune response profiling of tumor-derived exosomes for cancer diagnosis The present invention generally relates to the generation of tumour-derived exosome-induced immune response or cancer-specific response profile by isolating tumour-derived exosomes from blood sample of a patient having a specific cancer type, and measuring in vitro immunological impacts of tumour-derived exosomes on immune cells, in particular T cells. The tumour-derived exosome-induced immune response or cancer-specific response profile created can be used in methods for detecting or diagnosing cancer or cancer type in a subject and for identifying whether a subject having a cancer type is responding to treatment of that cancer type.
WO2019112521A1 An imprinted polymeric substrate The present invention relates to a method for preparing a plurality of imprints on an inner surface of a polymeric substrate comprising the steps of: a) contacting a liquid polymeric mixture with a mold having an imprint forming surface thereon; b) curing the liquid polymeric mixture of step a) to form said polymeric substrate having said plurality imprints on said inner surface, when cured; and c) removing said mold from said polymeric substrate. There is also provided a method of forming the mold having the imprint forming surface thereon.
WO2019112517A1 A system for respiratory secretion management Disclosed is a system for respiratory system secretion management. The system comprises an oscillatory wave generator for generating a wave for loosening secretion from a respiratory system of a subject, a nasal module in communication with the oscillatory wave generator, for delivering the wave through a nasal passage of the subject, a power module configured to power the system, and a communication module coupled to at least one of the nasal module and the oscillatory wave generator. The communication module is for selectively communicating power and/or one or more waveform characteristics to the respective nasal module and/or oscillatory wave generator.
WO2019112518A1 A multi-layered piezoelectric ceramic-containing structure A multi-layered piezoelectric ceramic-containing structure There is provided a multi-layered piezoelectric ceramic-containing structure comprising: a metal substrate; a metallic adhesive layer on a surface of the metal substrate; a non-metallic thermal barrier layer on the metallic adhesive layer; and a piezoelectric ceramic layer sandwiched between a first electrode layer and a second electrode layer, wherein the first electrode layer is on the non-metallic thermal barrier layer. There is also provided a method of forming the structure.
US20190177613A1 Fluorescent nanocomposite The present invention relates to a method for forming a nanocomposite having a core-shell structure, the method comprising the steps of: forming a core comprising a first fluorophore capable of aggregation induced emission, and depositing a second fluorophore capable of aggregation caused quenching onto the surface of the core to form a shell at least partially surrounding the core. The present invention also relates to a nanocomposite obtained by said method, and a method of altering the fluorescence of said nanocomposite. The nanocomposite may exhibit dual emission colours and opposite aggregation fluorescent behaviours.
US20190177678A1 Integrated microfluidic system for culturing and testing The present disclosure describes a microfluidic chip for culturing and in vitro testing of 3D organotypic cultures. The tests may be performed directly on the organotypic culture in the microfluidic chip. The microfluidic chip includes at least one microfluidic unit which includes two fluidic compartments, such as upper and lower, separated by a permeable supporting structure, one or more access opening for the fluidic compartments, and a set of lids interchangeable with a set of insets. The permeable support structure serves as a support for the organotypic culture. The upper and lower compartments may include inlets and outlets which allow fluids to be perfused into the lower compartment and fluids to be perfused into the upper compartment. The access opening may be closed with a lid or accommodate an inset.
US20190177405A1 Anti-annexin a2 monoclonal antibodies The present invention relates to an antigen-binding protein, preferably a monoclonal antibody, against annexin A2 (ANXA2), comprising (i) a heavy chain variable domain comprising a VHCDR1 of sequence GYSITSGYSWH, a VHCDR2 of sequence YIHYSGSTKYNPSLKS and a VHCDR3 of sequence GSNYGFDY; and (ii) a light chain variable domain comprising a VLCDR1 of sequence KSSQSLLYSNDQKNYLA, a VLCDR2 of sequence WASIRES, and a VLCDR3 of sequence QQYYIYPLT. Also provided is an ANXA2 binding protein comprising (i) a heavy chain variable domain comprising a VHCDR1 of sequence VYSITSGYSWH; a VHCDR2 of sequence YIHYSGSTKYNPSLKS, and a VHCDR3 of sequence GTDNAVDY; and (ii) a light chain variable domain comprising a VLCDR1 of sequence KSSQSLLYSSNQKNYLA, a VLCDR2 of sequence WASSRES, and a VLCDR3 of sequence QQYYIYPLT. The antibodies preferably bind to an N-linked glycan on ANXA2, and are internalised upon binding. They may be conjugated with cytotoxins and may be used in the treatment or detection of cancer.
US20190181877A1 Inverter-based resistors, analog-to-digital converters, and methods for dynamically generating resistance in a digital-only circuit According to various embodiments, an inverter-based resistor may be provided. The inverter-based resistor may include at least one digital inverter, wherein each of the at least one digital inverter is configured to receive an input and provide an output, each of the at least one digital inverter further includes a positive voltage rail and a negative voltage rail, where-in the digital inverter input is connected to the inverter output and the positive voltage rail is connected to the negative voltage rail, and wherein a current flowing through the inverter-based resistor varies in direction and magnitude in response to a digital input provided to the positive voltage rail and the negative voltage rail.
US10316079 Monoclonal antibody against muramyl peptides Disclosed is an isolated antibody or an antigen-binding fragment thereof The antibody is capable of binding to a muramyl peptide, or a derivative or an analog or a salt thereof. The muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid, and a salt thereof. Also disclosed are methods of producing the antibody, compositions comprising the antibody, methods of treating using the antibody, uses of the antibody, methods of detecting muramyl peptide, an assay for detecting muramyl peptide, an antibacterial agent, hybridomas and kits.
US10316210 Anti-scratch coating This invention relates to a hybrid composite polymer matrix, assembled by integrating two polymer networks, as an anti-scratch coating for automobiles. The two types of particulate silane cross-liners are utilized to construct two respective hybrid polymer networks with a unique chain-from-particle structure. At least one hybrid network is a covalently bound network that is interlocked with at least one physically bound hybrid network.
CN105189530B Chromatographic purification of antibodies from cell culture harvests lacking chromatin Methods for the improved purification of antibodies and other proteins from protein preparations including the steps of conditioning the protein preparation by contacting it with multivalent organic ions, then applying the conditioned preparation to an adsorptive chromatography medium.
US20190169389A1 One-step process for making a polymer composite coating with high barrier This invention relates to a a one-step process for making a polymer composite suspension for coating plastic films characterized in that a first polymer is synthesized in-situ optionally in the presence of other polymers and in the presence of clay. Preferably the polymer composite suspension comprises a) 1.0 to 11.0 wt % of clay or silane modified clay, b) 0.1 to 10.0 wt % of poly (acrylic acid), which is a copolymer of acrylic acid (AA) with at least one other monomer selected from 2-ethylhexyl acrylate (EHA), β-carboxyethyl acrylate (β-CEA), methacrylamidoethyl ethylene urea (WAM II) and ethoxylated behenyl methacrylate (β-FM), c) 1.0 to 15.0 wt % of other polymers, preferably poly (vinyl alcohol) and d) 70 to 97 wt % of water or mixture of water with 2-propanol. The coating films made from the suspensions show good barrier capabilities against water vapor and oxygen can be used to make barrier layers on or within plastic films for packaging applications. The invention also relates to methods for making silane modified clay usable in the process for making the suspensions.
WO2019108134A1 Chimeric molecule for targeting c-myc in cells Disclosed herein are chimeric fusion proteins comprising a c-Myc inhibitor fused to genetically modified Pseudomonas Aeruginosa Exotoxin A ('tPE'), said fusion proteins being capable of penetrating a nucleus of a cell and inhibiting c-Myc activity within the nucleus. In particular, the tPE comprises PE Domains la and I I, and the c-Myc inhibitor is H1 peptide derived from helix 1 carboxylic region of c-Myc. Also disclosed herein are pharmaceutical compositions comprising chimeric fusion proteins, methods of delivering, methods of preparing, and use of chimeric fusion proteins to prevent or treat a c-Myc dependent cancer.
WO2019108132A1 Antenna and method of forming the same Various embodiments may relate to an antenna. The antenna may include a substrate. The antenna may further include a radiator in contact with the substrate, the radiator including a plurality of grid cells. The antenna may also include a ground structure spaced from the radiator, the ground structure including a plurality of apertures. The antenna may additionally include a plurality of feeding couplers connected to the radiator, each of the plurality of feeding couplers passing through a respective aperture of the plurality of apertures.
WO2019108128A1 Privacy preserving IP traceback using group signature A method, a computer-readable medium, and an apparatus for IP traceback are provided. The apparatus may generate a group public key shared by a plurality of routers controlled by a service provider. The apparatus may generate a unique private signing key for a router of the plurality of routers. The private signing key may be used to generate a group signature for a session of network traffic. The group public key may be applied to the group signature to identify the service provider. The apparatus may identify the router by applying the group public key and a master secret key to the group signature. The apparatus may deploy preventive or mitigate action on the identified router.
SG10201809275WA Hybrid Nanodots for Bacteria Staining and Antimicrobial Applications Hybrid Nanodots for Bacteria Staining and Antimicrobial Applications 5 The present invention relates to a hybrid nanodot made by a process comprising a step of reacting a mixture of an amino acid and a polymer selected from polycationic polymers or any copolymers or derivatives of these polymers under hydrothermal reaction conditions. The present invention also relates to a process for 10 synthesizing said hybrid nanodots. [No suitable figure]
US20190161579A1 Method To Make Fluorescent Nanodots For Fast Bacteria Staining And Broad Spectrum Antimicrobial Applications The present invention relates to a hybrid nanodot made by a process comprising a step of reacting a mixture of an amino acid and a polymer selected from polycationic polymers or any copolymers or derivatives of these polymers under hydrothermal reaction conditions. The present invention also relates to a process for synthesizing said hybrid nanodots.
SG11201903913QA A method of detecting the presence of different target analytes and related kits thereof This disclosure relates to a multiplex diagnostic method and related kits thereof for detecting the presence of different target analytes in a sample, the method comprising providing the sample and a plurality of reporter particles such as gold nanoparticles having ω different colours to a substrate, the substrate having a assigned spatial regions; and determining, on the substrate, the presence of a colour arising from the reporter particles in each of a assigned spatial regions on the substrate, wherein each of the assigned spatial regions on the substrate is configured to immobilize a target analyte that is different from the other assigned spatial regions, wherein reporter particles of each different colour are configured to couple to a target analyte that is different from the reporter particles of the other different colours, and wherein a is an integer that is at least two and ω is an integer that is at least two. In one embodiment, the reporter particles are configured to give rise to a secondary colour when reporter particles of two or more different colours are colocalized in the same spatial region, wherein the secondary colour resulting from the colocalization of the reporter particles of two or more different colours from the ω different colours is distinct from another secondary colour resulting from the colocalization of reporter particles of other combinations of colours from the ω different colours.
SG11201903864PA Light emitting diode communication device, method of forming and operating the same Various embodiments may relate to a light emitting diode (LED) communication device including a communication interface configured to couple with an electronic device. The LED communication device may also include an electrical interface electrically coupled to the communication interface. The LED communication device may further include a light emitting diode electrically coupled to the electrical interface. The electrical interface may be configured to convert data signals received from the electronic device into driving signals transmitted to the light emitting diode during uplink, and to convert sensing signals received from the light emitting diode into data signals transmitted to the electronic device during downlink. The light emitting diode may be configured to convert the driving signals received from the electrical interface into a plurality of light pulses during uplink, and to convert a plurality of light pulses received by the light emitting diode into the sensing signals during downlink.
SG11201903714YA A resin formulation and uses thereof There is provided a resin formulation comprising a resin precursor, a crosslinking additive, a photoinitiator, and at least one luminescent dye, wherein the crosslinking additive comprises a functional group selected from the group consisting of hydroxyl, alkoxyl, carboxylic acid, amine, amide, alkylacrylate, acrylate, epoxy, alkyl and heterocycloalkyl. The crosslinking additive of the resin formulation may help to homogeneously disperse the luminescent dye in the resin formulation and decrease the viscosity by improving the miscibility and polarity between the resin precursor and the luminescent dye, leading to an increase of solidification rate of the resin formulation during 3D printing such as stereolithography and digital light processing (DLP). There is also provided a method of preparing the resin formulation and uses of the resin formulation thereof.
SG11201903189PA Device, system and method for intracellular delivery of substances The invention relates to an attachment configured to detachably couple to a fluid extruding device, the attachment comprising: a membrane having a plurality of pores configured to allow a cell to pass through while inducing a mechanical stress to the cell such that the introduction of one or more substances into the cell is facilitated; and an engaging member for coupling to the outlet of the fluid extruding device such that the membrane is in fluid communication with the outlet of the fluid extruding device, wherein the fluid extruding device is configured to extrude fluid via mechanical actuation. The fluid extruding device may include a pipette, micropipette, burette, syringe or liquid handling system. The pores of said membrane are preferably linear through the membrane and have an average pore diameter of 40% to 70% of the average diameter of the cell. The invention further includes methods of introducing substances into a cell, a fluid extruding device and a system thereof.
SG11201903628TA Hyperpolarized [3- 13c]acetoacetate and methods of using the same he present invention relates to hyperpolarized [3-13C]acetoacetate. Provided are [3-13C]acetoacetate and compositions comprising said [3-13C]acetoacetate. Further provided are methods of preparing and using hyperpolarized [3- 13C]acetoacetate in the determination of the spatial and temporal distribution and metabolism of [3-13C]acetoacetate and/or its metabolites in a cell or subject, preferably by magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and/or magnetic resonance spectroscopic imaging (MRSI), whereby conditions, diseases, or disorders associated with the metabolism of acetoacetate and/or other ketone bodies can be diagnosed. The conditions, diseases, or disorders to be diagnosed preferably are cancer, diabetes, cardiovascular diseases, or neurodegenerative diseases.
EP3487626A1 Apparatus for outer wall focusing for high volume fraction particle microfiltration and method for manufacture thereof An apparatus for microfiltration and a scalable method for manufacture of an inertial microfluidic device for such microfiltration apparatus are provided. The apparatus for microfiltration includes one or more inertial microfluidic devices, each including a plurality of spirals of a microfluidic channel. At least one of the inertial microfluidic devices is configured to utilize outer wall focusing for high volume fraction microfiltration of particles. In an embodiment, multiple inertial microfluidic devices are connected in sequence for combined inner wall and outer wall focusing. The scalable method for manufacture of the inertial microfluidic device includes micromachining on a polycarbonate-based substrate a rectangular spiral microchannel having one or more input channels and a plurality of output channels configured to utilize high volume fraction outer wall focusing for microfiltration of particles.
US10302555 Sensor for and method of sensing an analyte, and method of fabricating a sensor The invention relates to a sensor for sensing an analyte. The sensor comprises a detection sensing element having an electrical property variable with the amount of optical light received by the detection sensing element, a control sensing element having an electrical property variable with the amount of optical light received by the control sensing element, a detection optical element for contacting an analyte and transmitting a first amount of optical light received thereby to the detection sensing element in response to the contact with the analyte, a control optical element for contacting a control medium and transmitting a second amount of optical light received thereby to the control sensing element in response to the contact with the control medium, and an output arrangement configured to provide an indication based on the electrical property of the detection sensing element when the first amount of optical light is received by the detection sensing element, with respect to the electrical property of the control sensing element when the second amount of optical light is received by the control sensing element, thereby sensing said analyte. In various embodiments, the sensor is a pH sensor and electrical resistance is the electrical property variable in response to the amount of optical light received by the sensing elements.
EP3484501A1 Methods of diagnosis and treatment of pre-eclampsia The invention relates to an ELABELA polypeptide or nucleic acid for use in the treatment, alleviation or prophylaxis of pre-eclampsia in an individual. In another aspect of the invention, there is provided a method of diagnosing or detecting the susceptibility of an individual to pre-eclampsia, wherein the method comprises detecting modulation, preferably down -regulation of expression, amount or activity of ELABELA.
CN109790403A Cell-ruptured antimicrobial surface coated with metal oxide nanoarrays The present disclosure relates to an antimicrobial coating on a surface, a method for preparing and uses of the same. In particular it relates to a process for preparing an antimicrobial coating on a surface, the process comprising the steps of: a) providing a surface; b) coating a metal oxide or a metal hydroxide on the surface in the presence of a solvent in a hydrothermal synthesis step to form a coated surface having a plurality of nanostructures; c) optionally drying the coated surface, wherein said nanostructure is preferably in nanopillar structure. The coating of the present application exhibits excellent antimicrobial activity against different types of microorganism, such as bacteria and yeast. The nanostructures are able to exert stress to the microorganism, and therefore controlling or killing them.
CN109789406A Integrated microfluidic system for culture and experimentation The present disclosure describes a microfluidic chip for culturing and in vitro testing of 3D organotypic cultures. The tests may be performed directly on the organotypic culture in the microfluidic chip. The microfluidic chip includes at least one microfluidic unit which includes two fluidic compartments, such as upper and lower, separated by a permeable supporting structure, one or more access opening for the fluidic compartments, and a set of lids interchangeable with a set of insets. The permeable support structure serves as a support for the organotypic culture. The upper and lower compartments may include inlets and outlets which allow fluids to be perfused into the lower compartment and fluids to be perfused into the upper compartment. The access opening may be closed with a lid or accommodate an inset.
CN109789208A Anti-Anamin A2 monoclonal antibody The present invention relates to an antigen-binding protein, preferably a monoclonal antibody, against annexin A2 (ANXA2), comprising (i) a heavy chain variable domain comprising a VHCDR1 of sequence GYSITSGYSWH, a VHCDR2 of sequence YIHYSGSTKYNPSLKS and a VHCDR3 of sequence GSNYGFDY; and (ii) a light chain variable domain comprising a VLCDR1 of sequence KSSQSLLYSNDQKNYLA, a VLCDR2 of sequence WASIRES, and a VLCDR3 of sequence QQYYIYPLT. Also provided is an ANXA2 binding protein comprising (i) a heavy chain variable domain comprising a VHCDR1 of sequence VYSITSGYSWH; a VHCDR2 of sequence YIHYSGSTKYNPSLKS, and a VHCDR3 of sequence GTDNAVDY; and (ii) a light chain variable domain comprising a VLCDR1 of sequence KSSQSLLYSSNQKNYLA, a VLCDR2 of sequence WASSRES, and a VLCDR3 of sequence QQYYIYPLT. The antibodies preferably bind to an N-linked glycan on ANXA2, and are internalised upon binding. They may be conjugated with cytotoxins and may be used in the treatment or detection of cancer.
CN109791106A Optical sensing device, method of manufacturing optical sensing device, and optical sensing method Various embodiments may provide an optical sensing device based on surface plasmon resonance (SPR). The optical sensing device may include an optical arrangement configured to provide a first polarization light beam and a second polarization light beam, and a first optical member including a sensing surface, the first optical member configured to receive the first and second polarization light beams and reflect the first and second polarization light beams at the sensing surface. The optical sensing device may further include a second optical member arranged to receive the reflected first and second polarization light beams from the first optical member and configured to separate the reflected first and second polarization light beams in a first direction and a second direction, respectively. The optical device may additionally include a detector arrangement configured to detect the reflected first and second polarization light beams from the second optical member.
CN109789156A Use of miR-198 in the treatment and diagnosis of cutaneous squamous cell carcinoma The present invention refers to a method of treating a carcinoma by administration of one or more of an oligonucleotide comprising the sequence of miR-198 (SEQ ID NO: 1) or a functional part thereof, or an oligonucleotide which reduces expression of Follistatin-related protein 1 (FSTL1 ), Protein diaphanous homolog 1 (DIAPH1), Laminin subunit gamma-2 (LAMC2) or Urokinase-type plasminogen activator (PLAU). Preferably, the at least one or more oligonucleotides directed against FSTL1, DIAPH1, LAMC2 or PLAU is a shRNA or siRNA. Also provided is a method of determining the presence of carcinoma in a subject, comprising detecting and comparing the presence of miR-198 and/or at least one of FSTL1, DIAPH1, LAMC2 or PLAU, miR-181 a, epidermal growth factor (EGF), and epidermal growth factor receptor (EGFR), and comparing the detected levels with that in a control sample.
CN109776537A Anthraquinone as a regulator of WNT pathway The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.
CN104838483B Wafer dicing device and wafer dicing method According to one aspect of the invention, there is provided a wafer dicing apparatus. The wafer dicing apparatus includes a grille, a vacuum suction unit and a cutter. The grille includes an alternating rib and slot arrangement for supporting a wafer, wherein one slot is between two adjacent ribs. The vacuum suction unit is in fluid communication with the grille and sucks air through at least one slot of the grille. The cutter dices the wafer, where either the grille, the cutter or both is configured to align the wafer to be diced along the rib of the grille. There is also provided a wafer dicing method. The method includes providing a wafer, stressing the wafer along a length that extends between two opposite points of the wafer perimeter, and dicing the wafer along the length where the wafer is stressed
US20190144535A1 Il-1beta neutralizing human monoclonal antibodies The present invention is directed to antigen binding proteins and in particular to IL-1β antigen binding proteins. The present invention further provides compositions comprising the antigen binding proteins, use of the antigen binding proteins and methods for production.
US10287553 In vitro method for culturing stem cells There is provided a method for culturing a stem cell in vitro. The method comprises providing a substrate surface coated with a coating comprising a molecule having a catechol moiety or a polymer thereof; and growing a stem cell on said coated substrate surface in a growth medium.
US20190135949A1 Heparan sulphate A heparan sulphate that binds vitronectin is disclosed.
WO2019088929A1 Holographic security element and method of forming thereof There is provided a holographic security element including a substrate; and an array of nano-reflectors configured to form a pattern on the substrate and to generate a holographic image corresponding to the pattern at a predetermined distance from the substrate when irradiated with a predetermined light source. In particular, the array of nano-reflectors is configured to generate the holographic image at the predetermined distance to have a size that is larger than a size of the pattern. There is also provided a method of forming the holographic security element, and an article having one or more holographic security elements incorporated therein.
WO2019088930A1 Method and system for determining a magnetic resonance scan coverage of an internal anatomical structure There is provided a method for determining a magnetic resonance (MR) scan coverage of an internal anatomical structure, e.g. brain. The method includes: receiving a MR scan image of the internal anatomical structure; determining a first parameter and a second parameter associated with one or more anatomical features relating to the internal anatomical structure from the MR scan image using a deep neural network; determining a reference based on the first parameter and the second parameter; and determining the MR scan coverage of the internal anatomical structure based on the reference. In particular, the first parameter comprises position information, and the second parameter comprises angulation information. There is also provided a corresponding system for determining a MR scan coverage of an internal anatomical structure.
WO2019088922A1 Hollow silica spheres with raspberry-like structure and method for preparation thereof According to the present disclosure, a method of synthesizing hollow inorganic microparticles each having a raspberry-like structure is provided. The method comprises mixing a solution comprising microparticles and submicroparticles to obtain composite particles, wherein each of the composite particles comprises one microparticle having the submicroparticles disposed thereon, forming an inorganic layer on each of the composite particles, and removing the composite particles to obtain the hollow inorganic microparticles each having raspberry-like structure. A hollow inorganic microparticle having a raspberry-like structure, wherein the hollow inorganic microparticle comprises a hollow microparticle having hollow submicroparticles disposed thereon, is also disclosed.
WO2019088917A1 Imidazolium-quaternary ammonium copolymers as novel antibacterial and antifungal materials The present invention relates to quaternary ammonium-imidazolium copolymers having the following Formula (I): where the various groups are as defined in the specification. The present invention also relates to the polymer having the following Formula (II): where the various groups are as defined in the specification. The present invention also relates to the methods for their preparation, antimicrobial composition, antimicrobial gel containing these polymers of Formulae (I) and (II), and uses of these polymers in the treatment of a microbial infection or disease.
EP3478278A1 A wound healing composition Disclosed herein are pharmaceutical compositions comprising at least one polycationic aliphatic amine, in particular spermidine, spermine or a combination thereof. The compositions can further comprise one or more selected from decarboxylated S-adenosylmethionine and an inhibitor of ornithine decarboxylase 1 (ODC1 ) such as difluoromethyl ornithine (DFMO). Also disclosed herein are methods of determining the presence of a type of wound and methods for treating the same, i.e. acute or non-healing wounds, which in a particular embodiment, comprises determining the ratio of putrescine versus spermidine/spermine. The present disclosure also includes methods promoting re-epithelialisation of wounds and pharmaceutical compositions for the same use.
EP3122456B1 Method for preparing a sodium faujasite catalyst and its use in producing acrylic acid The invention relates generally to a sodium faujasite catalyst, and in particular the use of the sodium faujasite catalyst in producing acrylic acid. In particular, the invention relates to the use of the sodium faujasite catalyst in catalytic dehydration of lactic acid and 3-hydroxypropionic acid (3-HP) to produce acrylic acid.
CN107110860B Test strip for paper base determination This invention relates to a test strip for paper based assay, the test strip comprising a substrate addition zone for receiving a substrate and a test zone, the test zone comprising a capture agent, wherein the substrate addition zone is located upstream of the test zone. The invention 5 also relates to a paper-based enzyme assay comprising a test strip of the invention and methods of detecting the presence of an analyte in a sample using a test strip of the invention.
WO2019083460A1 Silicate polymeric emulsion for high barrier coating The present disclosure relates to a barrier layer composition comprising at least one silicate, a polymer emulsion and at least two silane coupling agents. The present disclosure also provides a method of preparing the barrier layer composition as disclosed herein. Advantageously, the barrier layer composition of the present disclosure exhibits low permeability toward gas and water vapor molecules. As such, the present invention also relates to a laminated film comprising a substrate deposited with the barrier layer composition as disclosed herein.
WO2019083445A1 Radiant cooler based on direct absorption and latent heat transfer, methods of forming and operating the same Various embodiments may relate to a radiant cooler. The radiant cooler may include a chamber. The radiant cooler may also include a vacuum pump connected to the chamber. The radiant cooler may further include an infrared absorber arranged within the chamber. A wall of the chamber may be configured to allow at least a portion of infrared light to pass through. The vacuum pump may be configured to generate a vacuum in the chamber. The infrared absorber may include a fluid, i.e. a liquid, configured to evaporate into the vacuum upon receiving thermal energy from at least the portion of infrared light.
WO2019083446A1 Apparatus for maintaining a presssure different from atmospheric pressure, methods of forming and operating the same Various embodiments may provide an apparatus for maintaining a pressure different from atmospheric pressure. The apparatus may include a plurality of structural members coupled together to at least partially define a space which is configured to have a pressure different from atmospheric pressure, a structural member of the plurality of structural members being a support structure having an array of holes. The apparatus may also include a film covering a surface of the support structure having an array of holes. The film maybe adapted to allow a predetermined range of wavelengths of electromagnetic waves to pass through.
CN105121457B Materials and methods for removing endotoxin from protein preparations A method includes (i) adding allantoin in a supersaturating amount to a protein preparation including a desired protein and at least one endotoxin as a contaminant, (ii) removing solids after the adding step to provide a sample for further purification by void exclusion chromatography on a packed particle bed of electropositive particles in a column, the packed particle bed having an interparticle volume, (iii) applying a sample volume to the packed particle bed, wherein the electropositive particles support void exclusion chromatography, and wherein the sample volume is not greater than the interparticle volume, and (iv) eluting a purified sample including the desired protein and a reduced amount of the endotoxin. The method is optionally carried out with only the allantoin treatment or only the void exclusion chromatography.
CN109689932A Redox active metal/metal oxide complex for antimicrobial applications The invention relates to a method of preparing a metal oxide/metal composite, comprising depositing a metal oxide from a dispersion in a liquid on a metal surface; or depositing a metal oxide in the presence of a metal from a dispersion in a liquid on a substrate; or depositing a metal oxide from a metal salt solution on a metal substrate. The metal oxide/metal composites obtained by the process show synergistic antimicrobial activity due to release of high concentrations of redox active species (ROS) at the metal oxide/metal heterojunction. The invention also relates to use of the metal oxide/metal composite as an antimicrobial coating.
WO2019078784A1 Transfer patterning on fibrous material The present disclosure relates to a method of forming a patterned fibrous material comprising the steps of providing a patterned sacrificial film having a pattern-forming material thereon; disposing a fibrous material onto said patterned sacrificial film; and subjecting said disposed fibrous material to an elastomeric substrate under strain to thereby transfer said pattern-forming material onto said fibrous material upon removal of said sacrificial film and upon release of the strain from said elastomeric substrate. The present disclosure also relates to an assembly of a three-dimensional (3D) array of a plurality of patterned fibrous material on an elastomeric substrate.
US20190122059A1 Signal light detection There is provided a method of signal light detection, and a corresponding signal light detection device. The method includes obtaining a dark frame of an environment, the dark frame comprising a plurality of light blobs captured corresponding to lights captured in the environment, obtaining a bright frame of the environment, the bright frame comprising a plurality of light blobs corresponding to lights captured in the environment, identifying a plurality of candidate light blobs from the plurality of light blobs in the dark frame, identifying a plurality of candidate regions in the bright frame based on the plurality of candidate light blobs identified from the dark frame, classifying each of the plurality of candidate light blobs based on the corresponding candidate region from the bright frame, and evaluating whether one or more of the plurality of classified candidate light blobs is a signal light from a particular type of signaling device.
US20190120760A1 A system and method for fluid analysis In a first aspect, a system for analysing a fluid sample is provided, comprises: a container configured to receive the fluid sample; a first light source optically coupled to the container and configured to project a first light having a first wavelength; a second light source optically coupled to the container and configured to project a second light having a second wavelength different from the first wavelength; one or more photo-sensors optically coupled to the container and configured to analyse the fluid sample in response to a first scattered light generated in response to projecting the fluid sample with the first light source and a second scattered light generated in response to projecting the fluid sample with the second light source. In a preferred embodiment, the nutritious compositions (such as the concentration of fats and protein) of milk samples are identified based on the scattering of the first and second light source by the milk sample.
US20190120770A1 System and method for imaging a surface defect on an object A system and a method for imaging a surface defect on an object are provided. The system includes an actuator, a sensor assembly connected to the actuator, and a processor configured to control the actuator and the sensor assembly. The sensor assembly includes at least one sensor configured to capture at least one image of the object. The processor is configured to control the actuator and the sensor assembly to identify the actuator and the sensor assembly, a region of a region of interest associated with the surface defect using an using an image of the object and to repeatedly identify at least one subsequent region of interest associated with the surface defect using at least a preceding region of interest such that the surface defect is identified according to a predetermined criterion.
US20190124648A1 All-digital software-defined cognitive heterogeneous network transceiver architecture A system for controlling a network is provided. The system may include a circuit configured to provide interface support to a plurality of remote radio heads. Each remote radio head may support multiple radio access technologies. The system may include a controller configured to control the circuit and the plurality of remote radio heads. The controller may be configured to control the circuit and the plurality of remote radio heads based on statistical information inferred from the data traversing through the circuit and the real time network state information of the network. The circuit may be connected to each remote radio head of the plurality of remote radio heads via one or more respective fronthaul links.
US20190119721A1 Single cell RNA and mutational analysis PCR (scrm-PCR): a method for simultaneous analysis of DNA and RNA at the single-cell level A method of simultaneously analyzing RNA and DNA in a sample, the method comprising the step (a) contacting the sample with a reverse primer from a first primer pair directed to a target RNA region to effect reverse transcription of RNA into cDNA with a reverse transcriptase; (b) subsequently contacting the sample with (i) a forward primer from the first primer pair directed to a second cDNA region, (ii) a forward and a reverse primers from a second primer pair targeted to a DNA region, and (ii) a DNA polymerase to simultaneously amplify the target cDNA and target DNA region; and (c) analyzing the amplified target cDNA region and/or amplified target DNA region. Also encompassed are uses of the method to analyze gene expression and mutations, kits comprising primers, enzymes, buffers.
EP3076860B1 Method of imaging living tissue A method of imaging living tissue is provided. The method includes introducing a photoacoustic contrast agent comprising or consisting of a photosensitizer into living tissue; and obtaining an image of the living tissue by photoacoustic imaging. Use of a photoacoustic contrast agent comprising or consisting of a photosensitizer in photoacoustic imaging is also provided.
US10266612 Heparan sulphates A novel class of structurally and functionally related isolated Heparan sulphate is disclosed. The novel class of Heparan sulphates has been found to bind FGF2 and enhance the proliferation of stem cells while maintaining their pluripotency/multipotency.
WO2019074447A1 A core-shell nanoparticle The present invention relates to a core-shell nanoparticle comprising (a) an inorganic core comprising a magnetic nanoparticle comprising a metal, a metal oxide or combination thereof (e.g. iron oxide), and a silica component (e.g. silicon dioxide); (b) a shell material comprising a copolymer having at least two polymers selected from a pH- responsive polymer and a hydrophobic polymer (e.g. poly(4-vinylpyridine)-poly(dimethylsiloxane)-poly(4-vinylpyridine) triblock copolymer); and (c) a crosslinker that conjugates the shell material to the inorganic core. There is also provided a method for producing the core-shell nanoparticle and uses of the core-shell nanoparticle as an absorbent in oil separation from an oil-in-water system.
WO2019074442A1 Chemical sensor and method of forming the same Various embodiments may relate a chemical sensor. The chemical sensor may include a substrate including a first sealed (or isolated) cavity and a second sealed (or isolated) cavity separate from the first sealed (or isolated) cavity. The chemical sensor may also include an emitter in the first sealed (or isolated) cavity, the emitter configured to emit infrared light. The chemical sensor may further include a detector in the second sealed (or isolated) cavity. The chemical sensor may also include a waveguide configured to carry the infrared light from the emitter to the detector. The waveguide may include a sensing portion configured such that a property of the infrared light carried through the sensing portion changes in response to a chemical entity in contact with the sensing portion. The detector may be configured to detect the change in the property (of the infrared light).
US20190114482A1 Methods for providing task related information to a user, user assistance systems, and computer-readable media According to various embodiments, a method for providing task related information to a user may be provided. The method may include: determining location information based on a spatial model; determining task information based on a task model; determining sensor information; determining output information based on the location information, task information and sensor information; and providing the output information to the user. In a specific embodiment, the output information may comprise an orientation cue, an error indication or a contextual cue to assist the user in performing the task associated with the location detected by a vision recognition method, and the output information can be provided to the user as augmented reality in a wearable device.
EP3468565A1 Use of mi r-198 in treating and diagnosing cutaneous squamous cell carcinoma The present invention refers to a method of treating a carcinoma by administration of one or more of an oligonucleotide comprising the sequence of miR-198 (SEQ ID NO: 1) or a functional part thereof, or an oligonucleotide which reduces expression of Follistatin-related protein 1 (FSTL1 ), Protein diaphanous homolog 1 (DIAPH1), Laminin subunit gamma-2 (LAMC2) or Urokinase-type plasminogen activator (PLAU). Preferably, the at least one or more oligonucleotides directed against FSTL1, DIAPH1, LAMC2 or PLAU is a shRNA or siRNA. Also provided is a method of determining the presence of carcinoma in a subject, comprising detecting and comparing the presence of miR-198 and/or at least one of FSTL1, DIAPH1, LAMC2 or PLAU, miR-181 a, epidermal growth factor (EGF), and epidermal growth factor receptor (EGFR), and comparing the detected levels with that in a control sample.
EP3469003A1 Prl3 antibody The present invention relates to humanised antibodies that bind phosphatase of regenerating liver-3 (PRL3) and use of said antibodies for the treatment of cancer. Also claimed is an in vitro method of determining the cellular localisation of PRL3 in a cell, wherein expression of PRL3 at the cell surface indicates that the cell is cancerous.
EP2890719B1 Solid supported artificial cell membrane system The present invention relates to an artificial cell membrane system comprising at least one membrane protein carrier associated with at least one membrane protein, wherein the at least one membrane protein carrier comprises or consists of a polymeric vesicle or a polymeric planar structure, and a solid support freely suspended in a fluid medium, wherein the at least one membrane protein carrier is attached to a surface of the solid support. A method of forming the artificial cell membrane system, and use of the artificial cell membrane system as a reagent are also provided.
US10259851 Protein extraction methods Methods are provided for extracting DNA-compaction proteins from biological samples.
CN104247545B Node, access point and wireless communication system and method for controlling same In various embodiments, a method of selecting one or more nodes from a plurality of nodes for establishing wireless communication with an access point including defining a filter, filtering the one or more nodes from the plurality of nodes using the filter and sending a linking signal from each of the one or more nodes to the access point for establishing wireless communication with the access point.
US10258676 Polypeptide vaccine We provide a polypeptide vaccine for treatment and prevention of cancer, particularly prevention of metastasis of cancer. Also provided are methods of treating or preventing cancer, and pharmaceutical compositions comprising the polypeptide vaccine.
WO2019070199A1 Biomarkers to detect and characterise cancer Disclosed herein are methods of detecting the presence or absence of cancer, comprising detecting the level of O- glycosylation of one or more endoplasmic reticulum (ER)-resident proteins in a sample obtained from a subject. In particular, the ER-resident proteins are selected from protein disulfide isomerase family A member 4 (PDIA4), calnexin (CANX), protein disulfide isomerase family A member 3 (PDIA3), endoplasmic reticulum lectin 1 (ERLEC1 ), and heat shock 70 kDa protein 5 (glucose-regulated protein 78 kDa) (HSPA5/GRP78/BIP). Also disclosed are methods of determining the malignancy, grade, or staging of a cancer, and kits for the methods disclosed herein.
WO2019070196A1 Clocking circuit arrangement and method of forming the same Various embodiments may relate to a clocking circuit arrangement. The clocking circuit arrangement may include a clock source, as well as a global monitoring circuit arrangement including a monitoring tunable clock buffer, a reference clock buffer, a glitch capturing circuit arrangement, and a voltage generation circuit arrangement. The clocking circuit arrangement may further include a main circuit arrangement including one or more further tunable clock buffers.
US10255939 Recording medium for heat assisted magnetic recording and method of forming the same Various aspects of this disclosure provide a recording medium for heat-assisted-magnetic-recording (HAMR). The recording medium may include a substrate. The recording medium may further include a recording layer. The recording medium may also include a thermal control layer between the recording layer and the substrate. The thermal control layer may have a thermal conductivity that increases with increasing temperature.
US10256797 Oscillator According to embodiments of the present invention, an oscillator is provided. The oscillator includes a switched capacitor circuit arrangement configured to generate a predetermined voltage, a transconductance-capacitor filter configured to receive the predetermined voltage and a reference voltage, and to generate an output filter voltage based on a differential result between the predetermined voltage and the reference voltage, wherein a value of the output filter voltage is variable in response to the differential result, and a period control circuit arrangement configured to receive the output filter voltage, and further configured to generate an oscillator signal, wherein a period of the oscillator signal is variable in response to the value of the output filter voltage, wherein the oscillator is configured to control the switched capacitor circuit arrangement based on the oscillator signal to generate the predetermined voltage to be matched to the reference voltage.
US10253063 Protein purification in the presence of nonionic organic polymers at elevated conductivity A method of purifying a desired protein from a preparation includes providing the preparation in a form having less than about 5% of the chromatin residing in the original production medium, contacting the preparation with a nonionic organic polymer in an amount sufficient to cause the desired protein to precipitate or adsorb on a nonionic hydrophilic surface, and adjusting a salt concentration before or during the contacting step, the adjusting step providing a sufficient salt concentration to produce a conductivity greater than physiological conductivity.
US10251568 Method and system for optical blood pressure monitoring An apparatus, methods and a system for cuffless blood pressure monitoring are provided. The system includes an optical BCG sensor, a PPG sensor, a transceiver and a signal processing device. The BCG sensor optically couples to the subject, acquires BCG signals from the subject, and optically transmits the subject's BCG signals. The PPG sensor optically couples to the subject for acquiring PPG signals from the subject and optically transmits the acquired subject's PPG signals. The transceiver is coupled to the BCG sensor and the PPG sensor for receiving the BCG signals and the PPG signals and generating a BCG electronic signal from the subject's BCG signals and a PPG electronic signal from the subject's PPG signals. And the signal processing device is coupled to the transceiver for receiving the BCG electronic signal and the PPG electronic signal and for monitoring the subject's blood pressure in response to predetermined BCG indicia of the BCG electronic signal and predetermined PPG indicia of the PPG electronic signal.
CN104255069B Station and method for controlling the station In various embodiments, a method of controlling a station may be provided. The method may include receiving a first signal from an access point, the first signal including information indicating a time period. The method may further include deactivating the station after receiving the first signal and before expiry of the time period. The method may also include activating the station upon expiry of the time period.
WO2019066727A1 Processes for production of carbon nanotubes from natural rubber A method for the synthesis of carbon nanotubes from natural rubber, including providing a first material, the first material may include natural rubber or derivatives thereof, thermally decomposing the first material at a first temperature into an intermediate material, contacting the intermediate material with a catalyst, treating the intermediate material in contact with the catalyst at a second temperature, for forming carbon nanotubes. Adjusting an average characteristic of resulting nanotubes, including carrying out the synthesis method as a reference method and for decreasing the average diameter of the nanotube: decreasing the second temperature and/or decreasing the reaction time and/or increasing the concentration of H2 in the forming gas in relation to the reference method. Or, for increasing the average diameter of the nanotube: increasing the second temperature and/or increasing the reaction time and/or decreasing the concentration of H2 in the forming gas in relation to the reference method.
WO2019066718A1 Self-assessing deep representational units A method, a computer-readable medium, and an apparatus for feature learning are provided. The apparatus may receive a data sample as an input to a feature learning model. The apparatus may calculate a reconstruction error based on the data sample and a plurality of features of the feature learning model. The apparatus may determine whether the reconstruction error satisfies a first threshold. The apparatus may add a feature into the feature learning model to represent the data sample if the data sample satisfies the first threshold. The apparatus may determine whether the reconstruction error satisfies a second threshold. The apparatus may ignore the data sample if the reconstruction error satisfies the second threshold. The apparatus may update the weights associated with the plurality of features of the feature learning model if the reconstruction error satisfies neither the first threshold nor the second threshold.
US20190104151A1 Cloud-based forensic IP traceback A method for IP traceback is provided comprising receiving a traceback request including the identity of a traceback-deployed autonomous system closest to the destination node in a network routing path, recursively querying a traceback server associated with the traceback-deployed autonomous system to receive the identity of a preceding traceback-deployed autonomous system in the network routing path, and determining the network routing path based on the received identities of traceback-deployed autonomous systems. Additionally, authentication for traceback request is achieved using token delivery, wherein token is fragmented and marking of a packet is performed when a field on the packet matches at least one token fragment.
US20190102288A1 Control modules, multi-level data storage devices, multi-level data storage methods, and computer readable media A control module for a multi-level data storage device having a plurality of memory devices is disclosed. The control module may include: an access determination circuit configured to determine that access has been made to a piece of data stored on at least one of the plurality of memory devices, the piece of data associated with a level being one of a first level, a second level, or a third level; a level management circuit configured to change the level from the third level to the second level or from the second level to the first level upon determining that access has been made to the piece of data; and a memory controller configured to promote the piece of data in response to whether the level is the first level, the second level or the third level, wherein at least two levels of the first level, the second level, and the third level are associated with one of the plurality of memory devices.
EP3066474B1 Bladder carcinoma biomarkers Disclosed are bladder cancer protein biomarkers, methods of determining whether a patient suffers from or shows recurrence of bladder cancer or early stage bladder cancer, or late stage bladder cancer using the bladder cancer protein biomarkers, a detection system, and kits thereof. Said bladder cancer biomarkers comprise at least one of Coronin-IA, Apolipoprotein A-IV, Semenogelin-2, Gamma-synuclein and DJ-1, and variants thereof.
US10246512 IL-2R beta/common gamma chain antibodies Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.
US10249593 Method for bonding a chip to a wafer A method for chip on wafer bonding is provided. The method includes the formation of a plurality of posts on at least one of a chip and a wafer, and a like plurality of contacts on the other of the chip and the wafer. After formation, a contact surface of each post is planarized, the respective planarized contact surface having a surface roughness height. A bonding material is then applied to at least one of the chip in a thickness no greater than the surface roughness height of the contact surface. The posts are then temporarily bonded to the contacts using the bonding material to stabilize a position of the chip relative to the wafer for permanent diffusion bonding of the chip to the wafer.
US10246506 Methods for reducing levels of protein-contaminant complexes and aggregates in protein preparations by treatment with electropositive organic additives Methods for reduction of aggregate levels in antibody and other protein preparations through treatment with low concentrations of electropositive organic additives (e.g., ethacridine, chlorhexidine, or polyethylenimine) in combination with ureides (e.g., urea, uric acid, or allantoin) or organic modulators (e.g., nonionic organic polymers, surfactants, organic solvent or ureides). Some aspects of the invention relate to methods for reducing the level of aggregates in conjunction with clarification of cell culture harvest. It further relates to the integration of these capabilities with other purification methods to achieve the desired level of final purification.
CN106457153B Apparatus and method for fractionating biological products Methods and apparatus for purification of biological molecules using combinations of tangential flow filtration subunits and adsorption sub-units in a single apparatus where the subunits may be operated independently or in series and where the apparatus and methods are suitable for use in a wide range of formats distinct from conditions required for chromatographic processes such as conducting process steps using adsorption subunits for purification of a biological molecule in a contaminated sample without prior buffer equilibration.
SG11201901313PA Diffractive optical element and method of forming thereof There is provided a diffractive optical element including a substrate, and an array of optical nanoantennas arranged on the substrate, the array of optical nanoantennas being spaced apart periodically in a lateral direction for supporting a plurality of diffraction orders at a predetermined wavelength. In particular, each optical nanoantenna in the array of optical nanoantennas is configured to control distribution of electromagnetic energy from an incident light having the predetermined wavelength amongst the plurality of diffraction orders so as to promote scattering of the electromagnetic energy in at least a first direction and suppress scattering of the electromagnetic energy in at least a second direction, the first direction and the second direction corresponding to a first diffraction order and a second diffraction order of the plurality of diffraction orders, respectively. There also provided a corresponding method of forming the diffractive optical element and a flat optical element, such as a flat lens.
SG11201901175YA Cell rupture-based antimicrobial surfaces coated with metal oxide nano-arrays The present disclosure relates to an antimicrobial coating on a surface, a method for preparing and uses of the same. In particular it relates to a process for preparing an antimicrobial coating on a surface, the process comprising the steps of: a) providing a surface; b) coating a metal oxide or a metal hydroxide on the surface in the presence of a solvent in a hydrothermal synthesis step to form a coated surface having a plurality of nanostructures; c) optionally drying the coated surface, wherein said nanostructure is preferably in nanopillar structure. The coating of the present application exhibits excellent antimicrobial activity against different types of microorganism, such as bacteria and yeast. The nanostructures are able to exert stress to the microorganism, and therefore controlling or killing them.
EP3458482A1 Anti-axl tyrosine kinase receptor antibodies and uses thereof The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof that bind to a glycan on the AXL receptor tyrosine kinase. The present invention also relates to antigen-binding proteins, or antigen-binding fragment conjugated to a radioisotope or cytotoxin, and wherein said antigen-binding proteins, or antigen-binding fragment is internalised into a cell upon binding to AXL receptor tyrosine kinase. Compositions comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen- binding fragment thereof, therapeutic use of the antigen-binding protein, or antigen-binding fragment thereof, methods for detecting cancer as well as kits when used in such methods are also provided.
EP3458572A1 Human stem cell derived endothelial cells, endothelial- hepatocyte co-culture system and uses thereof The present disclosure provides a method of deriving endothelial cells, comprising (a) culturing lateral plate mesoderm cells under oxygen-deprived condition to obtain endothelial lineage cells; and (b) culturing endothelial cells from (a) on an extracellular matrix to maintain and expand the endothelial lineage cells. Also disclosed herein is a cell co-culture system comprising an endothelial cell culture and a hepatocyte cell culture, as well as a microfluidic-based system comprising said cell co-culture system. Also disclosed herein is a method of disease modelling or drug testing using said cell co-culture system or said microfluidic-based system.
WO2019054948A1 Emulsions, methods and uses thereof The present disclosure relates to emulsions, methods of preparation thereof, and uses of said emulsions to fabricate porous polymeric microspheres as microcarriers for cell culture. In particular, the present disclosure relates to an emulsion with enhanced stability, characterized in that the emulsion comprises a) a water phase, the water phase is an aqueous solution comprising a salt; and b) an oil phase, the oil phase comprising a polymer; wherein the oil phase is immiscible with the water phase, and wherein the density differential of the water phase and oil phase is less than about 0.02 g/cm3. In a preferred embodiment, the polymer is polycaprolactone (PCL).
WO2019054944A1 Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase The present invention relates to compounds of general Formula (I), and/or tautomers, enantiomers, solvates, hydrates, and pharmaceutically acceptable salts thereof. The present invention also relates to compounds of Formula (I) for use in therapy, methods of treating isoprenylcysteine carboxyl methyltransferase (ICMT) related disorders or uses of compounds of Formula (I) in the manufacture of a medicament for the treatment of ICMT-related disorders, wherein the disorder is cancer and/or progeria. The present invention further relates to processes for synthesizing compounds of Formula (I).
WO2019054941A1 Wnt pathway modulators The application relates to a 2,6-dioxo-purine derivative, 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(6-(2-hydroxyphenyl)pyridazin-3-yl)acetamide, and the use of this compound in the modulation of the Wnt pathway, and treating a disease or condition associated with Wnt pathway activity, such as cancer, a fibrotic disease, a degenerative disease or a metabolic disease.
US20190086389A1 Method of identifying adipose stem cells Disclosed is a method of identifying the origin of adipose-derived stem cells, comprising detecting at least one cell-surface marker selected from a group consisting of CD 10, CD141, CD 142 and CD200. Also disclosed are methods of determining adipogenic capability of a cell capable of adipogenesis by determining the presence of CD 10 or CD200.
US20190084826A1 A through silicon interposer wafer and method of manufacturing the same A Through Silicon Interposer Wafer and Method of Manufacturing the Same A through silicon interposer wafer having at least one cavity formed therein for MEMS applications and a method of manufacturing the same are provided. The through silicon interposer wafer includes one or more filled silicon vias formed sufficiently proximate to the at least one cavity to provide support for walls of the at least one cavity during subsequent processing of the interposer wafer.
US20190083436A1 Methods of diagnosing cancer Disclosed are two methods of treating or preventing a proliferative disease as characterized and/or diagnosed by at least one selected from an accumulation of branched-chain amino acid(s) (BCAA), suppression of activity or transcripts level of BCAA catabolic enzyme(s) and a decrease in acylcarnitine level (C5:1), one comprising the administration of a BCAA catabolism enhancer and/or branched chain alpha-ketoacid dehydrogenase complex (BCKDC) kinase inhibitor and the other comprising administration of a meal replacement with low BCAA levels. In three separate embodiments, methods of diagnosis or prognosis are disclosed, each comprising the measurement of the levels of a different marker, i.e. BCAA, BCAA catabolic enzymes or acylcarnitine (C5:1). In preferred embodiments, the proliferative disease is cancer. Also disclosed is a kit or microarray chip useful for methods thereof.
US20190087445A1 Method of facilitating distributed data search in a federated cloud and system thereof There is provided a method of facilitating distributed data search in a federated cloud. The method includes generating, at a computing cloud of the federated cloud, a search tree structure for indexing a data set in the computing cloud; mapping a selected set of nodes of the search tree structure to respective peer nodes of a peer-to-peer tree structure spanning a plurality of servers in a plurality of computing clouds of the federated cloud, the peer-to-peer tree structure configured for routing a query for searching a data item in the federated cloud; and informing, for each selected node, the plurality of types of attribute conditions associated with the selected node to the corresponding mapped peer node such that the corresponding mapped peer node has associated therewith the plurality of types of attribute conditions.
US20190086330A1 Optical system, method of forming and operating the same Various embodiments may provide an optical system for determining a refractive index of a sample. The optical system may include a laser source configured to emit a laser beam, and a non-linear crystal configured to generate, based on the laser beam, an infrared light beam which passes through the sample, and a visible signal light beam. The optical system may further include a first mirror configured to reflect the visible signal light beam, a second mirror configured to reflect the infrared light beam so that the reflected infrared light beam interacts with the reflected visible signal light beam in the non-linear crystal, and a photodetector configured to determine a property of the reflected visible signal light beam which has interacted with the reflected infrared light beam for determining the refractive index of the sample.
US20190088276A1 A reader structure A reader structure, a method of biasing a free layer of a reader structure, and a read head are provided, the reader structure comprises a free layer having a reader edge for interacting with and being proximal to a magnetic media; a first magnetic bias member and a second magnetic bias member each provided adjacent to the free layer, the first and second magnetic bias members being configured to have a first magnetisation direction which is substantially parallel to the reader edge; an additional bias member disposed adjacent to the free layer, the additional bias member further being located proximal to at least one of the first magnetic bias member and the second magnetic bias member, and the additional bias member being configured to have a magnetisation direction that is substantially orthogonal to the first magnetisation direction.
US20190090275A1 Method of controlling data transmission in a wireless mesh network and node thereof There is provided a method of controlling data transmission in a wireless mesh network including a plurality of nodes capable of transmitting and receiving data packets. The method includes providing a frame comprising a plurality of time slots for data transmission, classifying the plurality of time slots into a plurality of sets of time slots, and determining, at a node of the plurality of nodes, a set of time slots amongst the plurality of sets of time slots for the node to transmit data packets, the set of time slots being determined based on a hop count associated with the node. There is also provided corresponding node(s) in a wireless mesh network configured to perform data transmission in the above manner.
US20190085171A1 Durable hydrophobic coating composition This invention relates to a hydrophobic coating material comprising a silane-modified polyorganosiloxane. The invention also relates to a method of making such a coating material, the use of such a coating material, a method for coating a substrate with such a coating material, and a coated substrate obtainable by such a method. In a preferred embodiment, the silane-modified polyorganosiloxane prepared by reacting hydride-containing polyorganosiloxane with vinylsilane; or reacting vinyl-containing polyorganosilane with trimethoxysilane, triethoxysilane or trichlorosilane through hydrosilylation reaction is provided.
EP3455260A1 Anti-erbb-2 antibodies and uses thereof The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof. In particular, the present invention relates to antigen-binding proteins, or antigen- binding fragments thereof that bind to ERBB2. Compositions comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment thereof, use of the antigen-binding protein, or antigen-binding fragment thereof, methods for detecting cancer as well as kits when used in such methods are also provided.
US10233297 One-step process for making a polymer composite coating with high barrier This invention relates to a a one-step process for making a polymer composite suspension for coating plastic films characterized in that a first polymer is synthesized in-situ optionally in the presence of other polymers and in the presence of clay. Preferably the polymer composite suspension comprises a) 1.0 to 11.0 wt % of clay or silane modified clay, b) 0.1 to 10.0 wt % of poly (acrylic acid), which is a copolymer of acrylic acid (AA) with at least one other monomer selected from 2-ethylhexyl acrylate (EHA), β-carboxyethyl acrylate (β-CEA), methacrylamidoethyl ethylene urea (WAM II) and ethoxylated behenyl methacrylate (β-EM), c) 1.0 to 15.0 wt % of other polymers, preferably poly (vinyl alcohol) and d) 70 to 97 wt % of water or mixture of water with 2-propanol. The coating films made from the suspensions show good barrier capabilities against water vapor and oxygen can be used to make barrier layers on or within plastic films for packaging applications. The invention also relates to methods for making silane modified clay usable in the process for making the suspensions.
WO2019050483A1 A sputtering system and method A sputtering system and a sputtering method are provided. The sputtering system includes a first electrode, a magnet and a second electrode. The first electrode is an elongated tube having a first end and a second end downstream of the first end. The first end is configured to receive a gas flow and the second end is placed next to a substrate. The magnet surrounds at least a portion of the elongated tube and is configured to generate a magnetic field in a space within the elongated tube. The second electrode is disposed within the elongated tube. A voltage is configured to be applied between the first and second electrodes to generate an electric field between the first and second electrodes.
WO2019050480A1 Methods of screening hair growth or hair cycle regulating agents A method of screening a candidate agent for promoting or inhibiting hair growth or hair cycle is disclosed, comprising: (a) obtaining a profile of genes that are differentially expressed in hair follicle cells when treated with reference agent(s) which promotes or inhibits hair growth or hair cycle, using microarray and hierarchical clustering; (b) obtaining a profile ofgenes that are differentially expressed in hair follicle cells when treated with the candidate agent using hierarchical clustering; (c) comparing the profile of genes that are differentially expressed in step (b) against the profile in step (a); and (d) determining the candidate agent as having hair growth or hair cycle promoting or inhibiting activity when the profile of genes that are differentially expressed in step (b) substantially matches the profile of genes that are differentially expressed in step (a),. A method of treating hair loss and excessive hair growth using agents identified by the methods, and a kit thereof are further disclosed.
WO2019050482A1 Reprogramming of a differentiated cell to an undifferentiated cell using exosome The present invention generally relates to methods of reprogramming cells using exosomes derived from stem cells. The present invention also relates methods of screening drugs suitable for cancer treatment using the reprogrammed cells, obtained from the methods described herein. The present invention also relates to therapeutic uses of the reprogrammed cells, obtained from the methods described herein.
WO2019050477A1 Photonic integrated circuit package and method of forming the same Various embodiments may relate to a method of forming a photonic integrated circuit package (PIC). The method may include forming a redistribution layer (RDL) over a carrier. The method may also include forming a through hole or cavity on the redistribution layer. The method may additionally include providing a stop-ring structure, the stop-ring structure including a ring of suitable material, the stop-ring structure defining a hollow space, over the redistribution layer so that the hollow space is over the through hole or cavity. The method may further include arranging a photonic integrated circuit (PIC) die over the redistribution layer so that the photonic integrated circuit (PIC) die is on the stop-ring structure. The method may also include forming a molded package by forming a mold structure to at least partially cover the photonic integrated circuit (PIC) die to form the photonic integrated circuit package.
US20190080974A1 Electrical connection structure, semiconductor package and method of forming the same Various embodiments may provide an electrical connection structure. The electrical connection structure may include a first substrate having a first surface defining a cavity, and an inner wall defining a via extending from the cavity. The electrical connection structure may also include an interconnect structure provided in the via so that at least a portion of the interconnect structure protrudes into the cavity. The electrical connection structure may further include a second substrate having a second surface facing the first surface. The electrical connection structure may additionally include a connection element on the second surface. At least a portion of the connection element may be received in the cavity so that the connection element is in electrical connection with the interconnect structure.
US20190077988A1 A polysiloxane hydrophobic coating material The present invention relates to a hydrophobic coating material comprising a plurality of polysiloxanes cross-linked by a cross-linker having at least one unsaturated functional group, a process for preparing said coating, a coated article as well as a process for coating said article. The coating material is prepared by reacting the plurality of polysiloxanes with the cross-linker in the presence of a catalyst. In a preferred embodiment, the unsaturated group of the cross-linker is a vinyl, methacrylate or acrylate group, such as pentaerythitol tetramethacrylate. The coated article may be a fabric.
US10230532 Entity authentication in network There is provided an entity authentication method for a network including a first entity and a second entity, the method including: selecting, at the first entity, one or more pieces of data processed by the first entity to be used for authenticating the second entity; tagging, at the first entity, each of the one or more pieces of data selected with a respective tag generated based on a first secret key of the first entity; sending, from the first entity, a set of authentication data comprising the one or more pieces of data and the respective tags to the second entity; and authenticating, by the first entity, the second entity using a challenge-response authentication technique based on the set of authentication data and the first secret key. There is also provided a corresponding system with entity authentication for a network, and an entity in a network with entity authentication.
US10229488 Method and system for determining a stage of fibrosis in a liver A method for determining a stage of fibrosis in a liver is disclosed. The method comprises the steps of: (1a) obtaining input data relating to the liver, the input data being generated using a second harmonic generation based imaging system; (1b) identifying a plurality of morphological features of the liver from the input data relating to the liver; (1c) generating a plurality of measurements based on the identified plurality of morphological features; and (1d) determining the stage of fibrosis in the liver based, on the generated plurality of measurements.
WO2019045653A1 Non-destructive systems and methods for identification of packaged medicine Systems and methods for non-destructive packaged tablet, capsule and liquid medicine identification is provided. The system also includes a digital optical phase conjugation system configured to THz time domain system sampling of the sample while defocusing the THz radiation to a sub-interface of packaging of the packaged tablet, capsule or liquid medicine, in order to avoid the direct reflection of the THz radiation. The method includes measuring THz radiation reflected from a surface of a sample of packaged tablet, capsule or liquid medicine and shifting a focal point of the THz radiation from the surface of the sample through the packaging until the focal point focuses the THz radiation on a container/medicine interface of the sample of packaged tablet, capsule or liquid medicine. The method also includes measuring THz radiation reflected from the container/medicine interface of the sample of packaged tablet, capsule or liquid medicine, calculating an absorption spectra of the measured THz radiation, and auto-identifying by a processing device in response to the absorption spectra of the measured THz radiation a type of medicine within the sample of packaged tablet, capsule or liquid medicine in response to cluster analysis to group the type of medicine within the sample of packaged tablet, capsule or liquid medicine with respect to a database of THz reflectance spectra information for a plurality of medicines.
WO2019045647A1 Sensing device, methods and uses thereof The invention relates to a sensing device for quantitatively measuring a concentration of an analyte. The device comprises a hydrophilic substrate having a surface that is partially impregnated with a hydrophobic material, a non- impregnated portion of the first surface defining at least one reaction zone. An enzyme is located in the reaction zone for converting the analyte into at least a charged species. The sensing device also comprises a pair of electrode spaced apart and in contact with the reaction zone for conducting a current generated by diffusion of the charged species so as to quantitatively measure the concentration of the analyte. In a preferred embodiment the hydrophilic substrate is paper, the hydrophobic material is wax and the enzyme is urease.
WO2019045649A1 Methods for enriching mesenchymal stem cells Methods of enriching non-senescent mesenchymal stem cells (MSCs) and methods of performing quality control for non-senescent MSCs are disclosed. The methods comprise contacting a sample comprising MSCs with a probe (specifically peanut agglutinin, PNA) that binds to a glycan (specifically glycan T-antigen) expressed on the surface of MSCs, with the separation or determination of non-senescent MSCs from senescent MSCs based on a difference in expression of the glycan at the cell surface, i.e. the non-senescent MSCs express more of the glycan than senescent MSCs. A high amount of non-senescent MSCs is indicative of a sample of acceptable quality.
US20190071416A1 Compounds for treatment of cancer and epigenetics Compounds For Inhibition Of Cancer and Epigenesis. The present invention relates to quinolines and 5,6,7,8-tetrahydroacridines of the formula (I) wherein Z1, Z2, X, R1 to R8 and Y are defined as described in the specification, or a pharmaceutically acceptable form or prodrug thereof, that are inhibitors of methyl transferases such as protein lysine methyltransferases and more particularly SMYD3. The present invention also relates to the methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with enzymes having methyl transferase activities/functions and/or via unspecified/multi-targeted mechanisms.
US10221253 Phase separated composite A composite is disclosed. The composite comprises a first conjugate of a polymer and a first phenol-containing moiety, and a second conjugate of a gelatin or collagen and a second phenol-containing moiety, wherein the polymer is selected so that the first conjugate is less cell-adhesive than the second conjugate, at least one of the first and second conjugates is crosslinked to form a matrix, and the composite comprises discrete regions that are rich in one of said first and second conjugates. A method of forming such composite is also disclosed. The method comprises mixing precursors for the first and second conjugates in a solution for forming said composite, and dispersing a catalyst in the solution to catalyze crosslinking of at least one of the first and second conjugates to form the matrix. The composite may be used to grow cells.
WO2019040000A1 Gyroscope, methods of forming and operating the same Various embodiments may provide a gyroscope. The gyroscope may include a piezoelectric substrate, an excitation transducer configured to generate a surface acoustic wave, and a sensing transducer configured to receive the surface acoustic wave generated by the excitation transducer. The gyroscope may additionally include a mass dot array between the excitation transducer and the sensing transducer, the mass dot array configured to generate a stress on the piezoelectric substrate based on a rotation of said gyroscope upon the surface acoustic wave passing through the mass dot array. The gyroscope may also include a light source, and an optical detector configured to receive one or more light beams generated by the light source to determine the rotation of the gyroscope based on a property of the one or more light beams. The property of the one or more light beams may be variable based on the stress on the piezoelectric substrate.
SG10201806248WA A broadband tunable thz wave manipulator and the method to form the same A BROADBAND TUNABLE THZ WAVE MANIPULATOR AND THE METHOD TO FORM THE SAME 5 This invention relates to semiconductor device comprising a semiconductor substrate having a metasurface layer configured with multiple pairs of finger portions in a repeating arrangement. The multiple pairs of finger portions are electrically configurable to modulate a radiation signal received by the semiconductor device. Each pair of finger 10 portions comprises first and second members where the first member is doped with a first dopant and the second member is doped with a second dopant being different to the first dopant. Any two adjacent first or second members are configured to be separated by at least deep subwavelength to enable the repeating arrangement. 15 Figure 2a
SG11201900291WA Optical sensing device, method of manufacturing the same, and optical sensing method Various embodiments may provide an optical sensing device based on surface plasmon resonance (SPR). The optical sensing device may include an optical arrangement configured to provide a first polarization light beam and a second polarization light beam, and a first optical member including a sensing surface, the first optical member configured to receive the first and second polarization light beams and reflect the first and second polarization light beams at the sensing surface. The optical sensing device may further include a second optical member arranged to receive the reflected first and second polarization light beams from the first optical member and configured to separate the reflected first and second polarization light beams in a first direction and a second direction, respectively. The optical device may additionally include a detector arrangement configured to detect the reflected first and second polarization light beams from the second optical member.
SG11201900058YA Method of generating mesenchymal stem cells and uses thereof The present disclosure provides a method of generating mature mesenchymal stem cells (MSC) from lateral plate mesoderm comprising culturing the lateral plate mesoderm cells on an extracellular matrix in a MSC cell culture media comprising (i) fibroblast growth factor; (ii) platelet-derived growth factor (PDGF); (iii) epidermal growth factor (EGF) and (iv) ascorbic acid. Also claimed are MSCs obtained by said culture method and a method of treating cartilage and bone disease in a patient using said cells. In addition, a culture medium for deriving primitive streak mesendoderm cells from pluripotent stem cells comprising (a) activin; (b) WNT-signalling activator; and/or (c) fibroblast growth factor and a culture medium for deriving lateral plate mesoderm cells from primitive streak mesendoderm cells comprising (1 ) fibroblast growth factor; (2) bone morphogenetic protein; (3) follistatin; and optionally Rho-associated protein kinase (ROCK) inhibitor are claimed.
US10215692 Optical waveguide structure and optical gas sensor, and methods of fabrication thereof There is provided an optical waveguide structure, including a substrate, an insulating layer disposed on the substrate whereby the insulating layer includes an air slot formed therein, a first material layer suspended over the air slot whereby the first material layer constitutes a waveguide core of the optical waveguide structure, and a second material layer disposed over the waveguide core whereby the waveguide core is suspended over the air slot by the second material layer. There is also provided an optical gas sensor incorporating the optical waveguide structure and methods of fabrication thereof.
US10214776 Nanoprobe-based genetic testing The present application relates to methods of detecting a mutation in a target nucleic acid molecule. Two phosphorodiamidate morpholino oligomer probes that differ by at least one base are each covalently coupled to a nano article and hybridized to a target sequence. The melting temperature of the complexes between each of the two probes and the target nucleic acid are measured and compared to determine whether the sample contains a nucleic acid with the mutation. Further, the present invention relates to kits comprising a first and second conjugate as described herein and to the use of such kits for the detection of mutations in a target nucleic acid molecule or for assigning a genotype to a target nucleic acid molecule.
CN105451801B Sound-induced sleep method and system for the same A method and system for sound-induced sleep is provided. The method includes detecting brainwave signals of a subject. The method further includes analyzing the brainwave signals to determine a current sleepy state of the subject and selecting a sound in response to the current sleepy state based on a quantified association index between the brainwave signals and acoustical features of the sound. The method further more includes playing the sound to the subject.
WO2019035773A1 Methods to identify protein interaction The present invention discloses methods for identifying a protein interaction comprising the steps of: a) exposing a sample comprising one first protein(s) and one further protein(s) to at least one preselected condition for one preselected duration; b) isolating and separating at least one soluble fraction from an insoluble fraction; and c) analysing the soluble/insoluble fraction to identify said protein interaction. In one embodiment, the preselected condition in step a) is at least one denaturing temperature that is capable of causing a change in precipitation of said first protein(s) when interacting with said further protein(s) compared to the first protein when not interacting with further protein(s), and use of a proximity co-aggregation (PCA) signature in step c) to identify dynamics of protein- protein interactions and protein complexes in cells or tissues. Use of said methods for screening for therapeutic drug targets and disease progression prognosis are also disclosed.
WO2019035766A1 A label-free method and system for measuring drug response kinetics of three-dimensional cellular structures Disclosed herein are methods of providing a computational model for predicting an activity of a test agent with respect to a 3D cell structure, such as spheroid, organoid and tumorsphere. Specifically, machine learning algorithm is employed to generate a quantitative model of drug response in the 3D cell structure using zone-specific image features, wherein the zones comprise a necrotic zone, a quiescent zone, and a proliferating zone. Also disclosed herein are label-free prediction methods using such computational model and a device configured to perform the methods as disclosed herein.
WO2019035763A1 Aptamers for detection of zika flaviviral protein Disclosed are one or more aptamers which bind to flaviviral non-structural protein 1 (NS1 ), particularly Zika NS1. Also disclosed are methods for detecting the presence of Zika NS1 in a sample and kit comprising the aptamers.
US20190055513A1 Cell culture medium The invention relates to serum-free cell culture medium, wherein the medium either contains maltose as the sole carbohydrate source, or contains maltose and at least one other saccharide as carbohydrate sources. In a preferred embodiment, the additional saccharide is a monosaccharide, preferably glucose, and the medium comprises DMEM-F12. In a preferred embodiment the cells to be cultured may be CHO or HEK293 cells. Also disclosed are methods of growing and/or culturing a cell using the cell culture medium as described herein, methods of increasing protein yield using the cell culture medium as described herein, and kits thereof.
US20190056328A1 Method for detecting an analyte using surface enhanced raman spectroscopy According to the present disclosure, a method for detecting an analyte using surface enhanced Raman spectroscopy (SERS) is provided. The method comprises (a) contacting one or more analyte-binding molecules with the analyte under conditions that allow binding of the analyte to the one or more analyte-binding molecules to form a first mixture, wherein the analyte is preferably haptogloblin and the analyte-binding molecule may comprise haemoglobin or is a haptogloblin antibody, (b) contacting a liquid reagent comprising a peroxidase substrate and a peroxide source with the first mixture to form a second mixture, while maintaining pH of the second mixture at 10 or less, (c) quenching the second mixture to form a third mixture, (d) optionally contacting the third mixture with a SERS-active substrate, and (e) detecting a surface enhanced Raman signal from the third mixture and/or a surface of the SERS-active substrate.
US20190057731A1 Circuit arrangement, method of forming and operating the same Various embodiments may provide a circuit arrangement. The circuit arrangement may include a first spin-orbit torque magnetic tunnel junction cell, a second spin-orbit torque magnetic tunnel junction cell, a first driver circuit arrangement, a second driver circuit arrangement, and a read circuit arrangement. The circuit arrangement allows for the operation of a non-volatile flip-flop based on spin-orbit torque effect.
EP3442988A1 A method of enhancing the performance of chromatography methods for purification of proteins This application describes compositions, kits, and methods for removing contaminants from a protein preparation, for example a cell culture harvest comprising a recombinant protein. The methods described herein can enhance the performance of a later applied chromatographic purification step. The method generally involves contacting a protein preparation comprising a desired protein with a combination of allantoin, a cationic polymer, and a fatty acid, thereby causing the formation of solids and removal of the solids using a suitable process. The method is exemplified by a combination of allantoin, caprylic acid and a cationic polymer selected from chitosan, polydiallyldimethylammonium chloride (pDADMAC) and polyallylamine. Further treatment by contacting the treated sample with a chemically reactive surface further enhances results achieved by the first purification step.
EP3443121A1 High throughput method for accurate prediction of compound-induced liver injury A method and system for predicting liver injury in vivo due to hepatocyte damage by a test compound are provided. The method includes acquiring images of fluorescently stained cells obtained from a cell culture in which the cells have been treated with a dose-range of at least the test compound and its vehicle. The cells may be hepatic cells including primary or immortalized hepatocytes, hepatoma cells or induced pluripotent stem cell-derived hepatocyte-like cells. The acquired images are segmented. The method further includes extracting and analyzing one or more phenotypic features from the segmented images, wherein the one or more phenotypic features are selected from the group of intensity, textural, morphological, or ratiometric features consisting of (a) features of DNA, (b) features of RELA (NF-KB p65), and (c) features of actin filaments at different subcellular regions and d) features of cellular organelles and their substructures in the segmented images. Finally, the method includes normalizing results from the treated samples to vehicle controls and predicting the probability of liver injury by the test compound based on test compound-induced normalized changes of the extracted and selected phenotypic features using machine learning methods.
EP2629782B1 Use of exosomes derived from mesenchymal stem cells to promote or enhance hair growth We describe the use of an exosome for the preparation of a pharmaceutical composition to promote or enhance would healing or hair growth, or both, in an individual. The exosome may be derived from a stem cell such as a mesenchymal stem cell (MSC).
US10211805 Micro-electromechanical resonators and methods of providing a reference frequency According to various embodiments, there is provided a micro-electromechanical resonator, including a substrate with a cavity therein; and a resonating structure suspended over the cavity, the resonating structure having a first end anchored to the substrate, wherein the resonating structure is configured to flex in a flexural mode along a width direction of the resonating structure, wherein the width direction is defined at least substantially perpendicular to a length direction of the resonating structure, wherein the length direction is defined from the first end to a second end of the resonating structure, wherein the second end opposes the first end.
CN105849554B Exosome recovery method using low molecular weight organic zwitterion A method of isolating exosomes includes conducting at least one purification step in the presence of an organic zwitterion having a molecular weight of less than about 350 Daltons, a buffering pK of a negatively charged portion of the organic zwitterion is at least one full pH unit below an operating pH at which the at least one purification step is conducted, and a buffering pK of the positively charged portion of the organic zwitterion is at least one full pH unit above the operating pH.
WO2019032054A1 Method for screening splicing variants or events The present invention relates to a high-throughput method of screening splicing variants of target genes as drug targets or for characterisation of their biological functions. The disclosure provides a method for the screening of splicing variants, comprising: (a) providing a first antisense oligonucleotide capable of inducing a first splice event on the target gene to express a first splicing variant, and a second antisense oligonucleotide capable of inducing a second splice event on the target gene to express a second splicing variant; (b) hybridising the first and second antisense oligonucleotides to a pre-mRNA of the target gene; and (c) characterising the effect of the splice event. In one embodiment, the first antisense oligonucleotide switches the splice event that expresses the second splicing variant towards one that expresses the first splicing variant, while the second antisense oligonucleotide switches the splice event that expresses the first splicing variant towards one that expresses the second splicing variant.
WO2019032051A1 A multilayer coating, a method of fabricating the same and use(s) thereof There is provided a multilayer coating comprising at least one metal layer disposed between at least two doped metal chalcogenide layers. There is also provided a method of fabricating a multilayer coating comprising: providing a metal layer; and depositing at least two doped metal chalcogenide layers on at least two surfaces of the metal layer. There is also provided use of the multilayer coating for coating a substrate. In a preferred embodiment, the multilayer coating is coated on a glass window, the multilayer coating may result in energy savings and be used on smart window applications.
WO2019032049A1 Rapid analysis and identification of lipids from liquid chromatography-mass spectrometry (lc-ms) data The present invention generally relates to a method for analyzing and identification of the plurality of lipids in a sample that is profiled using a combined Liquid Chromatography-Mass Spectrometry (LC-MS) technique, comprising the steps of: a) providing a list of Liquid Chromatography-Mass Spectrometry (LC-MS)-based mass features; b) deconvoluting said list of LC-MS-based mass features; c) inferring daughter ions from the deconvoluted list of LC-MS-based mass features; d) identifying one or more parental exact masses from the inferred daughter ions; e) scoring each of the one more parental exact masses based on the inferred daughter ions; f) determining characteristic mass features in response to the scoring of each of the one or more parental exact masses; and g) determining each of the plurality of lipids based on the characteristic mass features thereof. In particular, the present invention also relates to identification of the plurality of lipids undergoing in-source fragmentation.
WO2019032047A1 A circularly polarized antenna for radio frequency energy harvesting A circularly polarized (CP) antenna for Radio Frequency energy harvesting comprising: a top substrate; a bottom substrate disposed on a ground plane; a middle substrate disposed between the top substrate and the bottom substrate; a slotted patch comprising more than one slots, the slotted patch being disposed on the top substrate; a slitted patch comprising a plurality of slits, the slitted patch being disposed between the top substrate and the middle substrate; a microstrip feed line disposed between the middle substrate and the bottom substrate; and a via connecting the slotted-circular-patch and the microstrip feed line to enable the slotted-circular-patch to be fed by the microstrip feed line, wherein the more than one slots and the slits are arranged so as to generate more than one orthogonal modes with equal magnitude for receiving RF signals.
US20190049249A1 Optical gyroscope, electro-optic system, and methods of forming the same Various embodiments may provide an optical gyroscope. The optical gyroscope may include a ring resonator, an input source configured to generate or provide a first light beam and a second light beam to the ring resonator, and a switching pathway having an input end and an output end coupled to the ring resonator, and may include a plurality of switches. The optical gyroscope may include a control circuit configured to control the plurality of switches to allow the first light beam to propagate from the input end to the output end along the switching pathway during a first time interval, and allow the second light beam to propagate from the input end to the output end along the switching pathway during a second time interval. The optical gyroscope may additionally include a detector loop configured to receive the first light beam and the second light beam from the ring resonator.
US20190049788A1 Device and arrangement for controlling an electromagnetic wave, methods of forming and operating the same Various embodiments may provide a device for controlling an electromagnetic wave. The device may include a first electrode layer. The device may also include a second electrode layer. The device may further include a matrix layer between the first electrode layer and the second electrode layer. The matrix layer may include a liquid crystal layer. The matrix layer may also include at least one resonator element in contact with the liquid crystal layer. The liquid crystal layer may be configured to switch from, at least, a first state to a second state in response to a voltage applied between the first electrode layer and the second electrode layer, thereby changing an optical property of the matrix layer to control the electromagnetic wave received by the matrix layer.
EP3439669A1 Cancer biomarkers and methods of use The present disclosure relates to a method of determining the presence of lung cancer in a subject comprising the steps of detecting an expression level of miR-1246 alone or in combination with an expression level of miR-1290 in a sample obtained from the subject wherein the increase in miR-1246 and/or miR-1290 in the sample obtained from the subject relative to the expression level of miR-1246 or miR-1290 in the control sample indicates the presence of lung cancer in the subject. The disclosure further comprises a method of monitoring a response to therapy in a lung cancer patient, a method of prognosis of lung cancer in a patient and a method for treating lung cancer in a subject comprising the use of inhibitors of miR-1246 and/or miR-1290 alone or in combination. In a specific embodiment, miR-1246 and/or miR-1290 levels are used to predict response to chemotherapy and progression in human non-small cell lung cancer (NSCLC) patients.
US10204708 System and method for deriving parameters for homeostatic feedback control of an individual A method and system of deriving a physiological homeostatic operating set point of an individual comprising the steps of: obtaining a dataset of predetermined number of homeostatic measurements of the individual; fitting the dataset of predetermined number of homeostatic measurements according to a negative exponential decay function; identifying and setting the physiological homeostatic operating set point unique to the individual as the point corresponding to the point of maximum curvature on the fitted negative exponential decay function is disclosed. The method is especially suited for determining the [FT4]-[TSH] set point, which is unique for each individual.
WO2019027368A1 Method of preparing stapled peptides Described herein is an operationally simple, one-pot solid-supported preparation of saturated stapled peptides. Following completion of ruthenium-catalysed metathesis, solid-phase transfer hydrogenation was achieved using triethylhydrosilane at elevated temperatures. The utility of the method has been demonstrated on 14-and 16-mer peptides to yield the corresponding cyclic a- helix stabilised stapled peptides.
WO2019027366A1 Antimicrobial peptidomimetics The present invention relates to peptides containing guanidine and halogenated biphenyl moieties of the formula (I), and to salts and solvates of each of these peptides and to processes for the preparation thereof, compositions containing them and the uses of such compounds. It has been found that the compounds have a high microbicide activity and are suited to combat resistant bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) strains, at very low concentrations.
US20190043792A1 Semiconductor package and method of forming the same Various embodiments may provide a semiconductor package. The semiconductor package may include a routing layer including a plurality of first layer contact elements on a first side and a plurality of second layer contact elements on a second side opposite the first side, and a first semiconductor die including a plurality of first electrical die contact elements coupled to the plurality of first layer contact elements. The semiconductor package may further include a second semiconductor die including a plurality of second electrical die contact elements coupled to the plurality of second layer contact elements, and a mold structure covering the second semiconductor die. A first pitch between neighbouring first electrical die contact elements may be greater than a second pitch between neighbouring second electrical die contact elements.
US20190040136A1 Anti-LAG-3 antibodies Anti-LAG-3 antibodies are disclosed. Also disclosed are compositions comprising such antibodies, and uses and methods using the same.
US20190037841A1 Anti-bacterial patterned surfaces and methods of making the same The present invention relates to a substrate comprising a plurality of integrally formed surface features, said surface features being micro-sized and/or nano-sized, said surface features comprising at least one pointed terminus. As a result of this unique surface, said substrate exhibits a biocidal activity because the terminal ends of said surface feature pierce through cell membrane of any microbial cell that comes into contact with the substrate, thereby causing cell deformation and lysis. The present invention also relates to a method producing said substrate. By a simple treatment of copper or zinc foil with a reagent solution comprising an alkali and an oxidizing agent, Cu(OH)2 nanotube arrays, CuO nano-blades and ZnO nano-needles are prepared. These surfaces are proven to be very effective in killing bacterial (such as E. coli) via a physical interaction.
CN109311937A Method of enhancing performance of chromatography methods for purification of proteins The application describes compositions, kits, and methods for removing contaminants from a protein preparation, for example a cell culture harvest comprising a recombinant protein. The methods described herein can enhance the performance of a later applied chromatographic purification step. The method generally involves contacting a protein preparation comprising a desired protein with a combination of allantoin, a cationic polymer, and a fatty acid, thereby causing the formation of solids and removal of the solids using a suitable process. The method is exemplified by a combination of allantoin, caprylic acid and a cationic polymer selected from chitosan, polydiallyldimethylammonium chloride (pDADMAC) and polyallylamine. Further treatment by contacting the treated sample with a chemicallyreactive surface further enhances results achieved by the first purification step.
US10195593 Method for preparing a sodium faujasite catalyst and its use in producing acrylic acid The invention relates generally to a sodium faujasite catalyst, and in particular the use of the sodium faujasite catalyst in producing acrylic acid. In particular, the invention relates to the use of the sodium faujasite catalyst in catalytic dehydration of lactic acid and 3-hydroxypropionic acid (3-HP) to produce acrylic acid.
CN104797597B Monoclonal antibody against cell wall peptide Disclosed is an isolated antibody or an antigen-binding fragment thereof. The antibody is capable of binding to a muramyl peptide, or a derivative or an analog or a salt thereof. The muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid, and a salt thereof. Also disclosed are methods of producing the antibody, compositions comprising the antibody, methods of treating using the antibody, uses of the antibody, methods of detecting muramyl peptide, an assay for detecting muramyl peptide, an antibacterial agent, hybridomas and kits.
WO2019022667A1 Tracking physiological status of cardiomyocytes using metabolic reporter The present disclosure provides an isolated cell that can be used to simulate and monitor the physiological status of cardiomyocytes. Specifically, the isolated cell comprises a hexokinase gene and a first reporter gene, and/or an acyl- CoA dehydrogenase very long chain (ACADVL) gene and a second reporter gene, wherein the hexokinase gene is operably linked to the first reporter gene via a linker and/or the ACADVL gene is operably linked to the second reporter gene via a linker, and wherein the cell is an undifferentiated stem cell, a differentiating stem cell or a cardio myocyte. The present disclosure also provides use of the isolated cell as disclosed herein to screen for candidate agents that enhance or reduce cardiomyocyte maturation. Also disclosed herein are methods of determining the maturation status of a cardiomyocyte obtained from a subject.
US20190030455A1 Adsorbent material An adsorbent material is provided. The adsorbent material comprises a porous, non-particulate substrate comprising pores having a size in the range of about 1 μm to about 1 mm, and a conformal coating film deposited on the porous, non-particulate substrate, wherein the conformal coating film comprises topographical features having a feature size in the range of about 1 nm to about 1 μm. A method of preparing the adsorbent material and an adsorbent device are also provided.
US20190035069A1 Self-determining inspection method for automated optical wire bond inspection A self-determining inspection method for automated optical wire bond inspection comprising obtaining an image of a semiconductor component comprising wire bonds; detecting a plurality of wire bonds on the semiconductor component image; detecting a wire between at least two of the plurality of detected wire bonds; determining an inspection region of interest corresponding to at least one detected wire bond and at least one detected wire; and inspecting the detected wire bond along the region of interest.
US20190031502A1 SEAL RING FOR AL-Ge BONDING There is provided a method of bonding a first substrate and a second substrate, the method comprising: providing an aluminium (Al) connection having a first width on one side of a first substrate; providing a germanium (Ge) connection having a second width on one side of a second substrate, wherein the second width is larger than the first width; and bonding the Al connection on the first substrate and the Ge connection on the second substrate by eutectic bonding of at least a portion of the Al connection and at least a portion of the Ge connection to form an Al—Ge eutectic melt, wherein the Al—Ge eutectic melt is confined within the second width of the Ge connection.
US20190033075A1 Gyroscope devices and methods for fabricating gyroscope devices According to various embodiments, there is provided a gyroscope device including: an outer frame; and four cells arranged within the outer frame, each cell of the four cells including: a proof mass arranged at least substantially in a centre region of the cell; and four electrode frames, each electrode frame of the four electrode frames arranged at a corner region of the cell and coupled to a respective side of the proof mass.
US20190033218A1 Method for assessing a state of a living cell A method for assessing a state of a living cell using surface enhanced Raman spectroscopy (SERS) is provided. The method m ay include modifying one or more living eel Is with an alkyne-containing compound to form one or more modified living cells, mixing the one or more modified living cells with a SERS-active material to form a mixture, injecting the mixture into a conduitdefined by an innerwall of a hollow core photonic crystal fiber, and detecting a surface enhanced Raman signal from the mixture in the conduit. In preferred embodiments, the alkyne containing compound is linoleamide alkyne (LLA) for the detection of lipid peroxidation or 4-(dihydroxyborophenyl) acetylene (DBA) for the detection of sialic acid expression in cells, both using gold nanoparticles as the SERS-active material.
SG11201811721UA Semiconductor packaging structure and method of forming the same Various embodiments may provide a method of forming a semiconductor packaging structure. The method may include forming a plurality of semiconductor packages, each semiconductor package including a semiconductor die and a mold encapsulation structure. The method may also include arranging the plurality of semiconductor packages to form a vertical stacked arrangement with a mold portion including a plurality of mold encapsulation structures, the mold portion extending from a first side to a second side of the vertical stacked arrangement opposite the first side. The method may additionally include forming a first via on the mold portion at the first side of the vertical stacked arrangement, forming a second via on the mold portion at the second side of the vertical stacked arrangement, and forming an electrically conductive filled via extending through the mold portion from the first side to the second side of the vertical stacked arrangement.
EP3433605A1 Surface enhanced raman spectroscopy (SERS) microfluidics biosensor for detecting single and/or multiple analytes A biosensor for the detection of an analyte using surface-enhanced Raman spectroscopy (SERS) is provided. The biosensor includes a SERS-active substrate and a microfludic circuit device arranged to be in fluid communication with the SERS-active substrate. Method of manufacturing a biosensor, and methods for detecting an analyte using the biosensor, wherein the analyte may be haptoglobin, are also provided.
SG11201811561PA Carbon dioxide sensitive dielectric materials and methods of making A carbon dioxide (CO2) sensitive dielectric nanocomposite, a capacitive CO2 sensor and a method for fabrication of the capacitive CO2 sensor are provided. The CO2 sensitive dielectric nanocomposite includes a low molecular weight organic containing a CO2 sensitive functional group, a resin, and P-type carbon nanotubes (CNTs). The method for fabrication of the capacitive CO2 sensor includes forming a CO2 sensitive dielectric nanocomposite including dissolving a low molecular weight organic containing a CO2 sensitive functional group in an organic solvent to form a first solution, dispersing P-type carbon nanotubes in an organic solvent to form a second solution, mixing the first solution and the second solution to form a nanocomposite solution, and adding a resin to the nanocomposite solution. The method further includes depositing the nanocomposite solution with the resin to form a solid nanocomposite film on a surface of a substrate with capacitive electrodes, and curing the nanocomposite film on the electrodes to form the capacitive CO2 sensor.
US10193532 Method of operating a finite impulse response filter According to one aspect of the invention, there is provided a method of operating a finite impulse response filter comprising an input; an output; and a plurality of storage elements, each coupled to the input via a sample switch and to the output via a transfer switch, the method comprising: during charging of the plurality of storage elements, applying a sample clock signal to each of the sample switches that achieves an operation mode where up to every one of the sample switches is simultaneously closed to connect all of the plurality of storage elements to the input; and during averaging of the plurality of storage elements, applying a transfer clock signal to each of the transfer switches to close one or more of the transfer switches to connect the storage elements, having charge stored therein, to the output.
US10189842 Wnt pathway modulators The present invention relates to dihydropyrazolo[1,5-a]pyrimidine compounds of formula I, defined herein, as WNT pathways modulators, processes for making them, and pharmaceutical compositions comprising them. Methods of treatment of conditions mediated by WNT pathway signalling including cancer, fibrosis, stem cell and diabetic retinopathy, rheumatoid arthritis, psoriasis and myocardial infarction, comprising the compounds of formula I are also provided.
US20190025613A1 Broadband tunable thz wave manipulator and the method to form the same A semiconductor device includes a semiconductor substrate having a metasurface layer configured with multiple pairs of finger portions in a repeating arrangement. The multiple pairs of finger portions are electrically configurable to modulate a radiation signal received by the semiconductor device. Each pair of finger portions includes first and second members where the first member is doped with a first dopant and the second member is doped with a second dopant being different to the first dopant. Any two adjacent first or second members are configured to be separated by at least deep subwavelength to enable the repeating arrangement.
WO2019017846A1 Hexaazatriphenylene derivative and graphene oxide composites The present invention generally relates to composites comprising hexaazatnnaphthalene (HATN) or its derivatives and a conductive carbon material, which are suitable for use as cathode materials in lithium ion batteries. The HATN derivatives may contain groups that are capable of forming hydrogen bonds. The conductive carbon material is preferably graphene oxide (GO). The present invention also relates to a method of preparing said composites, comprising steps of heating a cydoketone with an amine, and mixing the produced compound with a conductive carbon material.
US20190024175A1 Method for detection of a genetic variant A method and kit for detecting a genetic variant associated with a disease or disorder, including incompatibility with a pharmaceutical. The method and kit using a first nano-particle coupled to at least one morpholino nucleic acid probe comprising a target complimentary region base sequence that is a perfect match to a genetic variant sequence.
EP3116991B1 Method for inducing pluripotency in a hematopoietic cell There is provided a method of inducing pluripotency in a hematopoietic cell. The method comprises providing a blood sample that has been collected from a subject in the absence of any polysaccharide preparation used for separating blood components. The sample is depleted of red blood cells by treating the sample with a hypotonic erythrocyte lysis buffer, in the absence of any polysaccharide preparation used for separating blood components, thus obtaining a remaining cell population. The remaining cell population in the sample is expanded in a hematopoietic expansion medium to obtain an expanded cell population that contains CD71+ cells, and the expanded cell population containing the CD71+ cells is then cultured in the presence of Oct4, Sox2, and Klf4, and optionally c-MYC, in human embryonic stem cell medium to induce pluripotency.
EP3431583A1 Method for differentiating induced pluripotent stem cells into renal proximal tubular cell-like cells A population of renal proximal tubular cell (PTC)-like cells differentiated from a population of induced pluripotent stem cells (iPSCs) seeded at a density of about 5 000 to about 10 000 viable cells/cm2, in renal epithelial cell culture medium in the presence of one or more extracellular matrix molecule, bone morphogenic protein 2, and bone morphogenic protein 7, for a period of from about 7 to about 10 days. A bioengineered tissue graft comprising a matrix, seeded with the population of cells. A bioartificial kidney device containing the population of cells for use in the treatment of a renal related disorder in a subject. The population of cells or the bioengineered tissue graft for use in treatment of a renal related disorder in a subject.
WO2019013707A1 Cell-penetrating glycosaminoglycan mimetics This invention relates to a glycosaminoglycan mimetic molecule comprising a polyproline backbone, an anionic pendant group and a fluorophore. The invention also relates to the use of the glycosaminoglycan mimetic molecule for internalizing a target molecule into a cell, a method for internalizing a target molecule into the cell, and a method for synthesizing a glycosaminoglycan mimetic molecule. [No suitable figure]
WO2019013703A1 Bicyclic alkyne derivatives and uses thereof The present invention relates to bicydic alkyne compounds of Formula (I) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNKIa, and MNKIb. The present invention further relates to pharmaceutical compositions comprising these compounds, and to these compounds for use in the prevention and treatment of diseases, disorders and conditions which would benefit from the modulation of MNK1 or MNK2, such as cancers, neurodegenerative diseases, autoimmune diseases, metabolic diseases and inflammatory diseases. The invention also relates to the use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.
US20190020028A1 Free-standing MOF-derived hybrid porous carbon nanofiber mats According to the present disclosure, a method of fabricating a metal-carbon fibrous structure is provided. The method comprises the steps of: (a) forming a fibrous support structure comprising composite nanocrystals and polymeric fibers, wherein each of the composite nanocrystals comprises metal ions connected by organic ligands; (b) growing the composite nanocrystals on the fibrous support structure; and (c) subjecting the fibrous support structure of step (b) to carbonization to form the metal-carbon fibrous structure, wherein the metal-carbon fibrous structure comprises metal nanoparticles derived from the composite nanocrystals comprising metal organic framework (MOF), particularly zeolitic imidazolate framework (ZIF). A metal-carbon fibrous structure comprising carbon based fibers arranged to form a porous network and the carbon based fibers are doped with metal nanoparticles, wherein the carbon based fibers have surfaces which comprise graphitic carbon, is also disclosed herein.
US20190018176A1 Polarization device for polarizing electromagnetic waves, methods of forming and operating the same Various embodiments may provide a polarization device for polarizing electromagnetic waves. The polarization device may include a stacked arrangement including a medium and an anti-reflection coating in contact with the medium. The polarization device may also include a periodic array of polarization elements in contact with the medium. The polarization device may be configured to, based on an electric response and a magnetic response of the periodic array of the polarization elements, transmit first polarized electromagnetic waves having a first polarization and reflect second polarized electromagnetic waves having a second polarization upon receiving the electromagnetic waves.
US20190017110A1 Determination of nucleic acid methylation The invention relates to methods and kits for determining the methylation status of a target nucleic acid molecule in a sample comprising (a) bisulfite treatment of the target nucleic acid, (b) amplifying the treated target nucleic acid with methylation-specific primers, (c) contacting the amplicons with a methylation-specific plasmonic nanoprobe and (d) determining the methylation status based on melting temperature Tm of the hybrid probe and the target nucleic acid. In particular, a plasmonic gold nanoparticle covalently coupled to a morpholino oligonucleotide probe. Also claimed are methods and kits for determining methylation status of the Septin 9 (SEPT9) gene promoter.
EP2834212B1 A method for synthesizing a sugar alcohol A method for synthesizing a sugar alcohol comprising the step of hydrolyzing a polysaccharide in the presence of hydrogen ions (H+), an alcoholic reducing agent and a hydrogen transfer catalyst to form the sugar alcohol.
US10179194 Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing The present invention relates to the use of peptides, peptoids and/or peptidomimetics capable of self-assembling and forming a (nanofibrous) hydrogel in biofabrication. The present invention further relates to methods for preparing hydrogels and to methods for preparing continuous fibres and to methods for obtaining multi-cellular constructs with defined, precise geometrics. The present invention further relates to various uses of such hydrogels for obtaining mini-hydrogel arrays and 3D organoid structures or 3D macromolecular biological constructs.
CN105026418B Protein purification method A method for the purification of a desired protein from a protein preparation includes conditioning the protein preparation by treatment with soluble organic multivalent ions, immobilized organic multivalent ions, or both, optionally in the presence of supersaturated allantoin, thereby removing at least 90% of chromatin, then (1) precipitating the desired protein with a nonionic organic polymer in the presence of non-protein-precipitating salts at greater than physiological concentration to provide a precipitate of the desired protein; or (2) precipitating the desired protein with a nonionic organic polymer in the absence of non-precipitating salts at greater than physiological concentration to provide a precipitate and subsequently washing the precipitate with a nonionic organic polymer in the presence of non-protein-precipitating salts at greater than physiological concentration.
US20190008830A1 Micellar nanocomplex The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.
WO2019009808A1 Non-enzymatic colorimetric test strip and method for detection of ethanol vapour content The present invention relates to a non-enzymatic colorimetric test strip for detection ofethanol vapour content in a vapour sample and a method of detecting ethanol vapourcontent using the test strip. The test strip comprises a substrate having a sampledetection zone and a control zone; a first dye deposited and immobilized onto a regionwithin the sample detection zone; and a second dye deposited and immobilized onto aregion within the control zone. The first dye in the sample detection zone undergoes acolour change in response to ethanol vapour in the vapour sample that comes intocontact with the first dye on the test strip. The method comprises contacting a vapoursample with the first dye in the sample detection zone of the test strip, capturing animage of the entire test strip and performing image analysis of the captured image todetect the presence of ethanol and determine the concentration of ethanol in thevapour sample.
WO2019009810A1 Fluorescent compounds specific for pluripotent stem cells and reprogramming-ready cells and methods of using the same The present invention provides fluorescent compounds of formula (I) as disclosed herein or pharmaceutically acceptable salts thereof. Further provided are uses of said fluorescent compounds in methods of determining, in a sample, the presence and/or amount of pluripotent stem cells or cells undergoing reprogramming to become induced pluripotent stem cells.
WO2019009806A1 Method and system for multi-modal imaging of tissue There is provided a method for multi-modal imaging of tissue. The method includes: providing a fiber probe over a target area of the tissue, the fiber probe including a plurality of source fiber channels, a plurality of detector fiber channels and a plurality of fiducial marker channels, the plurality of source fiber channels, the plurality of detector fiber channels and the plurality of fiducial marker channels having a predetermined spatial arrangement in the fiber probe; directing light through each of the plurality of source fiber channels of the fiber probe to the target area in succession for performing optical imaging of the target area; obtaining optical imaging data of the target area based on attenuated light from the target area detected through the plurality of detector fiber channels due to said light directed to the target area; obtaining MRI data of the target area based on a MRI of the target area; and coregistering the optical imaging data and the MRI data based on a plurality of fiducial features captured in the MRI data corresponding to the plurality of fiducial marker channels of the fiber probe. There is also provide a corresponding system for multi-modal imaging of tissue.
US10174126 Antibodies binding to an intracellular PRL-1 or PRL-3 polypeptide We provide an antibody capable of binding to an intracellular PRL-I or PRL-3 polypeptide, in which the antibody is capable of binding to an epitope bound by antibody 269, antibody 223 or antibody 318. Such anti-PRL antibodies may be capable of binding to intracellular PRL-I or PRL-3. They may be suitable for use as therapies against cancer or metastasis thereof, or in clinical diagnosis to identify PRL-3 or PRL-1 positive patients.
US10176573 Automatic region-of-interest segmentation and registration of dynamic contrast-enhanced images of colorectal tumors A method for dynamic contrast enhanced (DCE) image processing and kinetic modeling of an organ's region-of-interest is provided. The method includes deriving at least a contour of an exterior of the organ's region-of-interest from one or more of a plurality of images; generating a spline function in response to the derived contour of the exterior of the organ's region-of-interest from the one or more of the plurality of images; registering the plurality of images wherein the organ's region-of-interest has been segmented; deriving a tracer curve for the organ's region-of-interest in the registered images, the tracer curve indicating a change in concentration of a contrast agent flowing through the organ's region-of-interest over a time period; and kinetic modeling by fitting a kinetic model to the tracer curve to generate one or more maps of tissue physiological parameters associated with the kinetic model.
US10174076 Protein purification process A method of purifying a target protein includes contacting a cell culture harvest or a protein preparation including at least one target protein with at least one fatty acid having 8 to 10 carbon atoms to form a mixture, contacting the mixture with one or more solids to form a mixture, the one or more solids comprise a cationic functional group, a metal binding functional group, or both, the metal binding functional group including a nitrogen-containing moiety selected from (1) a polyamine, (2) an imine, (3) an N-heterocycle, (4) an amino acid, (5) an N-hydroxyamide, (6), an arylamine, and combinations thereof, and separating solid materials after contacting the mixture with the one or more solids to provide a solution comprising the target protein.
US10170693 Magnetoresistive device and method of forming the same According to embodiments of the present invention, a magnetoresistive device is provided. The magnetoresistive device includes a free magnetic layer structure having a variable magnetization orientation, a fixed magnetic layer structure having a fixed magnetization orientation, and a tilting magnetic layer structure configured to provide an interlayer exchange biasing field to tilt, at equilibrium, the fixed magnetization orientation or the variable magnetization orientation relative to the other to be along a tilting axis that is at least substantially non-parallel to at least one of a first easy axis of the fixed magnetization orientation or a second easy axis of the variable magnetization orientation. According to further embodiments of the present invention, a method of forming a magnetoresistive device is also provided.
US10167335 IL-1β neutralizing human monoclonal antibodies The present invention is directed to antigen binding proteins and in particular to IL-1β antigen binding proteins. The present invention further provides compositions comprising the antigen binding proteins, use of the antigen binding proteins and methods for production.
SG11201809883QA Fan-out wafer-level packaging method and the package produced thereof A fan-out wafer-level packaging method and the package produced thereof are provided in the present application. The method comprises steps including: providing a silicon substrate layer having a first thickness; forming one or more active/passive devices comprising at least sources and drains and one or more diffusion layers adjoining the sources and drains, wherein forming the one or more active/passive devices comprises forming the sources and the drains in a front-end-of-line (FEOL) layer on a first side of the silicon substrate layer while forming the one or more diffusion layers at locations in the silicon substrate layer adjoining the sources and the drains; forming a redistribution layer (RDL) over the FEOL layer by copper damascene formation of multiple metallization layers for connecting the one or more active/passive devices to the one or more IC dies when the one or more IC dies are mounted on a side of the RDL opposite the FEOL layer; thinning the silicon substrate layer to a second thickness to form a thinned silicon substrate, the thinned silicon substrate comprising at least the one or more diffusion layers; and patterning the thinned silicon substrate to form one or more silicon regions, each of the one or more silicon regions comprising the one or more diffusion layers.
US20180368914A1 Method and deployable multi-spine apparatus for catheter-based renal denervation A device for vascular denervation comprising a catheter for insertion into a vessel, at least one elongated catheter arm having alternating regions of flexible joints and rigid blocks along the at least one catheter arm, wherein each of the at least one catheter arm comprises at least one tactile sensor and at least one temperature sensor; at least one electrode and electrical circuitry disposed on each of the at least one catheter arm and at least one linkage connected to all of the elongated catheter arms. A method for batch fabricating a plurality of catheter arms for the vascular denervation device is also provided and comprises the steps of depositing a first polymer coating on a semiconductor substrate, forming metal traces on the first polymer coating, patterning and etching the substrate to the first polymer coating to create flexible joint regions.
EP3417076A1 Cancer epigenetic profiling The present invention relates to a method for determining the presence or absence of at least one super-enhancer in a cancerous biological sample based on signal intensity of the histone modification H3K27ac. The present invention also relates to a method for determining the prognosis of cancer in a subject, a method of determining the susceptibility of a subject to cancer or a gastrointestinal disease and a method of predicting cancer cell survival or cancer cell viability by determining the presence or absence of at least one super-enhancer. The present invention also relates to inhibitors of CDX2 and/or HNF4α, such as metformin, and use thereof for modulating the activity of a super-enhancer.
EP3417296A1 Epigenomic profiling reveals the somatic promoter landscape of primary gastric adenocarcinoma The present invention relates to a method for determining the presence or absence of at least one promoter or cancer associated promoter, or a method for cancer prognosis, each based on the isolation of a nucleic acid having signal ratio of H3K4me3 to H3K4me1 greater than 1 and detecting the change in signal intensity of H3K4me3 in the nucleic acid in the cancerous biological sample relative to the non-cancerous biological sample. A biomarker for cancer detection comprising a promoter having the change in signal intensity of H3K4me3 in the cancerous biological sample relative to a non-cancerous biological sample is also disclosed herein. In a separate invention, a method for modulating the activity of at least one cancer-associated promoter or a method for modulating the immune response is further disclosed, each involving an administered inhibitor of EZH2.
US10160784 Antibody purification process A method of purifying a target antibody includes contacting a cell culture harvest or a protein preparation including at least one target antibody with at least one fatty acid having 7 to 10 carbon atoms to form a mixture, contacting this mixture with allantoin, and then separating solid materials to provide a solution comprising the target antibody. Solid materials can be removed by filtration, sedimentation or centrifugation, and the fatty acids can be enanthic, caprylic, pelargonic, nonenoic or capric acid. The invention is also directed to kits used to facilitate this method of antibody purification.
CN109073197A Lighting device and inspection apparatus A lighting device for an inspection apparatus. The lighting device may include a hollow housing having an inner planar reflective surface and an opposing inner concave dome-shaped reflective surface.The lighting device may further include at least one light source disposed at the inner planar reflective surface. The hollow housing may include an opening configured to be a light outlet. An inspection apparatus including the lighting device and an imaging device coupled to the lighting device.
CN109073659A Epigenomic profiling and revealing somatic promoter landscape of primary gastric adenocarcinoma The present invention relates to a method for determining the presence or absence of at least one promoter or cancer associated promoter, or a method for cancer prognosis, each based on the isolationof a nucleic acid having signal ratio of H3K4me3 to H3K4me1 greater than 1 and detecting the change in signal intensity of H3K4me3 in the nucleic acid in the cancerous biological sample relative to the non-cancerous biological sample. A biomarker for cancer detection comprising a promoter having the change in signal intensity of H3K4me3 in the cancerous biological sample relative to a non-cancerous biological sample is also disclosed herein. In a separate invention, a method for modulating the activity of at least one cancer-associated promoter or a method for modulating the immune response isfurther disclosed, each involving an administered inhibitor of EZH2.
US10156532 System and method for detecting a defective sample In various embodiments, a system for detecting a defective sample may be provided. The system may include a chamber. The system may further include a pressure reducing mechanism coupled with the chamber. The system may additionally include a detector. The pressure reducing mechanism may be configured to reduce a pressure in the chamber. The detector may be configured to detect information indicating a temperature of the sample. Various embodiments may be capable of detecting water ingress or fluid ingress into the micro cracks or along the designed discontinuities, like bolts and rivets.
US20180354989A1 Antimicrobial peptidomimetics The present invention relates to peptidomimetics of the formula (I) or (I)c wherein L1, L2, L3, R1, R2, R3, R4, R5, R6, n, m, Q, X, Z1 and Z2 are defined as mentioned in the description and to salts and solvates of each of these compounds and to processes for the preparation thereof, compositions containing them and the uses of such compounds. It has been found that the compounds have a high microbicide activity and are suited to combat resistant bacteria, such as meticillin-resistant Staphylococcus aureus (MRSA) strains, at very low concentrations.
US20180355310A1 A cell culture substrate and method of making thereof A cell culture substrate comprising a substrate having a coating of a plurality of amine functionalized nanoparticles is disclosed. In one embodiment, the amine functionalized nanoparticle is a polymer of an acrylamide monomer, a cross-linker and an amine monomer. There is also provided a method of making the cell culture substrate either by drying the amine functionalized nanoparticles when spread onto the said substrate or by covalent linkages of the substrate with thiol terminated nanoparticles. In addition, there is provided a method of culturing stem cells on the cell culture substrate having a coating of a plurality of the amine functionalized nanoparticles thereon.
EP2234655B1 Forming porous scaffold from cellulose derivatives Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores.
US10151638 Bolometer, method of fabricating the same, and bolometric method Various aspects of this disclosure provide a bolometer including a substrate and a ring resonator structure over the substrate. The bolometer may also include a silicon oxide layer in thermal contact with the ring resonator structure. The bolometer may further include a first waveguide over the substrate and coupled to the ring resonator structure, the first waveguide configured to couple an infrared light to the ring resonator structure so that the infrared light generates a temperature increase in the silicon oxide layer. The bolometer may additionally include a second waveguide over the substrate and coupled to the ring resonator structure, the second waveguide configured to couple a probe light input to the ring resonator structure so that a probe light output is generated from the probe light input, the probe light output having a change in a characteristic from the probe light input based on the temperature increase.
US20180346626A1 A polymeric composition A polymeric composition comprising (i) a plurality of monomers selected from (a) a carboxylic acryloyi monomer; (b) a sulfonic acryloyi monomer; (c) an amine acryloyi monomer; (d) a hydroxyl acryloyi monomer; (e) an alkyl acryloyi monomer; and (f) a polyalkylene hydroxyl acryloyi monomer; (ii) a divalent metallic crosslinking agent; and (c) a stabilizing agent is disclosed herein. Also provided are the use of said polymeric composition as a hydrogel coating material, a method of synthesizing the polymeric composition and the use of the hydrogel material.
US20180346673A1 Method for preparing an oxide film on a polymeric substrate Various embodiments refer to a method for preparing an oxide film on a polymeric substrate, wherein the oxide film is a titanium oxide film (which is optionally niobium- or silicon-doped) or silicon oxide film. The method comprises contacting a polymeric substrate with a liquid reagent comprising a polyalkoxysilane such as 3-aminopropyltriethoxysilane to form a layer of the polyalkoxysilane on the polymeric substrate by self-assembly, and contacting said layer with an aqueous mixture comprising (i) titanium tetrafluoride and/or a fluorine-containing titanium complex such as ammonium hexafluorotitanate and/or a fluorine-containing silicon complex such as ammonium hexafluorosilicate, and (ii) a fluorine scavenger such as boric acid, at a temperature of less than about 100° C. to obtained the oxide film on the polymeric substrate. An oxide film prepared by said method is also provided.
US10134607 Method for low temperature bonding of wafers A method for bonding wafers is provided. The method comprises the steps of providing a first wafer having an exposed first layer, the first layer comprising a first metal; and providing a second wafer having an exposed second layer, the second layer comprising a second metal, the first metal and the second metal capable of forming a eutectic mixture having a eutectic melting temperature. The method further comprises the steps of contacting the first layer with the second layer; and applying a predetermined pressure at a predetermined temperature to form a solid-state diffusion bond between the first layer and the second layer, wherein the predetermined temperature is below the eutectic melting temperature.
US20180325111A1 Antibacterial particles functionalized with polyalkylene imine and its derivatives for water disinfection This invention relates to an antibacterial polymer-modified particle comprising a particle core, wherein a polymer is covalently bound to the particle core via a linker and said polymer comprises a branched, amphiphilic cationic polyalkylene imine backbone having amine or amino functional groups and wherein optionally all or some of the amine or amino groups of the polymer have been further reacted with amphiphilic cyclic carbonates carrying a quaternary ammonium group under formation of a urethane bond. In a preferred embodiment the core is a silica core functionalized with the polyelkyleneimine. The invention also relates to methods of making such particles and their use in water disinfection applications.
EP3328894B1 Il2rbeta/common gamma chain antibodies Anti-CD122 and/or yc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.
US10127114 Method of file system design and failure recovery with non-volatile memory A method of rebooting a file system using a non-volatile memory is provided. The method comprising persistently storing critical information in the non-volatile memory, the critical information indicating a status of the file system; in response to a predetermined event, obtaining critical information of the file system stored in the non-volatile memory; determining if the file system has crashed based on the critical information; and rebooting from metadata in the non-volatile memory if it is determined that the file system has crashed.
US10128503 Conductive fibrous materials There is provided a conductive fibrous material comprising a plurality of carbonaceous fibers, wherein each carbonaceous fiber is fused to at least one other fiber. The carbonaceous fibers may be fused at fiber-to-fiber contact points by a polymer. The process of making the conductive fibrous material comprises mixing a phenolic polymer with a second polymer to form a polymer solution, preparing phenolic fibers having nano- or micro-scale diameters by electrospinning the polymer solution, and subsequent carbonization of the obtained phenolic fibers, thereby generating carbonaceous fibers, wherein each carbonaceous fiber is fused to at least one other fiber. The conductive fibrous material may be useful in electrode materials for energy storage devices.
US20180320000A1 Antimicrobial coatings A coating comprising a metal-organic framework, wherein the metal-organic framework having a zeolitic structure comprising at least one multivalent metal species and at least one organic ligand (such as zeolitic imidazolate framework (ZIF)). Said coating has a topography comprising an array of projections, and each projection having at least one tapered distal end. There is also provided a method of coating substrates with the disclosed coating and use of said coating as a disinfectant, an antiseptic, or an antibiotic. Such use is possible because the tapered distal end of the disclosed zeolitic structure exerting higher pressure on any microbial cell that comes into contact with the disclosed coating, thereby piercing through the cell membrane more easily, causing cell deformation and lysis.
EP3398970A1 A method of synthesizing cellulose carbonate According to the present disclosure, a method of synthesizing cellulose carbonate is provided. The method includes mixing a solution comprising dimethyl sulfoxide and cellulose with an organic base in the presence of carbon dioxide to form a cellulose solution comprising cellulose carbonate anions, wherein the organic base is represented by a formula of: wherein each of R1, R2 and R3 is C1-C20 alkyl; and wherein each of R4 and R5 is hydrogen or C1-C20 alkyl. The method also includes contacting the cellulose solution with one or more organochlorides in the presence of carbon dioxide to form the cellulose carbonate, and adding an alcohol or water to precipitate the cellulose carbonate.
US10122381 Method of constructing flat XOR codes from integer indexed tanner graphs A method for defining an erasure code for system having a predetermined number of data disks is disclosed. The method includes selecting step, constructing step, determining step and repeating step. The selecting step includes selecting a predetermined acceptable number of failures for the system. The constructing step includes constructing a first Tanner graph for two failures acceptable system having predetermined number of data disks. The determining step includes determining erasure code from the first Tanner graph. The repeating step includes repeating the constructing step and the determining step by increasing the acceptable number of failures by one and constructing another Tanner graph in response to the increased acceptable number of failures by increasing number of parity nodes until the predetermined number of failures for the system is reached.
US10117946 Self-assembling ultrashort peptides modified with bioactive agents by click chemistry The present invention relates to hydrogels comprising a first peptide with a covalently linked bioactive agent and optionally a second peptide. The present invention further relates to uses of the hydrogel for delivery of the bioactive agent or as an implant. The present invention further relates to drug delivery devices, implant, pharmaceutical or cosmetic compositions comprising the hydrogel. The present invention further relates to methods of local treatment of diseases and to methods for preparing the first peptide and the hydrogels.
US20180311264A1 Composition for modulating IRAK1 The present invention relates to the treatment of breast cancer, more particularly triple negative breast cancer (TNBC), with the use of an inhibitor of Interleukin 1 Receptor Associated Kinase 1 (IRAK1) such as ginsenosides. It also relates to a method for aiding in categorising or determining prognosis in a breast cancer patient or in selecting a therapeutic strategy comprising assessing the level of IRAK1 nucleic acid, protein or activity in a sample and, in some aspects, further assessing the paclitaxel resistance status of the patient and if the patient is resistant to paclitaxel therapy, treating the patient with an inhibitor of IRAK1 activity. In addition, a screening method for identifying a compound useful for treating breast cancer comprises determining the effect of a test compound on IRAK1 nucleic acid, protein or activity level and selecting a compound that reduces said level.
US20180312399A1 Device arrangement Various embodiments may provide a device arrangement. The device arrangement may include a substrate including a conductive layer. The device arrangement may further include a microelectromechanical systems (MEMS) device monolithically integrated with the substrate, wherein the MEMS device may be electrically coupled to the conductive layer. A cavity may be defined through the conductive layer for acoustically isolating the MEMS device MEMS device from the substrate. At least one anchor structure may be defined by the conductive layer to support the MEMS device.
EP2931921B1 Label-free methods for isolation and analysis of nucleic acids on solid phase device Methods and system for the isolation and/or analysis of nucleic acids on a solid phase device comprising (i) incubating a nucleic acid sample with Dimethyl adipimidate (DMA) on said solid phase under conditions that allow formation of a complex of the nucleic acid with the DMA; contacting the complex of (i) with said surface; and isolating and/or analyzing the nucleic acid of the complex.
EP2816999B1 Organogels and emulsions for biological and non-biological applications The present invention relates to organogels and emulsions based on ultrasmall self-assembling peptides. It further relates to methods for producing such organogels and emulsions as well as to the use of the organogels and emulsions in biological and non-biological applications.
SG11201808550RA Window with noise management and related methods A window system, a method of managing noise and a method of installing a noise management system on a window are provided. The window system includes a ventilation channel and a noise management system in or adjacent the ventilation channel. The noise management system includes a multi-cell transparent electroactive film speaker and a control unit connected to the multi-cell transparent electroactive film speaker. The multi-cell transparent electroactive film speaker includes a plurality of individually operable electroactive cells. Each cell includes a respective series of resonance frequencies such that the multi-cell transparent electroactive film speaker is capable of multiple series of resonance frequencies. The control unit is configured to actively detect an incident noise entering the ventilation channel and control at least one cell of the multi-cell transparent electroactive film speaker to generate a corresponding counter noise to substantially cancel the incident noise.
SG11201808379PA Method and device for mesh routing in a channel-diverse mesh network Method and Device for Mesh Routing in a Channel-Diverse Mesh Network Embodiments of the invention relate to low-cost and low-complexity mesh routing method to provide connectivity within a channel-diverse mesh network in which there is no common channel available for the whole network and in which a single transceiver is provided in each node. The mesh routing method includes a procedure for flooding radio resource maps (RRMs), a procedure for determining the operating channel for each mesh node device, a routing procedure for establishing a route for a pair of source device and destination device, and a maintenance procedure for repairing routes and optimize selection of operating channel.
SG11201808576PA An electrochemical cell and method of making the same This invention relates to an electrochemical cell comprising an anode structure comprising an element selected from the group consisting of group 1, group 2, group 8, group 12 and group 13 of the Periodic Table of Elements; a cathode structure comprising a catalyst; and a hydrogel located between the anode structure and the cathode structure. In a preferred embodiment, the cell comprises the anode of Zinc, the catalyst of CoOx/C, the hydrogel of free-standing alkaline polyacrylamide hydrogel, wherein said hydrogel was first synthesized via UV-initiated radical polymerization of acrylamides, followed by exchange of water with an alkaline electrolyte of potassium hydroxide (KOH). The invention further relates to a method of manufacturing such an electrochemical cell and the use of a hydrogel in a metal/air battery.
SG11201808338RA Low profile wideband antenna A low-profile wideband monopole antenna is provided. The antenna may include a radiating element configured in a bent monopole arrangement to provide a vertical polarization such that an omni-directional radiating characteristic is achieved. The radiating element may include a plurality of slots formed at or edged from each side of the radiating element to increase the effective current path length of the radiating element. The antenna may include a feed and a feeding structure extending from the radiating element to the feed. The antenna may further include a ground plane. The radiating element may be arranged substantially parallel to the ground plane. The surface area of the radiating element may be smaller than the ground plane.
US10116286 Reference clock signal generators and methods for generating a reference clock signal According to various embodiments, there is provided a method for generating a reference clock signal, the method including discharging a capacitive element to a discharged state, when a reset signal has a predetermined reset state; charging the capacitive element from the discharged state to a first voltage, when a charge signal has a predetermined charge state; comparing the first voltage to a zero voltage, when a compare signal has a predetermined compare state; generating a second voltage based on the comparing of the first voltage to the zero voltage; generating a clock signal based on the second voltage, using an oscillator; and generating each of the reset signal, the charge signal and the compare signal, based on the clock signal.
US10112971 Protein purification in the presence of nonionic organic polymers and electropositive surfaces A method of purifying a desired protein from a preparation includes (a) providing the preparation in a form having less than about 5% of chromatin residing in an original production medium, (b) contacting the preparation with a nonionic organic polymer and a salt, a concentration of nonionic organic polymer being sufficient to precipitate the desired protein or cause its accretion on a hydrophilic surface, or maintain it in a precipitated state or accreted on the hydrophilic surface, the salt concentration being sufficient to produce greater than physiological conductivity, and (c) contacting the preparation with at least one electropositive surface, optionally in the presence of a salt concentration sufficient to produce greater than physiological conductivity, the desired protein does not substantially adsorb to the at least one electropositive surface while not preventing adsorption of acidic contaminants to the at least one electropositive surface.
US10111787 Apparatus for a diaper, a system, a diaper and a method of manufacturing an electrode Various embodiments provide an apparatus for a diaper. The apparatus has two electrodes and an electronic device. The electronic device is coupled to the two electrodes. The two electrodes are operable to generate a potential difference when they are electrically connected together by ionized liquid. The electronic device is operable to generate an alarm signal when the potential difference is generated. Various other embodiments relate to a corresponding system, diaper and method of manufacturing an electrode.
CN104854133B Optimal heavy and light chain signal peptides for the preparation of recombinant antibody therapeutics Antibodies of interest comprising a heavy chain signal peptide and/or a light chain signal peptide or combination thereof and compositions are described. The method of determining the signal peptide including creating data set of antibodies signal peptides, clustering, selecting and creating recombinant antibodies for enhanced expression and secretion are described.
CN104487447B Mixed polyfunctional metal affinity surface for reducing aggregate content in the field of protein preparations Compositions for reducing the aggregate content of a protein preparation include a first substrate having a first surface-bound ligand possessing a metal affinity functionality and a second surface-bound ligand optionally provided on a second substrate and having an aggregate charge opposite to that of the metal affinity functionality of the first substrate, wherein the first surface-bound ligand and the second surface-bound ligand are positioned such that the protein preparation may contact both the first surface-bound ligand and the second surface-bound ligand simultaneously.
US20180304309A1 Ultrasound transducer and method of forming the same Embodiments provide an ultrasound transducer. The ultrasound transducer may include a multi-layered membrane having a plurality of slits extending through the membrane, thereby forming a plurality of sections of the membrane at least partially separated by the slits. Each slit extends from a perimeter of the membrane to a respective end position at a predetermined distance away from a center of the membrane. The plurality of sections of the membrane are connected to each other at the center of the membrane.
EP2855504B1 Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities A method of purifying a sample containing a desired protein includes the steps of (i) providing a packed chromatographic column having positively charged porous particles, (ii) equilibrating the column to the conditions to which the desired protein in the sample is to elute, (iii) contacting the sample with the packed chromatographic column such that the sample volume applied to the packed chromatographic column is less than or equal to the interparticle space of the positively charged porous particles within the packed chromatographic column, (iv) eluting the desired protein from the packed chromatographic column, where the desired protein is in a purer state and in the conditions to which the packed chromatographic column was equilibrated; where the desired protein is an antibody, an antibody fragment, an antibody derivative, or an antibody fusion protein.
US10105454 Ultrashort peptides as exogenous second harmonic probes for bioimaging applications Various aspects of the present invention relate to a peptide based biomaterial for visualization by SHG microscopy. In particular the invention relates to the use of short peptides as a non-linear optical (NLO) material for second harmonic generation (SHG) microscopy. A preferred short peptide comprises LIVAGK (LK6) and contains a non-polar aliphatic tail (with decreasing hydrophobicity) and a polar head; and can self-assemble into hydrogels; wherein which the peptide forms a tunable fibrous structure for in vitro and in vivo imaging applications and is suitable in disease diagnostics such as amyloidosis, including 1) neuro-degenerative amyloidosis, e.g. Alzheimer's (AD), Parkinson's, Huntington's (PD), 2) non-neuropathic localized amyloidosis such as in Type II Diabetes, and 3) systemic amyloidosis that occurs in multiple tissues, e.g. cataracts and lattice corneal dystrophy (LCD), as well as drug delivery and/or wound dressings.
US10107748 Optical sensing device for surface plasmon resonance (SPR) and optical sensing method using surface plasmon resonance (SPR) An optical sensing device is provided, including a first polarizer, a second polarizer, wherein the first polarizer and the second polarizer have respective transmission axes aligned in orthogonal directions, an SPR sensor arrangement including an SPR sensing surface, the SPR sensor arrangement arranged to receive an incident light beam passed through a polarizer to be reflected at the SPR sensing surface and transmitted through a second polarizer to provide a transmitted light beam, a detector arrangement configured to detect the transmitted light beam, the transmitted light beam including a sensing signal and a reference signal, and a processor electrically coupled to the detector arrangement, the processor configured to perform a subtraction operation between the sensing signal and the reference signal. The optical sensing is based on a differential measurement scheme. The subtraction between the sensing signal and the reference signal cancels the common path noise and enhances the sensor resolution.
US10103359 Multilayer film for encapsulating oxygen and/or moisture sensitive electronic devices The present invention refers to a multilayer barrier film capable of encapsulating a moisture and/or oxygen sensitive electronic or optoelectronic device, the barrier film comprises at least one nanostructured layer comprising reactive nanoparticles capable of interacting with moisture and/or oxygen, the reactive nanoparticles being distributed within a polymeric binder, and at least one ultraviolet light neutralizing layer comprising a material capable of absorbing ultraviolet light, thereby limiting the transmission of ultraviolet light through the barrier film.
US20180291144A1 Process for making a polyester-based macroinitiator polymer This invention relates to a method of forming a polymer comprising a step of esterifying a polyester having at least one free hydroxyl group with acyl halides or a halogen-containing carboxylic acid. The modified polyesters, made with the inventive method can be halogen-containing macroinitiator materials for further synthesis, for example, atom transfer radical polymerization as shown in other aspects of the invention. The polymers are new base materials that provide access to new Green Plastics. Articles made from the polymers are also in the scope of the invention. As an example, polyglycerol sebacate (PGS) was initially esterified into a bromine-containing macroinitiator by using bromoisobutyryl bromide (BIBB) and followed by ATRP polymerization of methyl methacrylate (MMA), thereby forming a co-polymer of PGS-g-PMMA.
US20180290882A1 Semiconductor packages and methods for fabricating semiconductor packages According to various embodiments, there is provided a method for fabricating a semiconductor package, the method including forming a cap structure and a pillar from a first wafer; bonding the first wafer to a second wafer; and filling a gap between the pillar and the cap structure with a mold compound.
EP3383484A1 Wearable non-invasive apparatus for and method of enhancing lower limbs venous return of a subject In various embodiments, a wearable non -invasive apparatus for enhancing lower limb venous return of a subject may be provided. The apparatus may include a monitoring device configured to determine a venous state of a subject such as a photoplethysmography (PPG) sensor. The apparatus may also include a neuromuscular electrical stimulation (NMES) device configured to generate an electrical stimulus in response to the determinedvenous state and concurrently stimulate the triceps surae and the deep posterior calf muscle of the subject with the generated electrical stimulus to enhance lower limb venous return. In an alternative embodiment, electrical stimulation can be at the tibial nerve of the subject to retrograde target the triceps surae and the deep posterior calf muscle of the subject.
US20180279960A1 Method and apparatus for real-time discriminative ocular artefact removal from EEG signals There is provided a method and apparatus for real-time discriminative ocular artefact removal from EEG signals. This is facilitated by integrating inter-class dissimilarity and within-class similarity in a regularized framework based on oscillatory correlation. Correspondingly, components related to ocular movements are extracted from the raw data as pseudo-artefact channels so that it is applicable to single-channel EEG data without a dedicated EOG or eye-tracker.
US20180279961A1 Multi-channel ballistocardiography with cepstrum smoothing and quality-based dynamic channel selection A method for ballistocardiography (BCG) and a BCG system ballistocardiography (BCG) system for heart beat determination are provided. The method includes digitizing a plurality of signals received from a corresponding plurality of sensors, estimating a plurality of smoothed cepstra corresponding to each of the plurality of digitized signals in response to a smoothed cepstrum analysis of a digital signal at a reception time of each of the plurality of digitized signals, and estimating a fused cepstrum for the plurality of digitized signals in response to the plurality of smoothed cepstra. The method further includes determining a heart rate in response to the plurality of smoothed cepstra and the fused cepstrum.
US10087416 Culturing pluripotent stem cells A method for culturing and maintaining a pluripotent stem cell in an undifferentiated state is provided. The method comprises culturing the pluripotent stem cell in a medium comprising an MEK inhibitor, a GSK3 inhibitor, a dual inhibitor of AMPK and/or BMP signaling and LIF. A cell produced by the method, cell culture medium and a kit for performing the method described is also provided.
CN108603842A Method for assessing state of living cell A method for assessing a state of a living cell using surface enhanced Raman spectroscopy (SERS) is provided. The method may include modifying one or more living cells with an alkyne-containing compound to form one or more modified living cells, mixing the one or more modified living cells with a SERS-active material to form a mixture, injecting the mixture into a conduit defined by an inner wallof a hollow core photonic crystal fiber, and detecting a surface enhanced Raman signal from the mixture in the conduit. In preferred embodiments, the alkyne containing compound is linoleamide alkyne (LLA) for the detection of lipid peroxidation or 4-(dihydroxyborophenyl) acetylene (DBA) for the detection of sialic acid expression in cells, both using gold nanoparticles as the SERS-active material.
US20180273657A1 Resin formulation and uses thereof There is provided a resin formulation comprising a base acrylate monomer or oligomer, a solubilizing acrylate monomer or oligomer, a photoinitiator compound, a photoabsorber compound, and a photochromic dye, wherein the solubilizing acrylate monomer or oligomer comprises a functional group selected from the group consisting of hydroxyl, alkoxyl, carboxylic acid, amine, alkylamine, amide, alkylamide, alkylacrylate, acrylate, alkyl and heterocycloalkyl. There is also provided a method of preparing the resin formulation and uses of the resin formulation thereof.
SG11201807260RA Memory device and method of forming the same Embodiments provide a memory device, including a plurality of insulating layers and a plurality of lateral layer arrangements. The lateral layer arrangements and the insulating layers are arranged alternately on each other such that each lateral layer arrangement is sandwiched between neighboring insulating layers. Each lateral layer arrangement includes a first electrode layer, a second electrode layer, and a memory layer sandwiched between the first electrode layer and the second electrode layer. The memory layer and the second electrode layer are arranged at a lateral side of the first electrode layer. The memory device further include a selecting film arranged at a lateral side of the insulating layers and the lateral layer arrangements and extending in a direction at least substantially perpendicular to a lateral direction of the lateral layer arrangements, wherein the selecting film has a first surface in contact with the second electrode layer of each lateral layer arrangement. The memory device further include a third electrode layer arranged in contact with a second surface of the selecting film, the second surface being opposite to the first surface.
SG11201806879SA A simple one-step real-time molecular system for microrna detection The present application discloses an isolated nucleic acid molecule for detecting the presence of a target nucleic acid sequence and uses thereof, wherein said molecule is capable of forming bimolecular interactions with a target nucleic acid sequence and forms a ternary complex stabilising a detection agent when bound. The detection agent is preferably DFHBI ((Z)-4-(3,5-difluoro-4-hydroxybenzylidene)-1,2-dimethyl-1 H-imidazol-5(4H)-one. The target nucleic acid is preferably a miRNA sequence. Preferably, the isolated nucleic acid sequence comprises two domains that complementarily bind to the 5' and 3' ends of the target nucleic acid sequence. The isolated nucleic acid sequence also comprises regions of nucleic acids that do not bind with the target nucleic acid sequence and are capable of forming secondary structures, such as stems, stem loops, t-RNA type structures, cloverleaves, tetraloops and pseudoknots. The application further discloses corresponding methods of determining a disease in a subject by using the isolated nucleic acid sequence to detect one or more disease-specific target nucleic acids.
SG11201806837WA Access control methods, access control devices, and computer readable media An access control method, which may be applied in a cloud environment, is provided in various embodiments. The access control method includes: receiving from a user a request for access to a resource; determining a group access key related to the resource; determining a user key of the user; determining whether the group key is an integer multiple of the user key; and granting the user access to the resource if it is determined that the group access key is an integer multiple of the user key.
SG10201701148VA Self-powered sensor and method of forming the same SELFPOWERED SENSOR AND METHOD OF FORMING THE SAME Various embodiments provide a self-powered sensor. The self-powered sensor includes a solar cell having a transparent or semi-transparent electrode, wherein the solar cell is configured to at least substantially absorb light of a first wavelength range for generating electrical energy and configured to at least substantially transmit light of a second wavelength range. The self-powered sensor further includes an energy storage configured to store the electrical energy generated by the solar cell; and a detector electrically connected to the energy storage to receive the electrical energy and configured to detect the transmitted light of the second wavelength range. The electrode of the solar cell is configured to have at least one of a selected thickness or a selected material dependent on a desired absorptance of the solar cell for light of the first wavelength range and a desired transmittance of the solar cell for light of the second wavelength range. FIG. A and IB
CN105580461B Method and positioning device for positioning a mobile communication device According to one embodiment, a method for localization of a mobile communication device is described comprising transmitting a data message from the mobile communication device to a first access point, determining the reception times of the data message at the first access point and at second access points, transmitting an acknowledgement message for the data message from the first access point to the mobile communication device, determining the reception times of the acknowledgement message at the second access points and determining the position of the mobile communication device based on the reception times of the data message and the reception times of the acknowledgement message.
US20180265559A1 Polypeptides, nucleic acids and uses thereof We describe an ELABELA polypeptide comprising a sequence CXXXRCXXXHSRVPFP (SEQ ID NO: 1), in which X signifies an amino acid residue, such as a sequence selected from the group consisting of: SEQ ID NO: 2 to SEQ ID NO: 18, preferably CLQRRCMPLHSRVPFP (SEQ ID NO: 2), or a fragment, homologue, variant or derivative thereof, which polypeptide is capable of maintaining self-renewal and/or pluripotency of a stem cell.
US20180266014A1 Fusion protein crystal comprising a moiety A protein crystal comprising a first protein crystal having available space in the lattice, wherein a second protein crystal and a moiety can be accommodated in the available space in the lattice. The first and second proteins are co-expressed from one or more nucleic acid constructs. In a preferred embodiment, the first protein is the p21-activated kinase PAK4, the second protein is the PAK4 kinase inhibitor Inka1, and the moiety comprises a reporter molecule such as fluorescent proteins or tags and is fused to the iBox or iBox-C or Inka1. Preferably the crystal is formed in cellulo. Also provided is a fusion protein comprising the first protein and the second protein, wherein upon crystallisation the second protein fits within the available space in the lattice of the first protein, along with the moiety. Methods for producing the protein crystal are also disclosed.
EP2585421B1 Method of producing alkenes by dehydration of a mixture of alcohols The invention relates to a method of producing alkenes by dehydration of a mixture of alcohols using a metal-modified zeolite, wherein the method comprises providing two or more alcohols; contacting the mixture with a catalyst, wherein the catalyst is a metal-modified zeolite; and reacting the mixture in a temperature range of about 350 to about 500 °C, thereby producing the alkenes.
US10077227 Method for synthesizing an alkenoic acid There is provided a method for synthesizing an alkenoic acid, in particular acrylic acid comprising the step of oxidizing an alkenyl alcohol in the presence of a metal oxide catalyst to form the alkenoic acid. The invention further provides a step of deoxydehydrating a polyol, including glycerol to obtain said alkenyl alcohol including an allyl alcohol.
US10076772 Transducer and method for forming the same A transducer is provided, which includes a substrate, wherein a cavity is defined at least partially through the substrate, at least one stopper structure arranged within the cavity, a support layer arranged over the at least one stopper structure and the cavity to seal the cavity, and a piezoelectric functional arrangement arranged on the support layer. According to further embodiments of the present invention, a method for forming a transducer is also provided.
CN105899953B Bladder cancer biomarker Disclosed are bladder cancer protein biomarkers, methods of determining whether a patient suffers from or shows recurrence of bladder cancer or early stage bladder cancer, or late stage bladder cancer using the bladder cancer protein biomarkers, a detection system, and kits thereof. Said bladder cancer biomarkers comprise at least one of Coronin-IA, Apolipoprotein A-IV, Semenogelin-2, Gamma-synuclein and DJ-1, and variants thereof.
CN104884636B Effect of HBV on clinical outcomes of patients with hepatocellular carcinoma A method for predicting prognosis (clinical outcome) of hepatocellular carcinoma patients based on the detection of a Hepatitis B virus, determination of the HBV genotype, identification of the strain of the HBV genotype and its integration into the genome, in biological samples of such patients is provided.
US20180258400A1 Derivation of liver organoids from human pluripotent stem cells The present disclosure provides multipotent endoderm spheroid progenitor cells, liver organoids, intestinal organoids, and pancreatic spheroids, and methods for producing same from stem and progenitor cells.
US20180257302A1 A multi-modal printing system and method of operating the same A multi-modal printing system for printing a 3-dimensional object and method of operating the system are provided. The system comprises multiple layers of photoresin, in a stereolithography apparatus comprising a high speed resin applicator for applying the layers of photoresin, wherein the multi-modal printing system comprises a control mechanism configured to selectively control the high speed resin applicator to perform a discreet operation, a continuous operation, and a self-reset operation.
US20180260576A1 Network system, and methods of encrypting data, decrypting encrypted data in the same Various aspects of this disclosure provide a method of encrypting data in a network system. The method may include generating within a trusted network of the network system an associated private key based on an attribute associated with an user, a homomorphically encrypted associated private key based on the associated private key via homomorphic encryption, and a homomorphic key pair. The method may also include transmitting the homomorphically encrypted associated private key from the trusted network to a non-trusted network of the network system. The method may further include generating within the trusted network encrypted data based on said data, and a homomorphically and attribute based encrypted control key. The method may further include transmitting the encrypted data, and the homomorphically and attribute based encrypted control key, from the trusted network to the non-trusted network.
US10071115 Method of promoting wound healing Disclosed is a method of promoting wound healing or wound closure. The method comprises administration of a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide. Also disclosed are method of treating chronic cutaneous wounds, method of identifying a non-healing wound, use and a pharmaceutical composition comprising a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide.
US10071183 Amphiphilic linear peptide/peptoid and hydrogel comprising the same The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hy-drogel that includes the amphiphilic linear peptide/peptoid. The amphiphilic linear pep-tide/peptoid is capable of forming, a hydrogel. These peptides/peptoids include short amphi-philic sequences with a hydrophobic portion of aliphatic amino acids and at least one acidic, neutral, or basic polar amino acid. The amphiphilic linear peptide/peptoid is build up of non repetitive aliphatic amino acids, which may be in the L- or D-form. A plurality of such pep-tides/peptoids assembles to supramolecular helical fibers and forms peptide hydrogels after assembly: A corresponding hydrogel is formed in aqueous solutions at physiological pH and is thus useful for inter alia cell culture, tissue engineering, and drug release. Such hydrogels which are rigid, biocompatible and entrapping up to 99.9% of water are also well suited for applications utilizing electronic devices.
US20180250403A1 Conjugates The present invention relates to improved compositions for photodynamic therapy (PDT) for the selective destruction of malignant, diseased, or infected cells or infective agents without causing damage to normal cells. In an embodiment, the composition comprises a photosensitising agent coupled to a ligand, wherein the ligand selectively binds to a targeted receptor and comprises an isolated peptide molecule having less than 10 or 8 amino acids.
US10066019 Optimised heavy chain and light chain signal peptides for the production of recombinant antibody therapeutics Antibodies of interest comprising a heavy chain signal peptide and/or a light chain signal peptide or combination thereof and compositions are described. The method of determining the signal peptide including creating data set of antibodies signal peptides, clustering, selecting and creating recombinant antibodies for enhanced expression and secretion are described.
CN105917227B Real-time quantitative and endpoint colorimetric PCR device A colorimetric-based DNA diagnostic system which includes a detector module, a processor and a memory is provided. The detector module is disposed to record an image of a DNA sample illuminated by a light source. The memory includes computer program code which along with the memory is configured, with the processor, to perform (a) sending a signal to adjust the temperature of the DNA sample to be within an approximate temperature range over which the color of the DNA sample changes, (b) sending a signal to the detector module to capture an image of the DNA sample at defined intervals within the approximate temperature range, (c) processing the captured images to extract color information, and (d) processing the extracted color information to objectively determine a melting temperature within the approximate temperature range at which the color of the DNA sample changes.
CN104450783B Chinese hamster ovary cell line We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in which the CHO cell is obtainable by selection with Ricinus communis agglutinin I (RCA-I).
SG11201806464PA True random number generator and system comprising the same Embodiments provide a true random number generator. The true random number generator may include a first ring oscillator having a first frequency, a second ring oscillator having a second frequency, a third ring oscillator having a third frequency, and a capacitor connected between the second ring oscillator and the third ring oscillator to provide a capacitive coupling therebetween. The second frequency is lower than the first frequency, and the third frequency is lower than the second frequency. The true random number generator may further include a D-type flip-flop having a data input connected to an output of the first ring oscillator and having a clock input connected to an output of the third ring oscillator, wherein the D-type flip-flop is configured to generate an output signal representing a sequence of random numbers.
SG11201806308WA Textured surface ophthalmic device There is provided a textured surface ophthalmic device comprising a polymeric material having a micro or nano-sized textured surface integrally formed, wherein said polymeric material is configured for insertion into an eye of a human. In a preferred embodiment, the device comprises at least one amorphous metal or metal oxide layer deposited thereon, wherein the metal may be selected from gold or silver, and the oxide of a metal may be selected from titanium, cobalt, zinc or aluminium. A method of preparing the textured surface ophthalmic device is also disclosed.
SG11201806324UA Memory cell, memory device, and methods of forming the same Various embodiments may provide a memory cell including a magnetic pinned layer with a substantially fixed magnetization direction, a crystalline spacer layer in contact with the magnetic pinned layer, and a magnetic storage layer. The magnetic storage layer may include an amorphous interface sub-layer in contact with the crystalline spacer layer, the amorphous interface sub-layer including a first alloy of iron (Fe) and at least one element. The amorphous storage layer may also include an amorphous enhancement sub-layer in contact with the amorphous interface sub-layer, the amorphous enhancement sub-layer including a second alloy of iron (Fe) and at least one element. The memory cell may additionally include a cap layer in contact with the amorphous enhancement sub-layer. A concentration of the at least one further element comprised in the first alloy and a concentration of the at least one further element comprised in the second alloy may be different.
SG11201806104UA Hexagonal silica platelets and methods of synthesis thereof The present invention relates to a method for forming silica nanoparticles in an aqueous medium, the method comprising steps of providing a surfactant solution comprising a cationic surfactant in an aqueous medium; and mixing a silane source with the surfactant solution under pH conditions of about pH 5 to 8 for forming said silica nanoparticles. The present invention also relates to silica suspension comprising a plurality of hexagonally shaped silica platelets, said platelets being substantially monodisperse and having a width dimension from around 50 to 1000 nm, said platelets being suspended in an aqueous medium, wherein said aqueous medium comprises a single type of cationic surfactant. Furthermore, the invention relates to a silica nanoparticle prepared by reacting a silane source with a volumetric excess of a surfactant under pH of about 5 to about 8 in the presence of an aqueous solvent. Also, the present invention relates to a silica platelet obtainable by a method as disclosed herein.
US20180246104A1 Method for detecting circulating tumor cells and uses thereof A method for the detection and/or diagnosis of cancer in a patient is disclosed. The method involves detecting circulating tumor cells (CTCs) in a sample obtained from the patient using an antibody specifically binding to an antigen in a protein expressed by the CTCs, wherein the antigen comprises a mutation and wherein the mutation renders the patient receptive or resistance to an anti-cancer drug. Claimed methods include the use of an antibody specific for the EGFR L858R or EGFR exon 19 (ΔE746-A750) mutations for detecting lung cancers and the use of an antibody specific for the K-Ras G12V, K-Ras G12C, K-Ras G12S, K-Ras G12D, or K-Ras G13D mutations for detecting colorectal cancers.
US20180243441A1 Cytotoxic hexim1 peptides and uses thereof Disclosed are isolated cytotoxic peptides having similar sequences as the basic region (BR) of Hexamethylene Bisacetamide Inducible Protein 1 (HEXIM1). Preferred embodiments include QLGKKKHRRRPSKKKRHW (SEQ ID No: 3). QLGRRRHRRRPSRRRRHW (SEQ ID No: 4) and QLGKKILAARPSKKKRHW (SEQ ID No: 5). Also encompassed are isolated nucleic acid molecules encoding for the claimed peptides, vectors comprising the isolated nucleic acids, compositions comprising peptides conjugated to cell-targeting or penetrating peptides or antibodies, nucleic acid molecules or vectors expressing conjugates thereof; methods of treating or preventing diseases or conditions, including cancers and obesity as well as a method of eliminating undifferentiated stem cells.
US20180246793A1 Data stripping, allocation and reconstruction A method for data stripping, allocation and reconstruction in an active drive storage system including a plurality of active object storage devices, each of the plurality of active object storage devices including one or more storage devices and a controller is provided. The method includes the controller of the identified one of the plurality of active object storage devices segmenting the received data into a plurality of data chunks and generating one or more parity chunks in response to the plurality of data chunks. The method further includes the controller of the identified one of the plurality of active object storage devices reorganizing the plurality of data chunks and the one or more parity chunks in response to a number of the plurality of data chunks and a number of the one or more of the plurality of active object storage devices into which the received data is to be stored. Finally, the method includes the step of the controller of the identified one of the plurality of active object storage devices storing the plurality of data chunks and the one or more parity chunks into the one or more of the plurality of active object storage devices.
US20180245048A1 Methods and compositions for expansion and differentiation of skeletal muscle stem cells or progenitor cells The present disclosure describes compositions for preparing a myofiber or myotube from a skeletal muscle stem cell or progenitor cell comprising a carnitine and/or a derivative thereof, a fatty acid a steroid and combinations thereof. Preferred embodiment comprises of 0.1 mM L-carnitine, 0.2 mM 9-cis-linoleic acid and 10 mM dihydrotestosterone. Also disclosed is a composition for inducing expansion of skeletal muscle stem cells or progenitor cells comprising a fibroblast growth factor agonist, a Notch signalling agonist, a nucleic acid, and combinations thereof. Preferred embodiment comprises 20 ng/ml basic fibroblast growth factor (bFGF), 50 μg/ml Delta-like ligand 1 (DLL1), 10 mM hypoxanthine and 1.6 mM thymidine.
CN105745196B Biomass conversion and purification The present invention relates to a method for synthesizing an optionally substituted furoic acid by dehydrating a biomass and oxidizing the optionally substituted furan derived from the dehydration reaction. Water extraction has been incorporated as a step between the dehydration and the oxidation in order to purify the intermediate optionally substituted furan before having it oxidized. Prior to this water extraction, the organic solvent used for dehydration may be separated by evaporation. The provision of the water extraction allows impurities to be separated from the intermediate optionally substituted furan.
US20180236604A1 Method of forming an elongated body with an embedded channel A method of forming an elongated body with an embedded channel extending longitudinally beneath a surface along a length of the elongated body, comprising forming the elongated body with an opened channel recessed into the elongated body; the opened channel having an inner and outer portion proximal and distal to and from a channel bottom respectively of the opened channel. The method further comprises placing an elongated cover over the opened channel, and having a base and two slope surfaces extending from the base toward an apex opposite the base to cover the inner portion of the opened channel with the base, and to form two grooves each having a profile defined by a corresponding slope surface of the elongated cover and a corresponding outer portion of the opened channel forming the groove. The method further comprises filling the two grooves to join the elongated cover to the elongated body.
US10052604 Silica coating on nanoparticles This invention relates to a method for synthesizing a SiO2-coated nanoparticle, the method comprising the step of reacting a hydroxyl-functionalized silane with a nanoparticle in a substantially aqueous phase under conditions to induce silanization of the nanoparticle. The method enables silanization of the nanoparticle in aqueous phase that is substantially free of organic solvents.
US10053490 Antimicrobial peptidomimetics The present invention relates to peptidomimetics of the formula (I) or (I)c wherein L1, L2, L3, R1, R2, R3, R4, R5, R6, n, m, Q, X, Z1 and Z2 are defined as mentioned in the description and to salts and solvates of each of these compounds and to processes for the preparation thereof, compositions containing them and the uses of such compounds. It has been found that the compounds have a high microbicide activity and are suited to combat resistant bacteria, such as meticillin-resistant Staphylococcus aureus (MRSA) strains, at very low concentrations.
US10052389 Polymeric system for release of an active agent The present disclosure relates to a polymeric system for release of an active agent, comprising a first polymeric phase containing the active agent, the first polymeric phase forming discrete regions of a set size range and being dispersed within a second polymeric phase comprising a cross-linked polymer-phenol conjugate for release of the active agent therein. The present disclosure further provides an injectable hydrogel comprising the disclosed polymeric system, a carrier for delivering a biologically active substance or a drug comprising the injectable hydrogel, and a method for producing the disclosed polymeric system.
US20180229454A1 Method and system for forming a masking layer In various embodiments, a method of forming a masking layer on at least a portion of an object. The method may include providing a plurality of mould pieces. The method may include forming an assembled mould using the plurality of the mould pieces. The assembled mould may include one or more inner surfaces to define a cavity for holding the portion of the object. The method may include providing a masking fluid in said cavity. The method may include providing electromagnetic waves to cure the masking fluid to form the masking layer on the portion of the object.
US20180230544A1 Method of determining the risk of developing breast cancer by detecting the expression levels of micrornas (mirnas) The present disclosure describes methods of determining the risk of developing breast cancer in a subject or determining whether a subject suffers from breast cancer. The methods can comprise detecting the expression level of microRNAs (miRNAs) hsa-miR-186-5p (SEQ ID NO: 77) and/or hsa-miR-409-3p (SEQ ID NO: 178) in a bodily fluid sample obtained from the subject and determining whether it is upregulated or downregulated as compared to a control, wherein the upregulation of hsa-miR-186-5p (SEQ ID NO: 77) and/or downregulation of hsa-miR-409-3p (SEQ ID NO: 178) indicates that the subject has breast cancer or is at risk of developing breast cancers. Also encompassed are methods of prognosis or diagnosis of breast cancer by detecting expression levels of combinations of miRNAs and using a score based on a panel of miRNA markers.
US10050557 Energy harvesting apparatus and a method for operating an energy harvesting apparatus In various embodiments of the present disclosure, there is provided an energy harvesting apparatus, including: an energy harvester for generating electric power from an ambient source; a power conditioning circuit coupled to the output of the energy harvester; including: a boost converter module; a buck-boost converter module; and a power modification control module; wherein the power modification control module is configured to initialize the energy harvesting apparatus from inactivity to a normal energy harvesting state by operating the boost converter module, and operating the buck-boost converter when an output voltage of the power conditioning circuit rises to a predetermined value. A corresponding method of operating an energy harvesting apparatus is provided.
US20180221593A1 Vascular access device and guiding portion According to various embodiments, a method and system to obtain access to a blood vessel underneath a skin layer that may preserve lifespan of the blood vessel and reduce executional skill variability may be provided. The method includes placing a guiding portion between the blood vessel and the skin layer; and configuring the guiding portion to receive and guide a needle to reach the same location of the blood vessel repeatedly and consistently; and forming a resultant scarred track between the blood vessel and the skin layer as the guiding portion is resorbed over time. The system includes a vascular access device configurable to first possess strength to penetrate through a tissue layer, subsequently possess flexibility to conform to the surrounding tissue beneath the tissue layer; and a guiding portion which may be resorbable, wherein the inlet includes a larger diameter compared to the outlet.
US20180222929A1 Photoinitiators functioned as both initiators and nanofillers This invention relates to a photoinitiator compound comprising: a polyhedral oligomeric silsesquioxane (POSS) moiety and a photoinitiator moiety, wherein the photoinitiator compound having the structure according to formula (I): [R—SiO1.5]n (I), wherein n is 6, 8, 10 or 12 and R is independently selected from the group consisting of H, linear or branched (hetero)alkyl, linear or branched (hetero)alkenyl, (hetero)aryl, (hetero)alkyl aryl, (hetero)aryl alkyl and a photoinitiator moiety, wherein at least one R is a photoinitiator moiety and the photoinitiator compound is a nanoparticle. The present invention also relates to a method for the production of the photoinitiator compound of the invention, a photopolymerizable composition comprising the photoinitiator compound of the invention, the use of the photoinitiator compound of the invention for photopolymerization. The present invention is further related to a coated substrate comprising the photopolymerizable composition of the invention.
US20180224332A1 Hyperspectral imaging apparatus and method Various embodiments provide a hyperspectral imaging apparatus. The hyperspectral imaging apparatus includes a micro-lens array having a plurality of micro-lenses; and a filter array having a plurality of tunable filters. Each of the plurality of tunable filters is optically coupled to a respective micro-lens of the plurality of micro-lenses. Each micro-lens and the corresponding coupled tunable filter are configured to generate a spectrally filtered image of a scene, such that the micro-lens array and the filter array generate a plurality of spectrally filtered images of the scene for receiving by a plurality of areas of an image sensor. Each of the plurality of tunable filters is tunable to transmit a selected wavelength within a respective spectral band, wherein the spectral bands of the plurality of tunable filters are different from each other.
EP2875360B1 In vitro assay for predicting renal proximal tubular cell toxicity There is provided an in vitro assay for screening a test compound for toxicity in renal proximal tubular cells. The method comprises contacting a test compound with a test population of renal proximal tubular cells; and determining the expression level of an interleukin in the test population, the interleukin being interleukin-6 (IL-6) or interleukin-8 (IL-8), or both. Expression levels of the interleukin in the test population being greater than expression levels in a control population of renal proximal tubular cells not contacted with the test compound is indicative that the test compound is toxic for renal proximal tubular cells.
US10043563 Flip-flop circuit, method of controlling a flip-flop circuit and memory device According to embodiments of the present invention, a flip-flop circuit is provided. The flip-flop circuit includes a first stage circuit and a second stage circuit, wherein each of the first stage circuit and the second stage circuit is operable in two modes of operation, and a driver arrangement, wherein the first stage circuit includes a first transistor and a first non-volatile memory cell connected to each other, wherein the second stage circuit includes a second transistor and a second non-volatile memory cell connected to each other, and wherein the driver arrangement is configured, at a clock level, to drive the first stage circuit in one of the two modes of operation to access the first non-volatile memory cell and, at the clock level, to drive the second stage circuit in the other of the two modes of operation to access the second non-volatile memory cell.
US10041121 Method for detection of a genetic variant A method and kit for detecting a genetic variant associated with a disease or disorder, including incompatibility with a pharmaceutical. The method and kit using a first nano-particle coupled to at least one morpholino nucleic acid probe comprising a target complimentary region base sequence that is a perfect match to a genetic variant sequence.
US10045343 Digital auto frequency control for a general purpose if subsystem with multi-modulation schemes An automatic frequency control (AFC) device is provided. The AFC device includes an input module, a received signal strength indicator (RSSI) module and a carrier frequency offset (CFO) estimation module. The input module down converts and samples a received signal. The RSSI module is coupled to the input module and calculates a RSSI signal in response to the down converted and sampled received signal. The CFO estimation module is coupled to the input module and the RSSI module and calculates a moving average of binary elements of the down converted and sampled received signal. The CFO estimation module continues to calculate the moving average until the AFC converges.
CN104272382B Template-based personalized singing synthesis method and system The present invention provides systems and methods for speech to singing synthesis. The method includes obtaining a feature of a singing voice of a first person and modifying a sound feature of a second person's voice in response to a feature of the singing voice of the first person, thereby generating a synthetic singing voice of the second individual.In one embodiment, the method includes obtaining a template of the first speaking feature and the first singing feature in response to the speaking voice and the singing voice of the first person and extracting the second speaking feature from the speaking voice of the second individual, and then, according to The template modifies the second speaking feature to generate an approximate singing voice of the second person, and is responsive to the first speaking feature, the first singing feature, and the second speaking featureTo align the acoustic characteristics of the second person's approximate singing voice to generate a second person's synthetic singing voice.
CN105009174B Method and system for assessing tissue fibrosis A method for assessing fibrosis in a tissue is proposed. The method uses a test image which is an image of the tissue and comprises identifying, from the test image, a portal collagen area, a septal collagen area and a fibrillar collagen area respectively comprising pixels representing portal collagen, septal collagen and fibrillar collagen of the tissue, obtaining quantitative values of one or more features for each identified area based on characteristics of the identified area in the test image and assessing fibrosis using the quantitative values obtained for all the identified areas.
US20180214540A1 Method for eliciting an immune response to an immunogen The invention relates to methods for eliciting an immune response to an immunogen, and in particular, to such methods using polymersomes as carriers for immunogen.
US20180215849A1 Segment copolymer for making icephobic coatings This invention relates to segment copolymer comprising rigid and soft segments wherein the soft segments are doped with a wax. A model polymer of this new type can be synthesized by the free radical copolymerization of methyl methacrylate (MMA) (39 wt %), lauryl, methacrylate (LMA) (10 wt %) and an adduct monomer of glycidyl methacrylate (GMA) and 1-dodecylamine (DDA). Doping with paraffin wax is one suitable approach to obtain the inventive material. The invention further relates to a simple and low-cost process to make these polymers and coatings comprising the polymers. Using the polymer material a coating with a highly icephobic surface can be obtained comprising soft hydrophobic micro domains segregated and stabilized by rigid copolymer on its surface. The icephobic behaviour may find new application in aerospace applications.
SG11201805483VA Method of detecting fraud in procurement and system thereof There is provided a computer-implemented method of detecting fraud in procurement. The method includes generating a plurality of anomaly indicators for a transaction or proposed transaction between a first entity and a second entity based on an associated transactional data. A first primary indicator is then determined based on a combination of the plurality of anomaly indicators, providing a collective indication of fraud. The primary indicator can next be further combined with a second primary indicator which can be based on transaction history involving the first and/or the second entity, thus generating an overall indicator to provide an indication of fraud.
SG11201805366VA Durable superhydrophobic coating The invention relates to a polymeric coating material comprising a surface-functionalized such as vinyl functionalized nanoadditive covalently bound to an organopolysiloxane, such as poly(methylhydrosiloxane) (PMHS), wherein the nanoadditive comprises (a) a nanoadditive substrate and (b) a linker covalently bound by a silyloxy moiety to the nanoadditive substrate at one end and said organopolysiloxane at the other end. The invention also relates to a method of making such a coating material, the use of such a coating material, a method for coating a substrate with such a coating material, and a coated substrate obtainable by such a method.
SG11201805448YA A film coating The present disclosure describes a film for coating a surface, the film comprising a first layer of first core shell nanoparticles and a second layer of second core shell nanoparticles, wherein the core of the first core shell nanoparticles comprises a first oxide of a metal or an alloy thereof, for example, antimony tin oxide (ATO), selected to absorb UV and IR radiation and the core of the second core shell nanoparticles comprises a second oxide of a metal or an alloy thereof, for example titanium oxide (TiO2) or zinc oxide (ZnO); and, the shell of the first or second core shell nanoparticles comprises a silane, the first and second core shell nanoparticle being dispersed in a first transparent substrate. The present disclosure also describes a method for coating a surface with said film.
SG10201610586QA Dynamic Light Scattering Nanoplatform For High-Throughput Transcription Factor-DNA Interaction Determination For Drug And/Or Disease Screening DYNAMIC LIGHT SCATTERING NANOPLATFORM FOR HIGH-THROUGHPUT TRANSCRIPTION FACTOR-DNA INTERACTION DETERMINATION FOR DRUG AND/OR DISEASE SCREENING [0080] Methods, systems and nanoprobes for identifying sequence-specific transcription factor DNA interactions for drug and/or disease screening are provided. The method includes homogeneously mixing plasmonic metal nanoparticle probes with protein samples as an assay in multi-well plates. The plasmonic metal nanoparticle probes comprise a plurality of plasmonic metal nanoparticles and a specific DNA response element and the protein samples bind with the specific response elements to form an assembly of the plasmonic metal nanoparticle probes. The method further includes measuring particle size distribution of the assembly of the plasmonic metal nanoparticle probes in the solution by dynamic light scattering and determining one or more sequence-specific transcription factor DNA interactions from a curve of the particle size distribution determined from light scattered by the dynamic light scattering. The nanoprobe includes a plurality of plasmonic metal nanoparticles and a DNA linker. The DNA linker forms a link between the two plasmonic metal nanoparticles, the DNA linker including a double stranded region encoding a specific response element. FIG. 1
US20180209958A1 Modulation of hepatitis b virus replication Presently disclosed is a method of modulating Hepatitis B virus (HBV) replication, by contacting the cell with at least one agent that modulates at least one factor from a specified group consisting of SNAI2, SOX7 and other factors, the screening of said agent and use thereof in a medicament for treating HBV infection or disease or condition associated with a HBV infection in a subject. In one preferred embodiment, the agent is one peptide derived from SOX7 or SNAI2 or stapled peptides thereof. As a separate invention, a method of identifying at least one factor that modulates replication of a virus is also disclosed.
US20180209791A1 Motion measurement devices and methods for measuring motion According to various embodiments, there is provided a motion measurement device including a first proof mass and a second proof mass, each of the first proof mass and the second proof mass configured to be at least partially rotatable in-plane; a pair of resonators arranged between the first proof mass and the second proof mass; wherein a first resonator of the pair of resonators is configured to resonate at a first frequency and a second resonator of the pair of resonators is configured to resonate at a second frequency; and a determination circuit configured to determine an acceleration based on the first frequency and the second frequency.
US10033305 Energy harvesting device and method for forming the same According to embodiments of the present invention, an energy harvesting device is provided. The energy harvesting device includes a plurality of energy harvesting elements, each energy harvesting element including a transducer, and at least one spring arranged in between at least two energy harvesting elements of the plurality of energy harvesting elements to mechanically couple the at least two energy harvesting elements to each other. According to further embodiments of the present invention, a method for forming an energy harvesting device is also provided.
US20180201685A1 Methods for use of mixed multifunctional surfaces for reducing aggregate content in protein preparations Methods for reduction of aggregate levels in antibody and other protein preparations comprising the steps of treatment with an organic multivalent cation (e.g., ethacridine, chlorhexidine, or polyethylenimine) and treatment with a composition having a combination of surfaces bearing electronegative chemical moieties and surfaces bearing electropositive chemical moieties.
US10024820 Microfluidic device for gel electrophoresis and method of manufacturing thereof According to embodiments of the present invention, a microfluidic device for gel electrophoresis is provided. The microfluidic device includes a sample channel configured to receive a sample; a stacking channel comprising a preloaded stacking reagent; and a separation channel comprising a preloaded separation reagent, wherein the preloaded stacking reagent has a physical characteristic different from that of the preloaded separation reagent; and wherein the sample channel, the stacking channel and the separation channel are in fluid communication with one another. According to further embodiments of the present invention, a method of manufacturing a microfluidic device for gel electrophoresis is also provided.
US10022332 Stimuli-responsive interpolymer complex coated hollow silica vesicles A porous hollow silica particle with an interpolymer complex immobilized thereon is provided. The interpolymer complex comprises a first polymer immobilized to a surface of the silica particle, and a second polymer complexed with the first polymer. Pharmaceutical compositions comprising the silica particle, and methods of forming the silica particle are also provided.
US20180194853A1 Il2rbeta/common gamma chain antibodies Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.
US20180196611A1 Highly scalable computational active SSD storage device The present application relates to a computational active Solid-State Drive(SSD) storage device, comprising: an active interface configured for data communication with one or more host machines, the active interface being configured to at least receive one or more instructions from the one or more host machines; a CPU connected with the active interface; and non-volatile memory (NVM), wherein the NVM is configured to store metadata for utilisation by the CPU to handle the one or more instructions received from the one or more host machines.
US20180195045A1 Method and system for isolating adipose-derived stem cells The present invention refers to a non-invasive method for isolating adipose-derived stem cells from adipose tissue by illuminating the adipose tissue with at least one laser having a wavelength of between 360 nm to 480 nm or between 800 nm to 2 pm for a predetermined time for dissociating fat cells and blood vessels of the adipose tissue to release intact stem cells from the adipose tissue while maintaining the viability of the stem cells. In the preferred embodiment, the adipose tissue is illuminated with pulsed near infra-red (NIR) laser and a continuous wave (CW) diode blue laser. The present invention also contains a system adapted for isolating adipose-derived stem cells from adipose tissue using the method of the present invention.
US20180193849A1 Fluid jet dispenser using multilayer ceramic actuators A fluid jet dispenser using at least two multilayer piezoelectric actuators is provided. The fluid jet dispenser includes a dispensing head and an electrical driver. The dispensing head includes at least two d31-mode multilayer piezoelectric actuators, a displacement magnifying element mechanically coupled to the d31-mode multilayer piezoelectric actuators, a piston, and a nozzle. More preferably, the two d31-mode multilayer piezoelectric actuators operate in an anti-phase condition. The electrical driver is electrically coupled to the d31-mode multilayer piezoelectric actuators for displacing the actuators in directions substantially perpendicular to polarization of piezoelectric layers in the d31-mode multilayer piezoelectric actuators in response to charging and discharging of the actuators by the electrical driver, to generate a fast movement of the piston to jet a pressurized fluid out of the nozzle of the dispensing head.
EP3341022A2 Conjugates The present invention relates to improved compositions for photodynamic therapy (PDT) for the selective destruction of malignant, diseased, or infected cells or infective agents without causing damage to normal cells. In an embodiment, the composition comprises a photosensitising agent coupled to a ligand, wherein the ligand selectively binds to a targeted receptor and comprises an isolated peptide molecule having less than 10 or 8 amino acids.
CN104380832B Compression device, decompression device, compression method, and decompression method The present invention relates to a compression apparatus comprising: an identifier determination circuit configured to determine a first identifier value of a first communication terminal for identifying a network and a second identifier value of a second communication terminal for identifying a network a difference determination circuit configured to determine a difference value based on a difference between the first identifier value and the second identifier value; and a compression string generation circuit configured to insert the difference value into the compression string. A compression method, a decompression device, and a decompression method are also disclosed.
SG11201803878WA Engineering structurally defined non-saccharide glycosaminoglycan mimetics via a polyproline scaffold A non-saccharide glycosaminoglycan mimetic molecule comprising a polyproline backbone and one or more non- saccharide molecules, wherein the non-saccharide molecules are bound to one or more prolines and/or proline derivatives on the polyproline backbone, is disclosed herein. In a preferred embodiment the non-saccharide molecule is a negatively charged sulfate. The invention also relates to methods of synthesizing said non-saccharide glycosaminoglycan mimetic molecule and the use of the molecules thereof in targeting cell adhesion molecules such as selectin.
US10004801 HBV epitope reactive exogenous T cell receptor (TCR) and uses thereof There is provided at least one isolated cell comprising at least one HBV epitope-reactive exogenous T cell receptor and/or fragment thereof, and methods for producing them. In particular, there is provided polynucleotides, constructs and vectors encoding at least one HBV epitope-reactive exogenous T cell receptor for use in the treatment of Hepatitis B Virus (HBV) and Hepatocellular Carcinoma (HCC). The invention further provides kits and methods of detection of HBV and HCC.
US20180170932A1 Purine diones as WNT pathway modulators The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.
US9999743 Sound-induced sleep method and a system therefor A method and system for sound-induced sleep is provided. The method includes detecting brainwave signals of a subject. The method further includes analyzing the brainwave signals to determine a current sleepy state of the subject and selecting a sound in response to the current sleepy state based on a quantified association index between the brainwave signals and acoustical features of the sound. The method further more includes playing the sound to the subject.
US20180164236A1 Sensor arrangements and methods of operating a sensor arrangement According to various embodiments, there is provided a sensor arrangement including a filter configured to provide an output signal having an output wavelength, the output wavelength having a dependence on a temperature of the filter; a temperature module configured to change the temperature of the filter; a controller circuit configured to control the temperature module for changing the temperature of the filter until the output wavelength increases with decreasing temperature; and a determination circuit configured to determine a dew point of an environment surrounding the sensor arrangement, based on a minimum value of the output wavelength and the dependence.
EP3083631B1 WNT pathway modulators The present invention relates to dihydropyrazolo[l,5-a]pyrimidine compounds of formula I, defined herein, as WNT pathways modulators, processes for making them, and pharmaceutical compositions comprising them. Methods of treatment of conditions mediated by WNT pathway signalling including cancer, fibrosis, stem cell and diabetic retinopathy, rheumatoid arthritis, psoriasis and myocardial infarction, comprising the compounds of formula I are also provided.
EP3019599B1 Method for isolating stromal vascular fraction Disclosed is a method for recovering stromal vascular fraction from a sample. The method comprises providing a mechanical force capable of breaking the sample into a single cell suspension whilst maintaining intact stromal vascular fraction cells cellular structures, wherein the mechanical force is mincing and/or homogenization. Also disclosed are methods of using the stromal vascular fraction.
US9994644 mAB 2 anti-Met antibody Antibodies specifically binding an epitope comprised in the α-chain of c-Met, modifications, compositions and uses thereof are disclosed herein.
US9994611 Chromatographic purification of antibodies from chromatin-deficient cell culture harvests Methods for the improved purification of antibodies and other proteins from protein preparations including the steps of conditioning the protein preparation by contacting it with multivalent organic ions, then applying the conditioned preparation to an adsorptive chromatography medium.
CN105209883B A refractive index sensor and a manufacturing method for the analysis of the analyte A refractive index sensor is provided for analyzing an analyte, the sensor including: a strip waveguide for receiving an input light signal therein and transmitting the light signal, subject to manipulation as it propagates through the strip waveguide, to a detector for analysis with respect to the analyte; and a slot waveguide for sensing the analyte disposed thereon and for receiving a sensing signal, corresponding to said manipulation of the light signal, from the strip waveguide, wherein a grating is formed on a surface of the strip waveguide to enable coupling of the sensing signal from the strip waveguide to the slot waveguide, and the sensor is configured with enhanced sensitivity based on a sensitivity difference between the slot waveguide and the strip waveguide, and/or a group index difference between the slot waveguide and the strip waveguide.
US20180155540A1 Method of preparing fiber-reinforced polymer composites and fiber-reinforced polymer composites prepared thereof A method of preparing a fiber-reinforced polymer composite is provided. The method includes (a) providing a swollen clay material; (b) chemically modifying a surface of the swollen clay material with an organosilane to form a silane-modified clay material; (c) intercalating the silane-modified clay material with a binder to form an intercalated clay material; and (d) melt compounding the intercalated clay material with a mixture comprising a polymer and fiber to form the fiber-reinforced polymer composite. A fiber-reinforced polymer composite is also provided.
EP2983728B1 Polycaprolactone microcarriers for stem cell culture and fabrication thereof A method for manufacturing polycaprolactone microcarriers is disclosed together with uses of the microcarriers.
US9988418 Methods for reducing aggregate levels in protein preparations by treatment with thio-heterocyclic cations A method of reducing the aggregate content in a protein preparation having a target protein includes contacting the protein preparation with a thio-heterocyclic cation to form a mixture, contacting the mixture with at least one functionalized solid to remove excess thio-heterocyclic cations; and optionally contacting the mixture, simultaneously or sequentially, with at least one further functionalized solid to further reduce aggregate content of the protein preparation.
US9988419 Protein purification methods A method for the purification of a desired protein from a protein preparation includes conditioning the protein preparation by treatment with soluble organic multivalent ions, immobilized organic multivalent ions, or both, optionally in the presence of supersaturated allantoin, thereby removing at least 90% of chromatin, then (1) precipitating the desired protein with a nonionic organic polymer in the presence of non-protein-precipitating salts at greater than physiological concentration to provide a precipitate of the desired protein; or (2) precipitating the desired protein with a nonionic organic polymer in the absence of non-precipitating salts at greater than physiological concentration to provide a precipitate and subsequently washing the precipitate with a nonionic organic polymer in the presence of non-protein-precipitating salts at greater than physiological concentration.
US9988694 Effect of HBV on clinical outcome of hepatocellular carcinoma cancer patients A method for predicting prognosis (clinical outcome) of hepatocellular carcinoma patients based on the detection of a Hepatitis B virus, determination of the HBV genotype, identification of the strain of the HBV genotype and its integration into the genome, in biological samples of such patients is provided.
CN104684600B Vascular access devices with the guide portion According to various embodiments, a method and system to obtain access to a blood vessel underneath a skin layer that may preserve lifespan of the blood vessel and reduce executional skill variability may be provided. The method includes placing a guiding portion between the blood vessel and the skin layer; and configuring the guiding portion to receive and guide a needle to reach the same location of the blood vessel repeatedly and consistently; and forming a resultant scarred track between the blood vessel and the skin layer as the guiding portion is resorbed over time. The system includes a vascular access device configurable to first possess strength to penetrate through a tissue layer, subsequently possess flexibility to conform to the surrounding tissue beneath the tissue layer; and a guiding portion which may be resorbable, wherein the inlet includes a larger diameter compared to the outlet.
US9988423 Organogels and emulsions for biological and non-biological applications The present invention relates to organogels and emulsions based on ultrasmall self-assembling peptides. It further relates to methods for producing such organogels and emulsions as well as to the use of the organogels and emulsions in biological and non-biological applications.
CN103456304B For text-dependent speaker verification method and system for dual scoring The present invention provides a system and method for speaker verification.The method includes receiving speaker utterance and the response utterance determination text-independent speaker verification score and text-dependent speaker verification score.Further comprising in response to a text-dependent speaker verification score and the text-independent speaker verification score to determine the relationship between the UBM and the speaker-independent normalized score for each utterance and the speaker-independent UBM and a verification score related text speaker verification score is mapped to a two-dimensional score space, and to accept it into the score, and the score does not explicitly reject fraction corresponding three clusters.Confidence score for speaker verification is generated by the logical binary tree node identification identifying each function binary decision trees, and by performing logic functions in each node corresponding to the generated utterance confidence score for the utterance associated with the text the speaker verification score and the UBM-independent speaker verification score is mapped to a binary decision.
CN104115550B Compression device, decompression device, method of compression and decompression method Compression apparatus comprising: a subset determining circuit configured to determine a subset of the transmission indication map, the transmission indication map comprises a plurality of bits, each indicating a respective predetermined to be transmitted to the wireless communication terminal is present in the data access point; predetermined bit value determination circuit configured to determine whether the subset of bits includes a bit having a predetermined value; and a compression sequence generation circuit configured to, if the subset including bits having a predetermined value bits, then the subset includes indication bits having a predetermined bit value indicator and the subset of compression string is inserted, and is further configured to, if the subset does not include a bit having a predetermined bit value, then It does not indicate the subset indicator comprises inserting a predetermined bit value in the bit string of the compression.
US20180149608A1 Sensing device for measuring a level of an analyte, method of fabrication thereof There is provided a sensing device for measuring a level of an analyte. The sensing device includes a sensing element configured to sense the analyte and produce an electrical output which is variable based on the level of the analyte sensed, a measurement circuit including a reference element for providing an electrical property, the measurement circuit being connected to the sensing element and configured to provide a measurement output signal based on the electrical property of the reference element and the electrical output of the sensing element, whereby the measurement output signal indicates the level of the analyte sensed with respect to the electrical property of the reference element. There is also provided a corresponding method of fabricating the sensing device.
SG10201708777XA A Coating Formulation The present invention relates to a coating formulation comprising at least one carbonaceous material and a coating material. The present invention also relates to a method for preparing a coating formulation comprising at least one carbonaceous material and a coating material comprising the step of dispersing the at least one carbonaceous material in the coating material.
SG11201802992XA One-way vision privacy window based on light emitting diodes and switchable glass A privacy window system and methods for controlling directional visibility are provided. The system includes a switchable window, a first switchable light and a controller. The switchable window is located between a first space and a second space. The first switchable light source is located in the first space. The controller controls switching of the first switchable light source and the switchable window and is configured to synchronise switching of the first light source between an ON and OFF condition to switching of the window to control visibility from the first space into the second space, so that the first light source is switched to the ON condition depending on whether the window is in the transmitting condition or the non-transmitting condition. The controller switches the window and the first light source between respective said conditions at a rate greater than a frame rate of a human eye.
US9981964 Maleimide derivatives as modulators of wnt pathway The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein R1 represents optionally substituted alkyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkoxy); optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); or -alkylaryl; R2 represents H; or alkyl; R3 represents H; or alkyl; U, V and W represent —(CH2)—; or U and V together represent —CH═CH— and W represents C═O; Y represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6 alkoxy, —C(O)OC1-6alkyl, —C(O)C1-6alkyl and —C(O)NHC1-6alkyl); and Z represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6 alkoxy, —C(O)OC1-6alkyl, —C(O)C1-6alkyl and —C(O)NHC1-6alkyl).
CN104487446B Method for reducing aggregate content in protein preparations using a mixed polyfunctional surface Methods for reduction of aggregate levels in antibody and other protein preparations comprising the steps of treatment with an organic multivalent cation (e.g., ethacridine, chlorhexidine, or polyethylenimine) and treatment with a composition having a combination of surfaces bearing electronegative chemical moieties and surfaces bearing electropositive chemical moieties.
US20180141972A1 Native protein purification technology The present invention relates to an isolated polypeptide comprising (a) a protein of interest; (b) a first member of a pair of binding partners; (c) an affinity tag for immobilizing the polypeptide on a solid support; and (d) a modified endoprotease recognition site, wherein the modified endoprotease recognition site is located directly adjacent to the N-terminal amino acid of the protein of interest and comprises or only consists of the amino acid sequence N-terminal of the cleavage site of the native endoprotease recognition site. The present invention also relates to a nucleic acid encoding the above polypeptide and a host cell thereof, a method for isolating a protein of interest using the above polypeptide as a fusion partner and a protease fusion protein with the second member of the pair of binding partners and kits thereof. In addition, a method of degrading a target protein, a method of treatment and use of a fusion protease protein comprising a protease and a target protein binding element are also disclosed.
US9979908 Image processing devices and image processing methods with interpolation for improving image resolution According to various embodiments, an image processing device may be provided. The image processing device may include: an input circuit configured to receive input image data including pixels related to varying exposure times; an interpolation circuit configured to determine an output image based on an interpolation based on the input image data; and an output circuit configured to output the output image.
US9977014 Nanoparticle sensor for nucleic acid-protein interaction The present invention provides a sensor for sensing nucleic acid-protein interactions, comprising a noble metal nanoparticle (NP), a double stranded nucleic acid molecule capable of binding with a protein in an aqueous solution and a fluorescent conjugated polymer (CP). The present invention also provides a method for sensing nucleic acid-protein interactions with the sensor as defined above.
US9975919 Methods for reducing aggregate content in protein preparations A method of reducing aggregate and product-contaminant complex content in a protein preparation including a desired protein includes (i) contacting the protein preparation with at least one solid surface comprising at least one surface-bound ligand capable of binding a metal, the surface-bound ligand being capable of binding a metal is initially substantially devoid of a metal, the operating conditions are selected to substantially prevent the binding of the desired protein to the at least one solid surface and (ii) separating the protein preparation from the surface-bound ligand, such that when more than one surface-bound ligand is present, each surface-bound ligand is independently either of the same net charge or charge neutral.
CN104507953B Contaminants complexes and aggregate levels approach - with electropositive organic additive treatment to reduce protein by protein formulation Methods for reduction of aggregate levels in antibody and other protein preparations through treatment with low concentrations of electropositive organic additives (e.g., ethacridine, chlorhexidine, or polyethylenimine) in combination with ureides (e.g., urea, uric acid, or allantoin) or organic modulators (e.g., nonionic organic polymers, surfactants, organic solvent or ureides). Some aspects of the invention relate to methods for reducing the level of aggregates in conjunction with clarification of cell culture harvest. It further relates to the integration of these capabilities with other purification methods to achieve the desired level of final purification.
EP3321268A1 Bicyclic heteroaryl derivatives as mnk1 and mnk2 modulators and uses thereof The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, Alzheimer's disease), as well as methods of treating these diseases.
EP2331675B1 Markers of induced pluripotent stem cells The disclosure relates to the expression of podocalyxin-like protein (PODXL) on the surface of induced pluripotent stem cells and particularly, although not exclusively, to the use of PODXL as a marker of induced pluripotent stem cells.
US9972709 Semiconductor device fabrication There is provided a method for fabricating a semiconductor device having the following structure, and comprising the steps of growing a first and a second nucleation layer on a substrate; depositing a binary layer over these nucleation layers; and annealing the binary layer to form a first contact area and a second contact area on the substrate, wherein the annealed binary layer comprises a group 14 element selected from Si, Ge and their combination thereof, and the annealed binary layer in the first and second contact areas are capable of providing a lower contact resistance for a current to flow in the device. This method serves to provide an intermediate layer which enables the fabrication process to become CMOS compatible.
US20180128824A1 Novel design of enzyme-linked immunosorbent assay plates and systems and methods of use thereof The present disclosure refers to an enzyme-linked immunosorbent assay (ELISA) plate comprising at least one row of reaction chambers, wherein the reaction chambers in the same row are in fluid communication with each other. Also enclosed is a system for detecting one or more target analytes comprising an ELISA plate as described herein, a plurality of magnetic beads and a magnet configured to cooperate with the magnetic beads. Also encompassed is a method of performing an ELISA assay which comprises of moving magnetic beads through subsequent reaction chambers, wherein the reaction chambers are alternatingly filled with a non-aqueous liquid, such as silicone oil, and aqueous ELISA reagents.
US9963682 Nuclear receptor and mutant thereof and the use of the same in the reprogramming of cells According to the invention there is provided methods for inducing pluripotent stem cells in vitro, vectors and compositions for producing the same and methods for using the induced pluripotent stem cell for treating a patient in need of a pluripotent stem cell treatment.
US20180124686A1 Method and apparatus for broadcast geo-location database (GLDB) for television white space (TVWS) spectrum access Embodiments of the invention relate to method of operating television white space (TVWS) geo-location database (GLDB). The method comprises: embedding a plurality of data signals in a plurality of radio frequency (RF) broadcast signals of at least one existing television or radio channel, wherein the data signals comprise at least one of TVWS GLDB data, time reference data and broadcast transmitter data which comprises at least one of transmitter location data and transmitter identification; and transmitting, over a RF network which is other than an interne protocol (IP) network, the RF broadcast signals together with the embedded data signals to a plurality of white space devices.
US20180122051A1 Method and device for image haze removal Various embodiments provide a method of processing an input image to generate a de-hazed image. The method may include determining an atmospheric light based on the input image; determining a medium transmission map by applying an edge-preserving smoothing filter to the input image; and recovering scene radiances of the input image based on the determined atmospheric light and the determined medium transmission map. The recovered scene radiances form the de-hazed image.
US9957270 Fused pyrimidine-based hydroxamate derivatives The present invention relates to fused pyrimidine-based hydroxamate compounds of formula (I), comprising a hydroxamate group, that are inhibitors of histone deacetylase (HDAC) and kinases. More particularly, the present invention relates to hydroxamate substituted purine or 5H-pyrrolo[3,2-d]pyrimidine derivatives, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with enzymes having histone deacetylase, non-histone deacetylase and kinase activities/functions and/or via unspecified/multi-targeted mechanisms.
US9958433 Method and system for in vitro developmental toxicity testing A method and system of in vitro developmental toxicity testing comprising the steps of micropatterning an extracellular matrix; growing embryonic stem cells on the micropatterned extracellular matrix in the presence of mesoendodermal induction and testing for change of the geometrical mesoendoderm structure in the presence or absence of a test compound wherein (1) a decrease in mesoendodermal differentiation and/or (2) a change in morphology of the geometrical mesoendoderm structure in the presence of the test compound compared to cells in the absence of the test compound indicates that the test compound is a developmental toxic agent.
SG10201607303YA Antisense oligonucleotides to induce exon skipping The present invention relates to antisense oligonucleotides for modulating the activity of PRDM15 and use thereof in the treatment of cancer. In particular, said antisense oligonucleotides are capable of inducing the skipping of an exon of a PRDM15 mRNA. The present invention also relates to a method for determining prognosis in a patient with cancer, or selecting a therapeutic strategy for a patient with cancer, by assessing the level of PRDM15 nucleic acid, protein or activity in a sample.
US20180112087A1 Coating formulation The present invention relates to a coating formulation comprising at least one carbonaceous material and a coating material. The present invention also relates to a method for preparing a coating formulation comprising at least one carbonaceous material and a coating material comprising the step of dispersing the at least one carbonaceous material in the coating material.
CN106061974B Maleimide derivative as a regulator of the WNT pathway The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph therof, including all tautomers and stereoisomers thereof wherein R1represents optionally substituted alkyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkoxy); optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); or -alkylaryl; R2 represents H; or alkyl; R3 represents H; or alkyl; U, V and W represent -(CH2)-; or U and V together represent -CH=CH- and W represents C=O; Y represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1- 6haloalkyl, C1-6haloalkoxy and halo); or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6 alkoxy, -C(O)OC1-6alkyl, -C(O)C1-6alkyl and-C(O)NHC1-6alkyl); and Z represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1- 6haloalkyl, C1-6haloalkoxy and halo); or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6. alkoxy, -C(O)OC1-6alkyl, -C(O)C1-6alkyl and -C(O)NHC1-6alkyl).
US20180105860A1 Muteins of the pyrroline-5-carboxylate reductase 1 The invention relates to muteins of the pyrroline-5-carboxylate reductase 1 (PYCR1), to nucleic acid molecules comprising a nucleotide sequence encoding such muteins, to methods of determining in a subject a predisposition of having an age related disorder associated with PYCR1, to methods of identifying a compound capable of modifying the expression of PYCR1, and methods of treating a subject having an age-related disorder associated with PYCR1. The invention further relates to a genetically modified animal and a method of modifying the expression of the PYCR1 gene in an animal.
US20180105459A1 A multilayer coating The present disclosure describes a multilayer coating, comprising at least one metal oxide layer; and a composite layer provided on said metal oxide layer, said composite layer comprising at least one metal layer disposed between at least two barrier layers, and wherein said barrier layers are substantially impermeable to oxygen. The multilayer coating may be useful as transparent heat reflectors on glass, plastic, and on low temperature processing transparent substrate for energy saving application.
EP2214715B1 Method of delivering an Anti-cancer agent to a cell There is provided a delivery vehicle comprising an anti-cancer agent together with a conjugate of a delivery agent containing a free aldehyde and a flavonoid, having the delivery agent conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. The resulting delivery vehicles may be used to deliver an anti-cancer agent to a cell.
CN107922496A IL2R[beta]/Common [Gamma] Chain Antibodies The present invention discloses an anti-CD122 and/or [Gamma]c antibodies and fragments thereof. The present invention also discloses compositions comprising such antibodies and fragments, and uses andmethods using the same.
CN104870633B Method and system for developmental toxicity test in vitro Tested in vitro developmental toxicity of a method and system comprising the steps of: micropatterned extracellular matrix; in the present case where mesoderm induction medium, so that embryonic stem cells grown on micro extracellular matrix pattern cells; and in the presence or the absence of the test compound, changes germ layers of the test geometric shape, wherein, as compared to the lack of test drug cells in the presence of the test compound, (1) cells of endoderm reduced and / or (2) changes in the morphology of germ layers geometry indicates that the test compound is a developmental toxic agents.
EP2569273B1 Novel antimicrobial compounds and uses thereof The present invention relates to novel antimicrobial compounds, methods of their production as well as uses thereof.
EP3301192A1 Breast tumour grading There is described an in vitro method of assigning a grade to a breast tumour corresponding to histological Grade 1 or Grade 3, which grade is indicative of the aggressiveness of the tumour, the method comprising detecting the expression of (a) BRRN1, GenBank Accession Number D38553; (b) MELK, GenBank Accession Number NM_014791; (c) cDNA clone IMAGE 4452583, GenBank Accession Number BG492359; or (d) STK6, GenBank Accession Number NM_003158 or NM_003600.
US9933390 Devices for extracting at least one analyte A device for extracting at least one analyte may include: a sample reservoir configured to contain a sample comprising at least one target analyte and interfering materials; at least one extraction chamber connected to the sample reservoir; at least one porous structure lining one or more sides of the at least one extraction chamber; and a voltage source configured to provide a first voltage and a second voltage, wherein, when the first voltage is provided, the at least one target analyte and the interfering materials move towards the at least one extraction chamber or to a predetermined area from the at least one extraction chamber, wherein, when the second voltage is provided, the interfering materials pass through and exit the at least one extraction chamber, and the at least one target analyte is stopped from exiting the at least one extraction chamber by means of the at least one porous structure.
US9936454 Stations, access points, communication systems and methods of controlling the same In various embodiments, a method of controlling a station may be provided. The method may include receiving a first signal from an access point, the first signal including information indicating a time period. The method may further include deactivating the station after receiving the first signal and before expiry of the time period. The method may also include activating the station upon expiry of the time period.
US9935355 THz photomixer emitter and method A THz photomixer emitter is disclosed. The emitter comprises a photoconductive material, an antenna structure, and an electrode array. The electrode array is disposed such that an electric field associated with photocarriers generated in the photoconductive material is coupled to the antenna for emission of a THz wave via the antenna structure. The electrode array is configured such that an electric field resonance pattern of the electrode array is substantially aligned with an emission field pattern of the antenna structure.
US20180085862A1 Conductive polymer composite as plastic solder There is provided a method for soldering a first non-metallic component to one or more metallic or non-metallic component, the method comprising the step of removably securing the first non-metallic component to the one or more metallic component by using a conductive polymeric composite or removably securing the first non-metallic component to the one or more non-metallic component by using the conductive polymeric composite, wherein the conductive polymeric composite used in the method comprises a blend of at least one filler material and at least one thermoplastic polymer.
US20180086920A1 Near infrared reflective coating composition, coating and methods of forming the same A near infrared reflective coating composition comprising a polymer resin, a polyamide resin and a suitable solvent. Preferred embodiments for the polymer resin include epoxy resins, acrylic resins, polyester resins or polyisocyanate resins. The composition further comprises additives such as a hardener, surfactant, fumed silica, metal oxide or mixed metal oxide pigments such as titanium oxide, chromium oxide, iron oxide or aluminium oxide. A method for forming the coating is also provided.
SG10201606627QA Microfluidic chip The present disclosure describes a microfluidic chip for culturing and in vitro testing of 3D organotypic cultures. The tests may be performed directly on the organotypic culture in the microfluidic chip. The microfluidic chip includes at least one microfluidic unit which includes two fluidic compartments, such as upper and lower, separated by a permeable supporting structure, one or more access opening for the fluidic compartments, and a set of lids interchangeable with a set of insets. The permeable support structure serves as a support for the organotypic culture. The upper and lower compartments may include inlets and outlets which allow fluids to be perfused into the lower compartment and fluids to be perfused into the upper compartment. The access opening may be closed with a lid or accommodate an inset.
EP2904378B1 Refractive index sensor for analyzing an analyte, and method of fabrication thereof A refractive index sensor is provided for analyzing an analyte, the sensor including: a strip waveguide for receiving an input light signal therein and transmitting the light signal, subject to manipulation as it propagates through the strip waveguide, to a detector for analysis with respect to the analyte; and a slot waveguide for sensing the analyte disposed thereon and for receiving a sensing signal, corresponding to said manipulation of the light signal, from the strip waveguide, wherein a grating is formed on a surface of the strip waveguide to enable coupling of the sensing signal from the strip waveguide to the slot waveguide, and the sensor is configured with enhanced sensitivity based on a sensitivity difference between the slot waveguide and the strip waveguide, and/or a group index difference between the slot waveguide and the strip waveguide.
US9927427 Exosome recovery methods with low molecular weight organic zwitterions A method of isolating exosomes includes conducting at least one purification step in the presence of an organic zwitterion having a molecular weight of less than about 350 Daltons, a buffering pK of a negatively charged portion of the organic zwitterion is at least one full pH unit below an operating pH at which the at least one purification step is conducted, and a buffering pK of the positively charged portion of the organic zwitterion is at least one full pH unit above the operating pH.
US9926320 Purine diones as Wnt pathway modulators The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.
EP3083622B1 Maleimide derivatives as modulators of WNT pathway The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph therof, including all tautomers and stereoisomers thereof wherein R1represents optionally substituted alkyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkoxy); optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); or -alkylaryl; R2 represents H; or alkyl; R3 represents H; or alkyl; U, V and W represent -(CH2)-; or U and V together represent -CH=CH- and W represents C=O; Y represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1- 6haloalkyl, C1-6haloalkoxy and halo); or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6 alkoxy, -C(O)OC1-6alkyl, -C(O)C1-6alkyl and-C(O)NHC1-6alkyl); and Z represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1- 6haloalkyl, C1-6haloalkoxy and halo); or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6. alkoxy, -C(O)OC1-6alkyl, -C(O)C1-6alkyl and -C(O)NHC1-6alkyl).
EP3275901A8 Human embryonic stem cell methods and podxl expression A method of identifying an undifferentiated human embryonic stem cell in a sample which may contain such cells, the method comprising identifying the cell or cells within the sample that express podocalyxin-like protein (PODXL) on their surface. A method of isolating an undifferentiated human embryonic stem cell from a sample containing such cells, the method comprising isolating the cell or cells within the sample that express PODXL on their surface. Typically, the methods use an antibody which binds to PODXL. Undifferentiated human embryonic stem cells isolated by the method may be useful in cell therapy. Also, in particular, compositions of cells differentiated from a human embryonic stem cell but which composition has been depleted of undifferentiated human embryonic stem cells are provided which are useful in cell therapy.
US9920125 Methods for use of mixed multifunctional surfaces for reducing aggregate content in protein preparations Methods for reduction of aggregate levels in antibody and other protein preparations comprising the steps of treatment with an organic multivalent cation (e.g., ethacridine, chlorhexidine, or polyethylenimine) and treatment with a composition having a combination of surfaces bearing electronegative chemical moieties and surfaces bearing electropositive chemical moieties.
US20180072988A1 Generation of functional cells from stem cells The present disclosure provides a method of directly converting a stem cell into a lineage specific cell, comprising the steps of a) transfecting a stem cell with at least one expression vector comprising i) one or more cell lineage reprogramming factors operably linked to an inducible promoter and ii) a selection marker; and b) inducing the transfected stem cell from stem a) with an inducing agent to directly convert said stem cell into a lineage-specific cell. Particularly exemplified are methods of transfecting a stem cell with SA-ASCL1 (phospho-mutant), DLX2, LHX6 and miR-9/9*-124 linked to a doxycycline inducible promoter to convert the stem cell into an inhibitory neuron and transfecting with NeuroD2 linked to a doxycycline inducible promoter to convert a stem cell into an excitatory neuron. Methods of screening one or more factors and/or one or more genetic mutations that modulate a pre-selected activity of the lineage specific cell, kits and directly convertible stem cells obtained using method of the invention are also provided.
US20180077704A1 Radio communication methods and radio communication devices According to various embodiments, a radio communication method may be provided. The radio communication method may include: determining in a cell at least one first subframe; determining in the cell at least one second subframe; allocating downlink user traffic in the cell during the first subframe with a low priority; and transmitting a handover command to a user equipment based on the second subframe.
US20180066145A1 Functionalized quaternary ammonium halides and use thereof Provision of hydroxyl group functionalized quaternary ammonium halides, photocurable or hydrolytically curable urethane based polymers thereof and their use as antifouling agents.
US20180059054A1 Method and circuit for providing an accurate voltage for electrochemical sensing A method and devices for controlling a potentiostat control loop circuit to provide an accurate cell voltage for electrochemically sensing a sample, wherein the cell voltage corresponds to a difference between electrode voltages a a working electrode and a reference electrode of a three-electrode potentiostat are provided. The devices include a potentiostat control loop circuit having a first amplifier with an output connected to a counter electrode of the three electrode potentiostat and a first input connected to a first potential and a first switched capacitor network including a first capacitance device having a first electrode connected to a second input of the first amplifier. The first switched capacitor network is also operatively connected to the first amplifier for operating in a first mode and a second mode t switchably couple the second input of the first amplifier to the reference electrode of the three-electrode potentiostat. The method includes the step of, in the second mode, coupling the second input of the first amplifier to the reference electrode of the three-electrode potentiostat via the first capacitance device by coupling a second electrode of the firs capacitance device to the reference electrode of the three-electrode potentiostat.
US9902761 Polypeptides, nucleic acids and uses thereof We describe an ELABELA polypeptide comprising a sequence CXXXRCXXXHSRVPFP (SEQ ID NO: 1), in which X signifies an amino acid residue, such as a sequence selected from the group consisting of SEQ ID NO: 2 to SEQ ID NO: 18, preferably CLQRRCMPLHSRVPFP (SEQ ID NO: 2), or a fragment, homologue, variant or derivative thereof, which polypeptide is capable of maintaining self-renewal and/or pluripotency of a stem cell.
US9904165 Method of reducing the dimension of an imprint structure on a substrate A method of reducing the dimension of an imprint structure on a substrate, the method comprising the steps of:
    • (a) providing a substrate having at least one imprint structure thereon, said structure being formed of an inorganic-organic compound comprising an inorganic moiety and a polymer moiety, said polymer moiety having a lower vaporization temperature than the melting point of said inorganic moiety; and
    • (b) selectively removing at least part of the polymer moiety while enabling at least part of the inorganic moiety to form a substantially continuous inorganic phase in said imprint structure, wherein the removal of the at least part of the polymer moiety from the imprint structure reduces the dimension of the imprint structure.
US9897561 Method of detecting defects in an object based on active thermography and a system thereof There is provided a method of detecting defects in an object based on active thermography, the method including heating a surface of the object at a plurality of localized regions thereof, selecting at least one of the localized regions as a reference region, selecting at least another one of the localized regions as a comparison region, comparing a thermal response at the comparison region to a thermal response at the reference region due to the heating, and determining whether the object has a defect based on the comparison. There is also provided a corresponding system for detecting defects in an object.
US9896741 Method of producing metal carbonate from an ultramafic rock material A method of producing a metal carbonate from an ultramafic rock material is provided. The method includes providing an ultramafic rock material comprising a metal silicate; reacting the ultramafic rock material with an acid to form a mixture comprising a salt of the metal; contacting the mixture comprising a salt of the metal with oxygen so as to aerate impurities in the mixture and/or to remove residual acid from the mixture; heating the resultant mixture to decompose the salt of the metal to form metal oxide; and reacting the metal oxide with aqueous ammonium carbonate to obtain the metal carbonate. A system for producing a metal carbonate from ultramafic rock material is also provided.
US20180044640A1 Contractile cellular construct for cell culture The present invention relates to a method for producing a contractile cellular construct, comprising the steps of: a) seeding pre-selected cells onto a mold, wherein the pre-selected cells comprise signal emitting agents; and b) culturing the pre-selected cells to produce the cellular construct. The said method is exemplified by mixing cardiomyocytes with fluorescent microbeads, seeding the suspension on a polydimethylsiloxane (PDMS) mold and culturing to form a contractile device comprising of cardiac muscles. The present invention also relates to a method for measuring the contractility of the cellular construct by measuring the displacement of the signal emitting agents, and a method for screening a method for screening one or more agents for modulating the contractility of a contractile cellular construct.
US20180046754A1 Normalization methods for measuring gene copy number and expression The present invention provides method(s) for measuring gene copy number (CN) of a given locus of interest, comprising 1) obtaining the CN value of the locus of interest, 2) obtaining the CN value or values of one or more CN-invariant locus reference(s) (CNILR) in the biological sample, where the CNILR is a locus which is locally CN-invariant or a locus with a minimal coefficient of variation, 3) obtaining the CN value or values of one or more CN-invariant and survival insignificant locus reference reference(s) (CNISILR) determined based on survival prediction analysis for a specific subgroup; and 4) normalizing the CN value of the locus of interest by the CN values of one or more CNISILRs if defined, otherwise normalizing the CN value of the locus of interest by the CN values of said one or more CNILRs. In one embodiment, the CNILRs or CNISILRs is one or more loci from the group consisting of XRCC5, AUTS2, EIF5, PARN, YEATS2 and FHL2. Also encompassed are kits and computer program or computer device for use in the methods of the invention.
US20180044481A1 The synthesis of multiarm poly[(r)-3-hydroxybutyrate] and its derivatives Provided herein is a polymer having formula I: where m, n, and R1 are as defined herein, and the polymer has a number average molecular weight of the polymer of from 500 to 80,000 Daltons. Also provided herein are block copolymers of the polymer of formula I, as well as processes to make the polymer and block copolymers thereof.
US9890205 Chromatographic purification of immunoglobulin G preparations with particles having multimodal functionalities A method of purifying a sample containing a desired protein includes the steps of (i) providing a packed chromatographic column having positively charged porous particles, (ii) equilibrating the column to the conditions to which the desired protein in the sample is to elute, (iii) contacting the sample with the packed chromatographic column such that the sample volume applied to the packed chromatographic column is less than or equal to the interparticle space of the positively charged porous particles within the packed chromatographic column, (iv) eluting the desired protein from the packed chromatographic column, where the desired protein is in a purer state and in the conditions to which the packed chromatographic column was equilibrated; where the desired protein is an antibody, an antibody fragment, an antibody derivative, or an antibody fusion protein.
US9889180 Method of treating cancer The present invention relates to a pharmaceutical composition comprising a histone-lysine N-methyltransferase EZH2 (enhancer of zeste homolog 2) inhibitor and an enhancer of interferon-gamma receptor activity. The invention also relates to method of treating a patient having cancer, comprising administration of the pharmaceutical composition.
US20180036371A1 Dermatopontin as a therapeutic for metabolic disorders The present disclosure describes to a method of treating a metabolic disease in a subject, wherein the method comprises administration of dermatopontin to a subject, wherein the dermatopontin is recombinant dermatopontin and the metabolic disease is selected from a group consisting of weight gain, diet-induced weight gain, obesity, morbid obesity, metabolic syndrome, glucose homeostasis, insulin resistance, type I diabetes, type if diabetes and cardiovascular disease. Disclosed herein is also a method of determining or making a prognosis of a subject's susceptibility to metabolic diseases and obesity, the method comprising measuring the level of circulating dermatopontin in a sample obtained from a subject; and comparing the level of circulating dermatopontin obtained with the level of dermatopontin previously determined in a control; and determining the susceptibility of the subject to metabolic disease and obesity based on the difference between the level of circulating dermatopontin and the level of dermatopontin in the control.
US9884867 Bicyclic alkyne derivatives and uses thereof The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazopyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the prevention and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, autoimmune diseases, metabolic diseases, and neurodegenerative diseases (e.g. autism, autism spectrum disorders, Alzheimer's disease)), as well as methods of treating these diseases.
US20180033631A1 Self-aligning source, drain and gate process for iii-v nitride mishemts A method for fabrication of high electron mobility transistor (HEMT) semiconductor devices is presented. The method includes providing a substrate, growing a HEMT layer structure on the substrate; and self-aligned common metal stack formation of source, drain and gate electrodes on the HEMT layer structure using a single lithographic mask.
US20180030192A1 A copolymer comprising a lignin or lignin derivative and a poly(alkylene oxide) alkyl ether (METH)acrylate, and a hydrogel comprising the copolymer A copolymer comprising an oxygenated polyaromatic alcohol and a poly (alkylene oxide) alkyl ether (meth)acrylate is disclosed, wherein the oxygenated polyaromatic alcohol is preferably lignin or lignin derivative. A hydrogel comprising the copolymer and a cyclic oligosaccharide such as α-cyclodextrin is also disclosed, which can be used in biomedical or personal care industries, for example as a carrier for an active agent.
US20180029326A1 A composite laminate and its usage The present invention relates to a laminate for making a molded article comprising: (i) at least one reinforcement Iayer impregnated with a resin matrix; (ii) at least one deployable layer; and (iii) optionally, at least one material comprising at least one non-adhesive side, wherein the deployable layer are compactable, expandable or collapsible including Miura-Ori folds, honeycombs, foams or air mesh. The laminate may be used to form a molded article. The molded articles have uses in biomedical, health care and sport protective devices.
US20180030090A1 Non-membrane disruptive p53 activating stapled peptides The present invention relates to non-membrane disruptive and p53 activating stapled peptides, as well as methods of treatment of cancer involving the use of these peptides. In one embodiment, the peptide comprises or consist of the amino acid sequence of TSFXaa1EYWXaa3LLXaa2, where Xaa1 is (R)-2-(7′-octenyl)alanine or derivative thereof, or is (R)-2-(4′-pentenyl)alanine or derivative thereof; and Xaa2 and Xaa3 are independently any type of amino acid or modified amino acid. In another embodiment, the peptide comprising or consisting of the amino acid sequence of TSFXaa1EYW Xaa3LLXaa2ENXaa5, wherein Xaa1 and Xaa3 are any type of amino acid or modified amino acid; Xaa2 is S, or P, or (S)-2-(4′-pentenyl)alanine or a derivative of (S)-2-(4′-pentenyl)alanine; and wherein Xaa5 is F or Y.
US9879059 Tailoring multivalent interactions of biopolymers with a polyproline scaffold A glycopeptide, comprising a polyproline backbone and one or more carbohydrate molecules.
US20180016304A1 Self-assembling ultrashort aliphatic depsipeptides for biomedical applications The present invention relates to ultrashort depsipeptides which are capable of self-assembling into hydrogels. One preferred embodiment is of Ac-ILVaGK-NH2, where a represents lactic acid. The invention also relates to the use of these depsipeptides in formulating hydrogels, co-gels or co-hydrogels, and pharmaceutical compositions or biomedical device or surgical implants or kits comprising these depsipeptides for various therapeutic applications such as regenerative medicine, tissue regeneration and tissue re-placement.
US20180012652A1 Memory cell selector and method of operating memory cell Embodiments provide a selector device for selecting a memory cell. The selector device includes a first electrode; a second electrode; and a switching layer sandwiched between the first electrode and the second electrode. The switching layer includes at least one metal rich layer and at least one chalcogenide rich layer. The metal rich layer includes at least one of a metal or a metal compound, wherein metal content of the metal rich layer is greater than 50 at. %. The chalcogenide content of the chalcogenide rich layer is greater than 50 at. %.
US20180010096A1 Differentiation of macrophages from pluripotent stem cells The present invention relates to a method of culturing primitive-like macrophages from stem cells, a kit when used in the method thereof and uses of the primitive like macrophage for in-vitro disease models and for screening compounds for therapy. One embodied culture method comprises contacting and incubating embryonic stem cells or induced pluripotent stem cells with a serum-free culture media comprising a GSK3 inhibitor to differentiate stem cells into cells of the mesoderm lineage, followed by incubation with a culture media comprising Dickkopf-related protein 1 (DKK1) to differentiate the mesoderm into cells of hematopoietic lineage, maturing hematopoietic cells and incubating these cells with a culture media comprising M-CSF to drive differentiation into primitive-like macrophages. Another embodiment comprises incubating the stem cells with serum-free culture media comprising FGF2 and BMP4 to induce differentiation into cells of the mesoderm lineage, followed by incubating the cells with a culture media comprising FGF2, BMP4, Activin A and VEGF to differentiate the cells of the mesoderm lineage into cells of the hematopoietic cell lineage, maturing the cells of the hematopoietic cell lineage and lastly, incubating the matured hematopoietic cells with culture media comprising M-CSF to drive the differentiation of hematopoietic cells into primitive-like macrophages.
US9863956 Differentiation of isobaric amino acids and other species Techniques for differentiating isobaric species are described. An isobaric species may be substituted with a tagging species identified using mass spectrometry. The isobaric species may be a subunit of a first polymer having a defined sequence, e.g., the isobaric species may be an amino acid in a protein or a peptide sequence. A tagging species may be substituted for the isobaric species in a second polymer having an otherwise identical sequence as the first polymer. The second polymer may have the same number of sequences as the first polymer, and substantially the same sequence of subunits, with a few exceptions such as the tagging species for the isobaric species. The first polymer and the second polymer may be prepared in the same reaction vessel. A polymer/protein of defined subunit sequence containing an isobaric species or a tagging species may be analyzed by mass spectrometry to determine the sequence.
US9858678 Method and system for human motion recognition A system and method for human motion recognition are provided. The system includes a video sequence decomposer, a feature extractor, and a motion recognition module. The video sequence decomposer decomposes a video sequence into a plurality of atomic actions. The feature extractor extracts features from each of the plurality of atomic actions, the features including at least a motion feature and a shape feature. And the motion recognition module performs motion recognition for each of the plurality of atomic actions in response to the features.
CN105120909B For release of the active agent in the polymerization system The present disclosure relates to a polymeric system for release of an active agent, comprising a first polymeric phase containing the active agent, the first polymeric phase forming discrete regions of a set size range and being dispersed within a second polymeric phase comprising a cross-linked polymer-phenol conjugate for release of the active agent therein. The present disclosure further provides an injectable hydrogel comprising the disclosed polymeric system, a carrier for delivering a biologically active substance or a drug comprising the injectable hydrogel, and a method for producing the disclosed polymeric system.
US20170371886A1 Methods for identifying clusters in a dataset, methods of analyzing cytometry data with the aid of a computer and methods of detecting cell sub-populations in a plurality of cells According to various embodiments, there is provided a method for identifying clusters in a dataset, the method including: determining for each data point in the dataset, a plurality of parameters including a first parameter and a second parameter, the first parameter being a distance between the data point and a nearest other data point having a local density that is higher than a local density of the data point, and the second parameter being a function of the local density of the data point and the first parameter; running statistical tests on each of the first parameter and the second parameter across the dataset, to identify outliers of the first parameter and outliers of the second parameter; and designating each data point where both the first parameter and the second parameter are identified outliers, as a centre of a respective cluster.
US9851288 Event-driven coulter counter IC for high throughput particle counting A particle occurrence sensing circuit for microfluidic particle sensing includes a set of particle event indicators, each of which includes: a Coulter counter having a sensing electrode exposable to a fluid within a microfluidic channel and configured for providing a particle sensing signal; an input stage configured for providing an extracted particle sensing signal; and a particle event detector configured for providing a set of particle event occurrence signals. Each of the set of particle event occurrence signals indicates a sensed occurrence of a particle greater than or equal to a given reference particle size during fluid flow through the microfluidic channel to which the sensing electrode is exposed. The particle event detector includes a successive approximation (SA) analog-to-digital converter (ADC) configured for generating a plurality of reference particle size threshold values and successively comparing the extracted particle sensing signal amplitude with reference particle size threshold values.
US9854538 Base station, user terminals and wireless communication method The objective of the invention is to suppress, in a case of applying the RRH system in an environment having a plurality of cells (multi-cellular environment), the reduction of the throughput of the whole system. A base station, in the RRH system in which a plurality of antenna ports are dispersively placed in each of a plurality of cells, comprises: a selection unit that selects antenna ports, to which user terminals are to connect, from among the antenna ports of the cells in which the user terminals are existent; and a power setting unit that controls the transmission powers of the antenna ports. The selection unit and power setting unit set predetermined conditions for the target SINRs(t) of the user terminals and the transmission powers of the antenna ports, and select the antenna ports for the user terminals and control the transmission powers of the antenna ports such that the smallest one of the values of the SINRs of the user terminals of the plurality of cells is maximized.
US9853766 Radio communication devices, access points, method for controlling a radio communication device, and methods for controlling an access point According to various embodiments, a radio communication device may be provided. The radio communication device may include: a transmitter configured to transmit a null data packet. The null data packet may include acknowledgement data indicating acknowledgements for a plurality of packets. The null data packet may include a cyclic redundancy check field configured to provide information based on which the null data packet or acknowledgements may be checked for errors. The null data packet may include further information based on which the acknowledgements may be checked for errors.
US20170360362A1 Sleep profiling system with feature generation and auto-mapping A method for profiling sleep of an individual is provided. The method includes defining a sleep feature space for the individual, measuring a brain wave for the individual during the individual's sleep, and mapping the sleep feature space in response to a comparison of the brain wave and a previous brain wave measurement used to define the sleep feature space. The brain wave may comprise a brain wave spectrum. The sleep feature space may comprise, or be composed of, spectral power and envelope measures. The method also includes modelling the mapped sleep feature space in response to recognized neural network patterns corresponding to each of a plurality of sleep stages derived from recognizing the neural network patterns from the sleep feature space and deriving a sleep profile for the individual from sleep stages determined in response to the modelled mapped sleep feature space and the brain wave of the individual.
EP2344622B1 Apparatus for culturing anchorage dependent cells The invention relates to an apparatus (1) for culturing anchorage-dependent cells. The apparatus (1) comprises a housing (2) with an inlet (4) and an outlet (5), and a plurality of culture plates (6) removably stacked within the housing (2). The housing (2) has a circumferential wall (7), a base (8) and a top wall (9). The base (8) comprises the inlet (4) and the top wall (9) comprises the outlet (5). The circumferential wall (7) of the housing (2) defines a longitudinal axis thereof, as well as an inner cross section perpendicular to the longitudinal axis. Shape and dimensions of the inner cross section are essentially uniform along the longitudinal axis. The culture plates (6) are arranged at least essentially parallel to each other. Each plate (6) is mounted and sealed to the circumferential wall (7) of the housing (2). Plates (6) are arranged at a distance from each other. Each culture plate (6) has a through hole (14), so that inlet (4) and outlet (5) are in fluid communication. Each through hole (14) is positioned at an outer end of the respective culture plate (6), proximate the circumferential wall (7). Through holes (14) of adjacent culture plates (6) are distally positioned in the plane of the inner cross section of the housing (2).
US20170355879A1 Hydrophobic coatings (as amended) A hydrophobic or superhydrophobic polymer composite comprising a lattice of poiycyclic aromatic hydrocarbons such as reduced graphene oxide (rGO) modified with at least one siloxane polymer and a method of preparation thereof is disclosed. A method of coating a material comprising immersing a material in a coating solution made from the rGO and siloxane polymer is also disclosed.
US9841399 Chemical sensor package for highly pressured environment A package for a chemical sensor including an encapsulation and a pressure balancing structure is disclosed. The encapsulation encapsulates a chemical sensor and has a hole for exposing a chemical sensitive part of the chemical sensor. The pressure balancing structure balances pressure applied to the chemical sensor at the chemical sensitive part.
US20170342373A1 Technique for formation and assembly of 3D cellular structures In one example, the present invention refers to a method of making or producing a self-supporting cellular construct having a continuous channel within its central cavity, comprising the steps of providing a mould with a central opening, wherein the mould encloses a volume around the central opening (hole) capable of housing a plurality of cells. Each of the plurality of self-supporting cellular constructs, having a central opening in a series adjacent to one another such, is placed so that the central opening of each of the self-supporting cellular constructs having a central opening is aligned to one another to thereby form, for example, a continuous channel within its central cavity.
US9829358 Device for determining a property of a fluid and method of forming the same In various embodiments, a device for determining a property of a fluid may be provided. The device may include a fluid receiving structure configured to receive the fluid having a first condition. The device may further include a flow control structure coupled to the fluid receiving structure. The flow control structure may be configured to change the first condition of the fluid to a second condition. The device may further include a determination mechanism configured to determine the property of the fluid based on the second condition. The device may also include a voltage generation mechanism a voltage generation mechanism configured to generate a voltage based on the second condition.
US20170334912A1 Purine Diones As Wnt Pathway Modulators The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.
EP2349336B1 Mesoporous material excipients for poorly aqueous soluble ingredients The present invention encompasses formulations and methods for producing solid dispersions comprising mesoporous materials with poorly aqueous soluble active ingredients. The active ingredient is formed in the amorphous state and entrapped in the nanosized pores of the mesoporous excipients using a co-spray drying process. The pore walls of mesoporous channels stabilize the amorphous form of active ingredient against re-crystallization. The amorphous active ingredient entrapped in mesoporous channels exhibits good stability during extended storage under stress test conditions and possesses significantly enhanced dissolution rates.
EP1994144B1 Human embryonic stem cell methods and podxl expression A method of identifying an undifferentiated human embryonic stem cell in a sample which may contain such cells, the method comprising identifying the cell or cells within the sample that express podocalyxin-like protein (PODXL) on their surface. A method of isolating an undifferentiated human embryonic stem cell from a sample containing such cells, the method comprising isolating the cell or cells within the sample that express PODXL on their surface. Typically, the methods use an antibody which binds to PODXL. Undifferentiated human embryonic stem cells isolated by the method may be useful in cell therapy. Also, in particular, compositions of cells differentiated from a human embryonic stem cell but which composition has been depleted of undifferentiated human embryonic stem cells are provided which are useful in cell therapy.
US9822222 Biodegradable and biocompatible shape memory polymers This invention relates to shape memory block copolymers comprising: at least one switching segment having a Ttrans from 10 to 70° C.; and at least one soft segment, wherein at least one of the switching segments in linked to at least one of the soft segments by at least one linkage, and wherein the copolymer transforms from a first shape to a second shape by application of a first stimulus and the copolymer transforms back to the first shape from the second shape by application of a second stimulus. The shape memory block copolymers may be biocompatible and biodegradable.
US20170328837A1 SERS-based analyte detection The present invention relates to method detecting analytes by surface enhanced Raman spectroscopy (SERS), comprising contacting the analytes with at least one analyte binding molecule attached to a metal substrate surface that enhances Raman scattering via a Raman-active molecular linker; and detecting a surface enhanced Raman signal from said compound. In a further aspect, this invention relates to a conjugate and a biosensor suitable for the invented SERS-based analyte detection method.
US20170319615A1 Heparan sulphates for use in repair and/or regeneration of skin Affinity purification of fibroblast growth factor 2-binding heparan sulphate from porcine mucosa (HS8) is disclosed. Also disclosed is the use of HS8 in repair and regeneration of the skin for treating wounds, burns, ulcers and other skin injuries.
US20170322217A1 A method for prognosis of ovarian cancer, patient's stratification There are no reliable clinical bio-markers of survival prognosis, patient's risk stratification and treatment prediction for epithelial ovarian cancers(EOC). The most common type of the human EOC is a high grade serous EOC. This cancer is characterized with one of the lowest survival rates compared to other cancers. The present invention relates to an method for a prognosis of survival of a subject diagnosed with EOC, the method comprising determining in a sample of the subject gene expression level of at least one gene in the list of Evi1 pathway genes; and/or copy number of at least one gene in the MECOM locus; wherein the level against at least one expression threshold value will define the risk group of the subject and/or a risk of the disease progression after surgery treatment, and/or an effectiveness of post-surgery chemotherapy. The quantification method of Evi1/MECOM locus regulatory pathway provides a set of multigene prognostic signatures representing EVI1 pathway modules, which collectively provided a framwork of high-confidence, sensitive and specific prognosis assay(s) of EOC and stratification method for the EOC patient stratification according to disease relapse.
EP2061490B1 Modulators of candida hyphal morphogenesis and uses thereof The invention relates to modulation of fungal morphology between yeast-to-hyphal growth transition by controlling muramyl-L-alanine concentration and uses thereof.
US9809639 Purification of biological products by constrained cohydration chromatography Materials and methods for use of constrained cohydration agents in the purification of biological materials such as antibodies, viruses, cells, and cellular organelles in connection with convective chromatography, fluidized bed or co-precipitation applications.
EP2654801B1 Targeting glioma stem cells by sequence-specific functional inhibition of pro-survival oncomir-138 Methods for malignant glioma diagnosis/prognosis using miR-138 as a prognostic biomarker and methods for treating malignant glioma and inhibiting glioma stem cell growth by suppressing miR-138. Also disclosed herein are pharmaceutical compositions for use in treating malignant glioma, prolonging survival of malignant glioma patients, or eliminating GSCs and in turn tumor growth, the pharmaceutical composition comprising an oligonucleotide that targets miR-138.
US9802902 Antifungal compound There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.
US9802821 Method for preparing transition metal phosphide There is provided a method of preparing transition metal phosphide comprising the step of mixing a solution of a transition metal precursor and a phosphorous precursor under conditions to form the transition metal phosphide. There is also provided a transition metal phosphide particle made according to the method as defined herein. There is additionally provided a method of preparing a transition metal phosphide-based electrode used for producing hydrogen in the electrolysis of water.
US9803079 Method of preparing fiber-reinforced polymer composites and fiber-reinforced polymer composites prepared thereof A method of preparing a fiber-reinforced polymer composite is provided. The method includes (a) providing a swollen clay material; (b) chemically modifying a surface of the swollen clay material with an organosilane to form a silane-modified clay material; (c) intercalating the silane-modified clay material with a binder to form an intercalated clay material; and (d) melt compounding the intercalated clay material with a mixture comprising a polymer and fiber to form the fiber-reinforced polymer composite. A fiber-reinforced polymer composite is also provided.
SG11201706418QA Method for antigen loading of dendritic cells and vaccine There is provided a method of loading antigen in a dendritic cell for antigen presentation, the method comprising: modifying a pluripotent stem cell with a nucleic acid molecule encoding an antigen or one or more immunogenic epitopes thereof; inducing the pluripotent stem cell to differentiate into a dendritic cell that expresses and presents the antigen or the one or more immunogenic epitopes thereof. Dendritic cells, vaccines and methods of using the dendritic cells and vaccines are also provided.
SG11201707895UA Location system and method for determining location of a vehicle There is provided a method of determining a location of a vehicle including obtaining a curve segment of a path navigated by the vehicle (estimated by an inertial navigation system), selecting one or more candidate curve segments from a road network database resembling the curve segment of the navigated path obtained, identifying one of the candidate curve segments as matching the curve segment of the navigated path, and determining the location of the vehicle based on the matching curve segment identified. The method includes comparing the curve segment of the navigated path with a curve segment from the road network database to determine whether the curve segment from the road network database qualifies as a candidate curve segment, and scaling at least one of the curve segment of the navigated path and the curve segment from the road network database to reduce a difference in length therebetween for the comparison.
SG11201707249QA Anti-reflective and Anti-fogging materials The present invention provides a textured polymer substrate comprising nano-sized surface features that are arranged in a single array or in a hierarchical array, and at least one layer of an amorphous, hydrophilic layer deposited thereon. The disclosed textured polymer substrate is advantageously suited for providing anti-reflective, anti-fogging and anti-UV materials.
US20170308523A1 A method and system for sentiment classification and emotion classification A system and a method for classifying text messages, such as social media messages into sentiment valence categories are provided. The system comprising a module for decomposing text messages, a module for cleaning text messages, a module for producing feature data of text messages, and a module for classifying text messages into sentiment valence categories. The module for decomposing text messages is configured to: receive a text message, parse the text message into separate portions in response to parsing criteria based on sentence delimiters, wherein the separate portions are sentences, phrases and words, and rejoin at least some of the separate portions of the text message into sentences in response to predefined linguistic conditions.
US20170304369A1 Methods of differentiating stem cells into liver cell lineages The present disclosure provides methods and kits for the differentiation of stem cells into relevant liver cell lineages, as well as methods of using the relevant liver cell lineages in screening for a cellular response, a phenotype and in the treatment of a condition. In one embodiment, stem cells are first differentiated into cells of the definitive endoderm lineage, which are differentiated into posterior foregut (PFG) lineage cells by one or more of retinoic acid activators and/or one or more inhibitors of transforming growth factor-β (TGFβ). An additional embodiment provides a method for the differentiation of posterior foregut lineage cells into liver bud progenitors (LB) by one or more activators of TGFβ signalling, and/or one or more modulators of Wnt signalling, and/or one or more activators of cyclic AMP/PKA signaling; and a further embodiment provides a method for the differentiation of liver bud progenitors into hepatic progenitors by one or more inhibitors of TGFβ signalling and/or fibroblast growth factor (FGF) inhibitors and/or one or more Notch inhibitors. Another embodiment discloses the differentiation of hepatic progenitors into hepatocyte-like cells or perivenous hepatocyte-like cells by one or more of Notch inhibitors and/or activators of glucocorticoid signalling and/or one or more activators of insulin signalling and/or one or more of ascorbic acid signalling activators and/or additional factors. Methods and kits for maintaining LB in self renewal state, hepatocyte-like cells in perivenous or periportal state, as well as surface markers for LB and mid/hindgut (MHG) cells are also disclosed.
US9799854 Multilayer film for encapsulating oxygen and/or moisture sensitive electronic devices The present invention relates to a multilayer barrier film capable of encapsulating a moisture and/or oxygen sensitive electronic or optoelectronic device, the barrier film including at least one nanostructured layer including reactive nanoparticles capable of interacting with moisture and/or oxygen, the reactive nanoparticles being distributed within a polymeric binder, and at least one ultraviolet light neutralizing layer comprising a material capable of absorbing ultraviolet light, thereby limiting the transmission of ultraviolet light through the barrier film.
US20170296081A1 Frame based spike detection module A method and device for biomedical recording of biomedical spike signals is provided. The method includes extracting and aligning possible biomedical spike signals from received signals and, thereafter, performing spike detection by determining whether the possible biomedical spike signals are actual spike signals. The biomedical spike signals are preferably selected from electrocardiography (ECG), electroencephalography (EEG) and neural signals.
US20170298522A1 Formulation and method for inhibiting carbon-based deposits There is a formulation and a method for inhibiting carbon-based deposits on metal substrate. The method comprises the use of a formulation comprising at least one oxidizing agent and at least one etchant capable of forming free metal ions from the metal substrate, at least one sequestering agent having a ligand capable of forming a complex with the free metal ions and at least one chelating agent having a ligand capable of complexing with at least one surface metal atom.
US9794376 Compression devices, decompression devices, compression methods, and decompression methods The present invention is directed to a compression device including an identifier determination circuit configured to determine a first identifier value identifying a first communication terminal of a network, and a second identifier value identifying a second communication terminal of the network; a differential determination circuit configured to determine a differential value based on a difference between the first identifier value and the second identifier value; and a compressed string generation circuit configured to insert the differential value into a compressed string. A compression method, a decompression device and a decompression method are also disclosed.
US9790488 Mutated internal ribosomal entry site (IRES) for controlled gene expression The present invention relates to a nucleic acid molecule comprising one or multiple mutant IRES elements. Further, the present invention relates to methods of enhancing gene expression and to methods of differentially controlling expression of one or multiple gene(s) of interest. In addition, the present invention relates to a kit for studying interactions or any application requiring co-expression of multiple genes.
US9790503 VHZ for diagnosis and treatment of cancer We provide VHZ for use in a method of treatment, prophylaxis or alleviation of a cancer, such as breast cancer, in an individual. We provide an anti-VHZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to breast cancer comprising means for detection of VHZ expression in the individual or a sample taken from him or her as well as a method of detecting a cancer cell, the method comprising detecting modulation of expression, amount or activity of VHZ in the cell.
US20170285021A1 A Test Strip For Paper-Based Assay This invention relates to a test strip for paper based assay, the test strip comprising a substrate addition zone for receiving a substrate and a test zone, the test zone comprising a capture agent, wherein the substrate addition zone is located upstream of the test zone. The invention 5 also relates to a paper-based enzyme assay comprising a test strip of the invention and methods of detecting the presence of an analyte in a sample using a test strip of the invention.
US20170285022A1 Test Strip Assembly There is provided a test strip assembly for detecting the possible presence of at least one analyte in a sample, a device for detecting the possible presence of at least one analyte in a sample comprising the test strip assembly and methods of detecting the possible presence of at least one analyte in a sample using the device.
US20170282170A9 Phosphorus-containing catalysts The invention provides compounds of general structure I: (Ar1—Ar2—Ar3-E-P(=D)R2-)nMmXnLn″. In this structure: •Ar1, Ar2 and Ar3 are aromatic groups wherein: —Ar1 and Ar3 are in a 1,3 relationship on Ar2, —each of Ar1, Ar2 and Ar3 optionally comprises one or more ring substituents of formula YR′r wherein each Y independently is absent or is O, S, B, N or Si and each R′ is independently H, halogen, alkyl, cycloalkyl, aryl or heteroaryl and r is 1, 2 or 3, where r is 1 if Y is absent or is O or S, 2 if Y is B or N and 3 if Y is Si, —Ar1, Ar2 and Ar3 are each independently carbocyclic or heterocyclic and each is independently monocyclic, bicyclic or polycyclic and each ring of each of Ar1, Ar2 and Ar3 independently has 5, 6 or 7 ring atoms; •E is absent or is selected from the group consisting of O, S, NR″, SiR″2, AsR″2 and CR″2; •M is a complexing metal; •X is selected from the group consisting of H, F, Br, CI, I, OTf, dba (dibenzylidene acetone), OC(═O)CF3 and OAc; •L is selected from the group consisting of PR″2, NR″2, OR″, SR″, SiR″3, AsR″3, alkene, alkyne, aryl and heteroaryl, each of said alkene, alkyne, aryl and heteroaryl being optionally substituted, for example with one or more halogens and/or with one or more R groups as defined herein; •each R is independently alkyl, cycloalkyl, heterocyclyl, heterocycloalkyl, aryl or -, heteroaryl; •D is absent or is ═S or —O or —Z-linker-Z—, where each Z independently is O or NH or N-alkyl and linker is an alkyl chain of 2-5 carbon atoms in length; •each R″ is independently H, alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, each other than H being optionally substituted, or R″2 is —Z-linker-Z— as defined above; and •m is 0 or 1 or 2; wherein if m is 0, n is 1, n′ and n″ are 0 and -- is absent; and if m is 1 or 2, n is 1 or 2 and n′ and n″ are integers such that the coordination sphere of M is filled, and D is absent.
US20170259300A1 Amorphous metal oxide films A method for preparing an amorphous metal oxide film is provided. The method comprises providing an aqueous composition comprising a metal fluorine compound; and contacting a substrate with the aqueous composition at a temperature of less than about 100° C. to obtain said amorphous metal oxide film on the substrate. An amorphous metal oxide film, and use of the amorphous metal oxide film in various applications are also provided.
US20170260526A1 Modified antimir-138 oligonucleotides Disclosed is a modified oligonucleotide capable of reducing or inhibiting one or more activities miR-138. The modified oligonucleotide may comprise at least one locked nucleic acid (LNA) and wherein the oligonucleotide is substantially complementary to a nucleotide sequence of miR-138. Also disclosed are pharmaceutical compositions comprising the oligonucleotides, methods of using the oligonucleotides and uses thereof.
US9758583 Anti-CTLA-4 antibodies Anti-CTLA-4 antibodies are disclosed. Also disclosed are compositions comprising such antibodies, and uses and methods using the same.
CN104684850B Melamine-formaldehyde polymer Described herein is a melamine-aldehyde polymer, wherein the polymer has a pore volume in the range of about 1.5 to 5 cm3/g.
CN103221127B Porous polymer material The present disclosure relates to polymeric materials comprising melamine - formaldehyde copolymer bore extending between the nanoparticles, and wherein the micropores extend in the copolymer nanoparticles, the production of polymeric material and use thereof.
US9754356 Method and system for processing an input image based on a guidance image and weights determined thereform In various embodiments of the present disclosure, there is provided a method for processing an input image. The method includes generating a base layer portion and a detail layer portion from the input image by carrying out a linear transformation of pixels of a guidance image, and determining, for each of the pixels of the guidance image, a variance of the pixels in a surrounding window of pixels. Further, the method includes determining, for each of the pixels of the guidance image, a weight value of the pixels based on the determined variance, wherein the pixels are weighted in the linear transformation according to the determined weight value. Accordingly, a system for processing an input image is also provided.
SG11201705838YA Optical device and method of controlling the same According to embodiments of the present invention, an optical device is provided. The optical device includes a waveguide structure including a floating gate, and an optical waveguide arranged spaced apart from the floating gate, wherein the optical waveguide overlaps with the floating gate, a carrier injection portion arranged spaced apart from the floating gate, and an electrode arrangement, wherein, in response to a first voltage difference applied to the electrode arrangement, the optical device is configured to inject charge carriers from the carrier injection portion to the floating gate to cause a change in refractive index of the waveguide structure, and wherein, in response to a second voltage difference applied to the electrode arrangement, the optical device is configured to drive the charge carriers from the floating gate to the optical waveguide to deplete the charge carriers.
SG11201705789RA Memory device and method for operating thereof According to various embodiments, there is provided a memory device including at least one sense amplifier having a first side and a second side, wherein the second side opposes the first side; a first array including a plurality of memory cells arranged at the first side; a second array including a plurality of memory cells arranged at the second side; a first row including a plurality of mid-point reference units arranged at the first side; and a second row including a plurality of mid-point reference units arranged at the second side, wherein each mid-point reference unit of the first row is configured to generate a first reference voltage, and wherein each mid-point reference unit of the second row is configured to generate a second reference voltage; wherein the sense amplifier is configured to determine a resistance state of a memory cell of the first array based on the second reference voltage; wherein the sense amplifier is configured to determine a resistance state of a memory cell of the second array based on the first reference voltage.
US9746877 Detecting and correcting an error in a digital circuit A method for detecting and correcting an error in a circuit is provided. The circuit is configured to receive an input signal and clock the input signal with a rising and falling timing signal. The method includes detecting late arrival signal transition of the input signal, at an intermediate point of a path, the path being one through which the input signal transits. The method further includes predicting an error in the input signal in response to detecting the late arrival signal transition at the intermediate point of the path. In addition, the method includes correcting the error in the input signal by manipulating the timing signal and/or a supply voltage.
CN107098970A Antibodies bound to an intracellular PRL-1 or PRL-3 polypeptide We provide an antibody capable of binding to an intracellular PRL-I or PRL-3 polypeptide, in which the antibody is capable of binding to an epitope bound by antibody 269, antibody 223 or antibody 318. Such anti-PRL antibodies may be capable of binding to intracellular PRL-I or PRL-3. They may be suitable for use as therapies against cancer or metastasis thereof, or in clinical diagnosis to identify PRL-3 or PRL-1 positive patients.
US9738704 Binding molecules against Chikungunya virus and uses thereof The invention relates to binding molecules against Chikungunya virus, which are able of neutralizing Chikungunya virus infectivity, and which can be used with therapeutic, diagnosis or research purposes, as well as to a pharmaceutical composition comprising said binding molecules.
EP2831079B1 Bicyclic heterocyclic derivatives as mnk1 and mnk2 modulators and uses thereof The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, Alzheimer's disease), as well as methods of treating these diseases.
US9731997 Multilayer heat rejection coating There is provided a multilayer coating comprising a plurality of layers comprising a) one or more layers of an elemental transition metal; b) one or more layers of an elemental metalloid; and c) two or more layers of an oxide; characterized in that the transition metal and metalloid layers are between the oxide layers and the plurality of layers does not need to contain an additional transparent conductive film (TCF). The multilayer coatings show high transparency in the visible light range combined with heat shielding without the need of transparent conductive oxide which have been previously used to achieve these properties. The multilayers can be produced with conventional physical vapor deposition methods on glass and polymer substrates. The coatings may therefore be used for applications on windows, plastic sheets and window shields. The invention relates also to the process for making the multilayer coatings, articles comprising them and their use in building and other applications.
EP2673636B1 Methods of detecting therapeutic exosomes We describe a method of detecting a therapeutic exosome, the method comprising detecting an activity of an exosome. The activity may be selected from the group consisting of: (a) immunodulatory activity; (b) complement inhibition activity; (c) proteasome activity; (d) glycolytic enzyme activity; (e) anti-oxidative activity; (f) extracellular matrix (ECM) modifying activity; (g) NT5E (CD73) ecto-5'-ectonucleotidase activity; (h) ion homeostasis activity; and (i) chaperone activity. If the exosome is detected as having one or more such activities, the exosome is likely to comprise a therapeutic exosome having therapeutic activity.
US20170218011A1 Purification of biological products by constrained cohydration chromatography Materials and methods for use of constrained cohydration agents in the purification of biological materials such as antibodies, viruses, cells, and cellular organelles in connection with convective chromatography, fluidized bed or co-precipitation applications.
US20170217853A1 Method and system for producing an olefin There is provided a method for producing an optionally substituted olefin, comprising the steps of: dehydrogenating an optionally substituted alcohol in a first reaction zone comprising a first catalyst supported on a porous silica-based particle to form an optionally substituted carbonyl at a first set of reaction conditions; converting the optionally substituted alcohol and the optionally substituted carbonyl from the first reaction zone in a second reaction zone at a second set of reaction conditions that is different to the first set of reaction conditions and is selected to form the optionally substituted olefin, wherein the second reaction zone comprises a second catalyst supported on a porous silica-based particle. There is also provided a system for producing the optionally substituted olefin.
US20170216446A1 Polymer-flavonoid conjugate and uses thereof There is provided a polymer-flavonoid conjugate, or a pharmaceutically acceptable salt thereof, uses thereof, and methods of making thereof. The disclosed polymer-flavonoid conjugates may be useful in the therapeutic and/or prophylactic treatment of a joint condition in a subject.
US9717430 Real-time multi-functional ECG signal processing system, DSPE for the ECG signal processing system, and method thereof An electrocardiogram (ECG) signal processing system is provided. The ECG signal processing system comprises an analog-to-digital converter (ADC) configured to convert an input analog ECG signal into a digital ECG signal, and a digital signal processing engine (DSPE) coupled to the ADC to receive the digital ECG signal. The DSPE is configured to decompose and reconstruct the digital ECG signal. A dynamic system clock source is coupled to the ADC and the DSPE for dynamic signal sampling, the dynamic system clock source clocking the ADC and the DSPE at a first frequency f1 to detect one or more first parameters of the input analog ECG signal and at a second frequency f2 to detect one or more second parameters of the input analog ECG signal.
SG10201610516RA Encrypted data deduplication in cloud storage There is provided a method of storing data in a cloud storage system, the method including: generating a file identifier for a data file desired to be stored in the cloud storage system; encrypting the file identifier of the data file using a homomorphic encryption technique to produce an encrypted file identifier of the data file; and transmitting the encrypted file identifier to the cloud storage system for performing data deduplication in relation to the cloud storage system with respect to the data file. There is also provided an associated client device and cloud storage system.
EP2773696B1 Self-assembled composite ultrasmall peptide-polymer hydrogels The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z-(X)m-(Y)n-Z'p,wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine; Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative; Z' is a C-terminal protecting group; m is an integer selected from 2 to 6; n is selected from 1 or 2; and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents/moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.
US9715640 Robust graph representation and matching of retina images A numerical parameter indicative of the degree of match between two retina images is produced by comparing two graphs obtained from the respective images. Each graph is composed of edges and vertices. Each vertex is associated with a location the corresponding retina image, and with descriptor data describing a part of the corresponding retina image proximate the corresponding location.
US9710908 Method and system for assessing fibrosis in a tissue A method for assessing fibrosis in a tissue is proposed. The method uses a test image which is an image of the tissue and comprises identifying, from the test image, a portal collagen area, a septal collagen area and a fibrillar collagen area respectively comprising pixels representing portal collagen, septal collagen and fibrillar collagen of the tissue, obtaining quantitative values of one or more features for each identified area based on characteristics of the identified area in the test image and assessing fibrosis using the quantitative values obtained for all the identified areas.
US9707563 Reagent fluid dispensing device, and method of dispensing a reagent fluid According to various embodiments, a reagent fluid dispensing device may be provided. The reagent fluid dispensing device may include a chamber for receiving a reagent fluid, the chamber having a first opening and a second opening; a first fluid conduit connected to the first opening of the chamber; a reservoir connected to the first fluid conduit, the reservoir having a first opening, wherein the first opening of the reservoir is connected to the first fluid conduit to form a passive valve, wherein the reservoir is dimensionalized for storing a predetermined volume of the reagent fluid; and a pneumatic conduit connected to the second opening of the chamber, wherein selective application of pneumatic pressure to the chamber through the pneumatic conduit transfers the reagent fluid from the reservoir to the chamber through the first fluid conduit. According to various embodiments, a microfluidic device including the reagent fluid dispensing device, and a method of dispensing a reagent fluid may be provided.
US20170198055A1 A diagnostic and therapeutic tool for cancer Disclosed is a method for determining the likelihood of the presence or progression of a hepatocellular carcinoma in a subject, comprising determining the level of extracellular form of Agrin in an extracellular fluid obtained from the subject. Also disclosed are the use of anti Agrin agent for therapy, a pharmaceutical composition comprising anti-Agrin agent, a method of treating cancer comprising an anti-Agrin agent, a use of anti-Agrin agent and a kit thereof.
US9701585 Electro-optic ceramic materials The present invention provides a product and manufacturing method for electro-optic ceramic material having the composition (A′(1-y)A″y)1-XLnxM(1-2X/5)O3 wherein 0
EP2900807B1 Method and system for in vitro developmental toxicity testing A method and system of in vitro developmental toxicity testing comprising the steps of micropatterning an extracellular matrix; growing embryonic stem cells on the micropatterned extracellular matrix in the presence of mesoendermal induction and testing for change of the geometrical mesoendoderm structure in the presence or absence of a test compound wherein (1) a decrease in mesoendodermal differentiation and/or (2) a change in morphology of the geometrical mesoendoderm structure in the presence of the test compound compared to cells in the absence of the test compound indicates that the test compound is a developmental toxic agent.
EP2406729B1 A method, system and computer program product for the systematic evaluation of the prognostic properties of gene pairs for medical conditions. A method is proposed identification of pairs of genes for which the respective gene expression values in a subject are statistically significant in relation to a medical condition, for example cancer, or more particularly breast cancer. Many pairs of genes are generated, and for each pair of genes clinical data is used to fit a statistical model to obtain the statistical significance of the ratio of the corresponding expression values. The clinical data characterizes for each of the patients the level of expressions of the genes and times until a clinical endpoint of interest.
US9697894 Methods and circuit arrangements for determining resistances A method may include applying a first current through the memory element and a first selection component. The memory element and the first selection component may be located along a memory line. The method may also include measuring a first potential difference across the memory line. The method may further include applying a second current through a second selection component, wherein the second selection component is located along a dummy line, and measuring a second potential difference across the dummy line. The method may additionally include determining the resistance of the memory element based on the first potential difference and the second potential difference. The first selection component may be activated and the second selection component may be deactivated to apply the first current. The first selection component may be deactivated and the second selection component may be activated to apply the second current.
US9695216 Materials and methods for removing endotoxins from protein preparations A method includes (i) adding allantoin in a supersaturating amount to a protein preparation including a desired protein and at least one endotoxin as a contaminant, (ii) removing solids after the adding step to provide a sample for further purification by void exclusion chromatography on a packed particle bed of electropositive particles in a column, the packed particle bed having an interparticle volume, (iii) applying a sample volume to the packed particle bed, wherein the electropositive particles support void exclusion chromatography, and wherein the sample volume is not greater than the interparticle volume, and (iv) eluting a purified sample including the desired protein and a reduced amount of the endotoxin. The method is optionally carried out with only the allantoin treatment or only the void exclusion chromatography.
US9695231 Monoclonal antibody against muramyl peptides Disclosed is an isolated antibody or an antigen-binding fragment thereof. The antibody is capable of binding to a muramyl peptide, or a derivative or an analog or a salt thereof. The muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid, and a salt thereof. Also disclosed are methods of producing the antibody, compositions comprising the antibody, methods of treating using the antibody, uses of the antibody, methods of detecting muramyl peptide, an assay for detecting muramyl peptide, an antibacterial agent, hybridomas and kits.
US9694127 Bioreactor unit for use in bioartificial kidney device There is provided a bioreactor device having cells, including human primary proximal tubule cells (HPTCs) or HPTC-like cells on the exterior surface of hollow fiber membranes included within the device. Also provided are bioartificial kidney devices incorporate the bioreactor device and methods of using such devices.
SG11201703909VA Hydrophobic coatings comprising reduced graphene oxide modified with a siloxane polymer A hydrophobic or superhydrophobic polymer composite comprising a lattice of poiycyclic aromatic hydrocarbons such as reduced graphene oxide (rGO) modified with at least one siloxane polymer and a method of preparation thereof is disclosed. A method of coating a material comprising immersing a material in a coating solution made from the rGO and siloxane polymer is also disclosed.
US20170181915A1 A method and system for using haptic device and brain-computer interface for rehabilitation A method for calibrating and executing a rehabilitation exercise for a stroke-affected limb of a stroke patient is disclosed, the method comprising the steps of providing a haptic device for an able limb of the stroke patient to manipulate to perform a calibration action to result in a first position of the haptic device, and providing the haptic device for the stroke-affected limb to manipulate to perform the calibration action to result in a second position of the haptic device. The method further comprises the steps of moving the haptic device coupled with the stroke-affected limb from the second position towards the first position until a predetermined counterforce is detected, indicating an extreme position for the stroke-affected limb using the haptic device, and calibrating the haptic device with the extreme position such that during the rehabilitation exercise, the haptic device is prevented from moving beyond the extreme position.
EP2875349B1 In vitro assay for predicting renal proximal tubular cell toxicity There is provided an in vitro assay for screening a test compound for toxicity in renal proximal tubular cells. The method comprises contacting a test compound with a test population of renal proximal tubular cells; and examining one or more cell morphology features, examining one or more cytoskeleton features, and/or determining cell numbers of the renal proximal tubular cells in the test population and comparing such cell morphology, arrangement of cytoskeletal components and/or cell count with the respective features of a control population. A change in one or more cell morphology features, a change in arrangement of one or more cytoskeleton features or a decrease in cell numbers of the test population relative to the control population is indicative that the test compound is toxic for renal proximal tubular cells.
US9687591 Building stratified biomimetic tissues and organs using crosslinked ultrashort peptide hydrogel membranes The present invention relates to hydrogel membranes comprising a hydrogel, said hydrogel comprising a plurality of tetramer amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of tetramer amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to stratisfied biostructures and devices comprising at least two hydrogel membranes of the invention, which can be used e.g. to rebuild human skin and for tissue engineering of organs and tissues. The present invention further relates to corneal implants and devices comprising a hydrogel membrane of the invention.
US9689801 SERS-based analyte detection The present invention relates to method detecting analytes by surface enhanced Raman spectroscopy (SERS), comprising contacting the analytes with at least one analyte binding molecule attached to a metal substrate surface that enhances Raman scattering via a Raman-active molecular linker; and detecting a surface enhanced Raman signal from said compound. In a further aspect, this invention relates to a conjugate and a biosensor suitable for the invented SERS-based analyte detection method.
US20170173537A1 Apparatus and methods for fractionation of biological products Methods and apparatus for purification of biological molecules using combinations of tangential flow filtration subunits and adsorption sub-units in a single apparatus where the subunits may be operated independently or in series and where the apparatus and methods are suitable for use in a wide range of formats distinct from conditions required for chromatographic processes such as conducting process steps using adsorption subunits for purification of a biological molecule in a contaminated sample without prior buffer equilibration.
US9679379 Cost-sensitive linear reconstruction based optic cup localization A method is presented to obtain, from a retinal image, data characterizing the optic cup, such as data indicating the location and/or size of the optic cup in relation to the optic disc. A disc region of the retinal image of an eye, is expressed as a weighted sum of a plurality of pre-existing “reference” retinal images in a library, with the weights being chosen to minimize a cost function. The data characterizing the cup of the eye is obtained from cup data associated with the pre-existing disc images and the corresponding weights. The cost function includes (i) a construction error term indicating a difference between the disc region of the retinal image and a weighted sum of the reference retinal images, and (ii) a cost term, which may be generated using a weighted sum over the reference retinal images of a difference between the reference retinal images and the disc region of the retinal image.
US9678574 Computing system utilizing three-dimensional manipulation command gestures A computing system utilizing three-dimensional manipulation command gestures. An embodiment of an apparatus includes a sensing element to sense a presence or movement of a user of the apparatus, a processor, wherein operation of the processor includes interpretation of command gestures of the user to provide input to the apparatus, and a display screen to provide a display. The command gestures include one or more command gestures to manipulate at least a portion of the display, the one or more command gestures being gestures including motion along an axis between the display screen and the user.
EP2729485B1 Anti-amyloidogenic, alpha-helix breaking ultra-small peptide therapeutics The invention provides ultra-small peptide inhibitors that are capable of preventing amyloid formation/amyloidosis.
US9670462 Bioactive surface for hepatocyte-based applications The invention provides a surface, wherein said surface comprises (i) a polymer substrate and (ii) sugar groups and peptide groups coupled to said substrate suitable for culturing hepatocytes.
US20170151598A1 Imprinting Metallic Substrates at Hot Working Temperatures The present invention relates to a method of forming an imprint on a metal substrate. The method comprises a step of providing a mold having a defined imprint surface pattern in the nano-sized or micro-sized range and a step of pressing the metal substrate against the mold at hot-working temperature to form a nano-sized or micro-sized imprint thereon.
CN103548371B Dynamic bandwidth control for channels used for network coexistence The present invention is directed to a communication system comprising a network configured to operate in a first band; and a communication device of the network configured to send in a notification period a notification signal indicating that the first band is occupied and a notification signal indicating that a second band is occupied, wherein the second band includes the first band or a part thereof. A method of coordinating operations of networks is also disclosed.
SG11201703333XA An optical device and a method for fabricating thereof According to various embodiments, there is provided an optical device including a first waveguide configured to guide a light wave along a longitudinal axis; a first grating at least partially formed in the first waveguide, the first grating arranged away from the longitudinal axis in a first direction; and a second grating at least partially formed in the first waveguide, the second grating arranged away from the longitudinal axis in a second direction; wherein the second direction is different from the first direction.
SG10201508927SA Protein crystal A protein crystal comprising a first protein crystal having available space in the lattice, wherein a second protein crystal and a moiety can be accommodated in the available space in the lattice. The first and second proteins are co-expressed from one or more nucleic acid constructs. In a preferred embodiment, the first protein is the p21-activated kinase PAK4, the second protein is the PAK4 kinase inhibitor Inka1, and the moiety comprises a reporter molecule such as fluorescent proteins or tags and is fused to the iBox or iBox-C or Inka1. Preferably the crystal is formed in cellulo. Also provided is a fusion protein comprising the first protein and the second protein, wherein upon crystallisation the second protein fits within the available space in the lattice of the first protein, along with the moiety. Methods for producing the protein crystal are also disclosed.
SG10201508795XA Method for treating cancer The present invention relates to the treatment of breast cancer, more particularly triple negative breast cancer (TNBC), with the use of an inhibitor of Interleukin 1 Receptor Associated Kinase 1 (IRAK1) such as ginsenosides. It also relates to a method for aiding in categorising or determining prognosis in a breast cancer patient or in selecting a therapeutic strategy comprising assessing the level of IRAK1 nucleic acid, protein or activity in a sample and, in some aspects, further assessing the paclitaxel resistance status of the patient and if the patient is resistant to paclitaxel therapy, treating the patient with an inhibitor of IRAK1 activity. In addition, a screening method for identifying a compound useful for treating breast cancer comprises determining the effect of a test compound on IRAK1 nucleic acid, protein or activity level and selecting a compound that reduces said level.
US9663874 Device for manufacturing polymer fibers and uses thereof There is provided a device, and related method and uses, for drawing a polymer fiber, the device comprising: a. at least two polymer compartments, wherein each polymer compartment is capable of retaining a polymer solution, and wherein adjacent compartments comprise different polymer solutions; and b. a slider comprising at least one prong, wherein the prong is capable of contacting the different polymer solutions, and wherein the slider is arranged in a retractable manner from the at least two polymer compartments. There is further provided a system and a related method for manufacturing a polymer fiber.
US9668168 Method and device for mobile data offload Embodiments provide a mobile data offload method for associating a mobile client device with a wireless access point. The method may include transmitting a first authentication request from the mobile client device to the wireless access point via a first network being a Cellular Wide Area radio communication network; transmitting a second authentication request from the mobile client device to the wireless access point via a second network being a Short Range radio communication network or a Metropolitan Area System radio communication network; transmitting an authentication response from the wireless access point to the mobile client device via the second network upon receiving at least one of the first authentication request and the second authentication request at the wireless access point, and associating the mobile client device with the wireless access point upon receiving the authentication response at the mobile client device.
US20170143766A1 Stem cell subpopulations with differential GSTT1 expression or genotype A method for providing a sub-population of stem cell or plurality of stem cells by determining or modulating GSTT1 expression level or genotype is disclosed together with uses of the stem cells.
CN103548015B Method and apparatus for file retrieval index file Various embodiments provide a method for indexing a document for document retrieval. The document may include: generating a document vector indicating if each of a plurality of terms are present in the document; calculating a document semantic inference vector for each of the plurality of terms present in the document using the document vector and a semantic relation matrix, the semantic relation matrix identifying semantic relationships between different terms of the plurality of terms; and, indexing the document using a document semantic context inference vector calculated based on the document semantic inference vectors. Various embodiments provide a corresponding apparatus and computer readable medium.
US9650237 Electromechanical device including a suspended structure and method of fabricating the same An electromechanical device and method of fabrication thereof comprising: providing a first wafer with a circuit arrangement on a first surface thereof and a first electrode on a second surface thereof; forming first and second via structures from the first surface to the second surface of the first wafer, said first via electrically connecting the first electrode with the circuit arrangement; providing a second wafer with a suspended structure on a first surface thereof; forming a second electrode on the suspended structure; forming an interconnect structure on the first surface of the second wafer that electrically connects with the second electrode; bonding the first wafer to the second wafer with the second surface of the first wafer facing the first surface of the second wafer, with the second via structure electrically connecting the circuit arrangement to the interconnect structure, and the first and second electrodes forming a capacitive structure.
US20170128381A1 Stimulus-responsive core-shell particles There is provided a core-shell particle having pores extending through its shell and a plurality of polymers that are bonded to the outer surface of the shell, wherein the polymers are comprised of repeating monomer units of formula (1): [Formula should be inserted here] wherein the substituents are as defined herein. There is also provided a method of synthesizing the core-shell particle and use of the core-shell particle as a delivery agent.
US20170130077A1 Metal complexes The present invention provides a coating composition comprising a) a metal complex comprising an organic acid or anion thereof coordinated to a metal ion; and b) a polymer, wherein there is no covalent bond between said metal complex and the polymer.
US9644234 Methods and device to balance radiation transference A method and device for adjusting the temperature of a sample by heating a substrate with a laser diode light; said light projected on to the substrate to absorb the light and convert the light energy to a heat energy thereby raising the temperature of the substrate corresponding to the intensity of the light energy, the substrate configured to transfer the thermal energy substantially homogenously to the sample. The device or method suitable for amplification of a nucleic acid sample.
US20170121687A1 Methods of cellular reprogramming The present invention relates to a method for reprogramming a first cell type to an intermediate cell of a second cell type comprising the step of contacting the first cell with a first agent to modulate an integrin profile in the first cell type to provide an intermediate cell of the second cell type. The present invention also relates to a reprogrammed cell obtained by the method of the invention, a kit for reprogramming a first cell type to a second cell type as well as methods for treating a patient in need of cell based therapy, tissue replacement and cancer therapy.
SG11201702732UA Oxidant-dependent time indicator There is provided an irreversible, colorimetric, oxidant-dependent time indicator comprising: a) a porous material substrate; b) one or more redox-active dyes; c) one or more reductants; d) one or more non-alkaline additives; characterized in that the components b) to c) are deposited on the substrate a) substantially in the absence of a polymeric material or thickener in the component matrix and substantially in the absence of an oxidant semipermeable coating layer on the substrate. There is also provided a method of using the indicator, a process for making the indicator, a device comprising one or more of the indicators and a kit of parts comprising the device.
SG11201702736SA Hardware based crosstalk reduction for hard disk drives An actuator assembly for crosstalk reduction in hard disk drives (HDDs) is provided. The actuator assembly comprises a base plate; a pivot; a voice coil motor (VCM) with an upper yoke and a lower yoke; and a cut-out insert having a predetermined stiffness and predetermined magnetic properties, wherein the cut-out insert corresponds to a cut-out recess of the base plate, and wherein the lower yoke of the VCM and the pivot are coupled to the cut-out insert.
SG11201702612TA Triphasic system for direct conversion of sugars to furandicarboxylic acid There is provided a one-pot process for the conversion of sugars to furancarboxylic acids, such as 2,5-furancarboxylic acid (FDCA), in a triphasic system (e.g. water or tetraethylammonium bromide (TEAB) – methyl isobutyl ketone (MIBK) – water). In this reaction setup, sugars are first converted to 5-hydroxymethylfurfural (HMF) in a first phase. Then HMF is then extracted into a second phase and transferred to a third phase of water. In the third phase HMF is converted to the furancarboxylic acid. The overall acid yields obtainable are between about 78% and 50% for conversion from fructose and glucose, respectively. The invention further relates to an apparatus for the triphasic reaction. The apparatus comprises two chambers which allow for the chemically separated reaction of the sugars and the intermediate of the sugars to form the final product in one process. The process according to the invention may be useful for industrial fabrication.
SG11201701976QA Electrospun conductive carbon fibers A conductive carbonaceous fiber is provided, comprising a carbonaceous material obtained from carbonizing an electrospun fiber wherein said fiber comprises at least one conductive metal precursor. The electrospun fibers can be formed into fibrous mats during spinning, stabilization and carbonization that are conductive materials which can be used to make stretchable conductors for flexible electronic devices. The invention relates also to the process for making the fibers, corresponding elastomeric fibrous mesh/polymer composites as well as use of these composites for making stretchable electrical conductors. The obtainable elastomeric composite films (with a thickness in the range of 0.8 to 1.5 mm) exhibit good electrical conductivity and excellent electromechanical stability under mechanical deformations (e.g. elongating, twisting and bending). The scalable fabrication process and low-cost precursors make the elastic electrospun carbon fibers / polymer composite conductors promising materials for applications in flexible electronic devices, displays, sensors, wearable conducting clothes, implantable medical devices, etc.
US20170115170A1 Sensing device and method for sensing a force According to embodiments of the present invention, a sensing device is provided. The sensing device includes a sensor arrangement including an optical fiber, and at least one spacer element arranged adjacent to the optical fiber, wherein the optical fiber and the at least one spacer element are adapted to cooperate to receive a force applied to the sensor arrangement to modulate an optical signal propagating in the optical fiber. According to further embodiments of the present invention, a method for sensing a force is also provided.
SG10201702608VA A method and system for determining a stage of fibrosis in a liver A method for determining a stage of fibrosis in a liver is disclosed. The method comprises the steps of: (1a) obtaining input data relating to the liver, the input data being generated using a second harmonic generation based imaging system; (1b) identifying a plurality of morphological features of the liver from the input data relating to the liver; (1c) generating a plurality of measurements based on the identified plurality of morphological features; and (1d) determining the stage of fibrosis in the liver based, on the generated plurality of measurements.
US9633685 Method of writing to an optical data storage medium, method of reading from an optical data storage medium, and optical data storage medium According to embodiments of the present invention, a method of writing to an optical data storage medium is provided. The method includes receiving a plurality of data elements, each data element having one of a plurality of values, wherein each value of the plurality of values is associated with a wavelength, and forming, for each data element, a nanostructure arrangement on the optical data storage medium, the nanostructure arrangement configured to reflect light of the wavelength associated with the value of the data element in response to a light irradiated on the optical data storage medium. According to further embodiments of the present invention, a method of reading from an optical data storage medium and an optical data storage medium are also provided.
US9627633 Perylene functionalized porphyrin dyes for dye-sensitized solar cells The invention relates to dyes for dye-sensitized solar cells, and in particular, to perylene functionalized porphyrin dyes for dye-sensitized solar cells. The invention further relates to a dye molecule comprising perylene functionalized porphyrin moiety.
US9628243 Communication method with indications in the PHY header According to various embodiments, a communication method may be provided. The communication method may include: at least one of sending a first data unit including a physical layer (PHY) header or receiving a first data unit including a PHY header. The PHY header may include at least a field to indicate whether a response data unit is intended to follow the first data unit, and to indicate the type of the response data unit, when a response data unit is intended to follow the first data unit. The type of the response data unit may be used to estimate the duration of the response data unit.
EP2720768B1 Purification of biological products by constrained cohydration chromatography Materials and methods for use of constrained cohydration agents in the purification of biological materials such as antibodies, viruses, cells, and cellular organelles in connection with convective chromatography, fluidized bed or co-precipitation applications.
EP2513029B1 Carboxylation of terminal alkynes The present invention describes a process for converting a terminal alkyne into an alkynoic acid. In this process the alkyne is exposed to carbon dioxide in the presence of a copper (I) species, a base and a complexing agent capable of complexing copper (I).
US9614599 Method for determining precoding matrixes for communication and a system therefrom In various embodiments of the present disclosure, there is provided a method for determining precoding matrixes for a communication of a first base station and a second base station with a first mobile station and a second mobile station. Precoding matrixes for a plurality of signal channels between the base stations and the mobile stations are determined based on a signal to noise ratio (SNR) consideration. Accordingly, the method can include determining a first set of precoding matrixes based on a predetermined consideration of SNR between the first base station and the second base station and the first mobile station and the second mobile station and generating a second set of precoding matrixes based on the first set of precoding matrixes. A corresponding system for carrying out a determination of precoding matrixes is provided.
US20170092944A1 A method of forming a porous particle There is provided a method of forming a porous particle comprising an electrically conductive continuous shell encapsulating a core, said core comprising an elemental compound that reversibly reduces in the presence of a cation and oxidizes in the absence of said cation, said method comprising the steps of: a) encapsulating an elemental compound precursor with said electrically conductive shell; b) reacting said elemental compound precursor with an oxidation agent to oxidise said elemental compound precursor to form said elemental compound, thereby forming said electrically conductive shell encapsulating said core comprising said elemental compound.
EP2032721B1 Nucleic acid concatenation The present invention provides a method of manipulating nucleic acids. In particular, of length-controlled concatenating of nucleotide fragments, the method comprising: (a) providing at least two nucleotide fragments, wherein each fragment has one ligatable end and one non-ligatable end; and (b) allowing the two fragments to ligate at the ligatable ends to form an oligonucleotide comprising at least two concatenated nucleotide fragments. The present invention also provides an isolated oligonucleotide comprising at least two nucleotide fragments, wherein each fragment has at least one ligatable end and one non-ligatable end, and the fragments are ligated at the ligatable ends to form the oligonucleotide.
US20170085235A1 Single pole double throw amplifier A single-pole-double-throw (SPDT) amplifier having two inputs and one output is provided. The SPDT amplifier includes two distributed switchable base lines, each coupled to the two inputs. The SPDT further includes a two stage distributed amplifier connected between the distributed switchable base lines, coupled to the output.
US20170082610A1 METHOD FOR PREDICTING TOXICITY OF A COMPOUND BASED ON NUCLEAR FACTOR-kB TRANSLOCATION There is provided a method of screening for toxicity of a compound. The method comprises contacting a test compound with a test population of cells in which nuclear factor (NF)-κB has not been activated prior to the contacting; determining nuclear localization levels of NF-κB in the test population subsequent to the contacting; and comparing nuclear localization levels of NF-κB of a control population that has not been contacted with the test compound. An increase in nuclear localization levels of NF-κB as of the test population relative to the control population is indicative that the test compound injures the cells and/or induces a pro-inflammatory response and thus is toxic to the cell type used in the method.
CN104470606B With a negatively charged particles chromatographic purification of the polynucleotide A method of purifying a sample that includes a polynucleotide includes the steps of (i) providing a packed chromatographic column having negatively charged porous particles, (ii) equilibrating the column to the conditions to which the polynucleotide in the sample is to elute, (iii) contacting the sample with the packed chromatographic column such that the sample volume applied to the packed chromatographic column is less than or equal to the interparticle space of the negatively charged porous particles within the packed chromatographic column, (iv) eluting the polynucleotide from the packed chromatographic column, where the polynucleotide is in a purer state and in the conditions to which the packed chromatographic column was equilibrated.
US9601174 Magnetoelectric device, method for forming a magnetoelectric device, and writing method for a magnetoelectric device A magnetoelectric device is provided. The magnetoelectric device includes a reference magnetic layer structure having a fixed magnetization orientation, and a synthetic antiferromagnetic layer structure including a free magnetic layer structure and a coupling magnetic layer structure antiferromagnetically coupled to each other, each of the free magnetic layer structure and the coupling magnetic layer structure having a magnetization orientation that is variable, wherein the reference magnetic layer structure and the synthetic antiferromagnetic layer structure are arranged one over the other. According to further embodiments of the present invention, a method for forming a magnetoelectric device and a writing method for a magnetoelectric device are also provided.
US20170074781A1 Ellipsometry System For Measuring Molecular Binding, Adsorption And Desorption According to one aspect of the invention, there is provided an ellipsometry system for measuring any one or more of molecular binding, adsorption and desorption on a substrate, the system comprising: a) a cuvette comprising i) a body within which a cavity is formed and an opening on the body, wherein the cavity extends into the opening through which the substrate is immersed; ii) a window formed on each of two oppositely located walls of the body, wherein the windows are aligned to allow light to enter through one of the two windows to reflect off the portion of the substrate immersed in the cavity and exit through the other of the two windows; iii) a channel arrangement enclosed within the body of the cuvette and comprising two non-contiguous portions, wherein one of the two non-contiguous portions guides fluid into the cavity and the other non-contiguous portion guides fluid out of the cavity; b) a polarized light source disposed to provide the light that enters into one of the two windows on the body of the cuvette; and c) a detection stage disposed to receive the light that exits through the other of the two windows on the body of the cuvette, wherein the detection stage is configured to measure polarization rotation of the received light, the polarization rotation caused by any one or more of molecular binding, adsorption and desorption occurring on the substrate surface. The detection stage preferably contains a polarisation modulator, which is configured to measure polarization rotation of the received light.
US9586878 Method for synthesizing a sugar alcohol A method for synthesizing a sugar alcohol comprising the step of hydrolyzing a polysaccharide in the presence of hydrogen ions (H+), an alcoholic reducing agent and a hydrogen transfer catalyst to form the sugar alcohol.
US20170057992A1 Fractionation method Provided herein is a novel method of purifying an IgG antibody from a preparation by use of an electropositive membrane having a defined porosity.
US9580513 VHZ for diagnosis and treatment of cancers We provide VHZ for use in a method of treatment, prophylaxis or alleviation of a cancer in an individual selected from the group consisting of: colon cancer, lung cancer, squamous cell carcinoma including lip, larynx, vulva, cervix and penis cancer, pancreatic cancer, brain cancer, oesophageal cancer, stomach cancer, bladder cancer, kidney cancer, skin cancer, ovary cancer, prostate cancer and testicular cancer. We provide an anti-VHZ agent for the treatment, prophylaxis or alleviation of such a cancer. The anti-VHZ agent may comprise SEQ ID NO:4 or SEQ ID NO: 5, or both.
SG10201605758UA A Method For Preparing Transition Metal Phosphide There is provided a method of preparing transition metal phosphide comprising the step of mixing a solution of a transition metal precursor and a phosphorous precursor under conditions to form the transition metal phosphide. There is also provided a transition metal phosphide particle made according to the method as defined herein. There is additionally provided a method of preparing a transition metal phosphide-based electrode used for producing hydrogen in the electrolysis of water.
US20170043053A1 Heparan sulphates A heparan sulphate that binds TGPβ1 is disclosed.
US20170048058A1 Method and system for generating/decrypting ciphertext, and method and system for searching ciphertexts in a database There is provided a method of generating a ciphertext. The method includes encrypting an input data to produce an encrypted data, and randomizing the encrypted data to produce the ciphertext. In particular, the randomizing process includes performing an exclusive-or (xor) operation on the encrypted data with a cipher pad, whereby the cipher pad is generated based on an xor-homomorphic function of a first key using a second key generated based on the encrypted data. There is also provided a corresponding system for generating a ciphertext, a corresponding method and system for decrypting a ciphertext, and a corresponding method and system for searching ciphertexts in a database, such as at an untrusted server.
US9568466 In vitro assay for predicting renal proximal tubular cell toxicity There is provided an in vitro assay for screening a test compound for toxicity in renal proximal tubular cells. The method comprises contacting a test compound with a test population of renal proximal tubular cells; and examining one or more cell morphology features, examining one or more cytoskeleton features, and/or determining cell numbers of the renal proximal tubular cells in the test population and comparing such cell morphology, arrangement of cytoskeletal components and/or cell count with the respective features of a control population. A change in one or more cell morphology features, a change in arrangement of one or more cytoskeleton features or a decrease in cell numbers of the test population relative to the control population is indicative that the test compound is toxic for renal proximal tubular cells.
US20170037479A1 Markers for ovarian cancer and the uses thereof The present invention relates to markers for high-grade serous ovarian cancer (HG-SOC) and methods and uses thereof for diagnosing high-grade serous ovarian cancer (HG-SOC) and/or determining the prognosis of a subject suffering from high-grade serous ovarian cancer (HG-SOC) by determining the presence or absence of a mutation in a CHEK2 marker or mutations of markers from a 21-gene panel comprising ADAMTSL3, ATR, CHEK2, ENAH, ERN2, GLI2, GYPB, KIAA1324L, LRRN2, MAP3K6, MAPK15, MET, MLL4, NIPBL, PCDH15, PPP1CC, PTCH1, PTK2B, RPS6KA2, RSU1 and TNC. It also relates to the use of markers CHEK2, RPS6KA2 and MLL4 in predicting the risk of developing high-grade ovarian serous ovarian cancer by determining germline mutations in at least one of these three markers.
EP2288700B1 Hbv epitope reactive exogenous t cell receptor (TCR) and uses thereof There is provided at least one isolated cell comprising at least one HBV epitope-reactive exogenous T cell receptor and/or fragment thereof, and methods for producing them. In particular, there is provided polynucleotides, constructs and vectors encoding at least one HBV epitope-reactive exogenous T cell receptor for use in the treatment of Hepatitis B Virus (HBV) and Hepatocellular Carcinoma (HCC). The invention further provides kits and methods of detection of HBV and HCC.
US20170030944A1 Wireless piezoelectric accelerometer and system Wireless piezoelectric accelerometers and systems are provided. A wireless piezoelectric accelerometer may comprise a piezoelectric sensing element configured to sense mechanical acceleration and produce an electrical charge signal in response of the sensed mechanical acceleration, a signal processing module (SPM) configured to convert the electrical charge signal into a voltage signal, and process and digitize the voltage signal, and a wireless module configured to modulate and transmit the digitized voltage signal as wireless signals. The piezoelectric sensing element, the SPM and the wireless module are packaged in a casing. The casing comprises a metallic shielding chamber configured to enclose the piezoelectric sensing element. The casing further comprises a non-metallic portion located in relative to the wireless module to allow transmission of the wireless signals. Corresponding wireless piezoelectric accelerometer systems are also provided.
US20170029871A1 Microfluidic device There is provided a microfluidic device comprising: a plurality of wells, each well comprising one opening to function as an inlet and an outlet for the well, wherein each opening is in fluid communication with a common fluidic channel, and wherein each opening is connected to the common fluidic channel via an isolation channel, and wherein the plurality of wells is arranged on the device in a radially symmetrical pattern. There is also provided a system and method comprising the device.
US9557957 System and method for developing a model indicative of a subject's emotional state when listening to musical pieces A method for deriving optimal discriminating features indicative of a subject state when the subject listens to one of a set of musical pieces, comprising a step of extracting frequency features from the subject's EEG signal when the subject is in a first subject state and a second subject state, the frequency features being extracted from more than one frequency band in one set of time segments; and identifying optimal discriminating features from the extracted frequency features, the optimal discriminating features indicative of characteristics of the EEG signal when the subject is in the first subject state and the second subject state, wherein one of the first subject state and the second subject state indicates that the subject likes a musical piece while the other state indicates that the subject does not like the musical piece.
SG11201610966WA A method for low temperature bonding of wafers A method for bonding wafers is provided. The method comprises the steps of providing a first wafer having an exposed first layer, the first layer comprising a first metal; and providing a second wafer having an exposed second layer, the second layer comprising a second metal, the first metal and the second metal capable of forming a eutectic mixture having a eutectic melting temperature. The method further comprises the steps of contacting the first layer with the second layer; and applying a predetermined pressure at a predetermined temperature to form a solid-state diffusion bond between the first layer and the second layer, wherein the predetermined temperature is below the eutectic melting temperature.
SG11201610433PA A copolymer and a micellar particle comprising the copolymer There is provided a copolymer comprising a hydrophilic polymer, a hydrophobic polymer and a thermoresponsive polymer. There is also provided a micellar particle comprising the copolymer, and uses thereof. There is also provided a method of protecting a cargo at a temperature that typically cases thermal degradation of said cargo.
SG11201610165SA Electrocatalyst for hydrogen production The present invention relates to an electrocatalyst comprising amorphous Ru nanoparticles, including its use in a method and system for hydrogen production.
US9545420 Method of promoting wound healing Disclosed is a method of promoting wound healing or wound closure. The method comprises administration of a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide. Also disclosed are method of treating chronic cutaneous wounds, method of identifying a non-healing wound, use and a pharmaceutical composition comprising a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide.
EP2522352B1 Methods for stem cells modulation The present invention relates to a method of modulating pluripotency and/or self-renewing characteristics of a stem/progenitor cell. The method comprises administering to the respective cell a compound of the general formula (I) In the general formula A is C or N. R1, R4 and R5 are, independently selected, H or aliphatic, cycloaliphatic, aromatic, arylaliphatic, or arylcycloaliphatic hydrocarbyl groups, that comprise 0 - 3 heteroatoms being N, O, S, or Si. R4 and R5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge. R2 is H or a halogen, such as F or Cl. R3 is H, or an aliphatic or arylaliphatic hydrocarbyl group comprising 1 - 8 main chain carbon atoms and 0 - 3 heteroatoms being N, O, S, Si, or a halogen such as Cl or F. Also provided is a method for modulating gene expression in a cell that expresses the components of a polycomb repressive complex.
US9539222 Methods to inhibit intracellular growth of bacteria and to treat bacteria-mediated diseases Disclosed is a method of preventing, treating or inhibiting bacterial infections. The method comprises administering at least one of the compounds disclosed herein. Also disclosed are methods of increasing acidity of bacterial phagosomes to inhibit bacterial growth, methods of increasing mitochondrial reactive oxygen species (mROS) generation to inhibit bacterial growth in a cell, pharmaceutical compositions and uses thereof.
US9538934 Brain-computer interface system and method A method of training a classification algorithm for a Brain Computer Interface (BCI). The method includes the steps of: dividing a Electroencephalography (EEG) signal into a plurality of time segments; for each time segment, dividing a corresponding EEG signal portion into a plurality of frequency bands; for each frequency band, computing a spatial filtering projection matrix based on a Common Spatial Pattern (CSP) algorithm and a corresponding feature, and computing mutual information of each corresponding feature with respect to one or more motor imagery classes; for each time segment, summing the mutual information of all the corresponding features with respect to the respective classes; and selecting the corresponding features of the time segment with a maximum sum of mutual information for one class for training classifiers of the classification algorithm.
US20170002331A1 Cytotoxic antibody An antibody that binds a glycosylated protein is disclosed, wherein the glycosylation comprises the glycan motif Fucα1-2Galβ1-3GlcNAc1-3Galβ1 or Fucα1-2Galβ1-3GlcNAc. Antibodies that are cytotoxic against undifferentiated pluripotent cells are also disclosed.
US20170002041A1 Novel ultrashort hydrophobic peptides that self-assemble into nanofibrous hydrogels and their uses The present invention relates to hydrophobic peptides and/or peptidomimetics capable of forming a (nanofibrous) hydrogel and hydrogels comprising said hydrophobic peptides and/or peptidomimetics and to various uses, such as in regenerative medicine, injectable therapies, delivery of bioactive moieties, wound healing, 2D and 3D synthetic cell culture substrate, biosensor development, biofunctionalized surfaces, and biofabrication.
US9533023 EIF4E binding peptides The present invention relates to modified eIF4G1 peptides, uses thereof and pharmaceutical compositions comprising the modified eIF4G1 peptides.
US9537978 Compression devices, decompression devices, compression methods, and decompression methods The present invention is directed to a compression device including an identifier determination circuit configured to determine a first identifier value identifying a first communication terminal of a network, and a second identifier value identifying a second communication terminal of the network; a differential determination circuit configured to determine a differential value based on a difference between the first identifier value and the second identifier value; and a compressed string generation circuit configured to insert the differential value into a compressed string. A compression method, a decompression device and a decompression method are also disclosed.
SG11201609433VA A method for bonding a chip to a wafer A method for chip on wafer bonding is provided. The method includes the formation of a plurality of posts on at least one of a chip and a wafer, and a like plurality of contacts on the other of the chip and the wafer. After formation, a contact surface of each post is planarized, the respective planarized contact surface having a surface roughness height. A bonding material is then applied to at least one of the chip in a thickness no greater than the surface roughness height of the contact surface. The posts are then temporarily bonded to the contacts using the bonding material to stabilize a position of the chip relative to the wafer for permanent diffusion bonding of the chip to the wafer.
SG11201609879SA Novel promoters for high level expression The present invention provides for functional chimeric gene regulatory units capable of driving strong and sustained heterologous gene expression.
SG11201609432PA A single pole double throw amplifier A single-pole-double-throw (SPDT) amplifier having two inputs and one output is provided. The SPDT amplifier includes two distributed switchable base lines, each coupled to the two inputs. The SPDT further includes a two stage distributed amplifier connected between the distributed switchable base lines, coupled to the output.
SG11201609485RA Detection of acrylic acid There is provided a method for detecting the presence or absence of acrylic acid or its derivatives thereof in a sample, the method comprising the steps of: (a) introducing a probe comprising a diaryltetrazole compound to the sample; (b) exposing said sample to light; and (c) detecting the presence or absence of acrylic acid or its derivatives thereof in the sample based on fluorescence emitted by the sample after step (c).
US20160376558A1 Method for inducing pluripotency in a hematopoietic cell There is provided a method of inducing pluripotency in a hematopoietic cell. The method comprises providing a blood sample that has been collected from a subject in the absence of any polysaccharide preparation used for separating blood components. The sample is depleted of red blood cells by treating the sample with a hypotonic erythrocyte lysis buffer, in the absence of any polysaccharide preparation used for separating blood components, thus obtaining a remaining cell population. The remaining cell population in the sample is expanded in a hematopoietic expansion medium to obtain an expanded cell population that contains CD71+ cells, and the expanded cell population containing the CD71+ cells is then cultured in the presence of Oct4, Sox2, and Klf4, and optionally c-MYC, in human embryonic stem cell medium to induce pluripotency.
CN103056363B Powder feed nozzle, assembly and method for manufacturing a laser-assisted additives The invention provides an inner nozzle portion used for a powder feeding nozzle. The inner nozzle portion can be coaxially disposed in an outer nozzle portion of the powder feeding nozzle. The inner nozzle portion comprises an upper portion having a plurality of determined shapes disposed on a surface of the upper portion, the determined shapes being configured to operate power flows flowing through the surface of the upper portion; and a lower portion having a substantially flat cone-shaped surface so as to form a channel between the substantially flat cone-shaped surface and an inner surface of the outer nozzle portion when the inner nozzle portion is connected to the outer nozzle portion. The inner nozzle portion is communicated with the inlet of the power feeding nozzle so as to receive the power flows for flowing through the surface of the upper portion and passing through the channel and flowing to a power discharging port of the channel. The invention also provides the powder feeding nozzle of the inner nozzle portion coaxially disposed in the outer nozzle portion, and components and methods of the powder feeding nozzle for manufacturing laser assisted additive.
US9517252 P53 activating peptides The present invention is directed to p53 activating peptides. The present further describes methods for generating these peptides and the use of these peptides.
EP2483395B1 A nuclear receptor and mutant thereof and the use of the same in the reprogramming of cells According to the invention there is provided methods for inducing pluripotent stem cells in vitro, comprising introducing a gene or polypeptide of a nuclear receptor and one or more gene or polypeptide selected from the group consisting of Sox, Kr?ppel-like factor or the myc family, to cells in vitro. The present invention also provides vectors and compositions for producing the same and methods for using the induced pluripotent stem cell for treating a patient in need of a pluripotent stem cell treatment.
US9516604 Method of transmitting data between a plurality of base stations and a plurality of mobile stations A method of transmitting data between a plurality of base stations and a plurality of mobile stations is provided. The method includes ranking data links between the plurality of base stations and the plurality of mobile stations according to a quality criterion, and selecting a subset of data links for transmitting the data between the plurality of base stations and the plurality of mobile stations such that a predetermined requirement is satisfied. Selecting the subset of data links may include iteratively assigning a predetermined value to power of the data link having the lowest ranking and determining if the predetermined requirement is satisfied, until the predetermined requirement is no longer satisfied. The remaining data links may then be selected for transmitting the data between the plurality of base stations and the plurality of mobile stations.
SG11201608601TA Method and system for generating / decrypting ciphertext, and method and system for searching ciphertexts in a database There is provided a method of generating a ciphertext. The method includes encrypting an input data to produce an encrypted data, and randomizing the encrypted data to produce the ciphertext. In particular, the randomizing process includes performing an exclusive-or (xor) operation on the encrypted data with a cipher pad, whereby the cipher pad is generated based on an xor-homomorphic function of a first key using a second key generated based on the encrypted data. There is also provided a corresponding system for generating a ciphertext, a corresponding method and system for decrypting a ciphertext, and a corresponding method and system for searching ciphertexts in a database, such as at an untrusted server.
US9505612 Method for thin film encapsulation (TFE) of a microelectromechanical system (MEMS) device and the MEMS device encapsulated thereof A method for thin film encapsulation (TFE) of a microelectromechanical system (MEMS) device, including providing a substrate; forming a MEMS device on the substrate; forming one or more etching channels adjacent to the MEMS device; providing one or more cavities below the MEMS device; and forming one or more cavities above the MEMS device.
US9510121 Transducer and method of controlling the same According to embodiments of the present invention, a transducer is provided. The transducer includes a substrate, and a diaphragm suspended from the substrate, wherein the diaphragm is displaceable in response to an acoustic signal impinging on the diaphragm, wherein the transducer is configured, in a first mode of operation, to determine a direction of the acoustic signal based on a first displacement of the diaphragm in the first mode of operation, and to decide to accept or reject the acoustic signal based on at least one predetermined parameter and the determined direction of the acoustic signal, and in a second mode of operation, to sense the acoustic signal based on a second displacement of the diaphragm in the second mode of operation if the acoustic signal is accepted in the first mode of operation.
US9506823 Bonding stress testing arrangement and method of determining stress A bonding stress testing arrangement and a method of determining stress are provided. The bonding stress testing arrangement includes at least one bond pad; a sensor assembly comprising any one of a first sensor arrangement, a second sensor arrangement and a combination of the first sensor arrangement and the second sensor arrangement; wherein the first sensor arrangement is adapted to measure an average stress on a portion of a bonding area under the at least one bond pad, and the second sensor arrangement is adapted to determine stress distribution over a portion or an entire of the bonding area under the at least one bond pad.
US9506110 Processing of amplified DNA fragments for sequencing A processing method to trim ends of DNA fragments, exposing the internal DNA part to give original DNA sequence information enabling application of next generation sequencing for DNA samples to be amplified by DOP-PCR or other primer dependent amplification methods. Specifically, nucleic acids are amplified using primers comprising a recognition site for a restriction enzyme, for example Bpml or Mmel. Primer sequences are removed by cleavage with the restriction enzyme.
US9493424 Antifungal compound There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.
US9494562 Method and apparatus for defect detection in composite structures Methods and apparatus for non-destructive testing of a composite structure utilizing sonic or ultrasonic waves. In response to a wideband chirp wave sonic excitation signal transmitted from a probe to the composite structure, a probe signal received is correlated with a library of predetermined probe signals and a graphical representation of defects detected is generated. The graphical representation provides detailed information on defect type, defect location and defect shape. Also contemplated is a probe for non-destructive testing of a composite structure comprising three or more transducers wherein each transducer is separately configurable as a transmitter or as a receiver; and a controller coupled to each of transducer for providing signals thereto and receiving signals therefrom, wherein the signals provided thereto include signals for configuring each transducer as either a transmitter or a receiver, and signals for providing an excitation signal from each transducer which is configured as a transmitter.
US9493348 Nanoparticulate encapsulation barrier stack A barrier stack for encapsulating a moisture and/or oxygen sensitive electronic device is provided. The barrier stack comprises a multilayer film having at least one barrier layer having low moisture and/or oxygen permeability, and at least one sealing layer arranged to be in contact with a surface of the barrier layer, wherein the sealing material comprises reactive nanoparticles capable of interacting with moisture and/or oxygen, thereby retarding the permeation of moisture and/or oxygen through defects present in the barrier layer.
US20160330788A1 Mobile radio communication devices and methods for controlling a mobile radio communication device According to various embodiments, a mobile radio communication device may be provided. The mobile radio communication device may include: a receiver configured to receive data; an access point identification circuit configured to determine whether the received data is received from or sent to an access point corresponding to the mobile radio communication device; and a response indication deferral setting circuit configured to set a response indication deferral parameter based on the determination of the access point identification circuit.
EP2688912B1 Recombinant protein biosensors and a method for detecting the presence of an analyte molecule The present invention refers to a fusion protein and a method for detecting a presence or amount of an analyte molecule using the fusion protein. A kit for detecting a presence of an analyte molecule or an amount of analyte is also disclosed.
CN103141067B Band recognition method, apparatus According to embodiments of the present invention, a method for identifying one or more frequency bands in a received signal. The method comprising: calculating a wavelet product of the received signal; setting a threshold for local maxima of the wavelet product; and detecting one or more edges in the received signal based on local maxima of the wavelet product which are greater than the threshold to identify one or more frequency bands in the received signal. A corresponding apparatus and computer program product are also provided. Embodiments also relate to a method for evaluating performance of a method for identifying one or more frequency bands in a received signal. A corresponding apparatus and computer program product are also provided.
EP2545164B1 Use of markers of undifferentiated pluripotent stem cells The disclosure relates to methods of binding and identifying undifferentiated pluripotent stem cells and particularly, although not exclusively, to use of binding moieties which bind to PHB on the surface of undifferentiated pluripotent stem cells, such as PHB-binding peptides, and to methods for depleting undifferentiated stem cells from a sample.
US9487724 Lubricants for magnetic recording media The invention relates to lubricants for magnetic recording media, and in particular, to such lubricants containing cyclotriphosphazene. Methods for preparing the lubricants are also disclosed.
US9489950 Method and system for dual scoring for text-dependent speaker verification Embodiments of systems and methods for speaker verification are provided. In various embodiments, a method includes receiving an utterance from a speaker and determining a text-independent speaker verification score and a text-dependent speaker verification score in response to the utterance. Various embodiments include a system for speaker verification, the system comprising an audio receiving device for receiving an utterance from a speaker and converting the utterance to an utterance signal, and a processor coupled to the audio receiving device for determining speaker verification in response to the utterance signal, wherein the processor determines speaker verification in response to a UBM-independent speaker-normalized score.
US9485714 Addressing multiple communication terminals in a wireless communication network The present invention is directed to a communication device of a wireless communication network, the communication device including a message generator configured to generate a beacon message having a traffic indication map (TIM) information element (IE), wherein the TIM IE includes a partial virtual bitmap field including at least one cluster; a determiner configured to determine for at least one cluster information indicating whether data is available in the communication device to be transmitted to a plurality of communication terminals of the wireless communication network; an encoder configured to determine an encoding mode for the information depending on the information and to encode the information based on the encoding mode; and a transmitter configured to broadcast the beacon message to the plurality of communication terminals corresponding to the at least one cluster. Methods of simultaneously addressing a plurality of communication terminals in the wireless communication network are also disclosed.
SG11201607421SA Method for predicting toxicity of a compound based on nuclear factor-κb translocation There is provided a method of screening for toxicity of a compound. The method comprises contacting a test compound with a test population of cells in which nuclear factor (NF)-κB has not been activated prior to the contacting; determining nuclear localization levels of NF-κB in the test population subsequent to the contacting; and comparing nuclear localization levels of NF-κB of a control population that has not been contacted with the test compound. An increase in nuclear localization levels of NF-κB of the test population relative to the control population is indicative that the test compound injures the cells and/or induces a pro-inflammatory response and thus is toxic to the cell type used in the method.
SG11201607377WA Filter devices and filtering methods According to various embodiments, a filter device may be provided. The filter device may include: an anode; and a cathode provided at least substantially in parallel to the anode. At least one of the anode or the cathode may include (or may be or may be included in) a sieve.
SG11201607438SA Zeolites with mww framework formed of silicon and zinc or iron, and related methods A Zn-Si or Fe-Si zeolite having an MWW framework may be formed by treating a gel solution with a hydrothermal treatment. The gel solution includes water, a silicon source, a zinc or iron source, and an MWW-templating agent. The hydrothermal treatment may include dissolving the source materials in the gel solution, and heating the gel solution with the dissolved sources to induce hydrothermal crystallization in the gel solution. The zeolite can be substantially free of aluminum, and can be used in a catalyst, or in a separation or purification device.
US20160313316A1 Surface acoustic wave sensor for influenza detection An influenza detector for detecting a targeted influenza virus and a surface acoustic wave (SAW) sensor for Influenza A virus detection in liquid are provided. The influenza detector includes a liquid environment, the surface acoustic wave (SAW) sensor and an influenza specific binding agent such as an antibody. The agent is immobilized on a surface of the SAW sensor for selectively capturing an analyte for the targeted influenza virus. The SAW sensor is in contact with the liquid environment and includes a substrate comprising a piezo-electric material for producing a surface acoustic wave signal in response to an applied electric field and an insulative layer formed on top of the substrate and having a functionalized surface formed thereon for selectively immobilizing the influenza specific binding agent, the functionalized surface being in contact with the liquid environment. The surface acoustic wave signal produced by the SAW sensor changes in response to the analyte for the targeted influenza virus being present in the liquid environment and being captured by the influenza specific binding agent immobilized on the functionalized surface of the insulative layer of the SAW sensor.
US20160310010A1 Method of imaging living tissue A method of imaging living tissue is provided. The method includes introducing a photoacoustic contrast agent comprising or consisting of a photosensitizer into living tissue; and obtaining an image of the living tissue by photoacoustic imaging. Use of a photoacoustic contrast agent comprising or consisting of a photosensitizer in photoacoustic imaging is also provided.
EP2516995B1 SERS-based analyte detection The present invention relates to method detecting analytes by surface enhanced Raman spectroscopy (SERS), comprising contacting the analytes with at least one analyte binding molecule attached to a metal substrate surface that enhances Raman scattering via a Raman-active molecular linker; and detecting a surface enhanced Raman signal from said compound. In a further aspect, this invention relates to a conjugate and a biosensor suitable for the invented SERS-based analyte detection method.
US9466007 Method and device for image processing Embodiments provide a method for processing an input image having a plurality of pixels, wherein each pixel has a pixel position. The method may include determining, for each pixel position, a vector based on the input image; and determining, for each pixel position, a detail value for the pixel position based on the determined vectors at a plurality of neighboring pixel positions within a predetermined neighboring block of the pixel position.
US20160289462A1 Polymers for Making Superhydrophobic Surfaces The present disclosure relates to a process for making a comb-like polymer comprising the following steps of reacting an epoxy-functionalized monomer with a nucleophile comprising a C8-C20-alkyl group or halogen substituted C8-C20-alkyl group in the presence of an aqueous medium and polymerizing the reaction product. The comb-like polymer has functional groups on its backbone and long hydrophobic side chains. It can even be produced as a shell on a submicron sphere according to an alternative process according to the invention. The polymers obtainable by the inventive process can be polymerized with polyurethane prepolymers to achieve coating surfaces that show superhydrophobicity (see FIG.). Such coatings can have numerous applications especially in the aircraft industry for paints used on the airplane wings, because they avoid water droplet building.
SG11201607150TA Testing apparatuses, hierarchical priority encoders, methods for controlling a testing apparatus, and methods for controlling a hierarchical priority encoder According to various embodiments, a testing apparatus may be provided. The testing apparatus may include: a cell pair comprising two l-bit memory cells configured to represent a stored pattern of l-bit; and a converter configured to convert a query pattern of l-bit into a pair of voltages defined such that when applied to gates of the cell pair, the voltages make the cell pair into high resistance mode when the query pattern matches the stored pattern and into low resistance mode when the query pattern does not match the stored pattern.
SG11201607018QA Buck-boost power amplifier with independently controlled power stages and compensated nonlinear pulse width modulator A buck-boost power amplifier receiving a supply voltage and providing an output having a voltage swing higher than the supply voltage is provided. The buck-boost power amplifier comprises a buck power stage, a boost power stage, an inductor, and a non-linear pulse width modulator. The buck power stage and the boost power stage are independently controlled by the non-linear pulse width modulator. The non-linear pulse width modulator switches the buck-boost power amplifier between a buck mode wherein the output provides a voltage lower than the supply voltage and a boost mode wherein the output provides a voltage higher than the supply voltage.
SG11201605730RA Method for forming low emissivity doped zinc oxide films on a substrate The invention relates to a method for forming low emissivity doped zinc oxide films on a substrate, and in particular, to a method for forming low emissivity gallium doped zinc oxide films on a substrate via a low temperature chemical bath deposition technique.
CN103236395B The method of forming a nanostructure on a substrate and the use thereof PROBLEM TO BE SOLVED: To provide a method for manufacturing a silicon substrate which exhibits reduced reflectivity.SOLUTION: The disclosure is directed to a method for forming nanostructures on a substrate including silicon comprising the steps of: (a) depositing a layer of transition metal on the surface of the substrate; (b) annealing the layer of the transition metal to form a patterned transition metal layer; and (c) etching the substrate to form the nanostructures on the substrate surface.
EP2437939B1 Multilayer barrier film The present invention refers to a multilayer barrier film comprising a substrate layer coated with a barrier layer, wherein the barrier layer is made of a material selected from the group consisting of a metal oxide, a metal carbide, a metal nitride and a metal oxynitride; a nanostructured metal compound layer arranged on the barrier layer; and a planarising layer arranged on the nanostructured layer, wherein the planarising layer comprises a nanostructured material which is distributed in a polymeric binder, wherein the nanostructured material is made of carbon, or a metal or a metal oxide or a mixture of the aforementioned substances. The present invention also refers to a method of obtaining those multilayer barrier films.
EP2374816B1 Binding molecules against Chikungunya virus and uses thereof The invention relates to binding molecules against Chikungunya virus, which are able of neutralizing Chikungunya virus infectivity, and which can be used with therapeutic, diagnosis or research purposes, as well as to a pharmaceutical composition comprising said binding molecules.
US9454428 Error correction method and module for non-volatile memory There is provided an error correction method for a non-volatile memory. The method includes receiving a codeword read from the non-volatile memory, computing a reliability information for each bit of the codeword received, and performing a reduced-complexity soft-decision decoding (SDD) technique to decode the received codeword. In particular, the SDD technique includes forming a set of test patterns based on the reliability data, and determining whether to perform a HDD of a test pattern in the set of test patterns based on a distance between the test pattern and a candidate pattern. There is also provided an error correction module for a non-volatile memory and a memory system incorporating the error correction module.
US20160271178A1 Nanoparticle-containing hydrogels There is provided a nanoparticle-containing hydrogel comprising metal nanoparticles and at least one peptide. The nanoparticle-containing hydrogel may possess antibacterial activity. There is also provided a method for preparing the nanoparticle-containing hydrogel, and compositions and uses thereof.
CN105960466A Non-motorized optical multiplexing for simultaneous detection of DNA target amplicons in polymerase chain reaction solution A multiplexed polymerase chain reaction (PCR) DNA detection system and a method for DNA detection within the PCR system are provided. The PCR DNA detection system includes a color charge-coupled device (CCD) camera, fluorophore-quencher probes and an imaging chamber. The fluorophore-quencher probes are selected in response to fluorophores quenched by the fluorophore-quencher probes corresponding to three selected primary colors and peak channel responses of the CCD camera such that emission profiles of the fluorophores substantially match the three selected primary colors and peak emission profiles of the fluorophores correspond to the peak RGB channel responses of the CCD camera. A DNA sample and the fluorophore-quencher probes are located within the imaging chamber. The color CCD camera is focused on the imaging chamber for simultaneous detection of up to three targets from fluorescence of the DNA sample and the fluorophore-quencher probes.
US9450175 Method for preparing a lead-free piezoelectric thin film The present invention discloses a method of preparing a lead-free piezoelectric thin film comprising the steps of: providing a precursor solution comprising at least one alkali metal ion, a polyamino carboxylic acid, and an amine; depositing the precursor solution on a substrate to form a film; and annealing the film. The present invention also provides a lead-free piezoelectric thin film prepared according to the method, a precursor solution for use in the method and a method of preparing the precursor solution.
US9447407 Double coating procedure for the membranes of bioartificial kidneys The present invention generally relates to modified substrates such as membranes for use in bioartificial organs, such as bioartificial kidneys, and other applications. Certain aspects are generally directed to a membrane or other substrate modified to facilitate the attachment of cells. In one set of embodiments, the substrate or membrane may be at least partially coated with an adhesive such as 3,4-dihydroxy-L-phenylalanine (DOPA), poly(dopamine), or other adhesive comprising a molecule having a catechol moiety, for example on one side of the membrane or substrate. On at least a portion of the adhesive coated portion of the substrate, a protein may be coated, such as an extracellular matrix protein (for example, a collagen), to which cells such as primary human renal proximal tubule cells may be adhered. Surprisingly, such a dual coating may be used to promote the attachment of such cells to a membrane or other substrate that otherwise may not promote cell adhesion. In certain embodiments, the coating may also facilitate or promote not only cell adhesion, but also cell proliferation and/or differentiation. Such membranes or other substrates may be useful, for example, in bioartificial organs such as bioartificial kidneys, hemodialysis cartridges, bioimplants, biosensors, bioreactors, etc. In certain embodiments, cells may be attached to a membrane or other substrate on only one side, while the other side may be kept free of attached cells.
US9439886 Methods for producing crosslinked flavonoid hydrogels There is provided methods for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid including a method for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid. There is also provided a method for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid without the addition of an exogenous peroxide or peroxidase or without the addition of an exogenous peroxide. Hydrogels produced by such methods and methods of using the hydrogels are also described herein.
US9441032 Binding molecules against Chikungunya virus and uses thereof The invention relates to binding molecules against Chikungunya virus, which are able of neutralizing Chikungunya virus infectivity, and which can be used with therapeutic, diagnosis or research purposes, as well as to a pharmaceutical composition comprising said binding molecules.
EP2271747B1 Microcarriers for pluripotent stem cell culture We disclose a particle comprising a matrix coated thereon and having a positive charge, the particle being of a size to allow aggregation of primate or human stem cells attached thereto. The particle may comprise a substantially elongate, cylindrical or rod shaped particle having a longest dimension of between 50μm and 400μm, such as about 200μm. It may have a cross sectional dimension of between 20μm and 30μm. The particle may comprise a substantially compact or spherical shaped particle having a size of between about 20μm and about 120μm, for example about 65 μm. We also disclose a method of propagating primate or human stem cells, the method comprising: providing first and second primate or human stem cells attached to first and second respective particles, allowing the first primate or human stem cell to contact the second primate or human stem cell to form an aggregate of cells and culturing the aggregate to propagate the primate or human stem cells for at least one passage. A method of propagating human embryonic stem cells (hESCs) in long term suspension culture using microcarriers coated in Matrigel or hyaluronic acid is also disclosed. We also disclose a method for differentiating stem cells.
SG11201606318TA Method of maintaining data consistency A method of maintaining data consistency in a tree, the method including the steps of: storing leaf nodes in non-volatile memory, the leaf nodes comprising actual data; storing internal nodes in a memory space where data consistency is not required; and running a CPU instruction to maintain data consistency only during modification of the leaf nodes.
US9431315 Chemical sensor package for highly pressured environment A package for a chemical sensor including an encapsulation and a pressure balancing structure is disclosed. The encapsulation encapsulates a chemical sensor and has a hole for exposing a chemical sensitive part of the chemical sensor. The pressure balancing structure balances pressure applied to the chemical sensor at the chemical sensitive part.
US9427908 Modification of surface wetting properties of a substrate A method of modifying the wetting properties of the surface of a substrate, the method comprising the step of applying a first mold having an imprint forming surface to said substrate to form a first imprint thereon, said imprint forming surface being chosen to modify the wetting properties of the substrate surface.
US20160243550A1 Microfluidic device There is provided a microfluidic device comprising: a plurality of wells, each well having an inlet and an outlet, wherein the inlets are in fluid communication with one or more entry channels and the outlets are in fluid communication with one or more exit channels, wherein said outlet is connected to the exit channel via an outlet connecting channel and said inlet is connected to the entry channel via an inlet connecting channel wherein the dimension of the outlet connecting channel is configured such that the surface tension of a liquid comprised in the well prevents the release of the liquid through the outlet connecting channel. There is also provided a system, method and use of the device.
CN102753191B By antibody therapy or vaccination associated with the treatment and prevention of cancer intracellular oncoprotein We provide for the use of an intracellular antibody therapy for targeting intracellular oncoproteins or proteins to prevent cancer metastasis. We also provide for the use of an intracellular vaccine therapy comprising an oncoprotein protein for vaccination to stimulate a host to produce its own antibodies to prevent tumor formation. The antibody may comprise a chimeric antibody.
US9423295 Photo-sensor with a transparent substrate and an in-plane electrode pair According to one aspect of the invention, there is provided a photo-sensor comprising: an optically transparent substrate; an electrode pair; and a photoactive film with electrical polarization located between the optically transparent substrate and the electrode pair, wherein the optically transparent substrate is configured to transmit incident radiation received by the optically transparent substrate to the photoactive film and wherein the electrode pair is configured to receive charge carriers generated by the photoactive film in response to the transmitted incident radiation.
US9422525 Nuclear receptor and mutant thereof and the use of the same in the reprogramming of cells According to the invention there is provided methods for inducing pluripotent stem cells in vitro, comprising introducing a gene or polypeptide of a nuclear receptor and one or more gene or polypeptide selected from the group consisting of Sox, Krüppel-like factor or the myc family, to cells in vitro. The present invention also provides vectors and compositions for producing the same and methods for using the induced pluripotent stem cell for treating a patient in need of a pluripotent stem cell treatment.
US9419412 Integrated laser and method of fabrication thereof There is provided an integrated laser. The integrated laser includes a semiconductor waveguide having a first section, a second section and a third section. The integrated laser further includes an active region formed on the third section of the semiconductor waveguide, the active region configured for generating light, and a coupler formed on the second section of the semiconductor waveguide, the coupler configured for coupling said light between the semiconductor waveguide and the active region. In particular, the first section comprises a multi-branch splitter having a ring structure formed between two branches of the multi-branch splitter for emission wavelength control of the integrated laser. Preferably, the multi-branch splitter is a Y-branch splitter and the ring structure is formed in a space between two branches of the Y-branch splitter. There is also provided a method of fabrication thereof, an integrated tunable laser and an integrated tunable laser system.
CN103314572B A method and apparatus for image processing Embodiments provide a method for processing a first image based on a second image, wherein each pixel in the first image has a plurality of color components and has a corresponding pixel in the second image, and wherein each value of a color component in the first image corresponds to a value of a color component in the second image. The method may include deciding, for each color component of a pixel in the first image, whether to modify the value of the color component dependent on a predetermined criterion. The method may further include determining a similarity index between the pixel in the first image and the corresponding pixel in the second image based on, for each color component of the pixel, the value of the color component of the pixel, or if it is decided that the value of the color component of the pixel is to be modified, the corresponding value of the color component in the second image.
SG11201604591YA Chemical process to convert mucic acid to adipic acid The present invention provides a method of synthesizing an ester of a saturated carboxylic acid from a saturated polyhydroxycarboxylic acid by performing a deoxydehydration reaction and a hydrogen transfer reaction.
EP2506864B1 Treatment and prevention of cancers associated with intracellular oncoproteins by antibody therapy or vaccination We provide for the use of an intracellular antibody therapy for targeting intracellular oncoproteins or proteins to prevent cancer metastasis. We also provide for the use of an intracellular vaccine therapy comprising an oncoprotein protein for vaccination to stimulate a host to produce its own antibodies to prevent tumor formation. The antibody may comprise a chimeric antibody.
EP2753345B1 Polypeptide vaccine We provide a polypeptide vaccine for treatment and prevention of cancer, particularly prevention of metastasis of cancer. Also provided are methods of treating or preventing cancer, and pharmaceutical compositions comprising the polypeptide vaccine. Wherein the polypeptide vaccine comprises a polypeptide fragment of an intracellular oncoprotein.
CN104619388B Selective binding of biological targets to solid phase ureide A method of selectively separating a biological target from a sample including the biological target material or suspected of including the biological target includes the steps of (i) providing a solid including ureide moieties at its surface, (ii) contacting the sample with the solid, whereby a substantial fraction of the biological target in the sample binds to the ureide moieties, and (iii) separating the solid from the sample.
CN102958871B The method of dehydrating a mixture of alcohols ene The invention relates to a method of producing alkenes by dehydration of a mixture of alcohols using a metal-modified zeolite, wherein the method comprises providing two or more alcohols; contacting the mixture with a catalyst, wherein the catalyst is a metal-modified zeolite; and reacting the mixture in a temperature range of about 350 to about 500 °C, thereby producing the alkenes.
US9374090 Circuit arrangement and method of operating the same A circuit arrangement may be provided including a level shifting stage configured to be coupled to a first reference voltage and a second reference voltage. The circuit arrangement may also include a first input electrode in electrical connection with the level shifting stage for coupling a first input voltage and a second input electrode in electrical connection with the level shifting stage for coupling a second input voltage. The level shifting stage may be configured to generate an output voltage above a predetermined output level at the output node due to the first reference voltage when the first input voltage is in the first logic state and the second input voltage is in the second logic state. The circuit arrangement may also include a feedback circuit coupled to the output stage and the level shifting stage and a voltage stabilization circuit coupled to the level shifting stage.
US9364804 Microfluidic agitator devices and methods for agitation of a fluid According to various embodiments, a microfluidic agitator device may be provided. The microfluidic agitator device may include: an air inlet; an air outlet; an elastic diaphragm provided between the air inlet and the air outlet and configured to oscillate if an airflow from the air inlet to the air outlet is provided; and a chamber coupled to the elastic diaphragm.
US9362916 Circuit arrangements and methods of operating the same In various embodiments, a circuit arrangement may be provided. The circuit arrangement may include a level shifting stage configured to be coupled to a first reference voltage, the level shifting stage having an output node. The circuit arrangement may further include a first input electrode in electrical connection with the level shifting stage. The circuit arrangement may also include a second input electrode in electrical connection with the level shifting stage. The circuit arrangement may further include a load having a first end and a second end, the first end coupled to the level shifting stage and the second end for coupling to a second reference voltage. In addition, the circuit arrangement may include a bypass circuit element connected in parallel to the load. The bypass circuit element may be configured to allow current to flow through upon application of an external voltage for bypassing the load.
US9362126 Process for making a patterned metal oxide structure There is provided a process for making a patterned metal oxide structure comprising the step of heating an imprint structure comprising a polymerized organometallic compound to remove organic material and thereby form the patterned metal oxide structure, wherein the imprint structure is formed by polymerizing a resist mixture comprising at least one olefinic polymerizable compound and a polymerizable organometallic compound having, e.g., at least one carboxylate of Formula 1:_x000D_ _x000D_ _x000D_ wherein
  • n is 1-12; and
  • each R is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloakyl, cycloakenyl, aryl, and aralkyl.
US9354283 Sensor and method of controlling the same According to embodiments of the present invention, a sensor is provided. The sensor includes a substrate, a beam suspended from the substrate, and a plurality of conductive lines arranged on the beam, wherein the beam is adapted to be displaced in response to a current flowing through the plurality of conductive lines, and a magnetic field interacting with the beam, and wherein the sensor is configured to determine a property of the magnetic field based on the displacement of the beam. According to further embodiments of the present invention, a method of controlling a sensor is also provided.
US9352283 Tubular fiber membrane with nanoporous skin A wet spinning process for forming a tubular fiber membrane is provided. The tubular fiber membrane has a nanoporous skin layer and a microporous lumen layer. The skin layer defines an outer surface of the fiber membrane and the lumen layer defines a lumen surface of the fiber membrane. The pores in the skin layer may have an average pore size of less than about 7 nm, and pores in the lumen layer may have an average pore size of from about 0.5 to about 3 μm. The fiber membranes may be used in artificial renal proximal tubules, artificial kidneys, bioreactors, or fiber cartridges.
SG10201508234TA Nano-aperture fabrication using template guided thermal dewetting A method for fabrication of metal film with nanoapertures is provided. The method includes the steps of providing a nanopatterned template including a plurality of nanostructures, depositing of the metal film onto the nanopatterned template, and thermally induced dewetting of the metal film to define the nanoapertures in the metal film by diffusion and reflow of the metal film.
SG10201602518PA A Layered Silicate/Polymer Composite And A Method Of Forming The Same The present invention relates to a method for forming a layered silicate/polymer composite, the composite comprising individual exfoliated silicate layers separated in a continuous polymer matrix, wherein the polymer is a hydrophobic polymer, the method comprising: exfoliating sheet silicate in water to form a silicate suspension; replacing the water in the silicate suspension by an organic solvent to form a silicate/organic solvent suspension; contacting the silicate/organic solvent suspension with a solution of a hydrophobic polymer precursor in an organic solvent to form a silicate/polymer precursor suspension; coating the silicate/polymer precursor suspension on a substrate; removing the organic solvents; curing the hydrophobic polymer precursor of the coating of the silicate/polymer precursor; and annealing the cured coating to form the layered silicate/polymer composite on the substrate.
US20160145580A1 Method of culturing cancer stem cells There is provided a method for culturing a population of cancer stem cells. The method comprises introducing the cancer stem cells on or in a cell culture substrate, the cell culture substrate being in the form of a gel comprising a conjugate of a glycosaminoglycan and a substituted phenalkylamine.
US9348832 Method and device for reassembling a data file Embodiments provide a method for reassembling a data file from a starting file fragment and a plurality of file fragments stored on a digital storage device. The method includes determining, from the plurality of file fragments, one or more matched file fragments which match the starting file fragment based on a first predetermined criterion; associating the one or more matched file fragments with the starting file fragment; and determining one or more candidate data files based on the one or more matched file fragments. The method further includes checking if more than one file fragments have been determined to match the starting file fragment based on the first predetermined criterion. If more than one matched file fragments have been determined to match the starting file fragment based on the first predetermined criterion, the method further includes selecting a candidate data file from the candidate data files determined for the matched file fragments as the reassembled data file based on a second predetermined criterion.
CN103703079B Core - shell Microspheres The specification describes a substance comprising a plurality of microparticles. The microparticles comprise a core comprising a first polymer and a shell surrounding said core and comprising the first polymer and a second polymer, wherein the second polymer is less rapidly degradable than the first polymer. A process for making the microparticles and uses of the microparticles are also described.
US9341568 Refractive index sensor for analyzing an analyte, and method of fabricating thereof A refractive index sensor is provided for analyzing an analyte, the sensor including: a strip waveguide for receiving an input light signal therein and transmitting the light signal, subject to manipulation as it propagates through the strip waveguide, to a detector for analysis with respect to the analyte; and a slot waveguide for sensing the analyte disposed thereon and for receiving a sensing signal, corresponding to said manipulation of the light signal, from the strip waveguide, wherein a grating is formed on a surface of the strip waveguide to enable coupling of the sensing signal from the strip waveguide to the slot waveguide, and the sensor is configured with enhanced sensitivity based on a sensitivity difference between the slot waveguide and the strip waveguide, and/or a group index difference between the slot waveguide and the strip waveguide.
US9343128 Magnetoresistive device A magnetoresistive device having a magnetic junction including a first fixed magnetic layer structure, a second fixed magnetic layer structure, and a free magnetic layer structure, wherein the first, second and third fixed magnetic layer structures are arranged one over the other, have respective magnetization orientations configured to orient in a direction at least substantially perpendicular to a plane, wherein the respective magnetization orientations of the first fixed magnetic layer structure and the second fixed magnetic layer structure are oriented in opposite directions, and wherein the magnetization orientation of the first fixed magnetic layer structure is configured to oscillate in a first direction in response to a current or a voltage applied across the magnetic junction so as to change the magnetization orientation of the free magnetic layer structure.
EP2536851B1 Use of adenosine diphosphate glucose pyrophosphorylase for sequencing a nucleic acid molecule The invention provides for sequencing a nucleic acid molecule based on the detection of base incorporation by the release of pyrophosphate (PPi) using a new enzyme system comprising adenosine diphosphate (ADP)-glucose pyrophosphorylase (AGPase) and its substrate ADP-glucose.
US9334500 Methods and pharmaceutical compositions for treating cancer A method of treating cancer by inhibiting expression of ubiquitin associated and SH3 domain containing B (UBASH3B) gene or by inhibiting the activity of UBASH3B protein or a functional variant thereof.
US9335482 Fiber Bragg grating (FBG) sensor A fiber Bragg grating (FBG) sensor structure, a method of fabricating a FBG sensor structure, and a method of employing a FBG sensor structure comprising an optical fiber portion having at least one FBG formed therein. The FBG sensor structure comprises an optical fiber portion having at least one FBG formed therein; and a sleeve structure capable of transferring vibrations and/or strain along a length thereof; wherein the optical fiber portion is coupled to the sleeve structure such that the central wavelength of the FBG, is variable under the transferred vibrations and/or strain.
US9333257 FGFR1 antibodies and treatment of cancer The use of an FGFR1 antibody in the treatment of cancer is disclosed, wherein the FGFR1 antibody binds FGFR1 at an epitope that is positioned in the FGFR1 primary amino acid sequence no more than 50 contiguous amino acids away from the C- or N-terminal of the FGFR1 heparin binding domain.
US9334324 Podocalyxin-like-protein-1 binding antibody molecule The disclosure relates to novel markers of pluripotent stem cells and uses thereof, and particularly, though not exclusively, to antibody molecules based on fragments of mAb84 which bind to undifferentiated pluripotent stem cells via podocalyxin-like protein-1 (PODXL).
CN105557009A A method of performing an operation of a communication network and a network component A method of performing an operation of a communication network and a network component. One method of performing an operation of a communication network operating in a channel which overlaps, or resides in, a common channel spectrum band comprises the operating network periodically allocating notification periods (NPs) on the common channel spectrum band in a state in which no other network is operating in another channel which overlaps, or resides in, the common channel spectrum band; and the operating network at least transmitting a notification signal in each periodically allocated NP in the common channel spectrum band.
EP2456910B1 Differentiation of isobaric amino acids and other species Techniques for differentiating isobaric species are described. An isobaric species may be substituted with a tagging species identified using mass spectrometry. The isobaric species may be a subunit of a first polymer having a defined sequence, e.g., the isobaric species may be an amino acid in a protein or a peptide sequence. A tagging species may be substituted for the isobaric species in a second polymer having an otherwise identical sequence as the first polymer. The second polymer may have the same number of sequences as the first polymer, and substantially the same sequence of subunits, with a few exceptions such as the tagging species for the isobaric species. The first polymer and the second polymer may be prepared in the same reaction vessel. A polymer/protein of defined subunit sequence containing an isobaric species or a tagging species may be analyzed by mass spectrometry to determine the sequence.
US9331878 Frequency shift keying transmitter According to embodiments of the present invention, a frequency shift keying transmitter is provided. The frequency shift keying transmitter includes a logic gate arrangement that produces an output signal having a frequency that depends on input signals to the logic gate arrangement, a clock generator coupled to the logic gate arrangement, the clock generator adapted to produce a clock signal, and a sampling arrangement coupled to the logic gate arrangement, the sampling arrangement adapted to receive a data signal, wherein the sampling arrangement is configured to sample the clock signal to generate periodic waveforms delayed from each other by an interval determined by the point the clock signal is sampled, wherein the sampling arrangement is configured to be controlled by the data signal to have the logic gate arrangement select periodic waveforms that are delayed from each other by one of a set of intervals associated with the data signal, to be used as the input signals to the logic gate arrangement to produce the output signal.
US9327303 Microfluidic droplet generator A microfluidic droplet generator device, a kit of parts for assembling a microfluidic droplet generator device, and a method of generating microfluidic droplets. The generator device comprises a substrate; a microfluidic channel formed in the substrate; a fluid outlet in fluid communication with the microfluidic channel; and a mechanical element configured such that vibration of the mechanical element causes droplet dispensing from the fluid outlet.
US9329339 Plasmonic detector and method for manufacturing the same A plasmonic detector and method for manufacturing a plasmonic detector. The plasmonic detector comprises two nanoscale metallic rods coupled to a bias voltage; a nanoscale cavity formed between adjacent ends of the two nanoscale metallic rods; and an absorption material disposed in the nanoscale cavity for converting an electromagnetic field to an electric current for outputting via the nanoscale metallic rods.
SG11201601972XA Method and system for determining an optical eye diagram of a modulated optical beam of an interferometer device A method and a system for determining an optical eye diagram of a modulated optical beam of an interferometer device, a method of evaluating system performance of electro-optic devices, and a data storage medium having stored thereon data code means for instructing a computing device to execute the methods. The method of determining an optical eye diagram of a modulated optical beam of an interferometer device comprises obtaining AC parameters for one or more modulator structures of the interferometer device at respective DC bias voltages within a predetermined bias voltage range at an operating frequency of the one or more modulator structures from electrical simulation; obtaining a carrier concentration profile from the electrical simulation; obtaining optical parameters for the one or more modulator structures from optical simulation based on the carrier concentration profile; and determining the optical eye diagram of the modulated optical beam based on the AC parameters and the optical parameters.
SG11201601841UA A Dimerizer Compound There is provided a compound comprising at least two ligands that are individually coupled to a linker, wherein each ligand is independently selected from the group consisting of a substituted benzylguanine derivative, a substituted benzylcytosine derivative, a haloalkyl moiety, a drug, a peptide, a hormone, an inorganic compound and a protein. The compound may be part of an oligomer. The compound may be employed in a method of dimerizing a pair of proteins, which may alter a biological function in a cell. There is also provided a method of forming the compound.
US20160115251A1 Heparan Sulphates A novel class of structurally and functionally related isolated Heparan sulphate is disclosed. The novel class of Heparan sulphates has been found to bind FGF2 and enhance the proliferation of stem cells whilst maintaining their pluripotency/multipotency.
US9321845 Antibodies binding to an intracellular PRL-1 or PRL-3 polypeptide We provide an antibody capable of binding to an intracellular PRL-I or PRL-3 polypeptide, in which the antibody is capable of binding to an epitope bound by antibody 269, antibody 223 or antibody 318. Such anti-PRL antibodies may be capable of binding to intracellular PRL-I or PRL-3. They may be suitable for use as therapies against cancer or metastasis thereof, or in clinical diagnosis to identify PRL-3 or PRL-I positive patients.
US9316654 TAZ/WWTR1 for diagnosis and treatment of cancer We provide an anti-TAZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to breast cancer comprising means for detection of TAZ expression in the individual or a sample taken from him or her as well as a method of detecting a cancer cell, the method comprising detecting modulation of expression, amount or activity of TAZ in the cell.
CN103502459B Anti-gene silencing modified human cmv promoter The invention relates to a nucleic acid molecule comprising a functional promoter of a herpesvirus, a functional enhancer of a herpesvirus, and one or more internal elements of the CpG island of the aprt (adenine phosphoribosyl transferase) gene and/or a functional variant thereof. A method of producing a desired polypeptide using the nucleic acid molecule, a vector and a host cell containing the nucleic acid molecule are also disclosed.
US9309314 Polypeptides, nucleic acids and uses thereof We describe an ELABELA polypeptide comprising a sequence CXXXRCXXXHSRVPFP (SEQ ID NO: 1), in which X signifies an amino acid residue, such as a sequence selected from the group consisting of: SEQ ID NO: 2 to SEQ ID NO: 18, preferably CLQRRCMPLHSRVPFP (SEQ ID NO: 2), or a fragment, homolog, variant or derivative thereof, which polypeptide is capable of maintaining self-renewal and/or pluripotency of a stem cell.
US9308217 Targeting glioma stem cells by sequence-specific functional inhibition of pro-survival oncomir-138 Methods for malignant glioma diagnosis/prognosis using miR-138 as a prognostic biomarker and methods for treating malignant glioma and inhibiting glioma stem cell growth by suppressing miR-138. Also disclosed herein are pharmaceutical compositions for use in treating malignant glioma, prolonging survival of malignant glioma patients, or eliminating GSCs and in turn tumor growth, the pharmaceutical composition comprising an oligonucleotide that targets miR-138.
US9307444 Signaling data compression/decompression devices and methods for wireless communication networks A compression device which may include: a subset determination circuit configured to determine a subset of a traffic indication map, the traffic indication map including a plurality of bits, each bit indicating whether data to be transmitted to a respective pre-determined radio communication terminal is present in an access point; a pre-determined bit value determination circuit configured to determine whether the subset includes a bit of a pre-determined bit value; and a compressed string generation circuit configured to insert, if the subset includes a bit of the pre-determined bit value, into a compressed string the subset and an indicator indicating that the subset includes a bit of the pre-determined bit value, and further configured to include, if the subset does not includes a bit of the pre-determined bit value, into the compressed string an indicator indicating that the subset does not include a bit of the pre-determined bit value.
US9305372 Method and device for image processing Embodiments provide a method for processing a first image based on a second image, wherein each pixel in the first image has a plurality of color components and has a corresponding pixel in the second image, and wherein each value of a color component in the first image corresponds to a value of a color component in the second image. The method may include deciding, for each color component of a pixel in the first image, whether to modify the value of the color component dependent on a predetermined criterion. The method may further include determining a similarity index between the pixel in the first image and the corresponding pixel in the second image based on, for each color component of the pixel, the value of the color component of the pixel, or if it is decided that the value of the color component of the pixel is to be modified, the corresponding value of the color component in the second image.
SG11201601215QA Raid parity stripe reconstruction Data reconstruction in a RAID storage system, by determining if a parity stripe has been reconstructed and if the parity stripe has been allocated, by the checking of a reconstruction/rebuild table and a space allocation table. Before reconstruction of a parity stripe occurs, the non- volatile memory of a failed hybrid drive is checked to determine if it is accessible and if so the data is copied to the new hybrid drive instead of reconstruction occurring.
SG10201404895XA Diagnosis The data provided herewith show that, biomarkers found within the cells of a tumor or cancer may also be present at adequate levels within the patient's urine to enable detection. Method of diagnosis, patient selection and treatment are provided, along with kits and devices.
SG11201601451XA A method of treating a thermal barrier coating There is provided a method for treating a substance having a thermal barrier coating in contact with an alloy substrate comprising the step of irradiating the thermal barrier coating while the alloy substrate is maintained at a substantially constant temperature. There is also provided a system for treating a substance having a thermal barrier coating in contact with an alloy substrate. There is also provided a substance having an alloy substrate in contact with a radiation treated thermal barrier coating.
US9297813 Targeting metabolic enzymes in human cancer Targeting metabolic enzymes in human cancer Abstract Lung cancer is a devastating disease and a major therapeutic burden with poor prognosis. The functional heterogeneity of lung cancer (different tumor formation ability in bulk of tumor) is highly related with clinical chemoresistance and relapse. Here we find that, glycine dehydrogenase (GLDC), one of the metabolic enzyme involved in glycine metabolism, is overexpressed in various subtypes of human lung cancer and possibly several other types of cancers. GLDC was found to be highly expressed in tumor-initiating subpopulation of human lung cancer cells compared with non-tumorigenic subpopulation. By array studies we showed that normal lung cells express low levels of GLDC compared to xenograft and primary tumor. Functional studies showed that RNAi inhibition of GLDC inhibits significantly the clonal growth of tumor-initiating cells in vitro and tumor formation in immunodeficient mice. Overexpression of GLDC in non-tumorigenic subpopulation convert the cells to become tumorigenic. Furthermore, over-expression of GLDC in NIH/3T3 cells and human primary lung fibroblasts can transform these cells, displaying anchorage-independent growth in soft agar and tumor-forming in mice. Not only is GLDC is expressed human lung cancer, it is also up-regulated in other types of cancer, such as colon cancer. RNAi knockdown of GLDC in colon cancer cell line, CACO-2 cells, can also inhibit the tumor formation in mice. Thus GLDC maybe a new metabolic target for treatment of lung cancer, and other cancers.
CN103402907B The microfluidic droplet generator A microfluidic droplet generator device, a kit of parts for assembling a microfluidic droplet generator device, and a method of generating microfluidic droplets. The generator device comprises a substrate; a microfluidic channel formed in the substrate; a fluid outlet in fluid communication with the microfluidic channel; and a mechanical element configured such that vibration of the mechanical element causes droplet dispensing from the fluid outlet.
US9278993 Cell-targeting nanoparticles and uses thereof The invention generally refers to a cell-targeting nanoparticle, wherein the cell-targeting nanoparticle is directly conjugated to at least one cysteine-containing peptide, wherein the cysteine-containing peptide is selected from the group consisting of glutathione (GSM, a GSH-containing peptide, and a peptide comprising a nuclear localization signal (NLS) sequence and a transporter sequence, and methods of using the cell-targeting nanoparticle.
EP2552938B1 Amphiphilic linear peptide/peptoid and hydrogel comprising the same The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hy-drogel that includes the amphiphilic linear peptide/peptoid. The amphiphilic linear pep-tide/peptoid is capable of forming a hydrogel. These peptides/peptoids include short amphi-philic sequences with a hydrophobic portion of aliphatic amino acids and at least one acidic, neutral, or basic polar amino acid. The amphiphilic linear peptide/peptoid is build up of non repetitive aliphatic amino acids, which may be in the L- or D-form. A plurality of such pep-tides/peptoids assembles to supramolecular helical fibers and forms peptide hydrogels after assembly. A corresponding hydrogel is formed in aqueous solutions at physiological pH and is thus useful for inter alia cell culture, tissue engineering, and drug release. Such hydrogels which are rigid, biocompatible and entrapping up to 99.9% of water are also well suited for applications utilizing electronic devices.
US9273292 Chinese hamster ovary cell lines We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in which the CHO cell is obtainable by selection with Ricinus communis agglutinin I (RCA-I).
SG11201600584UA Superhydrophilic coatings Method for preparing a superhydrophilic coating consisting essentially of silicon oxide is provided. The method includes providing an aqueous mixture comprising a fluorine-containing silicon complex and a fluorine scavenger; and contacting a substrate with the aqueous mixture at a temperature of less than about 100 °C to obtain said superhydrophilic coating on the substrate. Superhydrophilic coating consisting essentially of silicon dioxide islands with each island having a size in the range of about 10 nm to about 50 nm, and use of the superhydrophilic coating in various applications, such as lens, goggles, anti-fouling coatings, self-cleaning surfaces, mirrors, windshields, windows, primer layer for surfaces, and covers for cookware, are also provided.
SG11201600599QA Method and positioning device for localization of a mobile communication device According to one embodiment, a method for localization of a mobile communication device is described comprising transmitting a data message from the mobile communication device to a first access point, determining the reception times of the data message at the first access point and at second access points, transmitting an acknowledgement message for the data message from the first access point to the mobile communication device, determining the reception times of the acknowledgement message at the second access points and determining the position of the mobile communication device based on the reception times of the data message and the reception times of the acknowledgement message.
CN103717284B Purification of biological products by co-hydration bound chromatography Materials and methods for use of constrained cohydration agents in the purification of biological materials such as antibodies, viruses, cells, and cellular organelles in connection with convective chromatography, fluidized bed or co-precipitation applications.
CN101932382B Modified catalyst composition for converting an alcohol to an olefin A catalyst composition for dehydration of an alcohol to prepare an alkene is provided. The catalyst composition comprises a catalyst and a modifying agent which is phosphoric acid, sulfuric acid or tungsten trioxide, or a derivative thereof. A process for preparing an alkene by dehydration of an alcohol is also provided. The process comprises mixing one or more alcohols and optionally water and the catalyst composition.
EP2496711B1 Methods for monitoring cellular states and for immortalizing mesenchymal stem cells We describe a method of monitoring the state of a cell, the method comprising establishing, for a selected microRNA (miRNA) species secreted by the cell, a ratio of: (a) a precursor form of the miRNA species (pre-miRNA); to (b) a mature form of the miRNA species (mature miRNA); in which the pre- to mature miRNA ratio so established is indicative of the state of the cell. We also describe amethod comprising the steps of: (a) providing a mesenchymal stem cell (MSC); and (b) introducing an oncogene into the mesenchymal stem cell to thereby transform it; in which the transformed mesenchymal stem cell does not secrete a gene product of the oncogene into a medium in which it is grown.
CN102985002B BCI system and method A system and method for brain-computer interface (BCI) based interaction. The method comprising the steps of: acquiring a person's EEG signal; processing the EEG signal to determine a motor imagery of the person; detecting a movement of the person using a detection device; and providing feedback to the person based on the motor imagery, the movement, or both; wherein providing the feedback comprises activating a stimulation element of the detection device for providing a stimulus to the person. The system comprising: means for acquiring a person's EEG signal; means for processing the EEG signal to determine a motor imagery of the person; means for detecting a movement of the person using a detection device; and means for providing feedback to the person based on the motor imagery, the movement, or both; wherein the means for providing the feedback comprises a stimulation element of the detection device for providing a stimulus to the person.
US9257177 Write control circuits and write control methods According to various embodiments, a write control circuit configured to control writing to a memory cell by applying a writing current to the memory cell may be provided. The write control circuit may include: a current application circuit configured to apply the writing current to the memory cell; a determination circuit configured to determine whether writing to the memory cell is finished; and a stop writing circuit configured to cut off the writing current from the memory cell if it is determined that writing to the memory cell is finished.
CN102812348B Based on analyte detection sers The present invention relates to method detecting analytes by surface enhanced Raman spectroscopy (SERS), comprising contacting the analytes with at least one analyte binding molecule attached to a metal substrate surface that enhances Raman scattering via a Raman-active molecular linker; and detecting a surface enhanced Raman signal from said compound. In a further aspect, this invention relates to a conjugate and a biosensor suitable for the invented SERS-based analyte detection method.
US9249466 Methods and compositions for treating cancer We describe a method of determining whether a cancer cell is likely to be resistant to treatment by an mTOR inhibitor. The method may comprise detecting PPP2R2B (GenBank Accession Number: NM_18167) in or of the cell. It may, alternatively, or in addition, comprise detecting PDK1 (GenBank Accession Number: NM_002613), in or of the cell. The method may comprise detecting methylation of the PPP2R2B promoter in or of the cell. It may comprise detecting the expression and/or activity of PPP2R2B in or of the cell. It may comprise detecting PDK1 mediated Myc phosphorylation activity. Methods of choosing a treatment for an individual suffering from or suspected to be suffering from a cancer, determining whether an individual suffering from or suspected to be suffering from a cancer will respond to treatment by an mTOR inhibitor, increasing the sensitivity of a cancer cell to treatment by an mTOR inhibitor, for treating or preventing cancer in an individual suffering or suspected to be suffering from cancer are also provided. We further provide for a combination of an inhibitor of PDK1 expression and/or activity and an mTOR inhibitor for use in a method of treatment or prevention of cancer.
US9249383 Apparatus for culturing anchorage dependent cells The invention relates to an apparatus (1) for culturing anchorage-dependent cells. The apparatus (1) comprises a housing (2) with an inlet (4) and an outlet (5), and a plurality of culture plates (6) removably stacked within the housing (2). The housing (2) has a circumferential wall (7), a base (8) and a top wall (9). The base (8) comprises the inlet (4) and the top wall (9) comprises the outlet (5). The circumferential wall (7) of the housing (2) defines a longitudinal axis thereof, as well as an inner cross section perpendicular to the longitudinal axis. Shape and dimensions of the inner cross section are essentially uniform along the longitudinal axis. The culture plates (6) are arranged at least essentially parallel to each other. Each plate (6) is mounted and sealed to the circumferential wall (7) of the housing (2). Plates (6) are arranged at a distance from each other. Each culture plate (6) has a through hole (14), so that inlet (4) and outlet (5) are in fluid communication. Each through hole (14) is positioned at an outer end of the respective culture plate (6), proximate the circumferential wall (7). Through holes (14) of adjacent culture plates (6) are distally positioned in the plane of the inner cross section of the housing (2).
SG11201509981WA A humanized mouse model for study of BONA FIDE hepatitis virus infection and use thereof This invention refers to a mouse for human hepatitis studies wherein the mouse has been injected with CD34+ stem cells and wherein the mouse is immunocompromised, as well as a method of manufacturing a mouse model comprising administering CD34+ stem cells as defined herein into an immunocompromised mouse as defined herein. The invention also refers to the use of a mouse as defined for testing the efficiency of putative anti-HBV or anti-HCV drugs or for characterizing changes in viral quasispecies during HBV or HCV infection.
US9243235 Method of producing recombinant proteins with mannose-terminated N-glycans We describe a method of expressing a recombinant protein comprising mannose-terminated N-glycans from a host cell, the method comprising: (a) introducing a nucleic acid encoding a recombinant protein into a Chinese Hamster Ovary (CHO) cell comprising a mutation in the GnT 1 gene (GenBank Accession Number AF343963) leading to loss of GnT 1 function; and (c) expressing the recombinant protein from the host cell, in which the expressed recombinant protein comprises a mannose-terminated glycan structure, and in which the method does not include a step of introducing functional GnT-I into the host cell. The method may be used for producing recombinant glucocerebrosidase with a mannose-terminated glycan structure, suitable for treatment or prevention of Gaucher's Disease.
US9240362 Layer arrangement and a wafer level package comprising the layer arrangement The invention relates to a layer arrangement and a wafer level package comprising the layer arrangement, and in particular, the layer arrangement comprises a getter layer and further comprises a sacrificial layer. The wafer level package may be used in microelectromechanical systems (MEMS) packaging at a vacuum level of about 10 mTorr or less such as close to 1 mTorr (i.e. MEMS vacuum packaging).
US9240690 Power transfer device A power transfer device is provided. The power transfer device includes a circuit arrangement including a primary side having a primary coil; a secondary side having a secondary coil inductively coupled to the primary coil and a load transformation unit; wherein the load transformation unit includes an inductor and a capacitor; wherein the secondary coil, the inductor and the capacitor respectively includes a first terminal and a second terminal; wherein the first terminal of the secondary coil is coupled to the first terminal of the capacitor, the second terminal of the capacitor is coupled to the first terminal of the inductor, and the second terminal of the inductor is coupled to the second terminal of the secondary coil.
US9237560 Cyclic prefix schemes Methods and systems are proposed for transmitting data from a source (110) to a destination (130) via a relay station (120) having multiple antennae (122, 124). The relay station (120) receives from the source a message containing the data and a first cyclic prefix. It does this using each of its antennae (122, 124), so producing multiple respective received signals. In certain embodiments, the relay station (120) removes the first cyclic prefix from the received signals, replacing it with a new one. In other embodiments, the relay station (120) removes only a portion of the first cyclic prefix. In either case, the relay station (120) may apply space-time coding to generate second signals, which it transmits to the destination (130), which extracts the data. Methods are also proposed for estimating parameters of the channel, to enable the destination (130) to decode the data.
US9236078 Recording medium for heat-assisted-magnetic-recording (HAMR) and method for manufacturing the same According to embodiments of the present invention, a method for manufacturing a recording medium for heat-assisted-magnetic-recording (HAMR) is provided. The method includes forming an underlayer on a substrate, the underlayer including a precursor material, epitaxially depositing an interlayer on the underlayer, forming a recording layer over the interlayer, and converting the precursor material to a converted material having a thermal conductivity that is higher than a thermal conductivity of the recording layer. According to further embodiments of the present invention, another method for manufacturing a recording medium for heat-assisted-magnetic-recording (HAMR) and a recording medium for heat-assisted-magnetic-recording (HAMR) are also provided.
US9233393 Process for creating lithographically-defined plasmonic structures with enhanced Q factors A method for plasmonic structure manufacture and for protecting a plasmonic nanostructure during annealing is provided. The method includes: lithographically forming a plasmonic nanostructure on a substrate; encapsulating the plasmonic nanostructure in high temperature resistant material; annealing the plasmonic nanostructure; and removing the high temperature resistant material to reveal the annealed plasmonic nanostructure.
EP2334304B1 Heparan sulphate 2 (HS-2) to induce therapeutic bone growth and regeneration The use of Herapan Sulphate 2 (HS-2) in therapeutic bone growth and regeneration is described. Herapan Sulphate 2 was identified as a variant of Heparan Sulphate purified from embryonic day (E10) of murine neuroepithelia.
US9226899 Particulate hyaluronic acid and flavonoid formulations for cellular delivery of bioactive agents There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent, for example an anti-cancer agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid, for example a catechin-based flavonoid, wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. The suspension is useful for delivery of the bioactive agent to cells, including cancer cells. There are also provided a therapeutic formulation comprising the suspension, as well as methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.
US9228977 Contactless conductivity detector A portable electrophoretic contactless conductivity detection (C4D) system for analysis on a microfluidic chip houses in one embodiment a fluidic compartment for receiving the microfluidic chip, and four detection electrodes: first and second emitting electrodes, and first and second receiving electrodes. The first emitting electrode and the first receiving electrode are adjacent to a first channel wall of the microfluidic chip, and the second emitting electrode and the second receiving electrode are adjacent to a second channel wall, where the second channel wall is opposite to the first channel wall. In an embodiment, the electrodes are provided as portions of a removable cartridge cell.
SG11201509409YA A reversible thermo-initiated system There is provided a reversible thermo-initiated system comprising a heat source comprising particles that act as heat initiators when excited by an electromagnetic source; and a plurality of micellar amphiphilic polymers that are capable of aggregating when heated by said heat source and which revert back to micellar amphiphilic polymers when cooled. There is also provided a hydrogel comprising the thermo-initiated system for delivering an active agent, and a method for producing the thermo-initiated system.
US20150367595A1 Process for forming a laminated structure There is provided a process for forming a laminated structure, the process comprising the step of bonding a polymer film to an array of structures disposed on a substrate, and wherein a plurality of cavities are formed between the polymer film and the array of structures during the bonding.
US9210643 Communication terminal and method for performing communication A method for enabling a forwarding to network operation in a cellular mobile communication system is described, the cellular mobile communication system comprising a plurality of mobile stations and at least one base station, the method comprising: reporting forwarding capability of a first mobile station of the plurality of mobile stations with the at least one base station; discovering neighboring mobile stations to the first mobile station; selecting a second mobile station from the neighboring mobile stations and establishing a forwarding link between the first mobile station and the second mobile station; allocating radio resources for a link between the first mobile station and the second mobile station; and synchronizing the link between the first mobile station and the second mobile station to establish the forwarding network.
US9205106 Therapeutic bone growth and regeneration The use of Herapan Sulphate 2 (HS-2) in therapeutic bone growth and regeneration is described. Herapan Sulphate 2 was identified as a variant of Heparan Sulphate purified from embryonic day (E10) of murine neuroepithelia.
US9199073 Nerve stump interface and axonal regeneration system for generating an electric field for promoting and guiding axonal regeneration The present invention provides a nerve stump interface for generating an electric field for promoting and guiding axonal regeneration and an electric field assisted axonal regeneration system. The nerve stump interface comprises a sieve having a plurality of holes. A strip is coupled to the sieve. A first electrode is provided at one of the plurality of holes and a second electrode is provided on the strip. The strip is arranged to space the second electrode from the first electrode. The first electrode and the second electrode are for generating the electric field. At least one securing element is provided on a side of the strip to allow that side of the strip to affix against an opposite side of the strip. The present invention also provides a method for assembling the electric field assisted axonal regeneration system.
US9204322 Communication devices and methods for performing communication A infrastructure station in a cellular mobile communication system, the infrastructure station includes a infrastructure station core configured to provide infrastructure station functionality to a plurality of dependent stations, a topographer configured to discover a network topology and designate a failover topology from the network topology for use in the event that the infrastructure station fails thereby no longer being capable of providing infrastructure station functionality to the plurality of dependent stations, the failover topology comprising failover stations, and a synchronizer configured to periodically provide timing estimates of dependent stations to the failover stations such that network reentry after infrastructure station failure is shorter than normal network entry.
SG11201508430SA Method and system for processing an input image In various embodiments of the present disclosure, there is provided a method for processing an input image. The method includes generating a base layer portion and a detail layer portion from the input image by carrying out a linear transformation of pixels of a guidance image, and determining, for each of the pixels of the guidance image, a variance of the pixels in a surrounding window of pixels. Further, the method includes determining, for each of the pixels of the guidance image, a weight value of the pixels based on the determined variance, wherein the pixels are weighted in the linear transformation according to the determined weight value. Accordingly, a system for processing an input image is also provided.
CN102958888B Carboxylated terminal alkyne The present invention describes a process for converting a terminal alkyne into an alkynoic acid. In this process the alkyne is exposed to carbon dioxide in the presence of a copper (I) species, a base and a complexing agent capable of complexing copper (I).
US9193668 Process for producing an aminopropyne or enaminone There is provided a process for producing an aminopropyne or an enaminone comprising the step of reacting a metal acetylide, an amine and a carbonyl-containing compound in the presence of a transition metal catalyst. There is also provided a process for producing an aminopropyne comprising the step of reacting a metal acetylide, an amine and a halide-containing compound in the presence of a transition metal catalyst at a reaction temperature of 50° C. to 150° C. There are also provided processes to further synthesize the aminopropyne produced to obtain a butyneamine, another aminopropyne or a triazol.
US20150329821A1 Methods of differentiating stem cells into one or more cell lineages The present disclosure provides an understanding of the regulation of the developmental phases of stem cells and their induction into relevant cell lineages, such as primitive streak, endoderm, mesoderm, or subterrotories of endoderm's. In particular, the present disclosure provides methods, culture medium and kits for the maintenance and differentiation of stem cells into relevant cell lineages.
US9189966 System for learning trail application creation A server configured to create a learning trail application for a geographic area. The server includes a processor configured to: provide a template having a plurality of fields including a location field configured to receive the geographic area and an image archive field configured to receive images; receive template data for placement as the content of one or more of the plurality of fields; receive instructions for determining the placement of the template data into one or more of the plurality of fields; and generate the learning trail application from the template with the received template data. During execution of the application, the application is configured to receive at least one input image, determine whether a match exists between the input images and the content in the image archive field and display the template data associated with the content in the image archive field, when a match exists.
US9175278 Method of producing recombinant proteins with mannose-terminated N-glycans We describe a method of expressing a recombinant protein comprising mannose-terminated N-glycans from a host cell, the method comprising: (a) introducing a nucleic acid encoding a recombinant protein into a Chinese Hamster Ovary (CHO) cell comprising a mutation in the GnT 1 gene (GenBank Accession Number AF343963) leading to loss of GnT 1 function; and (c) expressing the recombinant protein from the host cell, in which the expressed recombinant protein comprises a mannose-terminated glycan structure, and in which the method does not include a step of introducing functional GnT-1 into the host cell. The method may be used for producing recombinant glucocerebrosidase with a mannose-terminated glycan structure, suitable for treatment or prevention of Gaucher's Disease.
SG11201507640QA Electromechanical device and method of fabricating the same An electromechanical device and method of fabrication thereof comprising: providing a first wafer with a circuit arrangement on a first surface thereof and a first electrode on a second surface thereof; forming first and second via structures from the first surface to the second surface of the first wafer, said first via electrically connecting the first electrode with the circuit arrangement; providing a second wafer with a suspended structure on a first surface thereof; forming a second electrode on the suspended structure; forming an interconnect structure on the first surface of the second wafer that electrically connects with the second electrode; bonding the first wafer to the second wafer with the second surface of the first wafer facing the first surface of the second wafer, with the second via structure electrically connecting the circuit arrangement to the interconnect structure, and the first and second electrodes forming a capacitive structure.
SG11201507338PA Method for culturing cells A method of culturing a cell is provided comprising the step of contacting said cell with a cell culture medium comprising at least one of FGF, VEGF, or HGF. Also provided is a cell culture medium for culturing a cell comprising at least one of FGF, VEGF, or HGF; a kit for use in the method and a cell produced by the method.
US9172351 Piezoelectric resonator having electrode fingers with electrode patches According to embodiments of the present invention, a piezoelectric resonator is provided. The piezoelectric resonator includes a piezoelectric substrate, a first electrode comprising a first plurality of electrode fingers, a second electrode comprising a second plurality of electrode fingers, wherein the first plurality of electrode fingers and the second plurality of electrode fingers are interdigitated, and wherein electrode patches are arranged along the first plurality of electrode fingers and the second plurality of electrode fingers according to a 2-dimensional lattice.
US9166568 Low power high resolution sensor interface A sensor interface circuit is provided for resolving sensor signals from a plurality of sensors into a digital sensor signal. The sensor interface circuit includes a relaxation oscillator that receives and pre-processes the sensor signals to generate an analog sensor signal. The relaxation oscillator includes one or more dynamic circuits. The sensor interface circuit also includes a monitoring module for receiving the analog sensor signal and generating the digital sensor signal in response thereto. There is also provided a sensor system front-end and a relaxation oscillator.
US9157861 Sensor and method of detecting a target analyte A sensor and a method of detecting a target analyte are provided. The sensor includes a substrate; a layer comprising a plurality of through holes, wherein the layer is disposed above the substrate; a first element configured to detect a target analyte; a second element that can produce a detectable signal; wherein the first element and the second element are configured to couple the target analyte between the first element and the second element.
US9155814 Nanostructured material formulated with bone cement for effective antibiotic delivery This invention uses mesoporous silica nanoparticles and other nanostructured materials to formulate polyacrylate-based bone cement for achieving an enhanced and controlled elution of active ingredients such as antibiotics. This invention overcomes the limitation of low antibiotic release from commercial polyacrylate-based bone cements using for example, PMMA. In certain aspects, the formulation enables a sustained release of antibiotics from the bone cement over a period of 80 days and achieves 70% of total drug release, whereas the commercial antibiotic bone cement (e.g., SmartSet GHV) only releases about 5% of the antibiotics on the first day and subsequently an almost negligible amount. In addition, the mechanical properties of our formulated bone cements are well retained. The inventive bone cement exhibits good antibacterial properties and has very low cytotoxicity to mouse fibroblast cells.
SG10201501052XA Method And System For Monitoring Activity Of An Animal A method of monitoring activity of an animal, the method comprising the steps of: retaining the animal in an enclosed chamber; controlling a food supply to the animal in the enclosed chamber as a first stimulus; and monitoring the activity of the animal in response to the first stimulus, wherein monitoring the activity of the animal comprises analysing change in a volume of food in the food supply and location of the animal in the enclosed chamber over a predetermined period of time.
US9148323 Transmitter According to embodiments of the present invention, a transmitter is provided. The transmitter includes a frequency shift keying (FSK) circuit, and a phase shift keying (PSK) circuit coupled in series to the FSK circuit, wherein the FSK circuit is configured, in a first mode of operation, to provide a FSK modulated signal to the PSK circuit, and, in a second mode of operation, to provide a fixed frequency signal to the PSK circuit, and wherein the PSK circuit is configured, in the first mode of operation, to transmit the FSK modulated signal, and, in the second mode of operation, to provide a PSK modulated signal based on the fixed frequency signal received from the FSK circuit.
EP2552304B1 Brain-computer interface system and method A system and method for brain-computer interface (BCI) based interaction. The method comprising the steps of: acquiring a person's EEG signal; processing the EEG signal to determine a motor imagery of the person; detecting a movement of the person using a detection device; and providing feedback to the person based on the motor imagery, the movement, or both; wherein providing the feedback comprises activating a stimulation element of the detection device for providing a stimulus to the person. The system comprising: means for acquiring a person's EEG signal; means for processing the EEG signal to determine a motor imagery of the person; means for detecting a movement of the person using a detection device; and means for providing feedback to the person based on the motor imagery, the movement, or both; wherein the means for providing the feedback comprises a stimulation element of the detection device for providing a stimulus to the person.
US9139924 Systems and processes for forming molds such as nickel molds For forming a nickel mold, a metal and a corresponding etchant are selected such that the etchant selectively etches the metal over nickel. The metal is sputtered onto a surface of a template having nano-structures to form a sacrificial layer covering the nano-structures. Nickel is electroplated onto the sacrificial layer to form a nickel mold, but leaving a portion of the sacrificial layer exposed. The sacrificial layer is contacted with the etchant through the exposed portion of the sacrificial layer to etch away the sacrificial layer until the nickel mold is separated from the template. Subsequently, the nickel mold may be replicated or scaled-up to produce a replicate mold by electroplating, where the replicate mold has nano-structures that match the nano-structures on the template. The metal may be copper.
US9138977 Process for forming a laminated structure There is provided a process for forming a laminated structure, the process comprising the step of bonding a polymer film to an array of structures disposed on a substrate, and wherein a plurality of cavities are formed between the polymer film and the array of structures during the bonding.
CN101518151B Nanoparticles barrier packaging laminate A barrier stack for encapsulating a moisture and/or oxygen sensitive electronic device is provided. The barrier stack comprises a multilayer film having at least one barrier layer having low moisture and/or oxygen permeability, and at least one sealing layer arranged to be in contact with a surface of the barrier layer, wherein the sealing material comprises reactive nanoparticles capable of interacting with moisture and/or oxygen, thereby retarding the permeation of moisture and/or oxygen through defects present in the barrier layer.
US9129413 Method and device for aligning a plurality of digital pictures A method for aligning a plurality of first digital pictures. Each first digital picture includes a plurality of pixels wherein each pixel is associated with a pixel value. The method includes generating a second digital picture for each first digital picture. Generating the second digital picture for the first digital picture includes determining, for each of a plurality of pixels of the first digital picture, a number representing the pixel values of a plurality of pixels in a neighborhood of the pixel relatively to the pixel value of the pixel. The method further includes assigning the number as a pixel value to a pixel of the second digital image corresponding to the pixel of the first digital image. The method further includes generating aligning parameters based on the plurality of second digital pictures. The method further includes aligning the plurality of first digital pictures based on the aligning parameters.
US9125788 System and method for motor learning A method and system for motor learning. The method comprises the steps of detecting a user's motor intent; and giving robotic assistance to the user for executing a motor task associated with the motor intent based on the detected motor intent.
US9120841 Amphiphilic linear peptidepeptoid and hydrogel comprising the same The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hydrogel that includes the amphiphilic linear peptide/peptoid.
US9123884 Magnetoresistive device and a writing method for a magnetoresistive device According to embodiments of the present invention, a magnetoresistive device is provided. The magnetoresistive device includes at least two ferromagnetic soft layers, wherein the at least two ferromagnetic soft layers have different ranges of magnetization switching frequencies. Further embodiments provide a magnetoresistive device including at least two oscillating ferromagnetic structures, wherein ranges of operating current amplitudes at which oscillations are induced for the at least two oscillating ferromagnetic structures are different. According to further embodiments of the present invention, writing methods for the magnetoresistive devices are provided.
SG11201505077YA Organic electronic devices The present invention provides a product and manufacturing method for an organic electronic device. The electronic device comprises a first conductive layer and a second conductive layer, an organic layer disposed between said first and second conductive layer and an amphiphilic layer disposed between said organic layer and the second conductive layer.
SG11201505294SA A method and system for assessing fibrosis in a tissue A method for assessing fibrosis in a tissue is proposed. The method uses a test image which is an image of the tissue and comprises identifying, from the test image, a portal collagen area, a septal collagen area and a fibrillar collagen area respectively comprising pixels representing portal collagen, septal collagen and fibrillar collagen of the tissue, obtaining quantitative values of one or more features for each identified area based on characteristics of the identified area in the test image and assessing fibrosis using the quantitative values obtained for all the identified areas.
US9115340 Microfluidic continuous flow device A microfluidic continuous flow device comprising a channel which comprises a first and a second area wherein the first area of the channel is a compartment which is defined by partitioning elements and the second area of the channel is a space outside the compartment; wherein through passages which are formed between the partitioning elements are dimensioned such as to retain a biological material and optionally a sustained release composition which can be comprised in the compartment within the compartment; wherein the channel has a first inlet to the compartment through which biological material can be introduced into the compartment; a second inlet for introducing a cultivation medium into a space of the channel arranged outside of the compartment, and an outlet. The present invention further refers to methods of using the devices of the present invention and kits comprising the microfluidic continuous flow devices of the present invention.
SG11201504078TA Wafer dicing apparatus and wafer dicing method According to one aspect of the invention, there is provided a wafer dicing apparatus. The wafer dicing apparatus includes a grille, a vacuum suction unit and a cutter. The grille includes an alternating rib and slot arrangement for supporting a wafer, wherein one slot is between two adjacent ribs. The vacuum suction unit is in fluid communication with the grille and sucks air through at least one slot of the grille. The cutter dices the wafer, where either the grille, the cutter or both is configured to align the wafer to be diced along the rib of the grille. There is also provided a wafer dicing method. The method includes providing a wafer, stressing the wafer along a length that extends between two opposite points of the wafer perimeter, and dicing the wafer along the length where the wafer is stressed
SG11201504839PA Testing apparatuses, servers and methods for controlling a testing apparatus According to various embodiments, a testing apparatus may be provided. The testing apparatus may include: a plurality of cells, each cell of the plurality of cells including a plurality of terminals, the plurality of cells configured to define a string, wherein each cell of the plurality of cells includes a first terminal; a controller configured to control voltages to the respective first terminals of the plurality of terminals of each cell of the plurality of cells based on a query pattern, wherein a state of each cell of the plurality of cells is defined by the voltage supplied to the first terminal of the cell; and a determination circuit configured to determine whether the string corresponds to the query pattern based on the states of the plurality of cells.
US9089628 Biodegradable and biocompatible shape memory polymers This invention relates to shape memory block copolymers comprising: at least one switching segment having a Ttrans from 10 to 70° C.; and at least one soft segment, wherein at least one of the switching segments is linked to at least one of the soft segments by at least one linkage, and wherein the copolymer transforms from a first shape to a second shape by application of a first stimulus and the copolymer transforms back to the first shape from the second shape by application of a second stimulus. The shape memory block copolymers may be biocompatible and biodegradable.
US9087975 Resistive memory arrangement and a method of forming the same According to embodiments of the present invention, a resistive memory arrangement is provided. The resistive memory arrangement includes a nanowire, and a resistive memory cell including a resistive layer including a resistive changing material, wherein at least a section of the resistive layer is arranged covering at least a portion of a surface of the nanowire, and a conductive layer arranged on at least a part of the resistive layer. According to further embodiments of the present invention, a method of forming a resistive memory arrangement is also provided.
EP2889372A3 Use of a heparan sulphate which binds BMP2 in medicine The invention relates to heparan sulphate GAGs obtained by affinity chromatography using the heparan-binding domain of BMP2. The GAGs were obtained from osteoblast extracellular matrix and from a commercially available heparin sulphate (Celsus HS).
US9067084 Amphiphilic linear peptide/peptoid and hydrogel comprising the same The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hydrogel that includes the amphiphilic linear peptide/peptoid. The amphiphilic linear peptide/peptoid is capable of forming a hydrogel. These peptides/peptoids include short amphiphilic sequences with a hydrophobic portion of aliphatic amino acids and at least one acidic, neutral, or basic polar amino acid. The amphiphilic linear peptide/peptoid is build up of non repetitive aliphatic amino acids, which may be in the L- or D-form. A plurality of such peptides/peptoids assembles to supramolecular helical fibers and forms peptide hydrogels after assembly. A corresponding hydrogel is formed in aqueous solutions at physiological pH and is thus useful for inter alia cell culture, tissue engineering, and drug release. Such hydrogels which are rigid, biocompatible and entrapping up to 99.9% of water are also well suited for applications utilizing electronic devices.
SG11201503974SA Method, apparatus and system for virtual clothes modelling There is provided a method for virtual clothes modelling including receiving a plurality of frames of an input image stream of a user, generating an avatar based on one or more characteristics of the user, superimposing virtual clothes on the avatar, and synthesizing the plurality of frames with the clothed avatar to generate an output image stream that on display appears to resemble the user trying on the virtual clothes, wherein generating the avatar includes configuring the avatar to match the one or more characteristics of the user including a skin colour of the user, and configuring the avatar to match the skin colour of the user includes locating facial features of the user, extracting a colour of a facial area of the user, and applying a colour to the avatar computed based on the colour of the facial area, and/or wherein the avatar is three-dimensional and the input and output image streams are two-dimensional, and synthesizing the plurality of frames with the clothed avatar to generate the output image stream includes aligning the clothed avatar with each of the plurality of frames based on a set of three-dimensional to two-dimensional point correspondences between the clothed avatar and the user in the plurality of frames. There is also provided an apparatus and a system for virtual clothes modelling.
US20150168391A1 Method for treating a porous membrane and uses thereof The present invention relates to a method for treating a porous membrane, said method comprising contacting said porous membrane with at least one alcohol to reduce the pore size of said porous membrane relative to an untreated porous membrane. The invention further relates to an apparatus comprising the treated porous membrane.
US9058885 Magnetoresistive device and a writing method for a magnetoresistive device A magnetoresistive device including a fixed magnetic layer structure, a first free magnetic layer structure, and a second free magnetic layer structure, wherein the fixed magnetic layer structure is arranged in between the first free magnetic layer structure and the second free magnetic layer structure, wherein the magnetization orientation of the first free magnetic layer structure is variable in response to a first electrical signal of a first polarity and the magnetization orientation of the second free magnetic layer structure is at least substantially non-variable in response to the first electrical signal, and wherein the magnetization orientation of the second free magnetic layer structure is variable in response to a second electrical signal of a second polarity and the magnetization orientation of the first free magnetic layer structure is at least substantially non-variable in response to the second electrical signal, wherein the second polarity is opposite to the first polarity.
EP2531853B1 Use of novel markers of pluripotent stem cells The disclosure relates to novel markers of pluripotent stem cells and uses thereof, and particularly, though not exclusively, to antibody molecules based on fragments of mAb84 which bind to undifferentiated pluripotent stem cells via podocalyxin-like protein-1 (PODXL).
US9054694 Circuit arrangements and methods of operating the same In various embodiments, a circuit arrangement may be provided. The circuit arrangement may include a level shifting stage configured to be coupled to a first reference voltage, the level shifting stage having an output node. The circuit arrangement may further include a first input electrode in electrical connection with the level shifting stage. The circuit arrangement may also include a second input electrode in electrical connection with the level shifting stage. The circuit arrangement may further include a load having a first end and a second end, the first end coupled to the level shifting stage and the second end for coupling to a second reference voltage. In addition, the circuit arrangement may include a bypass circuit element connected in parallel to the load. The bypass circuit element may be configured to allow current to flow through upon application of an external voltage for bypassing the load.
US9048987 Joint detector/ decoder devices and joint detection/ decoding methods According to various embodiments, a joint detection/decoder device may be provided. The detector and decoder device may include: an input circuit configured to receive an input signal; a survivor splitting circuit configured to produce a plurality of survivors of a next instance based on at least one survivor of a previous instance and based on the input signal; and a survivor discarding circuit configured to discard survivors based on a set of predetermined criteria; wherein each survivor has an associated bit sequence.
US9046494 Optical sensing system and a method of determining a change in an effective refractive index of a resonator of an optical sensing system According to embodiments of the present invention, an optical sensing system is provided. The optical sensing system includes a resonator arrangement including a first resonator, wherein an effective refractive index of the first resonator is changeable in response to a change in a refractive index of a cladding of the first resonator, and a second resonator to which a current or voltage being adjustable in response to a change in the effective refractive index of the first resonator is applied, wherein the optical sensing system is configured to determine the change in the effective refractive index of the first resonator based on a change in the current or voltage applied to the second resonator. Further embodiments provide a method of determining a change in an effective refractive index of a resonator of an optical sensing system.
US9046526 Method for determining protein-nucleic acid interaction The present invention refers to a method of determining protein-nucleic acid interaction. The method comprises mixing a protein with a sample comprising a nucleic acid which is suspected to interact with the protein to form a first mixture. The first mixture can be incubated to allow interaction between the protein and nucleic acid. Metallic nanoparticles are added to the first mixture to obtain a second mixture. An electrolyte is added to the first or second mixture to determine the protein-nucleic acid interaction. The present invention also refers to a kit for determining protein-nucleic acid interaction. The kit comprises a protein capable of interacting with a nucleic acid or a nucleic acid capable of interacting with a protein, and at least one type of metallic nanoparticle.
SG11201503403QA Encapsulated Nanoparticles The invention relates to a composite substance comprising particles of an oxide of a metal dispersed in a porous silica matrix. The composite substance may be made by preparing a solution comprising a soluble salt of the metal and a surfactant; adjusting the solution to a basic pH at which a hydroxide of the metal precipitates from the solution; preparing an aqueous suspension of the hydroxide of the metal, said suspension being at pH greater than 7; adding to the suspension, with agitation, an alkoxysilane, so as to form composites comprising the hydroxide of the metal at least partially coated with silica; and calcining these composites so as to produce the composite substance.
SG11201502198VA Cipher devices and cipher methods According to various embodiments, a cipher device may be provided. The cipher device may include: a data collector configured to receive data to be processed; a cipher circuit configured to perform at least one of encryption or decryption of the data; and a control circuit configured to determine whether the amount of data received by the data collector fulfills a pre-determined criterion, and configured to instruct the cipher circuit to perform the at least one of encryption or decryption of the data if the amount of data received by the data collector fulfills the pre-determined criterion.
SG10201501829YA Anti-cancer agent delivery vehicles capable of improved loading There is provided a conjugate of a delivery agent containing a chemical moiety and at least one flavonoid. The flavonoid exists in a monomeric form or dimeric form before conjugation and remains in the monomeric form or dimeric form after conjugation. Preferably, the conjugate comprises two flavonoids. The delivery agent is conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. An anti-cancer agent delivery vehicle comprising an anti-cancer agent and the conjugate is also provided.
US9034364 Cell-adhesive, enzymatically crosslinked flavonoid hydrogels and methods for making same There are provided methods for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid, formed from a reaction using peroxide and peroxidase. Hydrogels produced by such methods and methods of using the hydrogels are also provided.
US9030865 Circuit arrangement and method of forming the same In various embodiments, a circuit arrangement may be provided including a data cell. The circuit arrangement may further include a first transistor and a second transistor. The first controlled electrode of the first transistor and the first controlled electrode of the second transistor may be coupled to the first electrode of the data cell. The second controlled electrode of the first transistor may be configured to electrically connect to a first reference voltage such that the first electrode of the data cell is electrically connected to the first reference voltage when the first transistor is activated. The second controlled electrode of the second transistor may be configured to electrically connect to a second reference voltage, such that the first electrode of the data cell is electrically connected to the second reference voltage when the second transistor is activated.
US9018348 eif4e binding peptides The present invention relates to modified eIF4G1 peptides, uses thereof and pharmaceutical compositions comprising the modified eIF4G1 peptides.
US9018005 Method of deriving progenitor cell line We disclose a method comprising: (a) providing an embryonic stem (ES) cell; and (b) establishing a progenitor cell line from the embryonic stem cell; in which the progenitor cell line is selected based on its ability to self-renew. Preferably, the method selects against somatic cells based on their inability to self-renew. Preferably, the progenitor cell line is derived or established in the absence of co-culture, preferably in the absence of feeder cells, which preferably selects against embryonic stem cells. Optionally, the method comprises (d) deriving a differentiated cell from the progenitor cell line.
EP2655636B1 Modified CMV promoters that are resistant to gene silencing The invention relates to a nucleic acid molecule comprising a functional promoter of a herpesvirus, a functional enhancer of a herpesvirus, and one or more internal elements of the CpG island of the aprt (adenine phosphoribosyl transferase) gene and/or a functional variant thereof. A method of producing a desired polypeptide using the nucleic acid molecule, a vector and a host cell containing the nucleic acid molecule are also disclosed.
US9012176 Chinese hamster ovary cell lines We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in which the CHO cell is obtainable by selection with Ricinus communis agglutinin I (RCA-I).
US9007075 Contactless conductivity detector The contactless conductivity detector in one embodiment includes a microfluidic chip having a channel (102) thereon and four detection electrodes: first and second emitting electrodes (100a, 101a), and first and second receiving electrodes (100b, 101b). The channel (102) is defined by channel walls. The first emitting electrode (100a) and the first receiving electrode (100b) are adjacent a first channel wall, and the second emitting electrode (101a) and the second receiving electrode (101b) are adjacent a second channel wall, the second channel wall being opposite the first channel wall.
EP2334786B1 Isolation and identification of glycosaminoglycans The isolation and identification of glycosaminoglycans capable of binding to proteins having a heparin-binding domain is disclosed, as well as the use of the glycosaminoglycans isolated in the growth and/or development of tissue.
US8994409 Stimulator and method for processing a stimulation signal Various embodiments provide a method for processing a stimulation signal. The method may include monitoring an output voltage on an electrode, the electrode being provided with the stimulation signal; determining whether the output voltage is lower than a threshold voltage; if it is determined that the output voltage is lower than the threshold voltage, modifying the waveform of the stimulation signal; and providing the modified stimulation signal to an object via the electrode.
US8993537 Forming porous scaffold from cellulose derivatives Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores.
SG11201500989SA An Antifungal Compound There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.
CN102884204B Sequence-selective recognition of nucleic acids using nanoparticle probes The present invention refers to a conjugate comprising a nanoparticle and at least one oligonucleotide analog, wherein the at least one oligonucleotide analog is a phosphorodiamidate morpholino oligo (PMO) or a derivative thereof that is covalently coupled to the nanoparticle, methods for detecting a target nucleic acid using the conjugate and a kit comprising the conjugate.
CN102640316B P-type materials and organic electronic devices There is presently provided compounds of formula (I), which are useful as p-type semiconductor materials and in devices comprising such p-type semiconductor materials.
EP2496599B1 Mutant SOX proteins and methods of inducing pluripotency There is presently provided mutant Sox2, Sox7 and Sox17 proteins that have acquired or increased ability to induce pluripotency in a partially differentiated or fully differentiated cell. Sox7 and Sox17 are mutated to resemble in part Sox2, or Sox2 is mutated to resemble in part Sox7 or Sox17. In one aspect, the Oct4 contact interface of Sox7 or Sox17 is mutated. In another aspect, the high mobility group (HMG) of Sox2 is fused to the C-terminal activation domain of Sox7 or Sox17. Methods relating to inducing pluripotency using a mutant Sox2, Sox7 or Sox17 protein are also provided.
CN102388544B Wireless transmission of layered signals in a relay network and device thereof The wireless transmission of layered signals, in a described embodiment, uses multiple relay nodes (304) to implement cooperative diversity. The method includes: (i) receiving layered signals from a source node (300), (ii) receiving, from a destination node (302), a relay allocation parameter to implement a cooperative relay strategy with one or more other relay nodes (304), and (iii) relaying the layered signals to the destination node (302) using the cooperative relay strategy.
US8976901 Phase shift keying transmitter circuit A phase shift keying transmitter circuit that includes: a variable frequency conversion stage adapted to receive a first data signal, wherein the variable frequency conversion stage comprises a plurality of frequency modulating elements, wherein the first data signal controls the number of the plurality of frequency modulating elements that are operated so as to control an operating frequency of the variable frequency conversion stage; and an output stage configured to switch between one of two possible outputs, the signals provided by one of the two possible outputs having an opposite polarity to the other, wherein the output stage is configured to receive a second data signal to control the switching between the two possible outputs, wherein the output stage is coupled to the variable frequency conversion stage and wherein the switching between the two possible outputs changes the phase of a signal from the variable frequency conversion stage by 180°.
US8969313 Methods and compounds for preventing and treating a tumour The invention relates to a method of preventing, inhibiting, arresting or reversing tumorigenesis in a cell as well as a method of inducing apoptosis in a tumor cell. The method includes increasing the amount and/or the activity of a DACT protein, or a functional fragment thereof, in the cell. Also provided is a pharmaceutical composition that comprises a compound of general formula (I), wherein A is CH or N, R1, R4 and R5 are independent from each other H, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group, and an arylalicyclic group comprising 0-3 heteroatoms. The heteroatoms may be N, O, S, or Si. R4 and R5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge. R2 is H or a halogen such as F, Cl, Br or L. R3 is H, F, Cl or an aliphatic or arylaliphatic group that includes 1-8 main chain carbon atoms and 0-3 heteroatoms. The pharmaceutical composition also comprises a histone deacetylase inhibitor.
EP2324065B1 A heparan sulphate which binds BMP2 The invention relates to heparan sulphate GAGs obtained by affinity chromatography using the heparin-binding domain of BMP2. The GAGs were obtained from osteoblast extracellular matrix and from a commercially available heparan sulfate (Celsus HS).
US8961679 Method for preparing a lead-free piezoelectric thin film The present invention discloses a method of preparing a lead-free piezoelectric thin film comprising the steps of: providing a precursor solution comprising at least one alkali metal ion, a polyamine carboxylic acid, and an amine; depositing the precursor solution on a substrate to form a film; and annealing the film. The present invention also provides a lead-free piezoelectric thin film prepared according to the method, a precursor solution for use in the method and a method of preparing the precursor solution.
US8961855 High aspect ratio adhesive structure and a method of forming the same A method of forming a high aspect ratio adhesive structure, the method comprising fabricating a porous template comprising at least a first tier and a second tier; introducing a softened polymer into the template; and separating the polymer from the template.
US8962318 Method of deriving mesenchymal stem cells from ES cells using FGF2 We disclose a method comprising: (a) providing an embryonic stem (ES) cell; and (b) establishing a progenitor cell line from the embryonic stem cell; in which the progenitor cell line is selected based on its ability to self-renew. Preferably, the method selects against somatic cells based on their inability to self-renew. Preferably, the progenitor cell line is derived or established in the absence of co-culture, preferably in the absence of feeder cells, which preferably selects against embryonic stem cells. Optionally, the method comprises (d) deriving a differentiated cell from the progenitor cell line.
US8957732 Amplifier and transceiver including the amplifier An amplifier and a transceiver including the amplifier are provided. The amplifier includes an input terminal; a first transistor of a first conductivity and a second transistor of a second conductivity, each transistor comprising a source terminal, a gate terminal and a drain terminal respectively, the source terminal of the first transistor being coupled to the source terminal of the second transistor, and the gate terminal of the first transistor and the gate terminal of the second transistor being coupled to the input terminal; and an output terminal coupled to the drain terminal of the first transistor and the drain terminal of the second transistor.
SG10201403483UA Method for Detecting Oxidants and Reductants in A Sample Method for Detecting Oxidants and Reductants in A Sample Abstract There is provided a method to detect oxidants and 5 reductants simultaneously by reaction of a sample with a substrate and observing a shift in fluorescence color. Metal nanoclusters templated with a DNA sequence can be used in the disclosed method. The method can be employed in assays which can be run in a one-pot system to 10 evaluate the unknown redox situation of a sample in real time. The assays may have a use for detecting free radicals or antioxidants potentially relating to aging processes or diseases as well as for evaluating the shelf-life of a food, beverage, health care, personal 15 care or sports product. (No suitable figure) 20 31
US8942024 Circuit arrangement and a method of writing states to a memory cell A method of writing a first state or a second state to a memory cell may be provided. Writing the first state to the memory cell may include electrically connecting a first switch in electrical connection to a first end of the memory cell to a first voltage and electrically connecting a second switch in electrical connection to a second end of the memory cell to a fourth voltage to apply a first potential difference to cause formation of the first state in the memory cell. Writing the second state to the memory cell may include electrically connecting the first switch to the second voltage and electrically connecting the second switch to the third voltage to apply a second potential difference to cause formation of the second state in the memory cell.
US8926937 Highly dispersed metal catalysts The present invention relates to a novel method for preparing a new type of catalyst for the oxidation of CO in a reactant gas or air. The method provides the preparation of a catalyst having nano-sized metal particles and a capping agent deposited on a solid support. The size and distribution of the metal particles can be easily controlled by adjusting reaction condition and the capping agent used. The catalyst prepared has high activity at low temperature toward selective oxidation of CO and is stable over an extended period of time. The catalyst can be used in air filter devices, hydrogen purification processes, automotive emission control devices (decomposition of NOx, x is the integer 1 or 2), F-T synthesis, preparation of fuel-cell electrode, photocatalysis and sensors.
SG11201407424TA Methods for determining information about a communication parameter and communication devices According to various embodiments, a method for determining information about a communication parameter may be provided. The method may include providing information about the communication parameter in at least one of an add block acknowledgement request signal, an acknowledgement signal for an add block acknowledgement request signal, an add block acknowledgement response signal, or an acknowledgement signal for an add block acknowledgement response signal.
SG11201407443RA Communication devices and methods for controlling a communication device According to various embodiments, a communication device may be provided. The communication device may include: a plurality of power amplifiers in a radio frequency transmit chain; a power amplifier selection circuit configured to determine for every power amplifier in the radio frequency transmit chain, whether the power amplifier should be used; and a transmitter circuit configured to use the one or more power amplifiers for which it has been determined that they should be used for transmitting data.
SG11201407445UA Methods for determining an activation scheme of a radio communication device and radio communication devices Various embodiments provide a method for determining an activation scheme of a radio communication device. The method may include determining a plurality of frames according to a multiple access scheme; and determining for each frame of the plurality of frames a first portion of the frame, during which the radio communication device performs communication, and a second portion of the frame during which the radio communication device does not perform communication.
SG11201406983TA A method of degrading organic compounds There is provided a method of degrading a heterocyclic aldehyde compound comprising the step of treating the heterocyclic aldehyde compound with Enterobacter sp. microorganisms. There is also provided a method of degrading a carboxylic acid compound comprising the step of treating the carboxylic acid compound with Bacillus sp. microorganisms.
US8923771 Method, apparatus and computer program product for identifying frequency bands, and a method, apparatus and computer program product for evaluating performance According to embodiments of the present invention, a method for identifying one or more frequency bands in a received signal. The method comprising: calculating a wavelet product of the received signal; setting a threshold for local maxima of the wavelet product; and detecting one or more edges in the received signal based on local maxima of the wavelet product which are greater than the threshold to identify one or more frequency bands in the received signal. A corresponding apparatus and computer program product are also provided. Embodiments also relate to a method for evaluating performance of a method for identifying one or more frequency bands in a received signal. A corresponding apparatus and computer program product are also provided.
US8917540 Memory device with soft-decision decoding According to embodiments of the present invention, a memory device with soft decision decoding is provided. The memory device includes a memory cell configured to store an input data bit; a memory sensor configured to read out a parameter associated with a state of the memory cell; a detector configured to determine, based on the parameter read out from the memory cell, a soft information indicating the likelihood that the input data bit stored in the memory cell is a “0” or the likelihood that the input data bit stored in the memory cell is a “1”; and a decoder configured to generate a decoded bit based on the soft information. Further embodiments relate to a method of performing soft-decision decoding on a data bit stored in a memory cell of a memory device.
US8915121 Encapsulated device with integrated gas permeation sensor An encapsulated device comprising an integrated gas permeation sensor is provided, comprising a base substrate with an electronic component arranged thereon being enclosed within an encapsulation for protecting the electronic component from moisture and/or oxygen; at least one sensor is arranged within the encapsulation to measure the permeation of gas into the encapsulation; each sensor comprises an electrically conductive sensing element comprising a moisture and/or oxygen sensitive material, wherein the reaction of said material with moisture and/or oxygen results in a change in the electrical resistance/conductivity of the sensor.
EP2422194B1 Vesicular system and uses thereof Disclosed is a vesicular system comprising a surface with a vesicle immobilized thereon. The immobilized vesicle has a circumferential membrane of an amphiphilic polymer. The vesicle is coupled to a surface by means of a molecule with a non-polar moiety. The non-polar moiety comprises a main chain of 3 to about 30 carbon atoms and 0 to about 12 heteroatoms selected from Si, O, S, and Se. The molecule with the non-polar moiety is coupled to the surface via a covalent or non-covalent bond. A portion of the non-polar moiety is integrated in the circumferential membrane.
US8906678 Use of markers of undifferentiated pluripotent stem cell The disclosure relates to methods of binding and identifying undifferentiated pluripotent stem cells and particularly, although not exclusively, to use of binding moieties which bind to PHB on the surface of undifferentiated pluripotent stem cells, such as PHB-binding peptides, and to methods for depleting undifferentiated stem cells from a sample.
US8907055 Mutant sox proteins and methods of inducing pluripotency There is presently provided mutant Sox2, Sox7 and Sox17 proteins that have acquired or increased ability to induce pluripotency in a partially differentiated or fully differentiated cell. Sox7 and Sox17 are mutated to resemble in part Sox2, or Sox2 is mutated to resemble in part Sox7 or Sox17. In one aspect, the Oct4 contact interface of Sox7 or Sox17 is mutated. In another aspect, the high mobility group (HMG) of Sox2 is fused to the C-terminal activation domain of Sox7 or Sox17. Methods relating to inducing pluripotency using a mutant Sox2, Sox7 or Sox17 protein are also provided.
EP2102630B1 Encapsulated device with integrated gas permeation sensor An encapsulated device comprising an integrated gas permeation sensor is provided, comprising a base substrate with an electronic component arranged thereon being enclosed within an encapsulation for protecting the electronic component from moisture and/or oxygen; at least one sensor is arranged within the encapsulation to measure the permeation of gas into the encapsulation; each sensor comprises an electrically conductive sensing element comprising a moisture and/or oxygen sensitive material, wherein the reaction of said material with moisture and/or oxygen results in a change in the electrical resistance/conductivity of the sensor.
SG11201406928TA A particle exhibiting catalytic activity A particle exhibiting catalytic activity comprising (a) an inner core formed of an alloy material; and (b) an outer shell formed of a metal material surrounding the inner core, wherein the alloy material is selected such that the inner core exerts a compressive strain on the outer shell.
SG11201406622UA An in vitro method for culturing stem cells There is provided a method for culturing a stem cell in vitro. The method comprises providing a substrate surface coated with a coating comprising a molecule having a catechol moiety or a polymer thereof; and growing a stem cell on said coated substrate surface in a growth medium.
SG11201405715VA Fibrous structure A fibrous structure comprising an assembly of hair follicle cells within a fibrous matrix.
US20140349933A1 Self-assembled composite ultrasmall peptide-polymer hydrogels The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z--(X).sub.m--(Y).sub.n--Z'.sub.p, wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine; Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative; Z' is a C-terminal protecting group; m is an integer selected from 2 to 6; n is selected from 1 or 2; and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents/moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.
EP2342320B1 Chinese hamster ovary cell lines We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in which the CHO cell is obtainable by selection with Ricinus communis agglutinin I (RCA-I).
US8889412 Methods of enhancing pluripotentcy We provide for the use of Tbx3 (GenBank Accession Number: NM_005996.3 (SEQ ID NO. 1), NP_005987.3 (SEQ ID NO. 2), NM_016569.3 (SEQ ID NO. 3), NP_057653.3 (SEQ ID NO. 4)) in a method of enhancing or inducing pluripotency in a cell such as a somatic cell. We describe a method of reprogramming a cell, the method comprising modulating the expression and/or activity of Tbx3 in the cell. The cell may become a pluripotent cell such as a stem cell. We further describe a method of causing a cell such as a somatic cell to display one or more characteristics of a pluripotent cell, the method comprising modulating the expression and/or activity of Tbx3 in the cell. The method may further comprise modulating the expression and/or activity of one or more, a combination of or all of Oct4, Sox2 and Klf4 in the cell.
SG10201403064QA A method for the systematic evaluation of the prognostic properties of gene pairs for medical conditions, and certain gene pairs identified A method of obtaining cut-off expression values should be selected so as to maximise the separation of the respective survival curves of the two groups of patients. Pairs of genes are statistically significant genes are generated by generating a plurality of models, each of which represents a way of partitioning a set of subjects based on the optimal cut-off expression values of the pair of genes. Those gene pairs are identified for which one of the models has a high prognostic significance. Novel survival significant gene sets forming functional modules which could be used to develop specific prognostic and predictive tests are derived.
US8871686 Methods of identifying a pair of binding partners The invention relates to methods of identifying a binding partner of a target molecule within a plurality of analyte molecules, including a plurality of peptides and/or proteins. The target molecule is physically combined with a target labeling nucleic acid molecule. Each member of the plurality of analyte molecules is physically linked to an analyte labeling nucleic acid molecule, each analyte labeling nucleic acid molecule comprising a selected nucleotide sequence. This specific nucleotide sequence may include a sequence encoding a peptide/protein combined therewith. The target molecule is contacted with the analyte molecules and a complex between the target molecule and an analyte molecule forms. The mixture is subdivided into compartments. The target labeling nucleic acid molecule and the analyte labeling nucleic acid molecule are linked and the plurality of compartments allowed to disintegrate. The linked nucleic acid molecule is retrieved and the sequence determined.
EP2352837B1 Novel polyamino polyketide antibiotics and uses thereof The present invention relates to novel polyamino polyketide antibiotics, methods of their production as well as methods of using these antibiotics, for example, for inhibition or removal of biofilm formation or for treating bacterial infection with these antibiotics.
US8867260 Reading circuit for a resistive memory cell A reading circuit for a resistive memory cell is provided, the circuit including a current source, a precharge switch, a comparator circuit including a first input node (in-node), and a second in-node, the precharge switch configured to couple the current source to the first in-node to apply a precharge voltage during a first reading time period, and to decouple the current source during a second reading time period, the comparator circuit configured to operate during a third reading time period, a memory cell access switch to enable a current flow at least partially during the second and the third reading time periods through a memory cell, the comparator circuit configured to compare a voltage at the first in-node with a reference voltage at the second in-node and to determine a programming state of the memory cell based on the voltage at the first in-node during the third reading time period.
EP2281420B1 Multilayer film for encapsulating oxygen and/or moisture sensitive electronic devices The present invention refers to a multilayer barrier film capable of encapsulating a moisture and/or oxygen sensitive electronic or optoelectronic device, the barrier film comprises at least one nanostructured layer comprising reactive nanoparticles capable of interacting with moisture and/or oxygen, the reactive nanoparticles being distributed within a polymeric binder, and at least one ultraviolet light neutralizing layer comprising a material capable of absorbing ultraviolet light, thereby limiting the transmission of ultraviolet light through the barrier film.
US8862581 Method and system for concentration detection There is a method and a system for concentration detection. The method for concentration detection includes the steps of extracting temporal features from brain signals; classifying the extracted temporal features using a classifier to give a score x1; extracting spectral-spatial features from brain signals; selecting spectral-spatial features containing discriminative information between concentration and non-concentration states from the set of extracted spectral-spatial features; classifying the selected spectral-spatial features using a classifier to give a score x2; combining the scores x1 and x2 to give a single score; and determining if the subject is in a concentration state based on the single score.
CN102144035B By enzymatic hydrolysis and subsequent chemical / enzymatic esterification to produce biodiesel A method for biodiesel production via enzymatic hydrolysis of oils or fats followed by chemical/enzymatic esterification of free fatty acids produced in a hydrolysis step. The process comprises enzymatically hydrolyzing a triglyceride to form a fatty acid and glycerol; and esterifying a lower alcohol with the fatty acid to form biodiesel.
US8853330 Hybrid polymers Described herein are polymers comprising a polyester and at least one polyhedral oligomeric silsesquioxane, wherein the polyester is capable of forming a stereocomplex with a polymer comprising a complimentary polyester and composites thereof.
US8847104 Wafer cutting method and a system thereof A method for cutting a semiconductor wafer by generating a crack within the wafer, and a system thereof, are provided. The method comprises irradiating a laser beam towards a surface of the wafer and converging the laser beam to form a focal point so that a focal volume defined by the focal point and a boundary of the laser beam within the wafer is formed. Energy encompassed within the focal volume causes the wafer located at the periphery of the focal volume to contract faster than the wafer located within the focal volume, thereby generating a crack within the wafer.
US20140272372A1 Layered silicate/polymer composite and a method of forming the same The present invention relates to a method for forming a layered silicate/polymer composite, the composite comprising individual exfoliated silicate layers separated in a continuous polymer matrix, wherein the polymer is a hydrophobic polymer, the method comprising: exfoliating sheet silicate in water to form a silicate suspension; replacing the water in the silicate suspension by an organic solvent to form a silicate/organic solvent suspension; contacting the silicate/organic solvent suspension with a solution of a hydrophobic polymer precursor in an organic solvent to form a silicate/polymer precursor suspension; coating the silicate/polymer precursor suspension on a substrate; removing the organic solvents; curing the hydrophobic polymer precursor of the coating of the silicate/polymer precursor; and annealing the cured coating to form the layered silicate/polymer composite on the substrate.
US8838094 Acquiring information from volatile memory of a mobile device According to various embodiments, there is provided a method of acquiring information from volatile memory of a mobile device, the method including: accessing the volatile memory of the mobile device used by an application operating on the mobile device to store communicated information with a communication device; acquiring a copy of data present in the volatile memory; and analyzing the copy of data to extract the communicated information.
US8833165 Miniaturized piezoelectric accelerometers The miniaturized piezoelectric accelerometer includes a support frame (102) having a cavity (104) and a seismic mass (108) supported by a plurality of suspension beams (110) extending from the support frame (102). Each of the suspension beams (110) has a piezoelectric thin film coated on a top surface thereof, with a pair of inter-digital electrodes (114) deposited on an upper surface of each piezoelectric thin film. The presence of acceleration excites bending and thus strain in the piezoelectric thin film, which in turn causes electrical signals to be generated over terminals of the electrodes (114). To collect constructively the output of the electrodes (114), one terminal of each of the electrodes (114) is routed to and electrically connected at a top surface (308) of the seismic mass (108).
US8829765 Piezoelectric actuator device A piezoelectric actuator device includes a substrate anchor region; a support beam arrangement having first and second ends, wherein the first end is fixed to the anchor region and the second end is freely suspended; first and second beams having first and second ends, wherein the first end of each beam is mechanically fixed to at least a part of the second end of the support beam arrangement and the second end of each beam is freely suspended; a coupling beam mechanically coupling the second end of the first and second beams; wherein the first and second beams are arranged such that the first end of the support beam arrangement is located between the coupling beam and the second end of the support beam arrangement.
US8823452 GM-ratioed amplifier Embodiments provide a gm-ratioed amplifier. The gm-ratioed amplifier comprises a first input voltage terminal and a second input voltage terminal, a first output voltage terminal and a second output voltage terminal, and an amplifying unit. The amplifying unit may be coupled between the input voltage terminals and the output voltage terminals and may be adapted to supply an output voltage to the output terminals in dependence on an input voltage supplied to the input terminals. The amplifying unit may comprise a gm-load, which comprises a first load branch comprising a first field effect transistor, and a second load branch comprising a second field effect transistor. A first source/drain terminal and a gate terminal of the first field effect transistor may be coupled to the first output voltage terminal, and a first source/drain terminal and a gate terminal of the second field effect transistor may be coupled to the second output voltage terminal. A second source/drain terminal of the first field effect transistor and a second source/drain terminal of the second field effect transistor may be coupled with each other through a first transistor arrangement such that a linearity of response of the output voltage to the input voltage is improved.
US8824759 Correcting axial tilt based on object positions in axial slices of three dimensional image A computer-implemented process is provided for reorienting a three-dimensional (3D) scan image of an object. The object has a generally flat surface. The image is constructed from image data obtained during rotation of the object about a rotation axis, which intersects the plane of the flat surface at an angle. Axial slices of the scan image are obtained, each of which represents a slice of the object that is perpendicular to the rotation axis and comprises a line representing the flat surface of the object. The axial slices are shifted to align lines representing the flat surface in different axial slices, thus forming a reoriented 3D image. Alternatively, an axial tilt angle is determined from the positions of these lines and the image is rotated by the determined angle to form a reoriented 3D image.
SG11201402211TA Method and a communication terminal for modulating a message for transmission in a wireless communication network The present invention is directed to a communication terminal in a wireless communication network. The communication terminal includes a receiver configured to receive a first message comprising a media access control (MAC) frame at a first transmission rate from a communication device in the wireless communication network; a message generator configured to generate a second message in response to the received first message, the second message comprising a control response frame; and a transmitter configured to transmit the control response frame at a second transmission rate, wherein the second transmission rate is lower than or equal to the first transmission rate; and wherein the second transmission rate is dependent on a difference in qualities between downlink communication and uplink communication between the communication device and the communication terminal. Methods of modulating a message for transmission in the wireless communication network are also disclosed.
US8816456 Magnetoresistive device and a method of forming the same According to embodiments of the present invention, a magnetoresistive device is provided. The magnetoresistive device includes a fixed magnetic layer structure having a fixed magnetization orientation along a first easy axis, a free magnetic layer structure having a variable magnetization orientation along a second easy axis, and an offsetting magnetic layer structure having a magnetization orientation along an axis at least substantially non-parallel to at least one of the first easy axis or the second easy axis, wherein the fixed magnetic layer structure, the free magnetic layer structure and the offsetting magnetic layer structure are arranged one over the other. According to further embodiments of the present invention, a method of forming a magnetoresistive device is also provided.
US8819529 Method of communication A method of communication comprising determining whether to use distributing coding between a source (S), relay (R) and destination (D), based on a predetermined transmission rate; if the determination is positive, determining a forward error correction scheme using distributed Alamouti space-time coding, wherein the scheme is determined based on the predetermined transmission rate, a channel signal-to-noise ratio (SNR) and a network topology; relaying coded data from the S to the D using the determined forward error correction.
US8809017 IRES mediated multicistronic vectors This invention relates to nucleic acid molecules comprising at least one nucleic acid sequence encoding for a peptide or protein of interest, at least one nucleic acid sequence encoding for a selectable marker, and at least one IRES sequence, wherein the at least one IRES sequence is located between the at least one nucleic acid sequence encoding for the peptide or protein of interest and the at least one nucleic acid sequence encoding for the selectable marker. Furthermore, this invention relates to host cells comprising such nucleic acid molecule and to methods of recombinant protein expression using such host cells.
US8811527 Ultra-wideband impulse radio transmitter with modulation A transmitter with modulation comprising a phase changing stage having a first switch and a second switch coupled t the first switch, a first transistor and a second transistor individually coupled to the each switch. The transmitter is configured to receive a phase changing signal having a first state and a second state. The first switch is configured t operate in an opposing manner to the second switch such that only the first transistor is configured to be turned on i the first state and only the second transistor is configured to be turned on in the second state upon receipt of the phase changing signal by the switches so as to achieve a change in an output phase of the transmitter when the phase changing signal switches from the first state to the second state.
US8812323 Dialogue system and a method for executing a fully mixed initiative dialogue (FMID) interaction between a human and a machine A method for executing a fully mixed initiative dialogue (FMID) interaction between a human and a machine, a dialogue system for a FMID interaction between a human and a machine and a computer readable data storage medium having stored thereon computer code for instructing a computer processor to execute a method for executing a FMID interaction between a human and a machine are provided. The method includes retrieving a predefined grammar setting out parameters for the interaction; receiving a voice input; analyzing the grammar to dynamically derive one or more semantic combinations based on the parameters; obtaining semantic content by performing voice recognition on the voice input; and assigning the semantic content as fulfilling the one or more semantic combinations.
US8802376 Methods for identifying candidate cytotoxic antibody molecules The disclosure relates to methods for screening candidate antibody molecules which bind to podocalyxin-like protein (PODXL) and/or to undifferentiated pluripotent stem cells and particularly, although not exclusively, to methods for identifying candidate cytotoxic antibody molecules.
US8805467 Probe element and method of forming a probe element A probe element and a method of forming a probe element are provided. The probe element includes a carrier comprising biodegradable and/or bioactive material; and at least one electrode coupled to the carrier.
EP2408903B1 Culture of pluripotent and multipotent cells on microcarriers A method is disclosed for culturing pluripotent or multipotent cells in vitro, the method comprising attaching pluripotent or multipotent cells to a plurality of microcarriers to form microcarrier-cell complexes, and culturing the microcarrier-cell complexes in suspension culture in the presence of a ROCK inhibitor.
US8796234 Crosslinking branched molecule through thiol-disulfide exchange to form hydrogel In a process for forming a hydrogel, a precursor crosslinkable through disulfide bonds for forming the hydrogel is provided in a solution. The precursor comprises a branched molecular structure, which comprises a plurality of branches. At least three of the branches each comprises a disulfide bond. The pH in the solution is adjusted to initiate thiol-disulfide exchange in the precursor, thus crosslinking the precursor through disulfide bonds formed by thiol-disulfide exchange. After the precursor is sufficiently crosslinked to form a hydrogel, the pH in the solution is adjusted to inhibit further thiol-disulfide exchange in the hydrogel. Further, a hydrogel matrix may comprise a polymer substantially crosslinked through disulfide bonds. The polymer may comprise a hydrophobic poly(amido amine) core and an amino-functionalized hydrophilic shell.
SG11201403281SA A layer arrangement and a wafer level package comprising the layer arrangement The invention relates to a layer arrangement and a wafer level package comprising the layer arrangement, and in particular, the layer arrangement comprises a getter layer and further comprises a sacrificial layer. The wafer level package may be used in microelectromechanical systems (MEMS) packaging at a vacuum level of about 10 mTorr or less such as close to 1 mTorr (i.e. MEMS vacuum packaging).
SG2014015028A A method for identification, prediction and prognosis of cancer aggressiveness A survival model, for each of one or more pairs of genes, includes a function of a corresponding measure of the ratio of expression levels of the pairs of genes. For each pair of genes, there is a corresponding a cut-off value, such that patients are classified according to whether the corresponding measure is above or below the cut-off value. It is proposed (in an algorithm called “DDgR”) that the cut-off value should be selected so as to maximise the separation of the respective survival curves of the two groups of patients. It is further proposed that, for each of a number of genes or gene pairs, a selection is made from multiple survival models. The selection is according to whether a proportionality assumption is obeyed and/or according to a measure of data fit, such as the Baysian Information Criterion (BIC). Specific gene pairs identified by the methods are named.
EP1888651B1 Aldehyde conjugated flavonoid preparations There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8 position of the flavonoid A ring. The resulting conjugates may be used to form delivery vehicles to deliver high doses of flavonoids, and may also be used as delivery vehicles to deliver an additional bioactive agent.
US8790633 Polymer coated magnetic particles The invention relates to a polymer comprising a segment of Formula (I): wherein, R is either absent or a linking group, n is an integer greater than 0; and m is an integer from 1 to 6.
US8786484 Analogue to digital converter, an integrated circuit and medical device An analogue to digital converter includes a first input connection to receive a first part of the analogue input signal, a second input connection to receive a second part of the analogue input signal, a first and second plurality of capacitors, each capacitor of the first plurality of capacitors forms a capacitor pair with a corresponding capacitor in the second plurality of capacitors During a sampling period, the first input connection couples the first part of the analogue input signal to a first contact of each capacitor of the first plurality of capacitors and the second input connection couples the second part of the analogue input signal to a first contact of each capacitor of the second plurality of capacitors. Further, a switching array couples a second contact of each capacitor of the first and second plurality of capacitors to a common mode voltage to determine a first bit of a digital output signal.
US8780618 Writing circuit for a magnetoresistive memory cell According to embodiments of the present invention, a writing circuit for a magnetoresistive memory cell is provided. The writing circuit includes a first connecting terminal configured to provide a first electrical signal to switch a variable magnetization orientation of the free magnetic layer from a first magnetization orientation to a second magnetization orientation; a second connecting terminal configured to provide a second electrical signal to switch the magnetization orientation from the second magnetization orientation to the first magnetization orientation; and a sourcing switch configured to provide for a write operation a connection of the first or second connecting terminal to a node coupleable to the magnetoresistive memory cell. The first and second electrical signals have different amplitudes, and the first and second electrical signals are of the same polarity. Further embodiments relate to a memory cell arrangement and a method of writing into a target magnetoresistive memory cell.
US8778401 Mesoporous material excipients for poorly aqueous soluble ingredients The present invention encompasses formulations and methods for producing solid dispersions comprising mesoporous materials with poorly aqueous soluble active ingredients. The active ingredient is formed in the amorphous state and entrapped in the nanosized pores of the mesoporous excipients using a co-spray drying process. The pore walls of mesoporous channels stabilize the amorphous form of active ingredient against re-crystallization. The amorphous active ingredient entrapped in mesoporous channels exhibits good stability during extended storage under stress test conditions and possesses significantly enhanced dissolution rates.
US8773897 Writing circuit for a magnetoresistive memory cell, memory cell arrangement and method of writing into a magnetoresistive memory cell of a memory cell arrangement A writing circuit for a magnetoresistive memory cell is provided. The writing circuit includes a first electrical connecting terminal, a second electrical connecting terminal, a third electrical connecting terminal, a fourth electrical connecting terminal, a first reference potential terminal, a second reference potential terminal, a first switch configured to couple one of the first electrical connecting terminal, the second electrical connecting terminal, the third electrical connecting terminal and the fourth electrical connecting terminal to the magnetoresistive memory cell, and a second switch configured to couple the first reference potential terminal to the magnetoresistive memory cell if the first electrical connecting terminal or the second electrical connecting terminal is coupled to the magnetoresistive memory cell, and to couple the second reference potential terminal to the magnetoresistive memory cell if the third electrical connecting terminal or the fourth electrical connecting terminal is coupled to the magnetoresistive memory cell.
US8767355 Piezoelectric actuator, head gimbal assembly including the same and method of forming the same According to embodiments of the present invention, a piezoelectric actuator is provided. The piezoelectric actuator includes a shear mode piezoelectric material including a first arm and a second arm intersecting each other, the shear mode piezoelectric material having a polarization direction oriented at least substantially along a length of the first arm, wherein the shear mode piezoelectric material has a first surface and a second surface opposite to the first surface, the first surface and the second surface being adapted to undergo a shear displacement relative to each other along an axis at least substantially parallel to the polarization direction in response to an electric field applied between the first surface and the second surface in a direction at least substantially perpendicular to the polarization direction.
US8768245 Cyclic prefix schemes Methods and systems are proposed for transmitting data from a source (110) to a destination (130) via a relay station (120) having multiple antennae (122, 124). The relay station (120) receives from the source a message containing the data and a first cyclic prefix. It does this using each of its antennae (122, 124), so producing multiple respective received signals. In certain embodiments, the relay station (120) removes the first cyclic prefix from the received signals, replacing it with a new one. In other embodiments, the relay station (120) removes only a portion of the first cyclic prefix. In either case, the relay station (120) may apply space-time coding to generate second signals, which it transmits to the destination (130), which extracts the data. Methods are also proposed for estimating parameters of the channel, to enable the destination (130) to decode the data.
US8765388 VHZ for diagnosis and treatment of cancer We provide VHZ for use in a method of treatment, prophylaxis or alleviation of a cancer, such as breast cancer, in an individual. We provide an anti-VHZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to breast cancer comprising means for detection of VHZ expression in the individual or a sample taken from him or her as well as a method of detecting a cancer cell, the method comprising detecting modulation of expression, amount or activity of VHZ in the cell.
US8753687 Particulate hyaluronic acid/flavonoid suspensions for cellular delivery of bioactive agents There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent, for example an anti-cancer agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid, for example a catechin-based flavonoid, wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. The suspension is useful for the delivery of the bioactive agent to cells, including cancer cells. There are also provided a therapeutic formulation comprising the suspension, as well as methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.
US8755106 Microelectromechanical system (MEMS) device, method of operating the same, and method of forming the same A microelectromechanical system (MEMS) device, method of operating the MEMS device, and a method of forming the MEMS device are provided. The MEMS device includes a positioning mechanism and a locking mechanism. The positioning mechanism includes a first arm structure having a first surface and a second surface; a second arm structure having a first surface and a second surface; wherein the first surface of the first arm structure faces the first surface of the second arm structure. The positioning mechanism also includes a first actuator disposed adjacent to the second surface of the first arm structure facing away from the second arm structure; and a second actuator disposed adjacent to the second surface of the second arm structure facing away from the first arm structure. The locking mechanism includes a first pair of locking elements arranged such that each locking element is disposed at two opposite side surfaces of the first arm structure between the first and second surfaces of the first arm structure; and a second pair of locking elements arranged such that each locking element is disposed at two opposite side surfaces of the second arm structure between the first and second surfaces of the second arm structure. The first and second pairs of locking elements are configured to engage with and disengage from the first and second arm structures respectively.
US8742963 Recording circuit and a method of controlling the same A recording circuit is provided. The recording circuit includes a multiplexing circuit configured to receive a plurality of input signals and to produce a multiplexed output signal including the plurality of input signals, and a plurality of sampling circuits electrically coupled in parallel to each other, each sampling circuit being configured to sample a portion of the multiplexed output signal corresponding to an input signal of the plurality of input signals and the sampling circuits configured to alternately produce an output signal corresponding to the sampled portion.
US8741292 Proteins and methods for modulating cell activity The present invention relates to a novel gene encoding a protein termed Coiled Coil Domain Containing 95 (CCDC95) or a peptide fragments thereof. The present invention also relates to the use of CCDC95 in Modulation of RGK small binding protein via altering concentration or sub-cellular localization of RGK small binding protein with CCDC95 or a peptide fragments thereof.
US8735750 Switching device and a method for forming a switching device Embodiments provide a switching device. The switching device includes a substrate, which includes a contact region. The switching device further includes a vertical layer arrangement extending from the substrate next to the contact region. The vertical layer arrangement includes a control layer. The switching device further includes a freestanding silicon cantilever extending vertically from the contact region.
US8725238 Electrocardiogram signal processing system An electrocardiogram signal processing system is provided which includes: a wavelet transformation unit comprising a plurality of outputs, each output being connected to one of a plurality of scales, wherein the wavelet transformation unit is adapted to transform an input electrocardiogram signal into a set of wavelets, each wavelet being output to one of the scales; a plurality of signal processing blocks, each of the signal processing blocks coupled to a respective output of the wavelet transformation unit and configured to receive and process the wavelet from the respective output, wherein the signal processing blocks provide processing functions which differ from one another.
US8715674 Antibodies binding to an intracellular PRL-1 or PRL-3 polypeptide We provide an antibody capable of binding to an intracellular PRL-1 or PRL-3 polypeptide, in which the antibody is capable of binding to an epitope bound by antibody 269, antibody 223 or antibody 318. Such anti-PRL antibodies may be capable of binding to intracellular PRL-1 or PRL-3. They may be suitable for use as therapies against cancer or metastasis thereof, or in clinical diagnosis to identify PRL-3 or PRL-1 positive patients.
US8709722 Methods for detecting DNA-binding proteins There is provided a method for detecting binding of a DNA-binding protein to a target recognition sequence. The method comprises mixing in a reaction buffer a first set of metal nanoparticles, a second set of metal nanoparticles and a DNA-binding protein to form a mixture, and detecting the aggregation state of the mixture of metal nanoparticles. Each set of metal nanoparticles has a conjugated double-stranded DNA molecule having a single-stranded overhang at one end. The single-stranded overhangs of each set of DNA-conjugated metal nanoparticles are complementary to each other such that annealing of the complementary overhangs results in formation of the target recognition sequence that specifically binds the DNA-binding protein. The reaction buffer comprises an ionic species in a concentration sufficient to result in aggregation of the metal nanoparticles upon annealing of the first and second single-stranded overhang.
US8711912 Method, device and computer readable medium for determining whether transmission signals are present in received signals A method is provided for determining whether transmission signals are present in received signals, the method comprising: receiving a first signal via a first radio resource; receiving a second signal via a second radio resource; determining whether a first transmission signal is present in the received first signal based on the received second signal; and determining whether a second transmission signal is present in the received second signal based on the received first signal.
SG11201400867PA Method of producing 5-hydroxymethylfurfural from carbohydrates Disclosed herein is a process for preparing 5-hydroxymethylfurfural comprising the step of contacting a carbohydrate and a Brønsted acid in an alcoholic solvent comprising an alcohol selected from the group consisting of secondary alcohols, tertiary alcohols, aryl alcohols and combinations thereof under conditions to dehydrate the carbohydrate thereby forming a reaction product containing 5-hydroxymethylfurfural.
SG11201400497WA An optical arrangement and a method of forming the same The present invention is directed to an optical arrangement. The optical arrangement includes a substrate, and a plurality of spaced apart elongate nanostructures extending from a surface of the substrate, wherein each elongate nanostructure includes a metal layer on the end distal from the surface of the substrate. The present invention also relates to a method of forming the optical arrangement.
US8696812 Thin films of ferroelectric materials and a method for preparing same Thin films of ferroelectric material with a high mole fraction of Pb(A2+1/3B5+2/3)O3 substantially in a perovskite phase, wherein A is zinc or a combination of zinc and magnesium, and B is a valence 5 element such as niobium or tantalum, have been prepared. Typically, the mole fraction of Pb(A2+1/3B5+2/3)O3 in the ferroelectric material is >0.7. The method for preparing the thin films of ferroelectric material comprises providing a precursor solution containing lead, A2+, and B5+; modifying the precursor solution by addition of a polymer species thereto; applying the modified precursor solution to a surface of a substrate and forming a coating thereon; and (d) subjecting the coating to a heat treatment and forming the film in the perovskite phase. Optimal results have been obtained with PEG200 as the polymer species.
US8691206 Formation of hydrogel in the presence of peroxidase and low concentration of hydrogen peroxide In a process of forming a hydrogel from a mixture comprising hydrogen peroxide (H2O2), horseradish peroxidase (HRP), and a polymer comprising a crosslinkable phenol group, the gelation rate in the solution and the crosslinking density in the hydrogel can be independently adjusted or controlled by selection of the molarity of H2O2 and concentration of HRP in the solution when the molarity of H2O2 is limited to be within a range and the concentration of HRP is limited to be above a threshold. A method for determining the range and threshold is disclosed. The hydrogel may be used to grow cells, in which case, the molarity of H2O2 may be selected to affect the differentiation or growth rate of the cells in the hydrogel. Also, the hydrogel system may be used for sustained delivery of a therapeutic protein, for example in the treatment of liver cancer, fibrosis or hepatitis.
US8686523 Magnetoresistive device A magnetoresistive device having a magnetic junction including a first fixed magnetic layer structure, a second fixed magnetic layer structure, and a free magnetic layer structure, wherein the first second and free magnetic layer structures are arranged one over the other. The first second and free magnetic layer structures have respective magnetization orientations configured to orient in a direction at least substantially perpendicular to a plane defined by an interface between the free magnetic layer structure and either one of the first fixed magnetic layer structure or the second fixed magnetic layer structure. The respective magnetization orientations of the first and the second fixed magnetic layer structures are oriented anti-parallel to each other, and the first fixed magnetic layer structure is a static fixed magnetic layer structure having a switching field that is larger than a switching field of the free magnetic layer structure.
US8687917 Method and apparatus for registration of an atlas to an image A method (100) and an apparatus (200) are disclosed for registering an input image and an atlas. The atlas is warped (130) using non-rigid registration. In particular, boundary displacements of structures in the atlas are calculated (132) which register those structures with equivalent structures in the input image. The boundaries of structures in the atlas are then warped (133) according to their respective boundary displacements using topology preserving propagation of boundary points of the structures.
US8671754 Sensor device In various embodiments, a sensor device is provided. The sensor includes a sensor receiving portion, a sensor arranged in the sensor receiving portion and a cap covering the sensor and the sensor receiving portion. The cap includes a plurality of recesses in the inner side wall of the cap for reducing the pressure measured by the sensor.
US8658099 Integrated apparatus for conducting and monitoring chemical reactions Apparatus for conducting and monitoring chemical reactions comprises a base and a thermal cycler mounted on the base. A plurality of heat-conducting receptacles are mounted on the thermal cycler and in heat-communication therewith. Each receptacle comprises an opaque body defining a bore having an open end, a first window, and a second window. A cartridge is removably mounted on the receptacles. The cartridge comprises a plurality of light-transmitting reaction vessels, and conduits connected to the reaction vessels for processing and transferring fluid. The reaction vessels are received in the bores of the receptacles through the open ends of the bores. A light emitter is mounted on the base for illuminating the reaction vessels through the first windows of the reaction vessels. A light detector is mounted on the base for selectively receiving and detecting light emitted from the reaction vessels through the second windows of the receptacles.
US20140031256A1 Methods of detecting therapeutic exosomes We describe a method of detecting a therapeutic exosome, the method comprising detecting an activity of an exosome. The activity may be selected from the group consisting of: (a) immunodulatory activity; (b) complement inhibition activity; (c) proteasome activity; (d) glycolytic enzyme activity; (e) anti-oxidative activity; (f) extracellular matrix (ECM) modifying activity; (g) NT5E (CD73) ecto-5′-ectonucleotidase activity; (h) ion homeostasis activity; and (i) chaperone activity. If the exosome is detected as having one or more such activities, the exosome is likely to comprise a therapeutic exosome having therapeutic activity.
SG195728A1 System and method for estimating quantum efficiency and spontaneous recombination lifetime A method and system for estimating a quantum efficiency and a spontaneous recombination lifetime of a photonic or photovoltaic device. The method comprises the steps of exciting the device using an excitation signal; measuring an excited signal from the device; calculating correlation coefficients at different respective noise frequencies between noise in the excitation signal and noise in the excited signal; estimating the quantum efficiency based on a high frequency saturation value of the square of the correlation coefficient; and estimating the spontaneous recombination lifetime from a curve fitting of the calculated correlation coefficients.
US8636937 Hierarchical nanopatterns by nanoimprint lithography A method for forming hierarchical patterns on an article by nanoimprinting is disclosed. The method includes using a first mold to form a primary pattern on the article at a first temperature and a first pressure, the first temperature and the first pressure being able to reduce the elastic modulus of the article; and using a second mold to form a second pattern on the primary pattern at a second temperature that is below the article's glass transition temperature, the forming of the second pattern being at a second pressure.
US8630310 Wireless transmission of layered signals in a relay network The wireless transmission of layered signals, in a described embodiment, uses multiple relay nodes (304) to implement cooperative diversity. The method includes: (i) receiving layered signals from a source node (300), (ii) receiving, from a destination node (302), a relay allocation parameter to implement a cooperative relay strategy with one or more other relay nodes (304), and (iii) relaying the layered signals to the destination node (302) using the cooperative relay strategy.
US8629425 Tunable wavelength light emitting diode A light emitting diode and a method of fabricating a light emitting diode, the diode has a first set of multiple quantum wells (MQWs), each of the MQWs of the first set comprising a wetting layer providing nucleation sites for quantum dots (QDs) or QD-like structures in a well layer of said each MQW; and a second set of MQWs, each of the MQWs of the second set formed so as to exhibit a photoluminescence (PL) peak wavelength shifted compared to the MQWs of the first set.
US8624232 Ambipolar polymeric semiconductor materials and organic electronic devices There is provided compounds of formula I, ambipolar semiconductor material derived from such compounds and devices comprising such ambipolar semiconductor material._x000D_ _x000D_ [Da-Acore-Db-Ac-]n  (I)
US8617879 Apparatus for cell or tissue culture The apparatus for cell or tissue culture comprises a base plate (1), an intermediate face (2) and a top plate (3). The intermediate face (2) is removably sandwiched between the base plate (1) and the top plate (3). The base plate (1) has a circumferential wall (13), a base (14) and a top wall (16). The top wall (16) of the base plate (1) comprises a plurality of recesses (12) arranged in n lines, wherein n is an integer from 1 to about 25. Each line of recesses (12) ranges from a first recess to a last recess. Each recess has a circumferential recess wall (15), which has one recess inlet and one recess outlet (40, 41). The circumferential wall (13) comprises a number of 2 n ports (11). Each port (11) is coupled to a single line of recesses (12). The recesses (12) of each line of recesses are in fluid communication with (i) each other via the recess inlets and a recess outlets (40, 41) and (ii) with a first and a second port (11) of the 2 n ports, such that the first recess of each line of recesses is coupled to a first port and the last recess of each line of recesses is coupled to a second port. The intermediate face (2) has a plurality of recesses (21) arranged in m lines, fitted into the plurality of recesses (12) of the top wall (16) of the base plate (13). m is an integer from 1 to about 25 equal to or smaller than n. The recesses (21) of the intermediate face (2) have water permeability. The top plate (3) is reversibly sealed to the intermediate face (2) and the intermediate face (2) is reversibly sealed to the base plate (1). Thus the recesses (12) of the top wall (16) of the base plate (1) define culture chambers. Each culture chamber has a circumferential wall defined by the recess wall (15) and a removable top, which is defined by a portion of the top plate (3).
SG194165A1 Analog-to-digital converter According to embodiments of the present invention, an analog-to-digital converter is provided. The analog-to-digital converter includes an input configured to receive an input signal, a feed-forward path connected to the input configured to feed forward the input signal, a processing path including a loop filter, wherein the loop filter includes at least one local feedback path configured to feed back an output signal of the loop filter to an input of the loop filter, a first combiner configured to combine the input signal fed forward by the feed-forward path with an output of the processing path, a quantizer configured to generate an output signal of the converter, a feed-back path configured to feed back the output signal, and a second combiner wherein the processing path is connected to the second combiner and the second combiner is configured to combine the input signal with the fed back output signal of the converter and supply the result of the combination to the processing path.
US8603917 Method of processing a wafer According to embodiments of the present invention, a method of processing a wafer is provided. The wafer includes a plurality of through-wafer interconnects extending from a frontside surface of the wafer to a backside surface of the wafer. The method includes removing a part of wafer material of the back-side such that a portion of the wafer material between the through-wafer interconnects is removed, thereby exposing a portion of the through-wafer interconnects, forming a layer of low-k dielectric material between the through-wafer interconnects, and planarizing the layer of low-k dielectric material such that a surface of the portion of the through-wafer interconnect is exposed.
US8603810 T-cell having a T-cell receptor that recognizes epitope HBC18-27 of hepatitis B viral core antigen There is provided at least one isolated cell comprising at least one HBV epitope-reactive exogenous T cell receptor and/or fragment thereof, and methods for producing them. In particular, there is provided polynucleotides, constructs and vectors encoding at least one HBV epitope-reactive exogenous T cell receptor for use in the treatment of Hepatitis B Virus (HBV) and Hepatocellular Carcinoma (HCC). The invention further provides kits and methods of detection of HBV and HCC.
US8603825 Sensor for measuring gas permeability of a test material A sensor for measuring gas permeability of a test material, comprising: an electrically conductive sensing element that comprises a water and/or oxygen sensitive material, wherein the reaction of said material with water or oxygen when the sensing element is contacted with water and/or oxygen results in a change in the electrical conductivity of the sensing element, and two electrodes electrically connected to the sensing element.
SG194332A1 Accelerometers and methods of fabricating thereof The present invention is directed to an accelerometer including a pivot arm having a first end region and a second end region opposite to the first end region; a pivot coupled to the pivot arm; an annular predefined mass having a peripheral part coupled to the first end region or the second end region of the pivot arm, a first capacitive sensor located at the first end region of the pivot arm; and a second capacitive sensor located at the second end region of the pivot arm such that the pivot is arranged between the first capacitive sensor and the second capacitive sensor, wherein the predefined mass is configured to move in response to an acceleration force along a predefined direction; and wherein the first and second capacitive sensors are configured to determine a differential capacitance value relating to the acceleration force. Method of fabricating an accelerometer is also disclosed.FIG. 5A
SG194265A1 A system for learning trail application creation According to one aspect, there is provided a server configured to create alearning trail application for a geographic area, the server including a processor configured to: provide a template having a plurality of fields, each performing a specific function, the plurality of fields comprising a location field and an image archive field, the location field configured to receive the geographic area and the image archive field configured to receive images; receive template data for placement as the content of one or more of the plurality of fields; receive instructions for determining the placement of the template data into one or more of the plurality of fields; and generate the learning trail application from the template with the received template data, wherein during execution of the learning trail application, the learning trail application is configured to receive at least one input image, determine whether a match exists between the input images and the content in the image archive field and display the template data associated with the content in the image archive field, when a match exists. Figure 3A
SG193995A1 A method, an apparatus and a computer-readable medium for indexing a document for document retrieval Various embodiments provide a method for indexing a document for document retrieval. The document may include: generating a document vector indicating if each of a plurality of terms are present in the document; calculating a document semantic inference vector for each of the plurality of terms present in the document using the document vector and a semantic relation matrix, the semantic relation matrix identifying semantic relationships between different terms of the plurality of terms; and, indexing the document using a document semantic context inference vector calculated based on the document semantic inference vectors. Various embodiments provide a corresponding apparatus and computer readable medium.
US8583225 System and method for detecting skin penetration A system and method for detecting skin penetration. The system comprises an invasive component for penetrating the skin; a dummy electrode for making contact with the surface of the skin; at least one penetrating electrode disposed in the invasive component; and a Wheatstone bridge circuit; wherein a resistance across the dummy electrode and the penetrating electrode constitutes one of the resistive legs of the Wheatstone bridge circuit and skin penetration of the invasive component is detected based on a differential output voltage from the Wheatstone bridge circuit.
CN101432073B Polyimidazolium salts and poly-N-hc-metal complexes The invention provides a polymeric salt, wherein the monomer unit of the polymeric salt comprises two nitrogen containing heterocyclic groups joined by a rigid linker group. The nitrogen atoms of the heterocyclic groups are disposed so as to enable a polymeric carbene formed by from the polymeric salt to complex with a metal atom. The invention also provides a polymeric metal complex which may be made from the polymeric salt, and which may be used in a Suzuki coupling reaction. The polymeric salt may be used as a heterogeneous organic catalyst for cyanation reaction.
US8541016 Cell-adhesive, enzymatically crosslinked flavonoid hydrogels and methods for making same There are provided methods for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid, formed from a reaction using peroxide and peroxidase. Hydrogels produced by such methods and methods of using the hydrogels are also provided.
US8537353 Sensor chip for biological and chemical sensing A sensor chip comprising:
    • a micro/nanofluidic channel;
    • at least one nanostructure provided in said channel along an optical path for the transmission of a light beam;
    • a light transparent element disposed along the optical path and arranged to allow transmission of light onto said nanostructure; and
    • a non-transparent element surrounding at least a portion of said optical path to at least partially reduce light scatter from the optical path.
US20130237613A1 Sugar-based surfactant microemulsions containing essential oils for cosmetic and pharmaceutical use The present invention relates to a thermodynamically stable, biocompatible, environment friendly, and temperature-insensitive microemulsion containing various botanical essential oils, sugar based surfactants, polyhydric alcohols, and an aqueous phase.
US8524174 Fluid cartridge, pump and fluid valve arrangement A fluid cartridge, comprising a channel layer within which at least one circumferentially sealed fluid channel is formed, the channel layer comprising a substrate and an elastic layer fixedly arranged on the substrate, wherein the substrate has a rigidity being greater than that of the elastic layer, and wherein the at least one fluid channel is defined on at least one side thereof by the elastic layer.
SG191246A1 Modified human CMV promoters that are resistant to gene silencing The invention relates to a nucleic acid molecule comprising a functional promoter of a herpesvirus, a functional enhancer of a herpesvirus, and one or more internal elements of the CpG island of the aprt (adenine phosphoribosyl transferase) gene and/or a functional variant thereof. A method of producing a desired polypeptide using the nucleic acid molecule, a vector and a host cell containing the nucleic acid molecule are also disclosed.
US8496796 Composite films comprising carbon nanotubes and polymer A process for forming a composite film on a substrate comprises providing a suspension comprising an ionised polymer and functionalised carbon nanotubes in a solvent, at least partially immersing the substrate and a counterelectrode in the suspension, and applying a voltage between the substrate and the counterelectrode so as to form the composite film on the substrate. Electrical charges on the polymer and on the nanotubes have the same sign and the voltage is applied such that the charge on the substrate has the opposite sign to the charge on the polymer and the nanotubes.
EP1684738B1 Inhibitors of yeast filamentous growth and method of their manufacture The invention broadly relates to the use of alpha, beta-unsaturated fatty acids to inhibit the filamentous growth of fungi and yeasts and to a method for producing same. In particular the invention relates to the use of optionally substituted C8 to C15 alpha, beta-unsaturated fatty acids or salts, esters or amides thereof for inhibiting or retarding the yeast-to-mycelium transition of organisms having a dimorphic life cycle.
US8492552 N-heterocyclic carbene metallacycle catalysts and methods The present invention generally relates to materials and methods for catalytic reactions, including transition metal-catalyzed cross-coupling reactions. The materials may be stable metal complexes that do not require special handling or processing conditions. In some cases, materials of the invention advantageously may be synthesized in one synthetic step without the need for isolation of intermediate compounds. Also, materials of the invention may be synthesized from inexpensive and readily available starting materials, under relatively mild reaction conditions that do not require the exclusion of air, water, and the like. In some embodiments, the material is a N-heterocyclic carbene metallacycle complex. Such materials and methods may be useful in the production of fine chemicals, advanced materials and specialty polymers.
US8486903 TAZ/WWTR1 for diagnosis and treatment of cancer We provide an anti-TAZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to breast cancer comprising means for detection of TAZ expression in the individual or a sample taken from him or her as well as a method of detecting a cancer cell, the method comprising detecting modulation of expression, amount or activity of TAZ in the cell.
GB2465907B Vhz for diagnosis and treatment of cancer We provide VHZ for use in a method of treatment, prophylaxis or alleviation of a cancer, such as breast cancer, in an individual. We provide an anti- VHZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to breast cancer comprising means for detection of VHZ expression in the individual or a sample taken from him or her as well as a method of detecting a cancer cell, the method comprising detecting modulation of expression, amount or activity of VHZ in the cell.
SG190064A1 A piezoelectric resonator According to embodiments of the present invention, a piezoelectric resonator is provided. The piezoelectric resonator includes a piezoelectric substrate, a first electrode comprising a first plurality of electrode fingers, a second electrode comprising a second plurality of electrode fingers, wherein the first plurality of electrode fingers and the second plurality of electrode fingers are interdigitated, and wherein electrode patches are arranged along the first plurality of electrode fingers and the second plurality of electrode fingers according to a 2-dimensional lattice.
US8470211 Ferroelectric ceramic material with a low sintering temperature The present invention provides new ferroelectric ceramic materials which can be sintered at a temperature lower than that of the conventional ferroelectric ceramic materials and upon sintering, devices formed of the new ferroelectric ceramic materials possesses excellent piezoelectric properties which are suitable for many industrial applications. The ferroelectric ceramic material includes a composition with a general formula of wPb(Ni1/3Nb2/3)O3-xPb(Zn1/3Nb2/3)O3-yPb(Mg1/3Nb2/3)O3-zPbZrO3-(1−w−x−y−z)PbTiO3, in which 0
CN101547858B Method of functionalizing a carbon material The present invention relates to a method of functionalizing a carbon material. A carbon material is contacted with a carboxylic acid, whereby a mixture is formed. The mixture is heated for a suitable period of time at a temperature below the thermal decomposition temperature of the carbon material.
US8463371 System and method for processing brain signals in a BCI system A system and method for processing brain signals in a BCI system. The method of processing brain signals in a BCI system includes the steps of processing the brain signals for control state detection to determine if a subject intends to use the BCI system; and processing the brain signals for command recognition if the control state detection method determines that the subject intends to use the BCI system.
SG189649A1 Powder feeding nozzle, assembly and method for laser aided additive manufacturing 15POWDER FEEDING NOZZLE, ASSEMBLY AND METHOD FOR LASER AIDED ADDITIVE MANUFACTURINGAn inner nozzle portion for a powder feeding nozzle is provided capable of being coaxially arranged within an outer nozzle portion of the powder feeding nozzle, the inner10 nozzle portion including: an upper section having a plurality of defined shapes on a surface thereof configured to manipulate a stream of powder flowing across said surface of the upper section; and a lower section having a substantially flat conical surface for forming a channel between said substantially flat conical surface and an inner surface of the outer nozzle portion when the inner nozzle portion is coupled to the outer nozzle15 portion, the inner nozzle portion being in communication with a powder inlet for receiving the stream of powder to flow across the surface of the upper section through the channel and towards a powder discharge outlet of the channel. There is also provided a powder feeding nozzle including the inner nozzle portion being coaxially arranged within the outer nozzle portion, an assembly and a method for laser aided additive manufacturing20 including the powder feeding nozzleFIG. 2
US8446947 Method for encoding a digital signal into a scalable bitstream; method for decoding a scalable bitstream A method for encoding a digital signal into a scalable bitstream comprising quantizing the digital signal, and encoding the quantized signal to form a core-layer bitstream, performing an error mapping based on the digital signal and the core-layer bitstream to remove information that has been encoded into the core-layer bitstream, resulting in an error signal, bit-plane coding the error signal based on perceptual information of the digital signal, resulting in an enhancement-layer bitstream, wherein the perceptual information of the digital signal is determined using a perceptual model, and multiplexing the core-layer bitstream and the enhancement-layer bitstream, thereby generating the scalable bitstream. A method for decoding a scalable bitstream into a digital signal comprising de-multiplexing the scalable bitstream into a core-layer bitstream and an enhancement-layer bitstream, decoding and de-quantizing the core-layer bitstream to generate a core-layer signal, bit-plane decoding the enhancement-layer bitstream based on perceptual information of the digital signal, and performing an error mapping based on the bit-plane decoded enhancement-layer bitstream and the de-quantized core-layer signal, resulting in an reconstructed transformed signal, wherein the reconstructed transformed signal is the digital signal.
SG188777A1 A sensor device In various embodiments, a sensor device is provided. The sensor includes a sensor receiving portion, a sensor arranged in the sensor receiving portion and a cap covering the sensor and the sensor receiving portion. The cap includes a plurality of recesses in the inner side wall of the cap for reducing the pressure measured by the sensor.Figure 1
SG188770A1 A process for making a patterned metal oxide structure A Process for Making a Patterned Metal Oxide StructureAbstractThere is provided a process for making a patterned metal oxide structure comprising the step of heating an imprint structure comprising a polymerized organometallic compound to remove organic material and thereby form the patterned metal oxide structure, wherein the imprintstructure is formed by polymerizing a resist mixture comprising at least one olefinic polymerizable compound and a polymerizable organometallic compound having, e.g., at least one carboxylate of Fo/mula 1:[err]Formula 1whereinn is 1-12; andeach R is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloakenyl, aryl, and aralkyl.(Fig. 1)
SG188757A1 A method for forming a piezoelectric device A Method For Forming A Piezoelectric Device AbstractThere is provided a method for forming a piezoelectricdevice comprising the steps of: (a) depositing a first electrode layer; (b) depositing a piezoelectric material layer on the first electrode layer to thereby cover the first electrode layer while leaving a region of the firstelectrode layer uncovered; (c) depositing a second electrode layer on the piezoelectric material layer; (d) depositing a piezoelectric material layer on the second electrode layer to thereby cover the second electrode layer while leaving a region of the second electrodelayer uncovered; and (e) repeating steps (a) to (c), and optionally step (d), to build multiple repeating first electrode layers separated from the second electrode layers by piezoelectric material layers, wherein all of the uncovered regions of the first electrode layersconverge at a point A to integrally form a first electrode and all of the uncovered regions of the second electrode layers converge at a point B to integrally form a second electrode in which point A is displaced at a distance from point B.(Fig. 1(S) and Fig. 1(t))
SG188738A1 A recording circuit and a method of controlling the same 5 According to embodiments of the present invention, a recording circuit is provided. Therecording circuit includes a multiplexing circuit configured to receive a plurality of input signals and to produce a multiplexed output signal including the plurality of input signals, and a plurality of sampling circuits electrically coupled in parallel to each other, each sampling circuit being configured to sample a portion of the multiplexed output signal10 corresponding to an input signal of the plurality of input signals and the sampling circuits configured to alternately produce an output signal corresponding to the sampled portion.Figure 4A
SG188840A1 A plasmonic detector and method for manufacturing the same A plasmonic detector and method for manufacturing a plasmonic detector. The plasmonic detector comprises two nanoscale metallic rods coupled to a bias voltage; a nanoscale cavity formed between adjacent ends of the two nanoscalemetallic rods; and an absorption material disposed in the nanoscale cavity for converting an electromagnetic field to an electric current for outputting via the nanoscale metallic rods.FIG. 1
US8433009 Method for determining as to whether a received signal includes a data signal A method of determining as to whether a received signal includes a data signal is provided. The method provided includes determining a first value based on a cyclic auto-correlation of the received signal and determining a second value based on the cyclic auto-correlation of the received signal. The method provided further includes determining as to whether a received signal includes a data signal based on a comparison of the first value and the second value.
US20130095054A1 copolymers Described herein are copolymers comprising at least one first water-soluble monomeric unit, at least one second water-soluble monomeric unit, and at least one monomeric unit containing a basic residue.
US8410165 Aldehyde conjugated flavonoid preparations There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8 position of the flavonoid A ring. The resulting conjugates may be used to form delivery vehicles to deliver high doses of flavonoids, and may also be used as delivery vehicles to deliver an additional bioactive agent.
SG188068A1 Method for detecting DNA-binding proteins There is provided a method for detecting binding of a DNA-binding protein to a target recognition sequence. The method comprises mixing in a reaction buffer a first set of metal nanoparticles, a second set of metal nanoparticles and a DNA-binding protein to form a mixture, and detecting the aggregation state of the mixture of metal nanoparticles. Each set of metal nanoparticles has a conjugated double-stranded DNA molecule having a single-stranded overhang at one end. The single-stranded overhangs of each set of DNA-conjugated metal nanoparticles are complementary to each other such that annealing of the complementary overhangs results in formation of the target recognition sequence that specifically binds the DNA-binding protein. The reaction buffer comprises an ionic species in a concentration sufficient to result in aggregation of the metal nanoparticles upon annealing of the first and second single-stranded overhang.Fioure 1
SG188067A1 Process for forming nickel molds [00105] For forming a nickel mold, a metal and a corresponding etchant areselected such that the etchant selectively etches the metal over nickel. The metal is sputtered onto a surface of a template having nano-structures to form a sacrificial layer covering the nano-structures. Nickel is electroplated onto the sacrificial layer to form a nickel mold, but leaving a portion of the sacrificial layer exposed. The sacrificial layer is contacted with the etchant through the exposed portion of the sacrificial layer to etch away the sacrificial layer until the nickel mold is separated from the template. Subsequently, the nickel mold may be replicated or scaled-up to produce a replicate mold by electroplating, where the replicate mold has nano-structures that match the nano-structures on the template. The metal may be copper.FIGURE 1C
SG187667A1 Microfabricated scaffold structures The present invention relates to a method for producing a three-dimensional scaffold construct comprising encapsulated cells, the method comprising: (a) providing a solution comprising cells, a photoinitiator, and a plurality of units capable of forming polymer chains; (b) providing a photolithography instrument comprising a two-photon laser; and (c) using the instrument to apply the laser to the solution to activate the photoinitiator thereby facilitating polymerisation of said units to form polymer chains, and, cross-linking of the polymer chains; wherein the laser is applied to the solution in three-dimensions in a pre-defined pattern to assemble said construct, and said cells are encapsulated within the assembled construct.
US20130061739A1 Energy dissipation composite material A composite material able to dissipate the kinetic energy of a moving object comprising a layer of ballistic material bonded to a layer of porous matrix material which is impregnated with shear thickening fluid.
US8389277 Forming cell structure with transient linker in cage In a method of forming a cellular structure, cells and a transient linker are supplied to a volume partially enclosed by a cage. The linker facilitates initial attachment of adjacent cells to form a cell aggregate. The cage defines distributed openings that are sized to retain the cell aggregate. A fluid comprising a cell culture medium is supplied to the volume. The fluid is withdrawn from the volume through the openings. Aggregated cells retained in the volume are cultured to form a cell structure. A cell culturing device is provided which comprises a conduit and a cage in the conduit. A fluid flows in the conduit. The fluid comprises the cells, the transient linker and the cell culture medium. The cage retains aggregated cells formed in the fluid, and defines distributed openings that allow the fluid to flow through.
EP1730490B1 A sensor for measuring gas permeability of a test material A sensor for measuring gas permeability of a test material, comprising: an electrically conductive sensing element that comprises a water and/or oxygen sensitive material, wherein the reaction of said material with water or oxygen when the sensing element is contacted with water and/or oxygen results in a change in the electrical conductivity of the sensing element, and two electrodes electrically connected to the sensing element.
US8377570 Poly(arylenevinylene) and poly(heteroarylenevinylene) light emitting polymer and polymer light-emitting devices The invention provides novel luminescent poly(arylenevinylene) and poly(heteroarylenevinylene) polymers. The polymers of the invention may be prepared as films and such films may be used as an emissive layer in polymeric light emitting devices. In one embodiment, a bulky aryl group is attached at position (2) of at least one phenylene ring of a poly(phenylenevinylene) backbone. In another embodiment, the bulky aryl is attached at position 3 of at least one 5-membered heteroarylene ring of a poly(heteroarylenevinylene) backbone.
SG186121A1 A photonic crystal fiber sensor A method for sensing, a photonic crystal fiber, a method for fabricating a photonic crystal fiber sensor, and a Surface Enhanced Raman Scattering (SERS) sensing apparatus. The method for sensing comprises the steps of providing a photonic crystal fiber comprising a hollow core and a plurality of cladding holes around the hollow core; providing Surface Enhanced Raman Scattering (SERS) active nanoparticles; and adapting the SERS active nanoparticles and/or the fiber for SERS sensing.
US8343773 Array of microcapsules for controlled loading of macromolecules, nanoparticles and other nanoscale items and a method of fabricating it The invention provides a microcapsule array comprising a plurality of microcapsules immobilized on a surface, optionally in microwells in said surface. Each of the microcapsules comprises an outer layer or shell defining a microcapsule interior, said outer layer having a permeability towards a nanoscale species which is dependent on an environmental condition to which said array is exposed.
US8343443 Fluid processing and transfer using inter-connected multi-chamber device A micro-fluidic device comprises a body. The body defines pneumatic ports, chambers for receiving liquids, and a connecting conduit. Each port is sealed with a seal and is shaped to couple to a pneumatic conduit through the seal. At least some of the chambers each have a top opening and a bottom opening. The top openings are in fluid communication with corresponding ports. The bottom openings are in fluid communication with one another through the connecting conduit, which is above the bottom openings. Selective application of pneumatic pressures to the chambers through the pneumatic conduits can transfer a liquid from one chamber to another through the connecting conduit, for example, for processing bio-samples within the device.
SG185897A1 Method and apparatus for forming structures on a resin METHOD AND APPARATUS FOR FORMING STRUCTURES ON A RESINAbstract5The present invention relates to a method for forming a structure on a resin substrate, the method comprising the steps of: (a) contacting a mold having a defined surface pattern with an ultra-violet (UV) curable10 resin substrate supported on an amorphous, photodegradable polymer substrate, the defined surface pattern forming a structure on the UV curable resin substrate; (b) curing the UV curable resin supported on the amorphous polymer substrate by exposing the UV15 curable resin to UV radiation; and (c) separating the cured resin from the mold. The present invention further provides an apparatus for doing the same.Fig. 120
SG185883A1 A self-powered remote control device 16AbstractA self-powered remote control device5A self-powered remote control device is proposed. The user shakes the remote control device in order to generate electrical power for the device to function. The remote control device has a movable body, such as a steel ball, that is free to move within a larger casing. When the user shakes the remote control device, the steel ball impacts10 against the side of the casing, striking the piezoelectric transducer mounted therein. The electricity generated is then passed through a step-down transformer, rectified by diodes, and then used to charge an electrical storage medium, such as a capacitor. The capacitor utilizes this energy to power an encoder and a wireless signal transmitter. When the user hits a button on the remote control device, the encoder performs an15 encoding operation according to the button pushed, sends the encoded signal to the wireless signal transmitter, and the wireless signal transmitter radiates the encoded signal away from the remote control device.: Fig. 1(a)]20 11111111111111111111111111111111111*162 62*
SG185706A1 An analogue to digital converter, an integrated circuit and a medical device An analogue to digital converter comprises a first input connection to receive a first part of the analogue input signal; a second input connection to receive a second part of the analogue input signal; a first and second plurality of capacitors, each capacitor of the first plurality of capacitors forms a capacitor pair with a corresponding capacitor in the second plurality of capacitors; wherein, during a sampling period, the first input connection couples the first part of the analogue input signal to a first contact of each capacitor of the first plurality of capacitors, the second input connection couples the second part of the analogue input signal to a first contact of each capacitor of the second plurality of capacitors, and a switching array couples a second contact of each capacitor of the first and second plurality of capacitors to a common mode voltage to determine a first bit of the digital output signal.
US8334454 Thin film photovoltaic device The present invention provides a thin film photovoltaic device and a method of forming a thin film photovoltaic device. The thin film photovoltaic device has a substrate, a thin film layer formed on the substrate and first and second electrodes formed on one side of the thin film layer. By applying an electric field over the first and second electrodes, the thin film layer is polarized in a direction parallel to the surface plane of the film. Upon exposure to light, the thin film layer converts light energy into electricity. According to the method, a thin film layer is formed on a substrate. A first electrode and a second electrode are formed on one side of the thin film layer. By applying an electric field over the first and second electrodes, the thin film layer is polarized in a direction parallel to the surface plane of the film.
SG184535A1 A photovoltaic UV detector A photovoltaic UV detector configured to generate an electrical output under UV irradiation. The photovoltaic UV detector comprises a first layer comprising an electrically polarized dielectric thin layer configured to generate a first electrical output under the UV irradiation; and a second, layer configured to form an electrical energy barrier at an interface between the second layer and the first layer so as to generate a second electrical output under the UV irradiation, the second electrical output having a same polarity as the first electrical output, the electrical output of the photovoltaic UV detector being a sum of at least the first electrical output and the second electrical output. The electrically polarized dielectric thin layer may be a ferroelectric thin film, which may comprise PZT or PZLT. The second layer may be a metal and the electrical energy barrier may be a Schottky barrier.
SG184287A1 Facial gender recognition A method and system for building a classifier for use in facial gender recognition, and a method and system for facial image gender recognition. The methods of building a classifier for use in facial image gender recognition and of facial image gender recognition are based on both LBP features and Gabor features.
SG184333A1 Brain- computer interface system and method A system and method for brain-computer interface (BCI) based interaction. The method comprising the steps of: acquiring a person's EEG signal; processing the EEG signal to determine a motor imagery of the person; detecting a movement of the person using a detection device; and providing feedback to the person based on the motor imagery, the movement, or both; wherein providing the feedback comprises activating a stimulation element of the detection device for providing a stimulus to the person. The system comprising: means for acquiring a person's EEG signal; means for processing the EEG signal to determine a motor imagery of the person; means for detecting a movement of the person using a detection device; and means for providing feedback to the person based on the motor imagery, the movement, or both; wherein the means for providing the feedback comprises a stimulation element of the detection device for providing a stimulus to the person.
SG184344A1 A barrier layer, a process of making a barrier layer and uses thereof There is provided a barrier layer comprising silicate chemically coupled to a polymer matrix. There is also provided a process for making the barrier layer and uses thereof.
SG184239A1 A GM-ratioed amplifier Embodiments provide a gm-ratioed amplifier. The gm-ratioed amplifier comprises a first input voltage terminal and a second input voltage terminal, a first output voltage terminal and a second output voltage terminal, and an amplifying unit. The amplifying unit may be coupled between the input voltage terminals and the output voltage terminals and may be adapted to supply an output voltage to the output terminals in dependence on an input voltage supplied to the input terminals. The amplifying unit may comprise a gm-load, which comprises a first load branch comprising a first field effect transistor, and a second load branch comprising a second field effect transistor. A first source/drain terminal and a gate terminal of the first field effect transistor may be coupled to the first output voltage terminal, and a first source/drain terminal and a gate terminal of the second field effect transistor may be coupled to the second output voltage terminal. A second source/drain terminal of the first field effect transistor and a second source/drain terminal of the second field effect transistor may be coupled with each other through a first transistor arrangement such that a linearity of response of the output voltage to the input voltage is improved.
US8320491 Method and system for encoding a data matrix and method and system for decoding an encoded data matrix According to one embodiment of the invention, a method for encoding a data matrix having at least a first component and a second component is provided wherein the value of the first component is determined, the number of bits to be used for encoding the second component is selected based on the value of the first component, the second component is encoded using the selected number of bits, and the first component is encoded.
US8315297 Method, device and computer program for classifying a received signal An embodiment of the invention provides a method for classifying a received signal. The method includes determining a covariance matrix of signal values of the received signal, and determining an eigenvalue matrix of the covariance matrix. The eigenvalue matrix includes the eigenvalues of the covariance matrix. A first function is determined from at least one eigenvalue of the eigenvalues of the covariance matrix. A second function is determined from at least one eigenvalue of the eigenvalues of the covariance matrix, wherein the second function is different from the first function. Dependent from a comparison between a value of the first function and a value of the second function, the received signal is classified into a signal comprising data or into a noise signal.
EP2074666B1 Tunable wavelength light emitting diode A light emitting diode and a method of fabricating a light emitting diode. the diode comprises a first set of multiple quantum wells (MQWs), each of the MQWs of the first set comprising a wetting layer providing nucleation sites for quantum dots (QDs) or QD-like structures in a well layer of said each MQW; and a second set of MQWs, each of the MQWs of the second set formed so as to exhibit a photoluminescence (PL) peak wavelength shifted compared to the MQWs of the first set.
SG184051A1 Method of producing recombinant proteins with mannose- terminated n-glycans We describe a method of expressing a recombinant protein comprising mannose- terminated N-glycans from a host cell, the method comprising: (a) introducing a nucleic acid encoding a recombinant protein into a Chinese Hamster Ovary (CHO) cell comprising a mutation in the GnT 1 gene (GenBank Accession Number AF343963) leading to loss of GnT 1 function; and (c) expressing the recombinant protein from the host cell, in which the expressed recombinant protein comprises a mannose-terminated glycan structure, and in which the method does not include a step of introducing functional GnT-1 into the host cell. The method may be used for producing recombinant glucocerebrosidase with a mannose- terminated glycan structure, suitable for treatment or prevention of Gaucher' s Disease.
SG184064A1 A process for forming a laminated structure There is provided a process for forming a laminated structure, the process comprising the step of bonding a polymer film to an array of structures disposed on a substrate, and wherein a plurality of cavities are formed between the polymer film and the array of structures during the bonding.
US8298467 Method of low temperature imprinting process with high pattern transfer yield The present invention is directed to novel methods of imprinting substrate-supported or freestanding structures at low cost, with high pattern transfer yield, and using low processing temperature. Such methods overcome many of the above-described limitations of the prior art. Generally, such methods of the present invention employ a sacrificial layer of film.
US8300904 Method and device for determining a similarity value between minutiae templates Embodiment of the invention provide a method and a device for determining a similarity value between a first template and a second template. A first cluster characteristic for each first cluster of a plurality of first clusters is determined, wherein each first cluster includes a plurality of first minutiae comprised in the first minutiae template. A second cluster characteristic for each second cluster of a plurality of second clusters is determined, wherein each second cluster includes a plurality of second minutiae comprised in the second minutiae template. The similarity value between the first minutiae template and the second minutiae template is determined based on the first cluster characteristics and the second cluster characteristics.
US8300226 Method for detecting surface plasmon resonance There is disclosed a method and system for detecting a surface plasmon resonance associated with a fluid sample. The method includes the step of providing a piezoelectric substrate having at least two electrodes thereon, wherein at least one of said electrodes is coupled to a fluid sample. A light beam is transmitted toward the fluid sample to induce a oscillation frequency in the piezoelectric substrate. The oscillation frequency from said electrodes is then measured during transmittance of the light to detect the surface plasmon resonance associated with the fluid sample.
EP2082512B1 Method for selecting transmission parameters for a data transmission and data transmission controller A method for selecting transmission parameters for a data transmission is provided comprising determining, for each of a plurality of transmission parameter settings, a data throughput that is expected when the transmission parameter setting is used for data transmission, wherein the data throughput is determined using a pre-generated mapping of transmission parameter settings to data throughputs and selecting a transmission parameter setting based on the determined expected data throughputs.
US8287906 Formation of hydrogel in the presence of peroxidase and low concentration of hydrogen peroxide In a process of forming a hydrogel from a mixture comprising hydrogen peroxide (H2O2), horseradish peroxidase (HRP), and a polymer comprising a crosslinkable phenol group, the gelation rate in the solution and the crosslinking density in the hydrogel can be independently adjusted or controlled by selection of the molarity of H2O2 and concentration of HRP in the solution when the molarity of H2O2 is limited to be within a range and the concentration of HRP is limited to be above a threshold. A method for determining the range and threshold is disclosed. The hydrogel may be used to grow cells, in which case, the molarity of H2O2 may be selected to affect the differentiation or growth rate of the cells in the hydrogel.
US8283028 Forming porous scaffold from cellulose derivatives Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores.
US8283622 Method and apparatus for testing magnetic properties of magnetic media A method and apparatus for testing a magnetic medium. The method comprises applying a magnetic field of a time-varying strength; directing a polarized optical beam towards a portion of the medium that is in the magnetic field, wherein the optical beam is reflected by a surface of the medium at a point of incidence in the magnetic field; moving the medium relative to the optical beam so as to cause the point of incidence to repeatedly traverse each of a plurality of sectors along a track on the surface; obtaining a series of Kerr signal measurements of the reflected optical beam; grouping measurements into ensembles such that the measurements in an individual ensemble are those obtained while the point of incidence was in a corresponding one of the sectors; and determining at least one magnetic property of at least one of the sectors from the measurements in the corresponding ensemble.
US8285757 File system for a storage device, methods of allocating storage, searching data and optimising performance of a storage device file system A file system for a storage device including a storage region, capable of storing one or more blocks of data; and a first data structure representing free space in the storage region, the first data structure comprising a location and a length of a block of free space in the storage region is disclosed. Methods of allocating storage, searching data and optimizing performance of the storage device file system are also disclosed.
US8278725 Micromechanical structure and a method of fabricating a micromechanical structure A micromechanical structure and a method of fabricating a micromechanical structure are provided. The micromechanical structure comprises a silicon (Si) based substrate; a micromechanical element formed directly on the substrate; and an undercut formed underneath a released portion of the micromechanical element; wherein the undercut is in the form of a recess formed in the Si based substrate.
SG183650A1 A photonic device and method of making the same A Photonic Device and Method of Making the Same 5 AbstractThe present invention relates to a photonic device comprising a plurality of nanostructures that extend from a substrate, each nanostructure comprising a generally longitudinal nanostructure body formed of a semiconductor10 material. Each nanostructure has a proximal end portion of a first crystal lattice structure and a distal end portion of a second crystal lattice structure that is expanded relative to the proximal end portion. Each nanostructure further comprises an optically active15 material optically associated with the distal end portion to form a heterojunction therebetween. The present invention further relates to a method of making the disclosed nanostructures. 20 Fig. 1
SG183367A1 A computer implemented method and apparatus for obtaining an optimal project makespan/cost A computer implemented method/apparatus for obtaining an optimal project makespan or cost is disclosed herein. In a described embodiment, the method includes deriving a critical chain for a project at step (306). The method further includes allocating additional resource to at least one critical task of the critical chain at step (314) to obtain a minimum project makespan and deriving a current project cost for the project based on the minimum project makespan. At step (326), a comparison is made and if the current project cost is equal or less than a predetermined budget, the minimum project makespan is identified as the optimal project makespan at step (332). On the other hand, at step (326), if the current project cost is more than the predetermined budget, then steps (328) (and 330) is performed to adjust the allocation of the additional resource to the at least one critical task to derive a project cost which is equal or less than the budget; the project cost being associated with; a revised project makespan; and the revised project makespan is identified as the optimal project makespan at step (332).
SG183406A1 Fiber-assembled tissue constructs The present invention relates to a fiber-assembled tissue construct comprising at least one sinusoid unit, the unit comprising at least two polymeric fibers arranged in a sinusoid structure and fused together, each of said fibers comprising a porous matrix supporting biological components encapsulated in the fiber, wherein the biological components are patterned in three-dimensions within the construct.
US8263367 Nucleic acid interaction analysis The present invention provides at least one isolated linear composite nucleic acid molecule comprising at least one first tag from at least one first nucleic acid molecule and at least one second tag from at least one second nucleic acid molecule, wherein the first and second nucleic acids interact in a nucleic acid mixture; and wherein the first and second tags are from different nucleic acid molecules. The invention also provides a method of producing at least one isolated linear composite nucleic acid and to a method of detecting and/or identifying nucleic acid interactions.
US8259897 Computed tomography method and apparatus for centre-of-rotation determination A method and apparatus is disclosed for determining the central ray of scanning an object on a detector in a computer tomography system. The method comprises producing a fan beam of x-rays at a fixed x-ray source and detecting the x-rays at the detector. The scanning projection data of the object under examination is received and the object is rotated under examination using a manipulator. After calculating the opposite projection pixel position and projection angle for each pixel, a mismatching is measured between the grey levels of all pixels and their calculated opposite projection pixels with a set of assumed central ray, and identifying the minimum of the measurement as the true central ray.
US8259783 Method of determining as to whether a received signal includes an information signal A method of determining as to whether a received signal includes an information signal is provided. The method provided includes determining a covariance matrix from a received signal and transforming the covariance matrix into a transformed covariance matrix, wherein the transformation is configured such that the transformed covariance matrix is a non-diagonal matrix in case the received signal includes the information signal, wherein the non-diagonal matrix includes non-zero non-diagonal matrix elements. The method provided further includes determining a first function using at least one of the non-zero non-diagonal matrix elements of the transformed covariance matrix, determining a second function using at least one matrix element of the transformed covariance matrix, wherein the second function is different from the first function, and determining as to whether a received signal includes an information signal based on a comparison of a value of the first function and a value of the second function.
SG182719A1 A method of communication A method of communication comprising: at time=t: a first multiple antenna relay node decoding and forwarding a first STBC coded signal from a source node, and a first decoded and forwarded STBC signal from a second multiple antenna relay node, and a destination DSTTD receiver decoding the first STBC coded signal from the source node, and the first decoded and forwarded STBC signal from the second multiple antenna relay node; at time=t+1 : the second multiple antenna relay node receiving a second STBC coded signal from the source node, and a second decoded and forwarded signal from the first multiple antenna relay node, and the destination DSTTD receiver decoding the second STBC coded signal from the source node, and the second decoded and forwarded signal from the first multiple antenna relay node.
SG182860A1 A substrate having an image thereon A Substrate Having An Image ThereonAbstractThere is provided substrate comprising plural nanostructure pixel arrays that are disposed and arranged on the substrate to form an image thereonFig. 4
SG182310A1 System and method of tracking objects A system and a method of tracking objects in a space area are provided. The system includes a plurality of passive radio frequency identification (RFID) tags, each passive RFID tag being disposed on an object; a plurality of active RFID tags, each active RFID tag being disposed at one of a plurality of checkpoints or on one of a plurality of mobile handling equipments in the space area; a plurality of passive RFID readers, each passive RFID reader being disposed at a respective checkpoint or on a respective mobile handling equipment and being configured to communicate with one or more detected passive RFID tags; a plurality of controllers, each controller being disposed at a respective checkpoint or on a respective mobile handling equipment and being configured to communicate with the corresponding passive RFID reader disposed at the checkpoint or on the mobile handling equipment; a plurality of active RFID readers, each active RFID reader being associated with one of a plurality of predefined zones of the space area and being configured to communicate with the active RFID tags of one or more checkpoints and/or the active RFID tags of one or more mobile handling equipments located in the associated predefined zone.
US20120203117A1 Vital signs detecting device and a method for detecting vital signs A vital signs detecting device and a method for detecting vital signs are provided. The vital signs detecting device comprises a detection unit; a multimode optical fiber configured to be connected to a light source and to the detection unit; a mechanical structure configured for receiving a pressure exerted by a person's body as a result of one or more of a group consisting of a movement of the person's body, a respiratory action of the person's body and a heart beat action of the person's body and to cause microbending of the multimode optical fiber under the exerted pressure and; wherein the multimode optical fiber is disposed between first and second sets of microbending elements of the mechanical structure substantially in a direction of the exerted pressure.
SG181671A1 Method and system for single view image 3 d face synthesis A method and system for of single view image 3D face synthesis. The method comprises the steps of a) extracting feature points from the single view image; b) transforming the feature points into 3D space; c) calculating radial basis function (RBF) parameters in 3D space based on the transformed feature points and corresponding points from a 3D generic model; d) applying RBF deformation to the generic 3D model based on the RBF parameters to determine a model for the synthesized 3D face; and e) determining texture coordinates for the synthesized 3D face in 2D image space; wherein step b) comprises symmetrically aligning the feature points, and step e) comprises projecting the generic 3D model or the model for the synthesized 3D face into 2D image space and applying RBF deformation to the projected generic 3D model or the projected model for the synthesized 3D face.
SG181855A1 Microfluidic mixing apparatus and method A microfluidic mixing device for mixing at least two fluids to form a mixed fluid comprising; a first mixing chamber (420) for receiving the fluids from at least two fluid paths (385, 410); a mixing zone (380) upstream from the mixing chamber (420) having a first and second fluid path; said first and second fluid paths overlapping at first and second discreet points so as to provide mutual fluid communication between the first and second paths at said discreet points.
US8216855 Method of processing a biological and/or chemical sample The invention provides a method of processing a biological and/or chemical sample. The method includes providing a fluid droplet, which includes an inner phase and an outer phase. The outer phase is immiscible with the inner phase, and the outer phase is surrounding the inner phase. The inner phase includes the biological and/or chemical sample. The fluid droplet furthermore comprises magnetically attractable matter. The method also includes providing at least one surface, which is of such a texture and such a wettability for the fluid of the inner phase of the fluid droplet, that the fluid droplet remains intact upon being contacted therewith. The method further includes disposing the fluid droplet onto the at least one surface. The method also includes performing a process on the biological and/or chemical sample in the fluid droplet.
US8218694 Method for transmitting a digital signal, method for receiving a digital signal, transmitter and receiver A transmitter (106) for transmitting a signal, the signal comprising a plurality of signal values, the signal values being grouped to at least one signal value block. The transmitter comprises a pre-transformation unit (101) adapted to process each signal value block by a pre-transformation to produce a block of modulation symbols, wherein the pre-transformation comprises a phase rotation of the signal block values, which corresponds to the multiplication of the signal value block with a phase rotation matrix. The transmitter also comprises a modulation unit (102) adapted to modulate at least one carrier signal based on the modulation symbols and a sending unit (104) adapted to send the modulated carrier signal.
US8211869 Methods for cancer therapy and stem cell modulation The present invention relates to a method of modulating pluripotency and/or self-renewing characteristics of a stem/progenitor cell. The method comprises administering to the respective cell a compound of the general formula (I)_x000D_ _x000D_ _x000D_ In the general formula A is C or N. R1, R4 and R5 are, independently selected, H or aliphatic, cycloaliphatic, aromatic, arylaliphatic, or arylcycloaliphatic hydrocarbyl groups, that comprise 0-3 heteroatoms being N, O, S, or Si. R4 and R5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge. R2 is H or a halogen. R3 is H, or an aliphatic or arylaliphatic hydrocarbyl group comprising 1-8 main chain carbon atoms and 0-3 heteroatoms being N, O, S, Si, or a halogen.
US8213754 Optical splitter, combiner and device An optical splitter, a combiner and a device. The optical splitter comprises a first longitudinal waveguide for receiving an incoming light wave; at least first and second pairs of output waveguides, the output waveguides of each pair being disposed on opposite sides of the first waveguide; wherein each of the output waveguides of each pair comprises a longitudinal portion disposed parallel to the first waveguide and such that optical power is coupled from the first waveguide into the respective longitudinal portions and the longitudinal portions of output waveguides of the first and second pairs are displaced along a length of the first waveguide; wherein each of the output waveguides of each pair further comprises a substantially S-shaped portion continuing from the respective longitudinal portions and such that optical power coupling between the respective S-shaped portions of output waveguides of the first and second pairs is substantially inhibited.
US20120164434A1 Multilayer barrier film The present invention refers to a multilayer barrier film comprising a substrate layer coated with a barrier layer, wherein the barrier layer is made of a material selected from the group consisting of a metal oxide, a metal carbide, a metal nitride and a metal oxynitride; a nanostructured metal compound layer arranged on the barrier layer; and a planarising layer arranged on the nanostructured layer, wherein the planarising layer comprises a nanostructured material which is distributed in a polymeric binder, wherein the nanostructured material is made of carbon, or a metal or a metal oxide or a mixture of the aforementioned substances. The present invention also refers to a method of obtaining those multilayer barrier films.
SG180364A1 A transmitter with modulation A transmitter with modulation comprising a phase changing stage having a first switch and a second switch coupled t the first switch, a first transistor and a second transistor individually coupled to the each switch. The transmitter is configured to receive a phase changing signal having a first state and a second state. The first switch is configured t operate in an opposing manner to the second switch such that only the first transistor is configured to be turned on i the first state and only the second transistor is configured to be turned on in the second state upon receipt of the phase changing signal by the switches so as to achieve a change in an output phase of the transmitter when the phase changing signal switches from the first state to the second state.
US8194247 SHG quantification of matrix-related tissue dynamic and disease A microscope for optical imaging of high optical scattering coefficient biological tissue, comprising an optical excitation source for irradiating a scan area of the sample and generating optical emissions, wherein the sample has a first face facing away from the source and a second face facing the source. A two dimensional element for scanning the light over the sample; a focusing element having a numerical aperture NAi to focus the light onto the sample; a first optical condenser to collect light from the first face, the collected light comprising source transmitted light and first optical emission generated in the sample, the condenser having a NA2 larger than NAi; an optical filter to block the transmitted source light; an aperture with a size corresponding to the irradiated area of the sample, the aperture at the conjugate image position of the sample generated by the condenser; and an optical detector collecting light from the first face for detecting the first optical emission from the scan area.
SG180146A1 A method of processing a wafer According to embodiments of the present invention, a method of processing a wafer isprovided. The wafer includes a plurality of through-wafer interconnects extending from a frontside surface of the wafer to a backside surface of the wafer. The method includes removing a part of wafer material of the back-side such that a portion of the wafer material between the through-wafer interconnects is removed, thereby exposing a portion of the through-wafer interconnects, forming a layer of low-k dielectric material between the through-wafer interconnects, and planarizing the layer of low-k dielectric material such that a surface of the portion of the through-wafer interconnect is exposed.Figure 2
US8180623 Integration of a discrete event simulation with a configurable software application In general terms, the invention can be described as a computer system for enhancing the performance of underlying policies and execution-rules of real-world activities. The computer system includes a demand input section for providing demand information to drive the system. A real-time software application has a series of discrete steps for implementing the underlying policies and execution-rules of the activities and converts the demand information into instructions. A simulation-time operations-simulation model implements the underlying policies and execution-rules of the activities and receives the instructions. A control section includes a synchronization clock which synchronizes the discrete steps of the software application with the operations-simulation model by delaying the execution of some of the discrete steps and which communicates the instructions from the software application to the operations-simulation model. An output section outputs data to enhance the performance of the underlying policies and the execution-rules of the activities.
US8163851 Polymeric salts and poly-NHC-metal complexes The invention provides a polymeric salt, wherein the monomer unit of the polymeric salt comprises two nitrogen containing heterocyclic groups joined by a rigid linker group. The nitrogen atoms of the heterocyclic groups are disposed so as to enable a polymeric carbene formed by from the polymeric salt to complex with a metal atom. The invention also provides a polymeric metal complex which may be made from the polymeric salt, and which may be used in a Suzuki coupling reaction. The polymeric salt may be used as a heterogeneous organic catalyst for cyanation reaction.
EP1774684B1 Receiver and method for receiving a digital signal A transmitter (106) for transmitting a signal, the signal comprising a plurality of signal values, the signal values being grouped to at least one signal value block. The transmitter comprises a pre-transformation unit (101) adapted to process each signal value block by a pre-transformation to produce a block of modulation symbols, wherein the pre-transformation comprises a phase rotation of the signal block values, which corresponds to the multiplication of the signal value block with a phase rotation matrix. The transmitter also comprises a modulation unit (102) adapted to modulate at least one carrier signal based on the modulation symbols and a sending unit (104) adapted to send the modulated carrier signal.
US8159413 Double-stacked EBG structure In a double-stacked electromagnetic bandgap (EBG) structure, a first conductive plane and a second conductive plane are spaced apart in parallel. At least two EBG layers are embedded in parallel between the first conductive plane and the second conductive plane. The at least two EBG layers have different stopband characteristics. A plurality of vias connect the at least two EBG layers respectively to one of the first and second conductive planes. At least the vias connecting one of the EBG layers pass through via holes in cells of another EBG layer.
US8159536 Method for detecting desired objects in a highly dynamic environment by a monitoring system A background image is generated based on a captured image. A data cluster is formed in pixel blocks of the background image using at least one feature of pixels in the pixel blocks. A data cluster formed in each pixel block includes a data distribution having a mean value and a standard deviation from the mean value. After generating the background image, each pixel of a subsequent captured image is compared with the data cluster of a pixel block of the background image to generate a first discrepancy value. A pixel of a subsequent image is compared with a data distribution of another adjacent pixel block of the background image to generate a second discrepancy value. Based on the discrepancy values, the pixels of the subsequent image are regarded as background or foreground pixels in a binary map, in which connected foreground pixels are marked to form a foreground object.
US8158355 Method to generate or determine nucleic acid tags corresponding to the terminal ends of DNA molecules using sequences analysis of gene expression (terminal SAGE) A method of providing an indication of an instance of expression of a gene is described herein, the method which may comprise the steps of: (a) providing a complementary deoxyribonucleic acid (cDNA) having a terminus comprising a terminal transcribed sequence of a gene; (b) linking the cDNA to an linker sequence thereby forming a linked nucleic acid, in which the linker sequence comprises a first recognition site for a first nucleic acid cleavage enzyme, preferably a restriction endonuclease, that allows nucleic acid cleavage at a site distant from the first recognition site; and (c) cleaving the linked nucleic acid with the first nucleic acid cleavage enzyme to provide a linked tag, in which the linked tag comprises a nucleotide sequence tag representative of a terminal transcribed sequence of the gene; and (d) detecting the presence or identity of the linked tag or the nucleotide sequence tag to provide an indication of an instance of gene expression.
US8155234 Method for processing a data signal, data processing unit and computer program product A method for processing a data signal received via a communication channel is described, comprising determining a first matrix comprising components describing characteristics of the communication channel and inverting the first matrix by sub-dividing the first matrix into at least four sub matrices, inverting a first sub matrix of the four sub matrices generating a second matrix by multiplying a second sub matrix of the four sub matrices with the inverted first matrix and a third sub matrix of the four sub matrices, determining the difference matrix between the second matrix and a fourth sub matrix of the four sub matrices inverting the difference matrix and calculating the inverted matrix based on the inverted difference matrix. The data signal is processed using the inverted first matrix.
US8148287 Catalyst immobilization on siliceous mesocellular foam via click chemistry The present invention relates to a method for preparing a heterogenised catalyst, comprising grafting a catalyst or catalyst precursor, via click chemistry, to a siliceous mesocellular foam (MCF). The invention also relates to a heterogenised catalyst comprising a catalyst species grafted onto a siliceous mesocellular foam (MCF) via a 1,2,3-triazole.
SG178563A1 Method and system for event detection A method and system for event detection. The system comprising: a plurality of sensors; and respective classifier units coupled to the sensors for processing respective sensor signals from the sensors for the event detection; wherein at least one of the classifier units is adapted for detecting an event based on the sensor signal processed in said at least one classifier unit as a main evidence and for issuing sub-evidence queries to the other classifier units for facilitating the event detection.
SG178326A1 A piezoelectric sensor and a method of fabricating a piezoelectric sensor A piezoelectric sensor comprising a piezoelectric film formed on a surface of an object to be monitored; a plurality of electrodes formed on a surface of the piezoelectric film; and wherein electrical polarization of the piezoelectric film is about coplanar with the surface of the piezoelectric film. A method of forming a piezoelectric sensor. The method comprises forming a piezoelectric film on a surface of an object to be monitored; forming electrodes on a surface of the piezoelectric film; and orientating electrical polarization in the piezoelectric film to be about coplanar with the surface of the piezoelectric film.
US8144827 Method for determining a residual frequency offset, communication system, method for transmitting a message, transmitter, method for processing a message and receiver A method of determining a residual frequency offset between a transmitter and a receiver in a transmission of data via a communication channel, is described, wherein the message is transmitted from the transmitter to the receiver via the communication channel and the message comprises at least one short preamble (201), at least one long preamble (202) and user data (203). The at least one long preamble (202) comprises residual frequency offset determination information based on which the residual frequency offset is determined.
GB2462048B Antibodies binding to an intracellular prl-1 or prl-3 polypeptide We provide an antibody capable of binding to an intracellular PRL-1 or PRL-3 polypeptide, in which the antibody is capable of binding to an epitope bound by an antibody 269, antibody 223 or antibody 318. Such anti-PRL antibodies may be capable of binding to intracellular PRL-1 or PRL-3. They may be suitable for use as therapies against cancer or metastasis thereof, or in clinical diagnosis to identify PRL-3 or PRL-1 positive patients.
US8138163 Aldehyde conjugated flavonoid preparations There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8 position of the flavonoid A ring. The resulting conjugates may be used to form delivery vehicles to deliver high doses of flavonoids, and may also be used as delivery vehicles to deliver an additional bioactive agent.
US8126108 Method and apparatus for reorientated resconstruction of computed tomography images of planar objects A system and method for micro computed tomography (CT) reconstruction of position scan data of planar objects, such as stacked integrated circuit chips and/or PCB, that automatically determines object orientation is disclosed for a preferred orientation of the reconstructed images. The object orientation of the sinogram of the scanning data is determined such that the reconstruction may be performed with any starting position. Additionally, planar object scan reconstructions with either a higher resolution in the thickness dimension without increasing the total computation resource or a faster processing speed under a given resolution in the thickness dimension may be achieved. The tilting angle with respect to the rotation axis may also be determined to perform a image rotation after a multi-slice reconstruction or cone-beam reconstruction.
US8124251 Thin films of ferroelectric materials and a method for preparing same Thin films of ferroelectric material with a high mole fraction of Pb(A2+1/3B5+2/3)O3 substantially in a perovskite phase, wherein A is zinc or a combination of zinc and magnesium, and B is a valence 5 element such as niobium or tantalum, have been prepared. Typically, the mole fraction of Pb(A2+1/3B5+2/3)O3 in the ferroelectric material is >0.7. The method for preparing the thin films of ferroelectric material comprises providing a precursor solution containing lead, A2+, and B5+; modifying the precursor solution by addition of a polymer species thereto; applying the modified precursor solution to a surface of a substrate and forming a coating thereon; and (d) subjecting the coating to a heat treatment and forming the film in the perovskite phase. Optimal results have been obtained with PEG200 as the polymer species.
US8126950 Method for performing a domain transformation of a digital signal from the time domain into the frequency domain and vice versa A method for performing a domain transformation of a digital signal from the time domain into the frequency domain and vice versa, the method including performing the transformation by a transforming element, the transformation element comprising a plurality of lifting stages, wherein the transformation corresponds to a transformation matrix and wherein at least one lifting stage of the plurality of lifting stages comprises at least one auxiliary transformation matrix and a rounding unit, the auxiliary transformation matrix comprising the transformation matrix itself or the corresponding transformation matrix of lower dimension. The method further comprising performing a rounding operation of the signal by the rounding unit after the transformation by the auxiliary transformation matrix.
US8126951 Method for transforming a digital signal from the time domain into the frequency domain and vice versa A method for transforming a digital signal from the time domain into the frequency domain and vice versa using a transformation function comprising a transformation matrix, the digital signal comprising data symbols which are grouped into a plurality of blocks, each block comprising a predefined number of the data symbols. The method includes the process of transforming two blocks of the digital signal by one transforming element, wherein the transforming element corresponds to a block-diagonal matrix comprising two sub matrices, wherein each sub-matrix comprises the transformation matrix and the transforming element comprises a plurality of lifting stages and wherein each lifting stage comprises the processing of blocks of the digital signal by an auxiliary transformation and by a rounding unit.
CN101583559B The method of manufacturing a micromechanical structure and micromechanical structure A micromechanical structure and a method of fabricating a micromechanical structure are provided. The micromechanical structure comprises a silicon (Si) based substrate; a micromechanical element formed directly on the substrate; and an undercut formed underneath a released portion of the micromechanical element; wherein the undercut is in the form of a recess formed in the Si based substrate.
US8114314 Electroconductive curable resins An electroconductive polymer composition comprises a curable liquid thermosetting resin matrix; conductive nano-fibers such as carbon nano-tubes, carbon nano-fibers, metallic nano-fibers or non-conductive nano-fibers with an electrically conductive coating; and a particulate non-conductive phase discontinuously dispersed throughout the thermosetting matrix. The conductive nano-particles are dispersed throughout the matrix whereby when the thermosetting resin is cured, a percolation threshold is established within the thermoset matrix. The particulate non-conductive phase is selected from thermoplastic resin powders or exfoliated particles of nano-clay intercalated with the liquid thermosetting resin.
CN101715552B Instruments and methods of use for processing a sample droplet A device for processing a sample in a liquid droplet containing a hydrophilic liquid is described. The device includes: a circumferential wall and a base including an immobilisation member. The circumferential wall and the base define a reservoir adapted to accommodate a hydrophobic medium immiscible with the liquid droplet. The medium is of a lower surface energy than a liquid of the liquid droplet. The immobilisation member includes a surface with a plurality of hydrophilic immobilisation areas and a hydrophobic area. The plurality of hydrophilic immobilisation areas is: (a) of a higher surface energy than the medium, (b) of a higher surface energy than the hydrophobic area, and (c) of a sufficient surface energy and a sufficient width to allow, in the medium, immobilisation of liquid droplets on the hydrophilic immobilisation areas via interfacial interactions. Methods of using and rinsing the device are also described.
CN101821861B Producing a red phosphorous-based nitride and the Bai Faguang diode A multiple quantum well (MQW) structure for a light emitting diode and a method for fabricating a MQW structure for a light emitting diode are provided. The MQW structure comprises a plurality of quantum well structures, each quantum well structure comprising: a barrier layer; and a well layer having quantum dot nanostructures embedded therein formed on the barrier layer, the barrier and the well layer comprising a first metal-nitride based material; wherein at least one of the quantum well structures further comprises a capping layer formed on the well layer, the capping layer comprising a second metal-nitride based material having a different metal element compared to the first metal-nitride based material.
EP2077620B1 System for scalably encoding and decoding data Systems and methods for scalably encoding and decoding coded data are presented. One exemplary method for scalably coding data includes classifying, based upon at least one predetermined criteria, each of the plurality of data received as either (i) perceptually relevant data or (ii) perceptually irrelevant data. The perceptually relevant data is scalably coded, and the perceptually irrelevant data is non-scalably coded. Subsequently, the scalably coded perceptually relevant data and the non-scalably coded perceptually irrelevant are combined into a coded data stream for transmission.
CN101076851B Spoken recognition system and method for training and operating the system A method for training a spoken language identification system to identify an unknown language as one of a plurality of known candidate languages includes the process of creating a sound inventory comprising a plurality of sound tokens, the collective plurality of sound tokens provided from a subset of the known candidate languages. The method further includes providing a plurality of training samples, each training sample composed within one of the known candidate languages. Further included is the process of generating one or more training vectors from each training database, wherein each training vector is defined as a function of said plurality of sound tokens provided from said subset of the known candidate languages. The method further includes associating each training vector with the candidate language of the corresponding training sample.
US8071296 Nucleic acid interaction analysis The present invention provides an isolated oligonucleotide and a method using the isolated oligonucleotide to detect and/or identify at least two polynucleotides from a nucleic acid-protein complex. The oligonucleotide comprises at least one first tag and at least one second tag, wherein the first and second tags are obtained from a nucleic acid-protein complex.
CN101288232B Methods and devices for decoding and encoding data A method for decoding an input data sequence is provided. The method comprises generating a plurality of test sequences, determining an order for the plurality of test sequences, such that each test sequence differs from its adjacent test sequences by a respective predefined number of bits, and carrying out a maximum likelihood process with the ordered test sequences and the input data sequence thereby generating a maximum likelihood sequence.
US8058258 Methods for cancer therapy and stem cell modulation The present invention relates to a method of inducing apoptosis in a tumour cell as well as modulating pluripotency and/or self-renewing characteristics of a stem/progenitor cell. The method comprises administering to the respective cell a compound of general formula (I). In general formula A is C or N. R1, R4 and R5 are, independently selected, H or aliphatic, cycloaliphatic aromatic, arylaliphatic, or arylcycloaliphatic hydrocarbyl groups, that comprise 0-3 heteroatoms being N, O, S, or Si. R4 and R5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge. R2 is H or a halogen, such as F or Cl. R3 is H, or an aliphatic or arylaliphatic hydrocarbyl group comprising 1-8 main chain carbon atoms and 0-3 heteroatoms being N, O, S, Si, or a halogen such as Cl or F. Also provided is a pharmaceutical composition for inducing apoptosis in a tumour cell and/or modulating pluripotency and/or self-renewing characteristics of a stem/progenitor cell. The pharmaceutical composition comprises a compound as defined above or a pharmaceutically acceptable salt thereof and a carrier or diluent.
SG174373A1 Devices for separating cells and methods of using them The present invention refers to a device for separating cells of a defined size from a sample and to a system comprising such devices and further components. Such devices can comprise different components, such as inlet module, intermediate module, outlet module and microsieve. The present invention also refers to methods of operating such devices and uses thereof.
SG173636A1 Label-free method for detecting presence or absence of nucleic acids The present invention is directed to a method of detecting presence or absence of a target nucleic acid using negatively charged metallic nanoparticles dissolved in a solution. A nucleic acid probe with a substantially neutral net charge is used for detecting the target nucleic acid. The present invention is also directed to a kit including at least one nucleic acid probe with a substantially neutral net charge and at least one type of negatively charged metallic nanoparticles for carrying out the method.
SG173662A1 A method of communication A method of communication comprising determining whether to use distributing coding between a source (S), relay (R) and destination (D), based on a predetermined transmission rate; if the determination is positive, determining a forward error correction scheme using distributed Alamouti space-time coding, wherein the scheme is determined based on the predetermined transmission rate, a channel signal-to-noise ratio (SNR) and a network topology; relaying coded data from the S to the D using the determined forward error correction.
US8003380 High throughput cell-based assays fabricated with integrated silicon and cell culture technologies The present invention relates to articles and methods involving porous materials (e.g., membranes) which may interact with species, such as biological molecules, cells, etc., whereby the species may adhere to or become immobilized with respect to a surface of the porous material or an adhesion layer coating the porous surface. The porous material may be capable of attaching species with control over the positioning and spatial distribution of the species across the surface of the material. Such articles and methods may be useful in, for example, biological assays, biological sensors, or in the culturing of biological cells.
US8005621 Transcript mapping method A transcript mapping method according to an embodiment of the invention is described hereinafter and combines short tag based (SAGE and MPSS) efficiency with the accuracy of full-length cDNA (flcDNA) for comprehensive characterization of transcriptomes. This method is also referred to as Gene Identification Signature (GIS) analysis. In this method, 5′ and 3′ terminal tags are obtained from a transcript and the terminal tags are for identifying 5′ and 3′ sites located on a genome sequence. Further, occurring segments and thus feasible gene locations are identified along the genome sequence after the 5′ and 3′ sites are identified. A data structure is also generated for indexing the genome sequence so that the terminal tags can be mapped to the genome sequence.
US8003125 Injectable drug delivery systems with cyclodextrin-polymer based hydrogels A cyclodextrin polymer-based injectable composition comprising cyclodextrin, a polymer which is capable of forming a hydrogel with the cyclodextrin, and a pharmacologically effective amount of at least one drug. The polymer is selected from poly(ethylene glycol), derivatives thereon or a copolymer with a poly(ethylene glycol) segment. The copolymer with a poly(ethylene glycol) segment may include a polymer selected from the group consisting of polyesters, polyurethanes, polyamides, polyethers, polysaccharides, poly(amino acid)s, polypeptides, and proteins. The composition may be injected subcutaneously, intramuscularly, intradermally, or intracranially.
US7994946 Systems and methods for scalably encoding and decoding data Systems and methods for scalably encoding and decoding coded data are presented. One exemplary method for scalably coding data includes classifying, based upon at least one predetermined criteria, each of the plurality of data received as either (i) perceptually relevant data or (ii) perceptually irrelevant data. The perceptually relevant data is scalably coded, and the perceptually irrelevant data is non-scalably coded. Subsequently, the scalably coded perceptually relevant data and the non-scalably coded perceptually irrelevant are combined into a coded data stream for transmission.
US7986743 Method for transmitting a digital data stream, transmitter, method for receiving a digital data stream and receiver A method for transmitting a digital signal is described, wherein the digital signal is to be transmitted by a plurality of antennas and a 2-domain pre-transformation is carried out, i.e., in course of a pre-transformation modulation symbols assigned to subcarriers having different frequencies and assigned to subcarriers sent by different antennas are linearly combined.
SG171165A1 A multiple access communication system A multiple access communication system is disclosed herein. In a described embodiment, there is disclosed a method of allocating system bandwidth of the communication system and the method comprises, at step (402), dividing the system bandwidth of the multiple access communication system to form resource blocks amongst which there is one or more pairs symmetric at a carrier frequency; at step (404), assigning a value to each resource block based on the channel qualities and the correlation between the resource block and its counterpart resource block symmetric to the carrier frequency; and at step (406), the symmetric resource blocks are mapped to form respective resource groups based on the values for allocation to respective mobile devices for signal transmission.
US7970064 Transmitter, method for generating a plurality of long preambles and communication device A transmitter that has a determination unit for determining a plurality of symbols (301) such that each symbol (301) has a tail component (302) and the plurality is determined in such a way that the tail components (302) are substantially equal and a tone generation unit for arranging the plurality of symbols (301) to form a plurality of long preambles (300) such that the plurality of long preambles (300) are tone-interleaved.
SG169724A1 A substrate having a surface thereon for inhibiting adhesion of a target cell thereon and a method of preparing the same A substrate having a surface for inhibiting adhesion of a target cell thereon, the substrate comprising an array of generally longitudinal projections having a longitudinal axis that extends from the surface of said substrate and having an aspect ratio of at least 2.5, wherein adjacent projections of said array are configured on the substrate such that the projections at least partially inhibit adhesion of a target cell thereon.
SG169717A1 Powered caster wheel assembly A powered caster wheel assembly is provided. The assembly comprises a first actuator for driving a wheel; a second actuator for steering the wheel; and a mechanical compensating mechanism coupled between the second actuator and the wheel; wherein the mechanical compensating mechanism is arranged for driving the wheel to counter a driving motion of the wheel induced by steering.
US7917361 Spoken language identification system and methods for training and operating same A method for training a spoken language identification system to identify an unknown language as one of a plurality of known candidate languages includes the process of creating a sound inventory comprising a plurality of sound tokens, the collective plurality of sound tokens provided from a subset of the known candidate languages. The method further includes providing a plurality of training samples, each training sample composed within one of the known candidate languages. Further included is the process of generating one or more training vectors from each training database, wherein each training vector is defined as a function of said plurality of sound tokens provided from said subset of the known candidate languages. The method further includes associating each training vector with the candidate language of the corresponding training sample.
US7901607 Method of low temperature imprinting process with high pattern transfer yield The present invention is directed to novel methods of imprinting substrate-supported or freestanding structures at low cost, with high pattern transfer yield, and using low processing temperature. Such methods overcome many of the above-described limitations of the prior art. Generally, such methods of the present invention employ a sacrificial layer of film.
SG168513A1 A method of reducing the dimension of an imprint structure on a substrate A method of reducing the dimension of an imprint structure on a substrate, the method comprising the steps of: (a) providing a substrate having at least one imprint structure thereon, said structure being formed of an inorganic-organic compound comprising an inorganic moiety and a polymer moiety, said polymer moiety having a lower vaporization temperature than the melting point of said inorganic moiety; and (b) selectively removing at least part of the polymer moiety while enabling at least part of the inorganic moiety to form a substantially continuous inorganic phase in said imprint structure, wherein the removal of the at least part of the polymer moiety from the imprint structure reduces the dimension of the imprint structure.
GB2456724B A method of determining as to whether a received signal includes an information signal A method of determining as to whether a received signal includes an information signal is provided. The method provided includes determining a covariance matrix from a received signal and transforming the covariance matrix into a transformed covariance matrix, wherein the transformation is configured such that the transformed covariance matrix is a non-diagonal matrix in case the received signal includes the information signal, wherein the non-diagonal matrix includes non-zero non-diagonal matrix elements. The method provided further includes determining a first function using at least one of the non-zero non-diagonal matrix elements of the transformed covariance matrix, determining a second function using at least one matrix element of the transformed covariance matrix, wherein the second function is different from the first function, and determining as to whether a received signal includes an information signal based on a comparison of a value of the first function and a value of the second function.
US7894516 Method for equalizing a digital signal and equalizer A method for equalizing a digital signal received via at least one communication channel is described, wherein a block of received signal values is processed by a block-iterative equalizer (200). The equalizer comprises a feedback unit (202) and a feed-forward unit (201) each corresponding to the multiplication by a respective matrix. The matrices are updated in the iterative process.
SG167528A1 Method, device, and computer readable medium for determining whether transmission signals are present in received signals A method is provided for determining whether transmission signals are present in received signals, the method comprising: receiving a first signal via a first radio resource; receiving a second signal via a second radio resource; determining whether a first transmission signal is present in the received first signal based on the received second signal; and determining whether a second transmission signal is present in the received second signal based on the received first signal.
SG167194A1 Method and system for maintaining a database of reference images A method and system for maintaining a database of reference images, the database including a plurality of sets of images, each set associated with one location or object. The method comprises the steps of identifying local features of each set of images; determining distances between each local feature of each set and the local features of all other sets; identifying discriminative features of each set of images by removing local features based on the determined distances; and storing the discriminative features of each set of images.
US7876670 Method for transmitting data, method for receiving data, transmitter, receiver, and computer program products A method for transmitting data comprising a plurality of bits is described wherein the data is mapped to a plurality of modulation symbols, each modulation symbol comprising at least one more significant bit and at least one less significant bit, at least one parity bit is generated for the plurality of bits and the plurality of bits are mapped to more significant bits of the plurality of modulation symbols and the at least one parity bit is mapped to at least one less significant bit of the plurality of modulation symbols.
US7876821 Method and an apparatus for controlling the rate of a video sequence; a video encoding device A method for rate control for encoding video sequence, wherein the video sequence includes a plurality of Group Of Pictures, wherein each Group of Picture includes at least and I-frame and an Inter-frame, where the rate control method includes the following steps for the encoding of the Inter-frame in the Group of Picture: determining a desired frame rate based on an available bandwidth of a channel for transmitting the video sequence and an available computational resources for the encoding process; determining a target buffer level based on the desired frame rate and the position of the Inter-frame with respect to the I-frame; and determining a target bit rate based on the target buffer level and the available channel bandwidth, wherein the target bit rate is used for controlling the rate of encoding the video sequence.
CN101189083B Method and apparatus for forging An apparatus (10) for forming an article by forging. The apparatus comprises at least one die (12) having a die cavity (14) to receive material, said material (16) being at least partially molten, and at least one punch (20) adapted to slidably engage the die cavity and to exert a forming pressure on material disposed in the cavity. There is also at least one pin (24) for forming an article feature. The pin is adapted to slidably engage the die and to contact the material, the pin being further adapted to recede upon exertion of the forming pressure and to exert a feature forming pressure when receded and thereby form the article (30) having the article feature when the material solidifies under the forming pressure.
US7868492 Nano-positioning electromagnetic linear actuator A flexure for an electromagnetic nano-positioning linear actuator having a support and an actuating body, the flexure comprising: a first resilient end for attaching to the support; a second resilient end for attaching to the actuating body; and a substantially rigid intermediate portion located between the first resilient end and the second resilient end.
US7869493 Method for detecting a signal, detector and computer program product A method for detecting a signal received via a communication channel, the communication channel being affected by noise, is described, wherein the received signal is processed according to a filtering step (202), the filtering step comprises multiplication of at least one component of the received signal with a filter coefficient and the filter coefficient comprises a noise variance offset which corresponds to the variance of the noise.
SG166297A1 Method of effecting de-differentiation of a cell The invention provides a method of effecting de-differentiation of an at least partially differentiated cell or of maintaining pluripotency and/or self-renewing characteristics of an undifferentiated cell. The method comprises increasing the amount or the activity of an Err protein, or a functional fragment thereof, in the cell.
SG166333A1 An electrically conducting structure for a light transmissible device An electrically conducting structure for a light transmissible device and a method of forming an electrically conducting structure for a light transmissible device are provided. The structure comprises a first transparent conducting material layer formed using first process conditions; at least one other transparent conducting material layer formed directly on the first layer, said at least one other transparent conducting material layer being formed using second process conditions that are different from the first process conditions; and wherein the first layer functions as a buffer layer to reduce adverse effects for the light transmissible device during formation of said at least one other transparent conducting material layer.
US7858080 Aldehyde conjugated flavonoid preparations There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8 position of the flavonoid A ring. The resulting conjugates may be used to form delivery vehicles to deliver high doses of flavonoids, and may also be used as delivery vehicles to deliver an additional bioactive agent.
CN101010367B Nanometer composite material and its preparing method The present invention relates to a process of forming a nanocomposite. The process comprises the steps of treating pristine clay with water in order to swell the clay, exchanging the water with an organic solvent while still maintaining the clay in a swollen state, treating the swollen clay with a modifier and then mixing the treated clay with a substance selected from the group consisting of monomers, oligomers and polymers and combinations thereof. Where necessary, the substance is polymerised and the solvent is being removed either prior to, during or after the polymerization.
SG165854A1 A method and system for concentration detection A method and system for concentration detection. The method for concentration detection comprises the steps of extracting temporal features from brain signals; classifying the extracted temporal features using a classifier to give a score x1; extracting spectral-spatial features from brain signals; selecting spectral-spatial features containing discriminative information between concentration and non-concentration states from the set of extracted spectral-spatial features; classifying the selected spectral-spatial features using a classifier to give a score x2; combining the scores x1 and x2 to give a single score and determining if the subject is in a concentration state based on the single score.
SG164858A1 A light emitting diode structure, a lamp device and a method of forming a light emitting diode structure A light emitting diode structure, a lamp device and a method of forming a light emitting diode structure are provided. The structure comprises a substrate coated with a first reflective material; an electrode coated with a second reflective material, one or more layers of light emitting material, the layers disposed between the substrate and electrode; wherein in use, the first reflective material and second reflective material reflects light out of the structure via at least one light emitting surface and in a direction away from the electrode.
US7822456 Locating a mid-sagittal plane Volumes of interest may be defined, within a three-dimensional brain image, for each of three orthogonal directions. Measures, which may, for example, be energy or entropy measures, are determined for slices of the volumes of interest in the three directions. The volume of interest corresponding to the sagittal direction is then identified. The slice, among the slices in the volume of interest corresponding to the identified sagittal direction, having the optical measure is used to define a first estimate of the mid-sagittal plane. The first estimate of the mid-sagittal plane may then be used to build an input to an optimization technique, which operates until a convergence criterion is satisfied, at which point a final estimate of the mid-sagittal plane may be produced._x000D_ 125
US7811846 Semiconductor devices grown in spherical cavity arrays and its preparation method A method for fabricating an array of semiconductor devices comprising the steps of providing a non-metallic substrate, placing a layer of spheres on said substrate, reducing diameter of the spheres, encapsulating the spheres in a matrix of rigid material, finishing an upper surface of said matrix to expose a portion of said spheres, removing the spheres to form an array of cavities within said matrix, and forming features in said cavities in contact with said substrate so as to form the device.
CN101133558B Method for transmitting data, method for receiving data, transmitter, receiver A method for transmitting data comprising a plurality of bits is described wherein the data is mapped to a plurality of modulation symbols, each modulation symbol comprising at least one more significant bit and at least one less significant bit, at least one parity bit is generated for the plurality of bits and the plurality of bits are mapped to more significant bits of the plurality of modulation symbols and the at least one parity bit is mapped to at least one less significant bit of the plurality of modulation symbols.
SG163846A1 Forming glutathione-capped and metal-doped zinc selenide/zinc sulfide core-shell quantum dots in aqueous solution In a process of forming a capped crystal structure, a precursor solution is heated. The solution comprises a mixture of zinc (Zn) precursor, selenium (Se) precursor, precursor for a dopant, glutathione (GSH), and water. The dopant comprises a transition metal (M). The molar ratio of Zn:Se in the solution may be about 10:3 to about 10:5. The solution is heated for a first period sufficient to allow Zn(M)Se crystal core to form. After the first period of heating, more zinc precursor and GSH are added to the heated solution, and the solution is heated for a second period sufficient to form ZnS crystal shell on the Zn(M)Se crystal core. GSH is added in a sufficient amount to form a GSH layer around the Zn(M)Se/ZnS quantum dot.
US7805001 Method and apparatus for determining asymmetry in an image A method for determining asymmetry in an image such as an MR image of a brain comprises determining a symmetry plane to divide the image into a first part and a second part representative of, for example, the hemispheres of the brain. The probability distributions of voxels against intensities are determined for the first and second parts and histograms of intensities representative of the parts are generated. Compensation is made for any relative shift along a predetermined axis between the histograms. A divergence value based on a distance between the first and second histograms is then calculated and it is determined if the calculated divergence value is greater than a predetermined threshold. A divergence of greater than the predetermined threshold is indicative of asymmetry in the image that may be considered as suspicious for abnormality. There is also disclosed an apparatus for determining asymmetry in an image.
SG162915A1 Novel peptides and protein and uses thereof The present invention relates to a novel gene encoding a protein termed Coiled Coil Domain Containing 95 (CCDC95) or a peptide fragments thereof. The present invention also relates to the use of CCDC95 in Modulation of RGK small binding protein via altering concentration or sub-cellular localisation of RGK small binding protein with CCDC95 or a peptide fragments thereof.
US7783132 Method and apparatus for atlas-assisted interpretation of magnetic resonance diffusion and perfusion images The present invention discloses a method for registering a measured MRI volume image with appropriate anatomical and blood supply territory Atlases to enable Atlas information to be mapped onto the measured MRI volume image. The disclosed arrangements provide an efficient method for mapping brain Atlas information (including gross anatomy and blood supply territories) into magnetic resonance perfusion and diffusion images.
US7783090 Automatic identification of the anterior and posterior commissure landmarks The AC and/or PC landmarks are identified in a midsagittal MRI image by firstly identifying structures in the brain (specifically the fornix and/or brainstem) as groups of pixels in a radiological image which have an intensity in ranges defined by one or more thresholds and which obey predefined geometrical criteria. The thresholds are varied until the predefined geometrical criteria are met. Initial estimates of the position of the AC and/or PC are derived from the identified structures. These estimates can be improved in various ways, especially by making use of axial and/or corona/radiological images in planes including, and/or proximate to, the initial estimated position of the AC and/or PC.
US7778500 Optical fiber strain sensor An optical fiber strain sensor, a method of fabricating the same, and a method of sensing strain. The method of strain sensing comprises providing an optical fiber having a fiber Bragg grating (FBG) formed therein; subjecting the optical fiber to a strain inducing force such that a grating period in a first portion of the FBG compresses and a grating period in a second portion of the FBG extends; and optically interrogating the FBG to determine a measure of a change in bandwidth of the FBG as a result of the compression and extension of the grating periods in the first and second portion respectively; whereby the measure of the change in the bandwidth is representative of the strain induced.
SG162770A1 Magnetically permeable liquid forged articles The present invention relates to magnetically permeable alloys, and articles formed by liquid forging of such alloys. More particularly, the invention relates to a liquid forgeable magnetically permeable Al alloy having at least one alloying element selected from the group consisting of. Fe, Ni and Co. The invention also relates to a method of forming an article with the alloy of any one of claims 1 to 4, the method comprising the steps of. (a) pouring the alloy in molten form into a die cavity; and (b) pressurizing the molten alloy with a punch during solidification of the alloy.
US7734556 Method and system for discovering knowledge from text documents using associating between concepts and sub-concepts A method and a system for discovering knowledge from text documents are disclosed, which involve extracting from text documents semi-structured meta-data, wherein the semi-structured meta-data includes a plurality of entities and a plurality of relations between the entities; identifying from the semi-structured meta-data a plurality of key entities and a corresponding plurality of key relations; deriving from a domain knowledge base a plurality of attributes relating to each of the plurality of entities relating to one of the plurality of key entities for forming a plurality of pairs of key entity and a plurality of attributes related thereto; formulating a plurality of patterns, each of the plurality of patterns relating to one of the plurality of pairs of key entity and a plurality of attributes related thereto; analyzing the plurality of patterns using an associative discoverer; and interpreting the output of the associative discoverer for discovering knowledge.
SG160686A1 A dialogue system and a method for executing a fully mixed initiative dialogue (FMID) interaction between a human and a machine A method for executing a fully mixed initiative dialogue (FMID) interaction between a human and a machine, a dialogue system for a FMID interaction between a human and a machine and a computer readable data storage medium having stored thereon computer code means for instructing a computer processor to execute a method for executing a FMID interaction between a human and a machine are provided. The method comprises retrieving a predefined grammar setting out parameters for the interaction; receiving a voice input; analysing the grammar to dynamically derive one or more semantic combinations based on the parameters; obtaining semantic content by performing voice recognition on the voice input; and assigning the semantic content as fulfilling the one or more semantic combinations.
CN1695306B A method and a device for processing bit symbols generated by a data source A method for processing bit symbols generated by a data source, in particular a video, still image or audio source, comprising the following steps of constructing a plurality of bit-planes from the data source, each bit-plane comprising a plurality of bit-plane symbols; scanning the bit-plane symbols of each bit-plane to generate a binary string of bit-plane symbols; and encoding the binary stringof the bit-plane symbols using a statistical model, wherein the statistical model is based on statistical properties of a Laplacian probability distribution function which characterizes the data source.
US7715607 Automated method for identifying landmarks within an image of the brain A method is disclosed for obtaining the location of a landmark in an MR image of a brain. In a first step, a region of interest in a plane within the MR image containing the landmark is defined. In a second step, the ROI is binarised into foreground and background voxels based on at least one threshold selected using anatomical knowledge. In a third step a set of object voxels is identified from the foreground voxels, excluding voxels which were only classified as object due to proximity of cortical and non-cortical structures. This can be done by morphological processing which reclassifies voxels which may have been incorrectly classified as object, followed by restoring voxels due to the partial volume effect and/or morphological erosion/opening. In a fourth step, an automatic process is then carried out to identify one or more landmarks in the modified binarised image.
US7709542 Proton-exchange composite containing nanoparticles having outer oligomeric ionomer, and methods of forming A proton-exchange composite includes a polymer matrix formed from a proton-exchange polymer and ionomer particles distributed therein. The polymer has side chains with ionic groups. The particles have an average particle size of less than 20 nm and include an oligomeric ionomer that interacts with the polymer and attracts the ionic groups on its side chains. The composite may be formed by a method in which an initiator is bonded to silica particulates. The initiator is used to initiate polymerization of a precursor monomer to form a salt form of the oligomeric ionomer bonded to the silica particulates, which is then reacted with an acid to produce the oligomeric ionomer, thus forming the ionomer particles. The ionomer particles are dispersed in a solution containing a solvent and the polymer dissolved therein. The solvent is removed. The residue is cured to form the composite.
CN101015125B System and method for scalable encoding and decoding data Systems and methods for scalably encoding and decoding coded data are presented. One exemplary method for scalably coding data includes classifying, based upon at least one predetermined criteria, each of the plurality of data received as either (i) perceptually relevant data or (ii) perceptually irrelevant data. The perceptually relevant data is scalably coded, and the perceptually irrelevant data is non-scalably coded. Subsequently, the scalably coded perceptually relevant data and the non-scalably coded perceptually irrelevant are combined into a coded data stream for transmission.
US7704432 Imprint lithographic method for making a polymeric structure An imprint lithographic method for making a polymeric structure comprising the steps of:
    • (a) providing a mold having a shape forming a mold pattern;
    • (b) providing a substrate having a higher surface energy relative to said mold;
    • (c) providing a polymer film on said mold, said polymer film having a selected thickness, wherein the selected thickness of the polymer film on the mold pattern is capable of forming at least one frangible region in the polymer film having a thickness that is less than the remainder of the polymer film;
    • (d) pressing the mold and the substrate relatively toward each other to form said frangible region; and
    • (e) releasing at least one of said mold and said substrate from the other, wherein after said releasing, said frangible region remains substantially attached to said mold while the remainder of said polymer film forms the polymeric structure attached to said substrate.
US7702190 Fiber Bragg grating sensor An optical fiber strain sensor, a method of fabricating the same, and a method of sensing strain (1200). The method of strain sensing comprises providing an optical fiber having at least a first fiber Bragg grating (FBG) and a second FBG formed therein (1202); subjecting the optical fiber to a strain inducing force such that a grating period in the first FBG compresses and a grating period in the second FBG extends (1204); and optically interrogating the first and second FBG to determine peak reflection wavelengths of the first and second FBGs respectively (1206), whereby a separation between the peak reflection wavelengths of the first and second FBGs is representative of the strain induced.
SG159198A1 A system and method for detecting skin penetration A system and method for detecting skin penetration. The system comprises an invasive component for penetrating the skin; a dummy electrode for making contact with the surface of the skin; at least one penetrating electrode disposed in the invasive component; and a Wheatstone bridge circuit; wherein a resistance across the dummy electrode and the penetrating electrode constitutes one of the resistive legs of the Wheatstone bridge circuit and skin penetration of the invasive component is detected based on a differential output voltage from the Wheatstone bridge circuit.
SG158462A1 Two-photon stereolithography using photocurable compositions Two-photon stereolithography can be performed using a photocurable material comprising a poly(meth)acrylate having a (meth)acrylate functionality of at least 3 and a molecular weight (MW) of at least 650, a urethane(meth)acrylate having a (meth)acrylate functionality of 2 to 4 and a MW of 400 to 10,000, a di(meth)acrylate made from bisphenol A or bisphenol F; and a photoinitiator. A beam of light is focused to a focus region of the material to induce two-photon absorption in the focus region, and thus polymerization of the material in the focus region. The beam is scanned across said material according to a pre-selected pattern so that the beam is focused to different pre-selected regions, to induce polymerization of the material at the pre-selected regions.
US7656319 Context-based encoding and decoding of signals A system for the context-based for the context-based encoding of an input signal includes a domain transform module and a context-based coding module. The domain transform module is operable to convert the input signal into a sequence of transform coefficients c[i]. The context-based coding module includes a bit-plane scanning module, and context modeling module, and a statistical encoding module. The bit-plane scanning module is operable to produce a bit-plane symbol bps [i,bp] for each transform coefficient c[i] and each bit-plane [bp]. The context modeling module is operable to assign one or more context values to each of the received bit plane symbols bps [i,bp]. The statistical coding module is operable to code each of the bit plane symbols bps [i,bp] as a function of one or more of the corresponding context values to produce a context-based encoded symbol stream.
CN100584023C Method and equipment for context-based signal coding and decoding A system for the context-based for the context-based encoding of an input signal includes a domain transform module and a context-based coding module. The domain transform module is operable to convert the input signal into a sequence of transform coefficients c[i]. The context-based coding module includes a bit-plane scanning module, and context modeling module, and a statistical encoding module. The bit-plane scanning module is operable to produce a bit-plane symbol bps [i, bp] for each transform coefficient c[i] and each bit-plane [bp]. The context modeling module is operable to assign one or more context values to each of the received bit plane symbols bps [i, bp]. The statistical coding module is operable to code each of the bit plane symbols bps [i, bp] as a function of one or more of the corresponding context values to produce a context-based encoded symbol stream.
SG156783A1 Ultraviolet detector and dosimeter A UV light detector is disclosed that has a UV sensing element comprising a substrate and a thin film layer formed on the substrate. The thin film layer is for receiving and converting UV light into electricity for a photovoltaic output. First and second electrodes are formed on one surface of the thin film layer and are configured to form an electric polarization in the thin film layer between the first and second electrodes and to collect the photovoltaic output. There is also an amplifier and an output display. The UV sensing element is configured to collect the photovoltaic output, the amplifier being configured to receive the photovoltaic output from the UV sensing element, the output display being configured to provide a display when UV light is received at the one surface, the display being derived from the photovoltaic output. A UV dosimeter is also disclosed.
US7598104 Method of forming a metal contact and passivation of a semiconductor feature A method of forming a metal contact and passivation of a semiconductor feature, and devices made using the method. The method comprises the steps of forming a dielectric mask on a semiconductor substrate utilising photolithography processes; etching the semiconductor substrate such that one or more features are formed underneath respective portions of the dielectric mask; depositing a passivation layer on the substrate with the dielectric mask in place above the features; subjecting the substrate to an etchant such that the dielectric mask is etched at a higher rate than the passivation layer, whereby portions of the passivation layer deposited on the dielectric mask are lifted off from the substrate; and depositing a metal layer on the substrate including over the remaining passivation layer and exposed portions of the features.
SG155143A1 Method of forming gallium arsenide-on-insulator A method of forming gallium arsenide (GaAs)-on-insulator including providing a substrate and forming a diffusion barrier layer of a compound of formula Al,Ga1_,As on the substrate. A layer of GaAs is formed on the diffusion barrier layer of Al,,Ga1_,,As. The layer of Al,,Ga1_ ,BAs is substantially completely oxidised to transform the layer of Al,,Ga1_,,As into an electrical insulator as well as a diffusion barrier.
SG154711A1 A system and method for processing brain signals in a BCI system A system and method for processing brain signals in a BCI system. The method of processing brain signals in a BCI system comprises the steps of processing the brain signals for control state detection to determine if a subject intends to use the BCI system; and processing the brain signals for command recognition if the control state detection method determines that the subject intends to use the BCI system.
SG152947A1 Method and apparatus for imaging a sample A method of imaging a stationary sample having features with anisotropic light scattering characteristics, the method comprising: performing a plurality of angular illuminations of the sample according to a pattern of angular illumination controlled by a controller so as to specify an optical path for light scattered by the sample; recording images of the sample corresponding to the plurality of angular illuminations of the sample; processing the recorded images to form a computed image.
SG152439A1 A micromechanical structure and a method of fabricating a micromechanical structure A micromechanical structure and a method of fabricating a micromechanical structure are provided. The micromechanical structure comprises a silicon (Si) based substrate; a micromechanical element formed directly on the substrate; and an undercut formed underneath a released portion of the micromechanical element; wherein the undercut is in the form of a recess formed in the Si based substrate.
SG141417A1 Micromachined electromechanical device A method for fabricating a MEMS device comprises providing a substrate having a back side, a front side opposite to the back side and a periphery portion. A desired microstructure is formed on the back side of the substrate. The substrate is then supported for rotation. A precursor solution is deposited on the front side of the substrate during rotation so that a thin film layer may be formed to thereon. During formation of the thin film layer, the substrate is supported and rotated that the microstructure formed on the back side is protected. (Figures 1A - 1H)
US7532763 Method and a device for processing bit symbols generated by a data source; a computer readable medium; a computer program element A method for processing bit symbols generated by a data source, in particular a video, still image or audio source, comprising the following steps of constructing a plurality of bit-planes from the data source, each bit-plane comprising a plurality of bit-plane symbols; scanning the bit-plane symbols of each bit-plane to generate a binary string of bit-plane symbols; and encoding the binary string of the bit-plane symbols using a statistical model, wherein the statistical model is based on statistical properties of a Laplacian probability distribution function which characterizes the data source.
SG150219A1 Power supply device and system A power supply device and system have an electrically polarized element in which a remnant electrical polarization is formed and retained. Electrodes are formed on the electrically polarized elements and the remnant electrical polarization generates an electrical potential on the electrodes. Electrical circuits are coupled to the electrically polarized element to control the external electric charges attracted and distributed on the electrodes, for establishing the electrical potential on the electrodes. The electrodes can output electric currents by controlling the external electric charges distribution. The electrically polarized element may be made of ferroelectric material, including a ferroelectric bulk ceramic, ferroelectric multilayer ceramic, ferroelectric single crystal, ferroelectric thin film, ferroelectric thick film and ferroelectric polymer, and all the other materials with electric polarization retained therein. Power supply devices and systems made according to the present invention have very long standby time, small in size and efficient for many applications including RF systems.
EP1756950B1 Systems and methods for scalably encoding and decoding data Systems and methods for scalably encoding and decoding coded data are presented. One exemplary method for scalably coding data includes classifying, based upon at least one predetermined criteria, each of the plurality of data received as either (i) perceptually relevant data or (ii) perceptually irrelevant data. The perceptually relevant data is scalably coded, and the perceptually irrelevant data is non-scalably coded. Subsequently, the scalably coded perceptually relevant data and the non-scalably coded perceptually irrelevant are combined into a coded data stream for transmission.
US7511807 Method and apparatus for detection of inclusion in glass Inclusions in a transparent panel (5) are detected by placing a light transmissive interface (3) in contact with the panel (5), and transmitting a beam of light (1) through interface (3) into panel (5). Within the panel (5), the light beam (7) propagates along a path including total internal reflections at surfaces of panel (5). When the light beam (1) intercepts inclusions (10) or other defects at least some of it is scattered, and leaves the panel (5). This scattered light is then observed. Thus, a large zone of the panel (5) can be inspected, with light only being detected in the case that it arises from scattering by inclusions or other defects.
SG149600A1 Compact optical detection system A detection system is provided, the detection system comprising a light source that generates excitation light having a wavelength sufficient to excite a fluorophore in a sample; an excitation filter positioned along a first line along a path of the excitation light, the excitation filter transmitting the excitation light from the light source; a beam splitter positioned along the first line, the beam splitter reflecting the excitation light transmitted by the excitation filter along a second line toward a mirror positioned on one side of the beam splitter, and passing emitted light reflected along the second line; the mirror, positioned to reflect the excitation light from the beam splitter to the fluorophore in the sample along a third line, normal to both the first and second lines, wherein the mirror further reflects emitted light emitted along the third line, along the second line toward the beam splitter; an emission filter positioned along the second line, on a second side of the beam splitter; and a detector that detects the emitted light transmi